Sirolimus: all 520 studies that test it

Page 3 of 6. Open to participants first (86), then studies with results posted, then the rest; newest registration first within each.

• Comparing Three Different Combination Chemotherapy Regimens in Treating Patients With Relapsed or Refractory Acute Myeloid LeukemiaCompletedNCT00634244Phase 2Results posted
• Rapamycin for Prevention of Chronic Graft-Versus-Host DiseaseTerminatedNCT00623012Phase 1/2Results posted
• Study of Oral Rapamycin Plus Bare Metal Stents vs Drug Eltuting StentsCompletedNCT00552669Phase 4Results posted
• Rapamycin Versus Mycophenolate Mofetil in Kidney-Pancreas RecipientsCompletedNCT00533442Phase 2Results posted
• Thymoglobulin, Sirolimus and Mycophenolate Mofetil for Prevention of Acute Graft-Versus-Host Disease (GVHD)TerminatedNCT00506948Phase 2Results posted
• Sirolimus in Treating Patients With Advanced Pancreatic CancerCompletedNCT00499486Phase 2Results posted
• Study Evaluating Rapamune® Maintenance RegimenCompletedNCT00478608Phase 3Results posted
• Efficacy and Safety of Sirolimus in LAMCompletedNCT00414648Phase 3Results posted
• A Phase II Study of Rapamycin and Trastuzumab for Patients With HER-2 Receptor Positive Metastatic Breast CancerCompletedNCT00411788Phase 2Results posted
• Sirolimus/Tacrolimus Versus Tacrolimus/Methotrexate for Preventing Graft-Versus-Host Disease (GVHD) (BMT CTN 0402)CompletedNCT00406393Phase 3Results posted
• Sirolimus for Autoimmune Disease of Blood CellsCompletedNCT00392951Phase 1/2Results posted
• Sirolimus as Treatment of Steroid-Refractory or Steroid-Dependent Chronic Graft-Versus-Host DiseaseCompletedNCT00388362Phase 2Results posted
• Tacrolimus and Methotrexate With or Without Sirolimus in Preventing Graft-Versus-Host Disease in Young Patients Undergoing Donor Stem Cell Transplant for Acute Lymphoblastic Leukemia in Complete RemissionCompletedNCT00382109Phase 3Results posted
• Study Of The Safety And Efficacy Of Conversion From A CNI To Sirolimus In Renally-Impaired Heart Transplant RecipientsCompletedNCT00369382Phase 4Results posted
• Fludarabine Phosphate, Cyclophosphamide, and Total-Body Irradiation Followed by Donor Bone Marrow Transplant and Cyclophosphamide, Mycophenolate Mofetil, Tacrolimus, and Sirolimus in Treating Patients With Primary Immunodeficiency Disorders or Noncancerous Inherited DisordersTerminatedNCT00358657Phase 2Results posted
• Erlotinib and Sirolimus for the Treatment of Metastatic Renal Cell CarcinomaCompletedNCT00353301Phase 2Results posted
• TBI Dose De-escalation for Fanconi AnemiaCompletedNCT00352976Phase 2/3Results posted
• Belatacept to Prevent Organ Rejection in Kidney Transplant PatientsTerminatedNCT00346151Phase 2Results posted
• De Novo Sirolimus-based Immunosuppression After Liver Transplantation for Hepatocellular CarcinomaCompletedNCT00328770Phase 2/3Results posted
• Comparison of Sirolimus and Azathioprine in Lung TransplantationCompletedNCT00321906Phase 4Results posted
• Sirolimus Before Surgery in Treating Patients With Advanced Localized Prostate CancerCompletedNCT00311623Phase 1/2Results posted
• Study Comparing Effect On Carotid Atherosclerosis Following Conversion From Tacrolimus To Sirolimus Post-Transplant In Kidney Transplant PatientsTerminatedNCT00311311Phase 3Results posted
• Infliximab, Sirolimus and Daclizumab to Treat Age-Related Macular DegenerationCompletedNCT00304954Phase 2Results posted
• Pilot Study of Rapamycin as Treatment for Autosomal Dominant Polycystic Kidney Disease (ADPKD)CompletedNCT00286156Phase 1/2Results posted
• Tacrolimus and Sirolimus as Prophylaxis After Allogenic Non-myeloablative Peripheral Blood Stem Cell TransplantationCompletedNCT00282282Phase 2Results posted
• Individualized Drug Treatment for Treating Patients With Pancreatic CancerTerminatedNCT00276744Phase 2Results posted
