AstraZeneca: Asthma trials

The registry lists 358 Asthma studies with AstraZeneca as lead sponsor. 18 are open to participants now and 129 have results posted.

Phase 1 46Phase 2 52Phase 3 122Phase 4 23No phase 117(a study in two phases counts in both)

Studies

Page 1 of 4. Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Changes in Symptom and Quality of Life in Patients With Uncontrolled Asthma Treated With Budesonide/Glycopyrronium/Formoterol Fumarate Metered Dose Inhaler (BGF MDI)Not yet recruitingNCT07933510
• Impact of GDMT in Uncontrolled Asthma Patients Receiving MHD Inhaled Corticosteroids + Long-acting β2 AgonistRecruitingNCT07718724Not applicable
• BREZTRI REGULATORY POST MARKETING SURVEILLANCE IN KOREARecruitingNCT07570394
• A Phase II Study to Investigate Lung Function With 2 Different Doses of Inhaled Glycopyrronium Taken With BFF Compared to BFF in Participants of 4 to Less Than 12 Years of Age With AsthmaRecruitingNCT07525375Phase 2
• Explore the Diagnostic Value of Bronchodilation Test With Portable Oscillometry in Asthma DiagnosisRecruitingNCT07516184Not applicable
• Roll-over Study for Participants Who Have Completed a Previous Clinical Study With Benralizumab (Fasenra) and Benefit From Continued TreatmentRecruitingNCT07444567Phase 3
• ReAl-woRld Evaluation of tEzepelumab for Chronic rhinoSinusitis With Nasal Polyps in RussiaRecruitingNCT07399665
• Phase 3b Study in Patients With Severe Asthma Treated With TezepelumabRecruitingNCT07363642Phase 3
• Assess Accuracy of Primary Care Asthma and COPD Diagnosis Using Oscillometry and FeNO vs Specialist DiagnosisRecruitingNCT07245576
• Tezepelumab (Tezspire) Regulatory Postmarketing Surveillance in KoreaNot yet recruitingNCT06998095
• Dose Range Finding Study to Assess Efficacy and Safety of Tozorakimab in Adults With Uncontrolled Asthma on Medium-to-High Dose Inhaled CorticosteroidsRecruitingNCT06932263Phase 2
• A Multicentre, Single Arm, Non-interventional, Real-world Study to Assess Demographic Characteristics and Patient Reported Outcomes in Patients With Severe Eosinophilic Asthma Treated With Benralizumab in ChinaRecruitingNCT06862206
• Clinical and demOgRaphic Features of Patients With Uncontrolled Severe Asthma in Russia (CORSAR)RecruitingNCT06472310
• A Study to Investigate Efficacy and Safety of PT027 Compared With PT007 in Symptomatic Chinese Adults With AsthmaRecruitingNCT06471257Phase 3
• A Non-interventional, Prospective Study With BenralizumabRecruitingNCT06422078
• A Translational Study to Describe Clinical Characteristics, Biomarkers and to Identify Phenotypes and Endotypes Associated With Differential Outcomes in Chinese PopulationRecruitingNCT06419413
• Evaluating the Efficacy and Safety of PT027 Compared With PT007 Administered As Needed in Participants 12 to < 18 Years of Age With AsthmaRecruitingNCT06307665Phase 3
• A Study to Investigate the Efficacy and Safety of Tezepelumab Compared With Placebo in Children 5 to < 12 Years Old With Severe AsthmaRecruitingNCT06023589Phase 3
• A Study Evaluating the Effect of Inhaled PT007(AS MDI) Versus Placebo MDI and Ventolin Evohaler on Lung Function in Adult Participants With AsthmaCompletedNCT06644924Phase 2Results posted
• A Study to Investigate the Effects of PT027 (Budesonide/Albuterol Sulfate) Metered-dose Inhaler Compared With Placebo on Exercise-Induced Bronchoconstriction in Adult Patients With AsthmaCompletedNCT06245551Phase 3Results posted
• Study to Assess Bronchospasm Potentially Induced by Next-Generation Propellant vs HFA Propellant in an MDI in Participants With Well/Partially Controlled AsthmaCompletedNCT05850494Phase 3Results posted
• A 12-week Study to Assess the Efficacy and Safety of Budesonide and Formoterol Fumarate Metered Dose Inhaler Relative to Budesonide Metered Dose Inhaler in Participants With Inadequately Controlled Asthma (LITHOS)CompletedNCT05755906Phase 3Results posted
• PT027 Compared to PT007 in Patients With Asthma With Mannitol-induced Acute Airway ObstructionCompletedNCT05555290Phase 3Results posted
• BURAN: Benralizumab on Airway Dynamics in Severe Eosinophilic Asthma Using Functional Respiratory ImagingCompletedNCT05552508Phase 4Results posted
