AstraZeneca: Asthma trials

The registry lists 359 Asthma studies with AstraZeneca as lead sponsor. 19 are open to participants now and 129 have results posted.

Phase 1 46Phase 2 52Phase 3 123Phase 4 23No phase 117(a study in two phases counts in both)

Studies

Page 2 of 4. Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• A 6 Month Safety Study Comparing Symbicort With Inhaled Corticosteroid Only in Asthmatic Adults and AdolescentsCompletedNCT01444430Phase 3Results posted
• Single Dose Study to Assess Efficacy, Safety and Tolerability of LAS100977 in Asthmatic Patients.CompletedNCT01425801Phase 2Results posted
• A Safety and Efficacy Study of Tralokinumab in Adults With AsthmaCompletedNCT01402986Phase 2Results posted
• New Breath Actuated MDI Symbicort Compared to Symbicort pMDI and Budesonide pMDI for 12 Weeks Twice a DayCompletedNCT01360021Phase 3Results posted
• Evaluation of the Pharmacokinetics and the Pharmacodynamics of Different Dry Powder Inhalation Formulations of AZD3199 in Patients With AsthmaCompletedNCT01348139Phase 2Results posted
• Study to Evaluate the Efficacy and Safety of MEDI-563 in Adults With Uncontrolled AsthmaCompletedNCT01238861Phase 2Results posted
• The Study Will Evaluate the Efficacy of AZD5423 in Patients With Mild Asthma Challenged With an Inhaled AllergenCompletedNCT01225549Phase 2Results posted
• Investigation of Efficacy, Safety and Tolerability of Once and Twice Daily Doses of AZD1981 in Asthmatic PatientsCompletedNCT01197794Phase 2Results posted
• A Study in Asthmatic Children (6 to <12 Yrs) Comparing Single Doses of Formoterol and Foradil® Evaluating EfficacyCompletedNCT01136655Phase 2Results posted
• A 6-week Study in Asthmatic Children Aged 6 to <12 Yrs Comparing Budesonide pMDI 160ug Twice Daily With PlaceboCompletedNCT01136382Phase 2Results posted
• To Investigate the Relative Efficacy of Terbutaline Turbuhaler® and Salbutamol Pressurized Metered Dose Inhaler (pMDI) a Single Blind StudyCompletedNCT01096017Phase 3Results posted
• The Tolerability and Effects of AZD8848 in Allergic Asthma Subjects Challenged With Inhaled AllergenCompletedNCT00999466Phase 2Results posted
• A Study to Assess Pharmacokinetics, Safety and Tolerability of Multiple Doses of CAT-354 in Subjects With Moderate AsthmaTerminatedNCT00974675Phase 1Results posted
• A Study to Evaluate the Effectiveness and Safety of MEDI-528 in AdultsCompletedNCT00968669Phase 2Results posted
• Study to Investigate Real Life Effectiveness of Symbicort Maintenance and Reliever Therapy in Asthma Patients Across AsiaCompletedNCT00939341Phase 4Results posted
• Study to Evaluate the Safety and Efficacy of CAT-354CompletedNCT00873860Phase 2Results posted
• Study to Evaluate Efficacy and Safety of Pulmicort Respules in Japanese Adult Asthmatic PatientsCompletedNCT00855959Phase 3Results posted
• Study to Investigate the Efficacy of Symbicort® SMART.CompletedNCT00839800Phase 3Results posted
• Study to Investigate the Safety and Efficacy of High Dose of Symbicort® SMART in Japanese PatientsCompletedNCT00837967Phase 3Results posted
• A Phase 2a Study to Evaluate the Safety and Tolerability of Benralizumab (MEDI-563) in Adults With AsthmaCompletedNCT00783289Phase 2Results posted
• A Phase 2 Study to Evaluate the Safety and Efficacy of Intravenously Administered Benralizumab (MEDI-563).CompletedNCT00768079Phase 2Results posted
• One Month Dose Response Study of AZD1981 in Asthma Patients Uncontrolled on Inhaled SteroidsCompletedNCT00758589Phase 2Results posted
• Single-dose Crossover Study to Investigate Pharmacodynamics of AZD3199CompletedNCT00736489Phase 2Results posted
• Phase4/Symbicort® Versus Pulmicort Flexhaler® in African AmericansCompletedNCT00702325Phase 4Results posted
