Drug
Zidovudine clinical trials
Also written Retrovir and ZDV.
Counted the way a researcher would: Zidovudine with its salts, dosage forms, brands and biosimilars. Looking for a trial to join? Including related medicines shows more you could take part in.
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How each study uses Zidovudine is sorted by a rule, right about nine times in ten. Readers can ask us to read every study one by one.Ask us to read each study
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Approvals
The first approval found in each region, with its record
- United States
- 19 Mar 1987 · RETROVIR · NDA 019655 (FDA, Drugs@FDA)
- European Union
- 18 Mar 1998 · Combivir · EMEA/H/C/000190 (EMA; in a combination)
From FDA's Drugs@FDA and Purple Book (through openFDA) and the European Medicines Agency, files of Sept 2026 and 27 Oct 2026. National approvals in Europe and other countries are not included. How this is worked out
How studies write it
Studies that test it under each name
Studies by the year they started
68 studies that test it; most in 2005 (8)
| Year | Studies |
|---|---|
| 1991 | 1 |
| 1993 | 1 |
| 1996 | 1 |
| 1997 | 1 |
| 1999 | 7 |
| 2000 | 1 |
| 2001 | 2 |
| 2002 | 2 |
| 2003 | 4 |
| 2004 | 7 |
| 2005 | 8 |
| 2006 | 5 |
| 2007 | 5 |
| 2008 | 4 |
| 2009 | 3 |
| 2010 | 1 |
| 2011 | 3 |
| 2012 | 3 |
| 2013 | 1 |
| 2015 | 3 |
| 2016 | 1 |
| 2018 | 1 |
| 2019 | 1 |
| 2020 | 1 |
| 2022 | 1 |
By phase
A phase 1/2 study counts in both.
What it is tested for
Each study’s main condition, where its own words name it, so a study counts once.
Who runs them
Industry 71 · Other 150
National Institute of Allergy and Infectious Diseases (NIAID) (108) · Glaxo Wellcome (24) · Hoffmann-La Roche (7) · Pharmacia and Upjohn (6) · Merck Sharp & Dohme LLC (5) · National Cancer Institute (NCI) (4) · Boehringer Ingelheim (4) · Bristol-Myers Squibb (4)
Often tested with
Tested in the same studies.
Lamivudine (68) · Nevirapine (21) · Didanosine (19) · Efavirenz (17) · Lopinavir-ritonavir drug combination (13) · Abacavir (13) · Stavudine (12) · Indinavir (12)
Related medicines
As reviewed, each with the page that says it.
Studies
Open first, then newest update. How each study uses Zidovudine is read from its arms, and is right about nine times in ten. Ask us to read each study. These are the studies that list it as an intervention; a search of ClinicalTrials.gov also finds studies that mention it only in a description, such as earlier treatment.
Testing it · 221
- Natural History Study of the KSHV Inflammatory Cytokine Syndrome (KICS)RecruitingPhase 2National Cancer Institute (NCI)NCT01419561Written as Zidovudine
- Virotherapy and Natural History Study of KHSV-Associated Multricentric Castleman s Disease With Correlates of Disease ActivityActive, not recruitingPhase 2National Cancer Institute (NCI)NCT00092222Written as Zidovudine
- Belinostat Therapy With Zidovudine for Adult T-Cell Leukemia-LymphomaCompletedPhase 2University of MiamiNCT02737046Written as Zidovudine
- Early Infant HIV Treatment in BotswanaActive, not recruitingPhase 2/3Harvard School of Public Health (HSPH)NCT02369406Written as Zidovudine
- Inhibition of Reverse Transcription in Aicardi-Goutières SyndromeCompletedPhase 2University of EdinburghNCT04731103Written as Abacavir (ABC)+Lamivudine (3TC)+Zidovudine (AZT)
- Safety and Pharmacokinetic Study of Fixed Dose Combination of Zidovudine, Lamivudine, and Nevirapine in HIV-Infected Children in ThailandCompletedPhase 1/2National Institute of Allergy and Infectious Diseases (NIAID)NCT00672412Written as Zidovudine
- Preventing Sexual Transmission of HIV With Anti-HIV DrugsCompletedPhase 3National Institute of Allergy and Infectious Diseases (NIAID)NCT00074581Written as Zidovudine/Lamivudine
- Reducing the Incidence of Nevirapine Resistance Mutations in Pregnant HIV Infected Women Who Receive Anti-HIV Drugs Prior to and After Giving BirthCompletedPhase 2National Institute of Allergy and Infectious Diseases (NIAID)NCT00109590Written as Zidovudine
- A Study of AZT in HIV-Infected Patients With AIDS-Related Kaposi's SarcomaCompletedPhase 3National Institute of Allergy and Infectious Diseases (NIAID)NCT00000994Written as Zidovudine
- A Study of Three Drugs Plus Zidovudine in the Prevention of Infections in HIV-Infected PatientsCompletedPhase 3National Institute of Allergy and Infectious Diseases (NIAID)NCT00000991Written as Zidovudine