• CARE FOR ALL：an Evaluation of an Asthma QIPCompletedNCT05440097Phase 4Results posted
• Tezepelumab Efficacy and Safety in Reducing Oral Corticosteroid Use in Adults With Oral Corticosteroid Dependent AsthmaTerminatedNCT05398263Phase 3Results posted
• FAsenra Safety Trial in IndiaCompletedNCT05384938Phase 4Results posted
• Effectiveness and Safety Study of Tezepelumab in Adults & Adolescent Participants With Severe Asthma in the United StatesCompletedNCT05329194Phase 4Results posted
• Study to Evaluate Efficacy and Safety of Tezepelumab in Reducing Oral Corticosteroid Use in Adult Patients With Severe AsthmaCompletedNCT05274815Phase 3Results posted
• A 24-Week Efficacy and Safety Study to Assess Budesonide and Formoterol Fumarate Metered Dose Inhaler in Adult and Adolescent Participants With Inadequately Controlled Asthma (VATHOS)CompletedNCT05202262Phase 3Results posted
• Study to Assess the Effect of Tezepelumab on the Immune Response to Influenza Vaccination in Participants With AsthmaCompletedNCT05062759Phase 3Results posted
• US PRECISION Implementation StudyCompletedNCT04891978Not applicableResults posted
• Managing Asthma Patients With AMAZE™: A Novel Disease Management PlatformCompletedNCT04868500Not applicableResults posted
• Study to Evaluate the Pharmacokinetics of Tezepelumab in Children With AsthmaCompletedNCT04673630Phase 1Results posted
• Efficacy and Safety of Inhaled AZD1402 Administered for Four Weeks in Adults With Asthma on Medium-to-High Dose Inhaled CorticosteroidsTerminatedNCT04643158Phase 2Results posted
• Study to Assess PT010 in Adult and Adolescent Participants With Inadequately Controlled Asthma (LOGOS)CompletedNCT04609904Phase 3Results posted
• Study to Assess PT010 in Adult and Adolescent Participants With Inadequately Controlled Asthma (KALOS)CompletedNCT04609878Phase 3Results posted
• Study to Assess the Efficacy and Safety of MEDI3506 in Adults With Uncontrolled Moderate-to-severe AsthmaCompletedNCT04570657Phase 2Results posted
• PK/PD and Long Term Safety Study of Benralizumab in Children With Severe Eosinophilic AsthmaCompletedNCT04305405Phase 3Results posted
• A Study to Assess the Reduction of Daily Maintenance ICS/LABA Treatment Towards Anti-Inflammatory Reliever Treatment in Patients With Severe Eosinophilic Asthma Treated With BenralizumabCompletedNCT04159519Phase 4Results posted
• Efficacy and Safety Study of Benralizumab in Patient With Eosinophilic Chronic Rhinosinusitis With Nasal Polyps (ORCHID)TerminatedNCT04157335Phase 3Results posted
• Long-term Safety of Tezepelumab in Japanese Subjects With Inadequately Controlled Severe AsthmaCompletedNCT04048343Phase 3Results posted
• Tezepelumab Home Use StudyCompletedNCT03968978Phase 3Results posted
• Study to Evaluate Tezepelumab in Adults With Severe Uncontrolled AsthmaCompletedNCT03927157Phase 3Results posted
• An Exploratory Study to Characterise Changes in Airway Inflammation, Symptoms, Lung Function and Reliever Use in Adult Asthma PatientsCompletedNCT03924635Phase 4Results posted
• A Study in Healthy Volunteers and Patients With Mild Asthma to Investigate the Safety, Anti-inflammatory Effect of Inhaled AZD0449CompletedNCT03766399Phase 1Results posted
• Extension Study to Evaluate the Safety and Tolerability of Tezepelumab in Adults and Adolescents With Severe, Uncontrolled AsthmaCompletedNCT03706079Phase 3Results posted
• Study to Evaluate Tezepelumab on Airway Inflammation in Adults With Uncontrolled Asthma (CASCADE)CompletedNCT03688074Phase 2Results posted
• A Study to Assess the Efficacy and Safety of Multiple Dose Levels of AZD7594 Administered Once Daily by Inhalation in Asthmatic SubjectsCompletedNCT03622112Phase 2Results posted
• Study to Evaluate Efficacy and Safety of Benralizumab in Reducing Oral Corticosteroid Use in Adult Patients With Severe AsthmaCompletedNCT03557307Phase 3Results posted
• Study to Evaluate the Efficacy and Safety of Tezepelumab in Reducing Oral Corticosteroid Use in Adults With Oral Corticosteroid Dependent AsthmaCompletedNCT03406078Phase 3Results posted
