Therapeutic Tumor Infiltrating Lymphocytes clinical trials
How each study uses Therapeutic Tumor Infiltrating Lymphocytes is sorted by a rule, right about nine times in ten. Readers can ask us to read every study one by one.Ask us to read each study
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Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your alerts, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
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Approvals
The first approval found in each region, with its record
- United States
- Not in FDA's approval records
- European Union
- Not in EMA's list of EU-wide authorizations
From FDA's Drugs@FDA and Purple Book (through openFDA) and the European Medicines Agency, files of Sept 2026 and 27 Oct 2026. National approvals in Europe and other countries are not included. How this is worked out
How studies write it
Studies that test it under each name
Studies by the year they started
48 studies that test it; most in 2021 (8)
| Year | Studies |
|---|---|
| 1999 | 1 |
| 2008 | 1 |
| 2009 | 1 |
| 2010 | 1 |
| 2011 | 2 |
| 2013 | 3 |
| 2014 | 3 |
| 2015 | 1 |
| 2016 | 2 |
| 2017 | 2 |
| 2018 | 1 |
| 2019 | 2 |
| 2020 | 4 |
| 2021 | 8 |
| 2022 | 3 |
| 2023 | 2 |
| 2024 | 5 |
| 2025 | 5 |
| 2026 | 1 |
By phase
A phase 1/2 study counts in both.
What it is tested for
Each study’s main condition, where its own words name it, so a study counts once.
Who runs them
Industry 11 · Other 37
Shanghai Juncell Therapeutics (7) · Inge Marie Svane (5) · National Cancer Institute (NCI) (5) · Essen Biotech (5) · Udai Kammula (3) · City of Hope Medical Center (2) · Christian Hinrichs (2) · H. Lee Moffitt Cancer Center and Research Institute (2)
Often tested with
Tested in the same studies.
Fludarabine (8) · Cyclophosphamide (8) · Interleukin-2 (3) · Aldesleukin (3) · Pembrolizumab (2) · Fludarabine phosphate (1) · Vemurafenib (1) · Interleukins (1)
Coming up
From the study records. Dates are the sponsors’ own estimates and often move.
Reaching primary completion within a year · 8
Studies that test Therapeutic Tumor Infiltrating Lymphocytes.
- Dec 2026A Study of GC101 TIL in Advanced Breast Cancer (10hospital)Early Phase 1 · Shanghai Juncell Therapeutics
- Dec 2026Study of GC101 TIL in Brain Glioma (Soochow2)Early Phase 1 · Shanghai Juncell Therapeutics
- Jan 2027E7 TCR-T Cell Immunotherapy for Human Papillomavirus (HPV) Associated CancersPhase 2 · Christian Hinrichs
- May 2027Evaluate the Safety and Efficacy of Autologous Tumor-infiltrating Lymphocyte in Patients With Refractory Melanoma Who Failed to Immune Checkpoint InhibitorsNot applicable · Samsung Medical Center
- Jun 2027Clinical Trial of CD40L-Augmented TIL for Patients With EGFR, ALK, ROS1 or HER2-Driven NSCLCPhase 1 · H. Lee Moffitt Cancer Center and Research Institute
- Jul 2027Circadian-Optimized Light Therapy for the Treatment of Patients With Advanced Melanoma Receiving Tumor-Infiltrating Lymphocyte TherapyPhase 1 · City of Hope Medical Center
- Jul 2027Adoptive Transfer of Tumor Infiltrating Lymphocytes for Metastatic Uveal MelanomaPhase 2 · Udai Kammula
- Oct 2027T Cell Receptor Immunotherapy for Patients With Metastatic Non-Small Cell Lung CancerPhase 2 · National Cancer Institute (NCI)
Studies
Open first, then newest update. How each study uses Therapeutic Tumor Infiltrating Lymphocytes is read from its arms, and is right about nine times in ten. Ask us to read each study. These are the studies that list it as an intervention; a search of ClinicalTrials.gov also finds studies that mention it only in a description, such as earlier treatment.