- A Multicenter, Double Blind, Comparative Study of Zidovudine Alone Versus Zidovudine and Acyclovir as Treatment for HIV-Infected Patients With CD4+ Counts Less Than 200 Cells/mm3CompletedPhase 2National Institute of Allergy and Infectious Diseases (NIAID)NCT00000712Written as Zidovudine
- A Study of Zidovudine in HIV-Infected Patients With Liver DiseaseCompletedNot applicableNational Institute of Allergy and Infectious Diseases (NIAID)NCT00001001Written as Zidovudine
- A Randomized, Comparative Trial of Zidovudine (AZT) Versus 2',3'-Didehydro-3'-Deoxythymidine (Stavudine; d4T) in Children With HIV InfectionCompletedPhase 2National Institute of Allergy and Infectious Diseases (NIAID)NCT00000789Written as Zidovudine
- The Safety and Effectiveness of Interleukin-2 Plus Zidovudine in Patients With AIDS or AIDS Related ComplexCompletedPhase 1National Institute of Allergy and Infectious Diseases (NIAID)NCT00000986Written as Zidovudine
- A Study of Zidovudine Plus Acyclovir in HIV-Infected PatientsCompletedPhase 1National Institute of Allergy and Infectious Diseases (NIAID)NCT00001010Written as Zidovudine
- The Safety and Effectiveness of Injections of Human Recombinant Interferon-gamma in Patients With AIDS Who Have Taken ZidovudineCompletedPhase 1National Institute of Allergy and Infectious Diseases (NIAID)NCT00001112Written as Zidovudine
- A Study of Indinavir Sulfate Plus Zidovudine (AZT) Plus Lamivudine in HIV-Infected Patients Who Have Taken AZT for Six or More MonthsCompletedPhase 3National Institute of Allergy and Infectious Diseases (NIAID)NCT00000841Written as Zidovudine
- A Comparison of Zidovudine (AZT) Used Alone or in Combination With Didanosine (ddI) or Dideoxycytidine (ddC) in HIV-Infected PatientsCompletedPhase 3National Institute of Allergy and Infectious Diseases (NIAID)NCT00001022Written as Zidovudine
- The Effectiveness of Three Drug Combinations in HIV-Infected Patients Who Have Taken Zidovudine for More Than 12 WeeksCompletedPhase 2National Institute of Allergy and Infectious Diseases (NIAID)NCT00001063Written as Zidovudine
- A Phase II Double-Blind Study of Delavirdine Mesylate ( U-90152 ) in Combination With Zidovudine ( AZT ) and/or Didanosine ( ddI ) Versus AZT and ddI Combination TherapyCompletedPhase 2National Institute of Allergy and Infectious Diseases (NIAID)NCT00000803Written as Zidovudine
See all 221 studies that test Zidovudine →
Given beside what is tested · 16 — Zidovudine is usual care or a partner of the new treatment
- A Study to Evaluate the Pharmacokinetics, Safety, Tolerability, and Antiviral Activity of Rilpivirine (TMC278) in Human Immunodeficiency Virus Infected Adolescents and Children Aged Greater Than or Equal to 6 YearsCompletedPhase 2Janssen Sciences Ireland UCNCT00799864Written as Zidovudine
- Antiretroviral Regime for Viral Eradication in NewbornsCompletedPhase 4National Center for Women and Children's Health, China CDCNCT02712801Written as Zidovudine
- Tocilizumab for KSHV-Associated Multicentric Castleman DiseaseCompletedPhase 2National Cancer Institute (NCI)NCT01441063Written as Zidovudine
- Protease Inhibitors to Reduce Malaria Morbidity in HIV-Infected Pregnant WomenCompletedPhase 3University of California, San FranciscoNCT00993031Written as Zidovudine
- Zidovudine, Interferon Alfa-2b, PEG-Interferon Alfa-2b in Patients With HTLV-I Associated Adult T-Cell Leukemia/LymphomaTerminatedPhase 4University of MiamiNCT00854581Written as Zidovudine
- SSAT063- Pharmacokinetics of Efavirenz 400 mg Once Daily During Pregnancy in HIV-1 Infected WomenCompletedPhase 1St Stephens Aids TrustNCT02499874Written as lamivudine/zidovudine
- Pharmacokinetics of Efavirenz in the Presence of Rifampicin and IsoniazidStatus unknownPhase 1St Stephens Aids TrustNCT02832778Written as lamivudine/zidovudine
- Antiviral Responses to NNRTI-Based vs. PI-Based ARV Therapy in HIV Infected Infants Who Have or Have Not Received Single Dose NVP for Prevention of Mother-to-Child Transmission of HIVCompletedPhase 2International Maternal Pediatric Adolescent AIDS Clinical Trials GroupNCT00307151Written as Zidovudine
- Maternal/Infant Peripartum NVP, Versus Infant Only Peripartum NVP, or Maternal LPV/r in Addition to Standard ZDV Prophylaxis for the Prevention of Perinatal (PMTCT) HIV in ThailandTerminatedPhase 3Institut de Recherche pour le DeveloppementNCT00409591Written as zidovudine