• Assessment of the Safety, Efficacy, PK, and Extrapulmonary Pharmacodynamics (PD) of Albuterol Sulfate Pressurized Inhalation Suspension (Hereafter Referred to as AS MDI) Compared to Proventil as an Active Control in Subjects With AsthmaCompletedNCT03371459Phase 2Results posted
• Study to Compare PT007 to Placebo MDI and Open-Label Proventil® HFA in Adult and Adolescent Subjects With AsthmaCompletedNCT03364608Phase 2Results posted
• Efficacy and Safety of PT001 to Placebo and Open-label Spiriva® Respimat® in Subjects With Persistant AsthmaCompletedNCT03358147Phase 2/3Results posted
• Study to Evaluate Tezepelumab in Adults & Adolescents With Severe Uncontrolled AsthmaCompletedNCT03347279Phase 3Results posted
• Efficacy and Safety Study of Benralizumab in Patients With Uncontrolled Asthma on Medium to High Dose Inhaled Corticosteroid Plus LABA (MIRACLE)CompletedNCT03186209Phase 3Results posted
• A Study of the Safety and Effectiveness of Benralizumab to Treat Patients With Severe Uncontrolled Asthma.CompletedNCT03170271Phase 3Results posted
• Pharmacokinetic Comparability of Benralizumab Using Accessorized Pre-Filled Syringe or Autoinjector in Healthy VolunteersCompletedNCT02968914Phase 1Results posted
• Study to Assess Functionality, Reliability, and Performance of a Single-Use Auto-Injector With Benralizumab Administered at HomeCompletedNCT02918071Phase 3Results posted
• A Study to Evaluate the Safety of Tralokinumab in Adults and Adolescents With Uncontrolled AsthmaTerminatedNCT02902809Phase 3Results posted
• AZD1419 Ph2a StudyCompletedNCT02898662Phase 2Results posted
• A Study to Evaluate the Onset of Effect and Time Course of Change in Lung Function With Benralizumab in Severe, Uncontrolled Asthma Patients With Eosinophilic InflammationCompletedNCT02869438Phase 3Results posted
• Study to Evaluate the Effect of Benralizumab on Allergen-Induced Inflammation in Mild, Atopic AsthmaticsCompletedNCT02821416Phase 3Results posted
• Safety, Tolerability and Pharmacokinetics of Multiple Ascending Doses of AZD8871 in Healthy SubjectsCompletedNCT02814656Phase 1Results posted
• Study to Evaluate the Potential Effect of Benralizumab on the Humoral Immune Response to the Seasonal Influenza Vaccination in Adolescent and Young Adult Patients With Severe AsthmaCompletedNCT02814643Phase 3Results posted
• A Safety Extension Study With Benralizumab for Asthmatic Adults on Inhaled Corticosteroid Plus Long-acting β2 AgonistCompletedNCT02808819Phase 3Results posted
• A Single Dose PD & PK Study With Two Formulations of Abediterol in Patients With AsthmaCompletedNCT02777827Phase 1Results posted
• A Study to Assess the Bioavailability and to Compare the Pharmacokinetics of AZD7594 Inhaled Via Monodose Inhaler and Multiple-dose Dry Powder Inhalers (DPI) or Pressurized Metered-dose Inhaler (pMDI) in Healthy Male SubjectsCompletedNCT02648438Phase 1Results posted
• A Study to Assess the Safety, Tolerability and Pharmacokinetics of AZD7594 Inhaled Formulation in Healthy Japanese MenCompletedNCT02645253Phase 1Results posted
• Two-part Safety, Tolerability, Pharmacodynamic and -Kinetic Study of Inhaled AZD8871 in Asthmatic and COPD SubjectsCompletedNCT02573155Phase 1Results posted
• A Study to Evaluate the Pharmacokinetics of MEDI9929 (AMG 157) in Adolescents With Mild to Moderate AsthmaCompletedNCT02512900Phase 1Results posted
• A Study in Asthma Patients to Evaluate Efficacy, Safety and Tolerability of 14 Days Once Daily Inhaled Interferon Beta-1a After the Onset of Symptoms of an Upper Respiratory Tract InfectionCompletedNCT02491684Phase 2Results posted
• A Multiple Dosing (14 Days) Study to Assess Efficacy and Safety of Three Dose Levels of AZD7594, Given Once Daily by Inhalation, in Patients With Mild to Moderate AsthmaCompletedNCT02479412Phase 2Results posted
• Study to Evaluate Efficacy & Safety of Tralokinumab in Subjects With Asthma Inadequately Controlled on CorticosteroidsCompletedNCT02449473Phase 2Results posted
• Chronic Dosing Cross-Over Study to Assess the Efficacy and Safety of Glycopyrronium (PT001) in Adult Subjects With Intermittent Asthma or Mild to Moderate Persistent AsthmaCompletedNCT02433834Phase 2Results posted