• Safety in Immunomodulatory Functions of Alemtuzumab (Campath) in Pediatric Kidney Transplantation RecipientsCompletedNCT00240994Phase 2Results posted
• Mycophenolate Mofetil and Rapamycin as Secondary Intervention vs. Continuation of Calcineurin Inhibitors in Patients at Risk for Chronic Renal Allograft FailureCompletedNCT00223678Phase 4Results posted
• Study Evaluating Sirolimus in Kidney Transplant RecipientsCompletedNCT00195273Phase 3Results posted
• Efficacy of Sirolimus-Based, Steroid Avoidance Immunosuppression African AmericansCompletedNCT00189202Phase 2/3Results posted
• A Trial of Two Steroid-Free Approaches Toward Mycophenolate Mofetil-Based Monotherapy ImmunosuppressionTerminatedNCT00166712Phase 4Results posted
• Study Evaluating the Effect of Sirolimus on Non-Melanoma Skin Cancer in Kidney Transplant RecipientsCompletedNCT00129961Phase 4Results posted
• RAPAMYCIN FOR KIDNEY ANGIOMYOLIPOMASCompletedNCT00126672Phase 2Results posted
• Kidney Spare the Nephron (STN) Study - A Study of CellCept (Mycophenolate Mofetil) and Rapamune (Sirolimus) in Kidney Transplant RecipientsCompletedNCT00121810Phase 4Results posted
• Tacrolimus and Mycophenolate Mofetil With or Without Sirolimus in Preventing Acute Graft-Versus-Host Disease in Patients Who Are Undergoing Donor Stem Cell Transplant for Hematologic CancerCompletedNCT00105001Phase 2Results posted
• Study Evaluating of Calcineurin Inhibitor and Sirolimus (Rapamune) Treatment in Liver Transplant RecipientsTerminatedNCT00086346Phase 3Results posted
• Sirolimus as Secondary Therapy in Chronic Graft-Versus-Host Disease Not Responding To Prior TreatmentCompletedNCT00079183Phase 2Results posted
• Combination Immunosuppressive Therapy to Prevent Kidney Transplant Rejection in AdultsCompletedNCT00078559Phase 1/2Results posted
• Combination Drug Therapy Followed by Single Drug Steroid Free Therapy to Prevent Organ Rejection in Kidney TransplantationCompletedNCT00076570Phase 2Results posted
• Improving the Results of Bone Marrow Transplantation for Patients With Severe Congenital AnemiasActive, not recruitingNCT00061568Phase 1/2Results posted
• Stem Cell Transplantation in Patients With High-Risk and Recurrent Pediatric SarcomasCompletedNCT00043979Phase 2Results posted
• Study Comparing Conversion to Sirolimus vs. Continued Use of Calcineurin Inhibitors in Kidney Transplant RecipientsCompletedNCT00038948Phase 3Results posted
• Islet Transplantation for Type 1 DiabetesCompletedNCT00014911Phase 2Results posted
• Sirolimus and Thymoglobulin to Prevent Kidney Transplant RejectionCompletedNCT00006178Phase 2Results posted
• Sirolimus Treatment in Pediatric Patients With Ataxia-TelangiectasiaCompletedNCT07820579Phase 2
• Combination Gerotherapeutic Interventions for Healthspan ImprovementActive, not recruitingNCT07475546Phase 3
• A Pilot Study on Reverse Aging (The REVERSE Study)Active, not recruitingNCT07354620Early Phase 1
• A Study of Exercise and Pharmacologic Intervention on Systemic InflammationActive, not recruitingNCT07058974Phase 1
• Sirolimus for Injection (Albumin-bound) in Combination With Endocrine Therapy for HR+/HER2- Advanced/Metastatic Breast Cancer Patients Who Have Failed Standard TherapyActive, not recruitingNCT06957379Phase 2
• Evaluating the Safety and Efficacy of Topical Sirolimus 0.2% to Treat Acanthosis NigricansCompletedNCT06940895Phase 2
• Combination Therapy (Mirdametinib and Sirolimus) for RAS Mutated Relapsed Refractory Multiple MyelomaSuspendedNCT06876142Phase 1/2
• Sirolimus for Improving Social Abilities in People With PTEN Germline MutationsWithdrawnNCT06080165Phase 1/2
• Evaluating Rapamycin Treatment in Alzheimer's Disease Using Positron Emission TomographyCompletedNCT06022068Phase 1/2
• Topical Sirolimus in Chemoprevention of Facial Squamous Cell Carcinomas in Solid Organ Transplant Recipients (SiroSkin)Active, not recruitingNCT05860881Phase 3