• Study Comparing Budesonide Hydrofluoroalkane (HFA) vs Chlorofluorocarbon (CFC) Pressurized Metered Dose Inhalers (pMDI) in Patients With Mild to Moderate AsthmaCompletedNCT00667992Phase 3Results posted
• A Study to Assess the Efficacy, Safety, and Tolerability of CAT-354 in Subjects With AsthmaTerminatedNCT00640016Phase 2Results posted
• A Study to Assess Bioavailability and Pharmacokinetics of CAT- 354CompletedNCT00638989Phase 1Results posted
• A Comparison of Symbicort® Single Inhaler Therapy and Conventional Best Practice for the Treatment of Persistent AsthmaCompletedNCT00628758Phase 3Results posted
• A Post Marketing Evaluation of the Effectiveness of FluMist Risk Minimization Plan in ChildrenCompletedNCT00626808Results posted
• A Phase 2A Study to Evaluate the Safety and Effect on Exercise Challenge Testing of MEDI-528 in Adults With AsthmaTerminatedNCT00590720Phase 2Results posted
• Symbicort Maintenance and Reliever Therapy - Experience in Real Life Setting in MalaysiaCompletedNCT00576316Phase 4Results posted
• Evaluation of Safety and Efficacy of Symbicort® pMDI, With or Without Spacer, in Children (6-11 Years) With AsthmaCompletedNCT00536913Phase 3Results posted
• Symbicort Rapihaler Therapeutic Equivalence StudyCompletedNCT00536731Phase 3Results posted
• Safety and Efficacy Study of Budesonide (Pulmicort®) Turbuhaler® in Japanese Children With Bronchial AsthmaCompletedNCT00509028Phase 3Results posted
• A Study to Evaluate the Safety and Tolerability of the Administration of MEDI-528 When Administered in Multiple Doses to Adults With Mild Persistent AsthmaCompletedNCT00507130Phase 2Results posted
• A Study to Evaluate the Effect of a Single-Dose Intravenous Administration of MEDI-528TerminatedNCT00483041Phase 2Results posted
• Local Phase 4 Pan-European SMART StudyCompletedNCT00463866Phase 4Results posted
• A Comparison of SYMBICORT® pMDI With Budesonide HFA pMDI in African American Subjects With Asthma.CompletedNCT00419952Phase 3Results posted
• An Efficacy Study Comparing SYMBICORT® Pressurised Metered Dose Inhaler (pMDI) With Budesonide Hydrofluoroalkanes (HFA) pMDI, in Hispanic Subjects With ICS Dependent AsthmaCompletedNCT00419757Phase 3Results posted
• Asthma Care With Alvesco® (Ciclesonide) in Primary Care in Adults - The ACCEPT-study (BY9010/CA-102)CompletedNCT00404547Phase 4Results posted
• A Study to Evaluate the Efficacy of MEDI-528 on Late Asthmatic Response With Atopic AsthmaCompletedNCT00394654Phase 2Results posted
• Efficacy and Safety of Ciclesonide (CIC) Administered Twice Daily in Pediatric Patients With Asthma.CompletedNCT00392288Phase 3Results posted
• Symbicort Single Inhaler Therapy vs Conventional Best Practice for the Treatment of Persistent Asthma in AdultsTerminatedNCT00385593Phase 3Results posted
• A Comparative Study of Inhaled Ciclesonide Versus Placebo in Children (6-11 Years) With AsthmaCompletedNCT00384189Phase 3Results posted
• Safety and Efficacy Study to Determine Anti-Asthmatic Effect of Esomeprazole Magnesium; Nexium Reflux AsthmaCompletedNCT00317044Phase 2Results posted
• Responsiveness of Lower Airways in Adult Patients (18-60 Years) With Stable Asthma After Treatment With Ciclesonide and Fluticasone Propionate (BY9010/NL-101)CompletedNCT00306163Phase 3Results posted
• Study to Evaluate the Safety, Tolerability,Immunogenicity, and Pharmacokinetics of MEDI-528 in Healthy Adult VolunteersCompletedNCT00192296Phase 1Results posted
• Efficacy of Ciclesonide Inhaled Once Daily Versus Other Corticosteroids Used for Treatment of Mild Asthma in Children (4 to 11 Years) (BY9010/CA-101)CompletedNCT00163293Phase 3Results posted
• QUARTZ: Comparative Effectiveness of Switching From Albuterol to Albuterol/Budesonide Versus Adding Low-dose ICS or LTRA to AlbuterolCompletedNCT07787117