• Study to Assess Functionality, Reliability, and Performance of a Pre-filled Syringe With Benralizumab Administered at HomeCompletedNCT02417961Phase 3Results posted
• Comparing the Efficacy of Bricanyl M2 and Bricanyl M3 at 0.5 and 1.5 mg Dose Levels, to Allow for a Switch From Bricanyl Turbuhaler M2 to Bricanyl Turbuhaler M3CompletedNCT02322788Phase 3Results posted
• Study to Evaluate the Efficacy and Safety of Benralizumab in Adult Patients With Mild to Moderate Persistent AsthmaCompletedNCT02322775Phase 3Results posted
• Phase 3 Study to Evaluate the Efficacy & Safety of Tralokinumab in Adults & Adolescents With OCS Dependent AsthmaCompletedNCT02281357Phase 3Results posted
• A Safety Extension Study to Evaluate the Safety and Tolerability of Benralizumab (MEDI-563) in Asthmatic Adults and Adolescents on Inhaled Corticosteroid Plus LABACompletedNCT02258542Phase 3Results posted
• A Clinical Study to Evaluate Symbicort Turbuhaler Used 'as Needed' in Adults and Adolescents With AsthmaCompletedNCT02224157Phase 3Results posted
• A Phase 3 Study to Evaluate the Efficacy and Safety of Tralokinumab in Adults and Adolescents With Uncontrolled AsthmaCompletedNCT02194699Phase 3Results posted
• A Phase 3 Study to Evaluate the Efficacy and Safety of Tralokinumab in Adults and Adolescents With Uncontrolled AsthmaCompletedNCT02161757Phase 3Results posted
• A Clinical Study to Evaluate Symbicort Turbuhaler Used 'as Needed' in Adults and Adolescents With Asthma.CompletedNCT02149199Phase 3Results posted
• Study to Assess the Efficacy and Safety of Budesonide (PT008) in Adult Subjects With Mild to Moderate Persistent AsthmaCompletedNCT02105012Phase 2Results posted
• A 12-Week Study in Asthmatic Children Ages 6 to <12 Years, Investigating the Efficacy and Safety of Symbicort pMDI 80/2.25 μg and Symbicort pMDI 80/4.5 μg, Compared With Budesonide pMDI 80 μgCompletedNCT02091986Phase 3Results posted
• A Study of Tralokinumab When Delivered Subcutaneously at Different Flow Rates to Healthy VolunteersCompletedNCT02085473Phase 1Results posted
• Efficacy and Safety Study of Benralizumab to Reduce OCS Use in Patients With Uncontrolled Asthma on High Dose Inhaled Corticosteroid Plus LABA and Chronic OCS TherapyCompletedNCT02075255Phase 3Results posted
• Two-part Pharmacokinetic and Pharmacodynamic Study of LAS190792 in Patients With Asthma and COPDCompletedNCT02059434Phase 1Results posted
• Study to Evaluate the Efficacy and Safety of MEDI9929 (AMG 157) in Adult Subjects With Inadequately Controlled, Severe AsthmaCompletedNCT02054130Phase 2Results posted
• Efficacy and Safety Study of Benralizumab Added to Medium-dose Inhaled Corticosteroid Plus LABA in Patients With Uncontrolled AsthmaTerminatedNCT01947946Phase 3Results posted
• Efficacy and Safety Study of Benralizumab Added to High-dose Inhaled Corticosteroid Plus LABA in Patients With Uncontrolled AsthmaCompletedNCT01928771Phase 3Results posted
• Efficacy and Safety Study of Benralizumab in Adults and Adolescents Inadequately Controlled on Inhaled Corticosteroid Plus Long-acting β2 AgonistCompletedNCT01914757Phase 3Results posted
• Distribution of Neutrophils in Bronchial Mucosal Tissue in Asthma Patients Before and After 4 Weeks Treatment With AZD 5069CompletedNCT01890148Phase 1Results posted
• Roflumilast Plus Montelukast in Adults With Severe AsthmaCompletedNCT01765192Phase 2Results posted
• A Phase II Study to Evaluate the Efficacy, Safety and Tolerability of AZD5069 in Patients With Uncontrolled Persistent Asthma.CompletedNCT01704495Phase 2Results posted
• Efficacy and Safety Study to Compare Formoterol Fumerate in the Pressair DPI to the Foradil Aerolizer in Patient With Mild to Moderate AsthmaCompletedNCT01641081Phase 2Results posted
• A Phase 1, Open-label Study to Investigate the Pharmacokinetics of Tralokinumab (CAT-354) in Adolescents With AsthmaCompletedNCT01592396Phase 1Results posted
• Effect of High Dose Ciclesonide on Asthma ControlCompletedNCT01455194Phase 3Results posted
• A 6 Month Safety Study Comparing Symbicort With Inhaled Corticosteroid Only in Asthmatic Adults and AdolescentsCompletedNCT01444430Phase 3Results posted