Testing it · 48
- Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic CancerRecruitingPhase 2National Cancer Institute (NCI)NCT01174121Written as Young TIL
- Treatment of Advanced or Metastatic Triple-negative Breast Cancer With Adoptive Therapy of PD1+ TILSRecruitingPhase 1/2Fundacio Clinic BarcelonaNCT05451784Written as PD1+ TILs (NUMARZU-001) product infusion
- E7 TCR-T Cell Immunotherapy for Human Papillomavirus (HPV) Associated CancersRecruitingPhase 2Christian HinrichsNCT05686226Written as E7 TCR-T cells
- E7 T-cell Receptor (TCR) -T Cell Induction Therapy for Locoregionally Advanced HPV-associated CancersRecruitingPhase 1/2Christian HinrichsNCT05639972Written as E7 TCR-T cells
- T Cell Receptor Immunotherapy for Patients With Metastatic Non-Small Cell Lung CancerRecruitingPhase 2National Cancer Institute (NCI)NCT02133196Written as Young TIL
- Tumor Infiltrating Lymphocyte Therapy for Pediatric High Risk Solid TumorsRecruitingPhase 1H. Lee Moffitt Cancer Center and Research InstituteNCT06047977Written as Tumor Infiltrating Lymphocytes, Fludarabine, Cyclophosphamide, Interleukin-2
- Clinical Trial of CD40L-Augmented TIL for Patients With EGFR, ALK, ROS1 or HER2-Driven NSCLCRecruitingPhase 1H. Lee Moffitt Cancer Center and Research InstituteNCT05681780Written as Tumor-infiltrating Lymphocytes (TIL)
- A Study of GC101 TIL in r/r Gastrointestinal Tumors (10hospital)RecruitingEarly Phase 1Shanghai Juncell TherapeuticsNCT04960072Written as Tumor Infiltrating Lymphocytes (TIL)
- Study of GC101 TIL in Brain Glioma (Soochow2)RecruitingEarly Phase 1Shanghai Juncell TherapeuticsNCT04943913Written as Tumor Infiltrating Lymphocytes (TIL)
- A Clinical Study on TIL for the Treatment of Advanced Solid TumorsRecruitingEarly Phase 1Shanghai Juncell TherapeuticsNCT05087745Written as Tumor Infiltrating Lymphocytes
- A Study of GC101 TIL in Advanced Solid Tumors (TR)RecruitingEarly Phase 1Shanghai Juncell TherapeuticsNCT04967833Written as Tumor Infiltrating Lymphocytes (TIL)
- Circadian-Optimized Light Therapy for the Treatment of Patients With Advanced Melanoma Receiving Tumor-Infiltrating Lymphocyte TherapyNot yet recruitingPhase 1City of Hope Medical CenterNCT07628894Written as Therapeutic Tumor Infiltrating Lymphocytes
- A Study of GC101 TIL in Advanced Breast Cancer (10hospital)RecruitingEarly Phase 1Shanghai Juncell TherapeuticsNCT05142475Written as Tumor Infiltrating Lymphocytes (TIL)
- A Study of GC101 TIL in Advanced Melanoma (10hospital)RecruitingEarly Phase 1Shanghai Juncell TherapeuticsNCT05098184Written as Tumor Infiltrating Lymphocyte
- A Study of GC101 TIL in Advanced Hepatobiliary-Pancreatic Cancers (10hospital)RecruitingEarly Phase 1Shanghai Juncell TherapeuticsNCT05098197Written as Tumor Infiltrating Lymphocyte
- Evaluate the Safety and Efficacy of Autologous Tumor-infiltrating Lymphocyte in Patients With Refractory Melanoma Who Failed to Immune Checkpoint InhibitorsNot yet recruitingNot applicableSamsung Medical CenterNCT07028008Written as tumor-infiltrating lymphocyte (TIL)
- TIL Gean Therapy Combined With Immunotherapy for Advanced or Metastatic Refractory Breast CancerRecruitingPhase 1/2Essen BiotechNCT06532812Written as Tumor Infiltrating Lymphocytes (TIL)
- TIL Therapy Combined With Pembrolizumab for Advanced or Metastatic Refractory Stomach and Esophageal CancerRecruitingPhase 1/2Essen BiotechNCT06532799Written as Tumor Infiltrating Lymphocytes (TIL)
- TIL Therapy Combined With Pembrolizumab for Advanced Brain Cancer Including Gliomas and MeningiomasRecruitingPhase 1/2Essen BiotechNCT06640582Written as Tumor Infiltrating Lymphocytes (TIL)
- Biological Tumor Infiltrating Lymphocytes Therapy With Immunotherapy for Colon and Rectum CancerRecruitingPhase 1/2Essen BiotechNCT06530303Written as Tumor Infiltrating Lymphocytes (TIL)