• A Study to Investigate How Budesonide and Formoterol Move Through the Body (Pharmacokinetics) When Delivered With Different Devices in Participants Aged 4 to Less Than 12 Years Old With AsthmaCompletedNCT07433569Phase 1
• Characterization and Clinical Outcomes of Severe Asthma Patients in Israel Treated With Benralizumab (SAIL-B)Active, not recruitingNCT07218172
• Study in Portuguese Hospitals to Describe Patient Characteristics, Treatment Patterns and OutcomesCompletedNCT07159295
• GRANITE: Airsupra Effectiveness in the Real WorldCompletedNCT07141277
• A Study of Inhaled AZD8630 in Adolescents With AsthmaCompletedNCT07065331Phase 1
• Characterize and Assess Clinical Outcomes of Patients Receiving Tezepelumab After Marketing Approval in SpainCompletedNCT07013760
• Observational Study on the Clinical Profile of Patients With Uncontrolled Severe Asthma Treated With Tezepelumab in ItalyActive, not recruitingNCT06948396
• A Safety, Pharmacokinetic, and Pharmacodynamic Study of Once Daily Inhaled AZD8630 in Adults With AsthmaCompletedNCT06795906Phase 1
• Study to Evaluate the Pharmacokinetics and Pharmacodynamics of AZD4604 Given Via the Turbuhaler® Device in Adults With Mild Asthma.CompletedNCT06732882Phase 1
• EVOLVE Study: The Real-life Clinical Practice With Tezepelumab in GreeceActive, not recruitingNCT06724575
• A Study to Investigate the Exposure of Budesonide, Glycopyrronium, and Formoterol (BGF) Delivered by Hydrofluoroolefin (HFO) Propellant Metered Dose Inhaler (MDI) Compared to a Hydrofluoroalkane (HFA) Propellant MDI in Healthy AdultsCompletedNCT06723756Phase 1
• An Observational, Prospective, Multicenter Study to Evaluate the Biologic Use and Outcomes in Chinese Asthma PatientsCompletedNCT06605885
• Real-world Study Assessing Efficacy of TezepeLumaB in Patients With Severe Asthma Regardless of Phenotype in RussiaCompletedNCT06566885
• Study to Investigate Changes in Airway Inflammation, Symptoms, and Rescue Therapy Utilization With AIRSUPRA Compared to Albuterol as Needed in Adults With Mild AsthmaCompletedNCT06563102Phase 4
• A Study to Investigate the Relative Bioavailability of AZD8630 Following a Device and Formulation Transition in Healthy Participants.CompletedNCT06531811Phase 1
• A Dose Range-Finding Study to Assess the Efficacy and Safety of Multiple Dose Levels of AZD8630 in Adults With Uncontrolled Asthma at Risk of ExacerbationsCompletedNCT06529419Phase 2
• Clinical& Demographic Profiles of patIents With unControllEd Asthma in Russia: Multi-center oBsErvational ReGistry StudyActive, not recruitingNCT06521229
• A Study to Investigate the Effect on Lung Function of BDA Formulated With a Next Generation Propellant Compared With an Approved Asthma Treatment (BDA With HFA Propellant) in Participants With AsthmaCompletedNCT06502366Phase 3
• Observational Retrospective Study To Characterize and Assess Clinical Outcomes of Patients Receiving Tezepelumab in the Framework Of Use in Special Situations Prior to Commercialisation in SpainCompletedNCT06487065
• Open-label Study to Assess Reduction of Background Asthma Medication While Sustaining Asthma Control and Clinical Remission With Tezepelumab in Patients 12-80yrs With Severe Asthma.Active, not recruitingNCT06473779Phase 3
• Patient Characteristics, Treatment Patterns and Outcomes of Patients With Severe Asthma Treated With Tezepelumab in the Real World; a Retrospective, Observational Medical Chart Review Conducted in UK Severe Asthma CentresCompletedNCT06455462
• Phase II Study to Evaluate the Effect of AZD4604 on Airway Inflammation and Biomarkers in Adults With AsthmaCompletedNCT06435273Phase 2
• Fasenra Pediatric Japan Post-Marketing Study(PMS)Active, not recruitingNCT06427876