- Part A: Drug Interaction Study of Sofosbuvir and Antiretroviral Therapy (ART) Combinations in HIV and Hepatitis C Virus (HCV) Co-infected Patients. Part B: Efficacy and Safety of Sofosbuvir for 12 Weeks in HIV/HCV Co-infected Patients.CompletedPhase 1/2Gilead SciencesNCT01565889Written as ZDV/3TC
- Comparison of the Effect of Tipranavir and Ritonavir or Tipranavir and Ritonavir on the Pharmacokinetic Characteristics of Zidovudine in Healthy VolunteersCompletedPhase 1Boehringer IngelheimNCT02249416Written as Zidovudine
- Trial of Maraviroc (UK-427,857) in Combination With Zidovudine/Lamivudine Versus Efavirenz in Combination With Zidovudine/LamivudineCompletedPhase 3ViiV HealthcareNCT00098293Written as Maraviroc + Zidovudine/Lamivudine
- A Study to Evaluate Antiviral Activity of Darunavir + Ritonavir in HIV-1 Infected AdolescentsCompletedPhase 2Tibotec Pharmaceuticals, IrelandNCT00915655Written as zidovudine
- Combination Chemotherapy in Treating Patients With AIDS-Related LymphomaCompletedPhase 2M.D. Anderson Cancer CenterNCT00002524Written as Zidovudine (AZT)
- A Study to Determine Effective Prophylaxis and Treatment of Nelfinavir-Associated DiarrheaTerminatedPhase 3PfizerNCT00650637Written as lamivudine + zidovudine
- Anti-HIV Drugs for Ugandan Patients With HIV and TuberculosisCompletedPhase 3National Institute of Allergy and Infectious Diseases (NIAID)NCT00078247Written as Zidovudine
As the comparator · 11 — what is tested is compared with Zidovudine
- Study of HIV-Infected and Uninfected Pregnant Woman/Child Dyads in Gaborone, BotswanaCompletedPhase 4Ann & Robert H Lurie Children's Hospital of ChicagoNCT03088410Written as Zidovudine
- Evaluating Strategies to Reduce Mother-to-Child Transmission of HIV Infection in Resource-Limited CountriesCompletedPhase 3National Institute of Allergy and Infectious Diseases (NIAID)NCT01061151Written as Zidovudine (ZDV)
- Safety and Efficacy of Switching From Stavudine or Zidovudine to Tenofovir DF in HIV-1 Infected ChildrenCompletedPhase 3Gilead SciencesNCT00528957Written as Zidovudine
- A Trial to Confirm a Sustained Virological Suppression Defined as HIV-RNA <50 Copies/ml of 3 Different Doses of Fozivudine in Context to a Standard Zidovudine Based Antiretroviral Therapy RegimenCompletedPhase 2Michael HoelscherNCT01714414Written as AZT
- Human Immunodeficiency Virus (HIV) Postexposure Prophylaxis (PEP) With Darunavir/Ritonavir (DRV/r)CompletedPhase 3Janssen-Cilag G.m.b.HNCT01516970Written as Zidovudine
- Peripheral Body Fat Distribution After Switching Zidovudine and Lamivudine to TruvadaCompletedPhase 4Gilead SciencesNCT00324649Written as Zidovudine/lamivudine
- Tenofovir in HIV/HBV CoinfectionCompletedPhase 4Kirby InstituteNCT00192595Written as Zidovudine (AZT), lamivudine (LAM), efavirenz (EFV)
- Efficacy of Nevirapine Compared to ZDV + 3TC Administered in Labor and Again at Postdelivery in HIV Positive WomenCompletedPhase 3Boehringer IngelheimNCT02181933Written as Zidovudine (ZDV)
- Trial of Maraviroc (UK-427,857) in Combination With Zidovudine/Lamivudine Versus Efavirenz in Combination With Zidovudine/LamivudineCompletedPhase 3ViiV HealthcareNCT00098293Written as Maraviroc + Zidovudine/Lamivudine
- Tenofovir Disoproxil Fumarate/Emtricitabine/Efavirenz Versus Combivir/Efavirenz in Antiretroviral-Naive HIV-1 Infected SubjectsCompletedPhase 3Gilead SciencesNCT00112047Written as Lamivudine/zidovudine
- FREE Study: Efficacy and Toxicity of TrizivirCompletedPhase 3Rijnstate HospitalNCT00405925Written as zidovudine,lamivudine,abacavir
Codes
What other systems call Zidovudine · ClinicalTrials.gg INT008446
- MeSH (NLM) D015215ZidovudineConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) 4B9XT59T7SZIDOVUDINEConfirmed FDA, NLM, Wikidata
- RxNorm 11413Confirmed FDA, Wikidata
- Wikidata Q198504zidovudineConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C947ZidovudineOne source FDA
- DrugBank DB00495One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D015215 | Zidovudine | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | 4B9XT59T7S | ZIDOVUDINE | Confirmed FDA, NLM, Wikidata |
| RxNorm | 11413 | — | Confirmed FDA, Wikidata |
| Wikidata | Q198504 | zidovudine | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C947 | Zidovudine | One source FDA |
| DrugBank | DB00495 | — | One source Wikidata |
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.