See all 48 studies that test Therapeutic Tumor Infiltrating Lymphocytes →
Given beside what is tested · 15 — Therapeutic Tumor Infiltrating Lymphocytes is usual care or a partner of the new treatment
- A Phase 2 Trial for Metastatic Melanoma Using Adoptive Cell Therapy With Tumor Infiltrating Lymphocytes Plus IL-2 Either Alone or Following the Administration of PembrolizumabRecruitingPhase 2National Cancer Institute (NCI)NCT02621021Written as young TIL
- Adoptive Cell Therapy Following a Non-myeloablative, Lymphodepleting Induction Regimen in Metastatic Melanoma PatientsRecruitingPhase 2Sheba Medical CenterNCT03166397Written as TIL
- TNFα and IL-2 Coding Oncolytic Adenovirus TILT-123 With Lymphocyte-depleting Chemotherapy and TILs in the Treatment of MelanomaActive, not recruitingPhase 1TILT Biotherapeutics Ltd.NCT06961786Written as TIL
- Lymphodepletion Plus Adoptive Cell Therapy With High Dose IL-2 in Adolescent and Young Adult Patients With Soft Tissue SarcomaCompletedPhase 1H. Lee Moffitt Cancer Center and Research InstituteNCT04052334Written as TIL
- Prospective Randomized Study of Cell Transfer Therapy for Metastatic Melanoma Using Tumor Infiltrating Lymphocytes Plus IL-2 Following Non-Myeloablative Lymphocyte Depleting Chemo Regimen Alone or in Conjunction With 12Gy Total Body Irradiation (TBI...CompletedPhase 2National Cancer Institute (NCI)NCT01319565Written as Young TIL
- Combining PD-1 Blockade, CD137 Agonism and Adoptive Cell Therapy for Metastatic MelanomaCompletedEarly Phase 1H. Lee Moffitt Cancer Center and Research InstituteNCT02652455Written as TIL Infusion
- T-cell Therapy in Combination With Nivolumab, Relatlimab and Ipilimumab for Patients With Metastatic Ovarian CancerTerminatedPhase 1/2Inge Marie SvaneNCT04611126Written as Tumor Infiltrating Lymphocytes infusion
- Pembrolizumab, Standard Chemotherapy, Tumor Infiltrating Lymphocytes, and High- or Low-Dose Aldesleukin in Treating Patients With Metastatic MelanomaCompletedPhase 2M.D. Anderson Cancer CenterNCT02500576Written as Therapeutic Tumor Infiltrating Lymphocytes
- A Pilot Study Using Short-Term Cultured Anti-Tumor Autologous LymphocytesTerminatedEarly Phase 1Yale UniversityNCT03526185Written as Tumor Infiltrating Lymphocytes
- Adoptive T Cell Therapy in Patients With Recurrent Ovarian CancerStatus unknownPhase 1/2Leiden University Medical CenterNCT04072263Written as Tumor Infiltrating Lymphocytes (TIL)
- The ACTIVATE (Adoptive Cell Therapy InVigorated to Augment Tumor Eradication) TrialCompletedPhase 1University Health Network, TorontoNCT03158935Written as Tumor-Infiltrating Lymphocytes (TILs)
- Vemurafenib and White Blood Cell Therapy for Advanced MelanomaTerminatedPhase 1National Cancer Institute (NCI)NCT01585415Written as Young TIL
- Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic Human Papillomavirus-Associated CancersCompletedPhase 2National Cancer Institute (NCI)NCT01585428Written as Young TIL
- Cyclophosphamide, Fludarabine, and Total-Body Irradiation Followed By Cellular Adoptive Immunotherapy, Autologous Stem Cell Transplantation, and Interleukin-2 in Treating Patients With Metastatic MelanomaCompletedPhase 2National Institutes of Health Clinical Center (CC)NCT00096382Written as therapeutic tumor infiltrating lymphocytes
- Use of IL-15 After Chemotherapy and Lymphocyte Transfer in Metastatic MelanomaTerminatedPhase 1/2National Cancer Institute (NCI)NCT01369888Written as Tumor Infiltrating Lymphocytes
What changed recently
From the registry's own updates since Oct 16, 2026.
Stopped1
- TIL Therapy for Patients With Advanced Solid TumorsTerminatedNov 13, 2026NCT06107894