• Combination Short-Acting BroNchodilator and Inhaled Corticosteroid Rescue Therapy on Health Outcomes in Routine CareActive, not recruitingNCT06422689Phase 4
• A Study To Evaluate The Treatment Pattern Of Moderate-to-Severe Asthma Patients In ChinaCompletedNCT06422663
• A Study to Investigate Relative Bioavailability of Two Different Dosage Forms for Tozorakimab Via Subcutaneous Administration in Healthy VolunteersCompletedNCT06304961Phase 1
• REACT - REAl Care for AsThma - A Disease Study to Identify Patients With Severe Uncontrolled AsthmaTerminatedNCT06299306
• PROPE Severe Asthma Study in EgyptCompletedNCT06283290
• A Retrospective Chart Review to Investigate Clinical Remission in Patients With Severe Asthma Treated With Biologics in the United Kingdom National Health ServiceCompletedNCT06261567
• A Study to Evaluate the Consistency of Oscillometry and Spirometry Test Results in Patients With Confirmed or Suspected Asthma or COPDCompletedNCT06172777
• An ADME Study of [14C]AZD4604 and the Absolute Bioavailability of AZD4604CompletedNCT06157255Phase 1
• Phase 2a Study to Assess the Efficacy and Safety of AZD4604 in Adult Patients With Moderate-to-Severe Asthma Uncontrolled on Medium-High Dose ICS-LABACompletedNCT06020014Phase 2
• Benralizumab Patient Access Programme Study: Retrospective Study in UK Severe Asthma CentresCompletedNCT05932849
• Tezepelumab PRO StudyCompletedNCT05922891
• Patient-Reported Outcomes of Benralizumab in Real-World Use in Severe Eosinophilic Asthma Patients in Taiwan (BEAT)CompletedNCT05734339
• TEZSPIRE (Tezepelumab) Asthma Japan Post-Marketing Study (PMS)Active, not recruitingNCT05729711
• A Multicentre, Randomised, Double-blind, Parallel Group, Placebo-controlled, Time-to-first Asthma Exacerbation Phase III Efficacy and Safety Study of Benralizumab in Paediatric Patients With Severe Eosinophilic AsthmaActive, not recruitingNCT05692180Phase 3
• A Study for Observing Severe Asthma in Patients Treated With TezepelumabCompletedNCT05677139
• Patient-Reported OUTcomes of Benralizumab in Real-World Use in Severe EosiNophilic Asthma PatientsCompletedNCT05603845
• A Real World Study to Capture Clinical and Patient Centered Outcomes in Adults With Severe Eosinophilic Asthma Treated With Benralizumab.CompletedNCT05440656
• Study to Assess the Efficacy and Safety of Atuliflapon in Moderate-to-Severe Uncontrolled AsthmaCompletedNCT05251259Phase 2
• Prevalence and Characterisation of Asthma Patients According to Disease Severity in PortugalCompletedNCT05169619
• Comparative Study of the Efficacy of Biologics vs Usual Treatment on OCS Reduction for Severe Asthma Patients Using Health Insurance Claim DatabaseCompletedNCT05136547
• A Study to Investigate the Safety, Tolerability and Effects of AZD8630 in Healthy Subjects and Subjects With Asthma on Inhaled Corticosteroids and Long-acting Beta-agonistsCompletedNCT05110976Phase 1
• FASENRA Regulatory Postmarketing Surveillance in KoreaCompletedNCT05091333
• Descriptive Study of the Incidence of Malignancy in Severe Asthma Patients Receiving Benralizumab and Other Biologic Therapy, a Post Authorization Safety StudyCompletedNCT04991805
• The Impact of PCCM on Healthcare Among Asthma or Chronic Obstructive Pulmonary Disease (COPD) or Asthma-COPD Overlap PatientsCompletedNCT04905420
• AMAZE™ Asthma Implementation QI StudyCompletedNCT04901260
• A Study to Compare Severe Asthma Patients Who Start Biologics and Who do Not Start (PROSPECT)CompletedNCT04808518
• A Clinical Trial in Healthy Volunteers and Patients With Mild Asthma to Investigate a New Medicine (AZD4604) for the Treatment of AsthmaCompletedNCT04769869Phase 1
• Observational Retrospective Study on Clinical Outcomes of Patients Receiving Benralizumab in Spain.CompletedNCT04648839