• Effect of Rapamycin in Ovarian AgingActive, not recruitingNCT05836025Phase 2
• REpurposing SirolimUS in Compensated Advanced Chronic Liver Disease. the RESUS Proof of Concept StudyCompletedNCT05663944Phase 2
• A Study of Safety and Efficacy of Sirolimus for Injection (Albumin-bound) in Patients With Advanced Malignant Perivascular Epithelioid Cell Tumor (PEComa)Status unknownNCT05625919Phase 1/2
• Low-dose Interleukin-2 and Rapamycin on sjögren's SyndromeCompletedNCT05605665Phase 1/2
• Rapamycin Plus Methylprednisolone Versus Methylprednisolone Alone in Active, Moderate-to-severe Graves' Orbitopathy.Status unknownNCT05532072Early Phase 1
• A Study of Sirolimus for Injection (Albumin-bound) in Patients With Advanced Solid TumorsStatus unknownNCT05508620Phase 1
• This Study Consists of Two Study Parts Conducted Under a Single IRB. Part I: Short Term ApoE-dependent Cerebral Blood Flow Response to Sirolimus in Cognitively Normal Adults Part II: Short Term ApoE-dependent Cerebral Blood Flow and Lung Perfusion Response to Sirolimus in Cognitively Normal AdultsActive, not recruitingNCT05386914Phase 1
• Addition of JSP191 (C-kit Antibody) to Nonmyeloablative Hematopoietic Cell Transplantation for Sickle Cell Disease and Beta-ThalassemiaActive, not recruitingNCT05357482Phase 1/2
• Daily Topical Rapamycin for VitiligoActive, not recruitingNCT05342519Phase 2
• Study to Compare the Efficacy and Safety After Conversion to RaparoBell® or My-Rept® in Kidney Transplant PatientsActive, not recruitingNCT05193565Phase 4
• A Study of Sirolimus for Injection (Albumin Bound) in Patients With Advanced Solid TumorsStatus unknownNCT05125523Phase 1
• Reduced Intensity Allogeneic HCT in Advanced Hematologic Malignancies w/T-Cell Depleted GraftActive, not recruitingNCT05088356Phase 1
• Effect of Rapamycin to Improve Cardiac Function in Frail Older AdultsCompletedNCT04996719Phase 1
• Assessing the Efficacy of Sirolimus in Patients With COVID-19 Pneumonia for Prevention of Post-COVID FibrosisActive, not recruitingNCT04948203Phase 2/3
• Sirolimus in Treatment of Proteinuric Flares of Lupus NephritisStatus unknownNCT04892212Phase 2/3
• Phase III Trial of Sirolimus in IBMActive, not recruitingNCT04789070Phase 3
• Efficacy and Safety of Different Concentrations of Sirolimus in the Treatment of Kaposiform Hemangioendothelioma.CompletedNCT04775173Phase 2
• Effect of mTOR Inhibition & Other Metabolism Modulating Interventions on the Elderly [SubStudy Rapa & cMRI to Evaluate Cardiac Function]Active, not recruitingNCT04742777Phase 2
• Sirolimus for Retinal Astrocytic HamartomaCompletedNCT04707209Not applicable
• Rapamycin - Effects on Alzheimer's and Cognitive HealthActive, not recruitingNCT04629495Phase 2
• Efficacy and Safety of Sirolimus in Active Systemic Lupus ErythematosusActive, not recruitingNCT04582136Phase 3
• Participatory Evaluation (of) Aging (With) Rapamycin (for) Longevity StudyCompletedNCT04488601Phase 2
• Effects of mTOR Inhibition With Sirolimus (RAPA) in Patients With COVID-19 to Moderate the Progression of ARDSWithdrawnNCT04482712Phase 1/2
• Sirolimus Treatment for Newly Diagnosed Primary Acquired PRCACompletedNCT04470804Phase 4
• Efficacy and Safety of Sirolimus in COVID-19 InfectionStatus unknownNCT04461340Phase 2
• Guided Discontinuation Versus Maintenance Treatment of Sirolimus in Pediatric Patients With Kaposiform HemangioendotheliomaCompletedNCT04448873Phase 4
• Phase 1/2 Clinical Trial of PR001 in Infants With Type 2 Gaucher Disease (PROVIDE)Active, not recruitingNCT04411654Phase 1/2
• SCMC Trial on KHE With KMP (V.2020)Status unknownNCT04409691Phase 1
• Sirolimus in COVID-19 Phase 1WithdrawnNCT04371640Phase 1
• Reduced Intensity Transplantation for Severe Sickle Cell DiseaseActive, not recruitingNCT04362293Phase 2
• Sirolimus Combined With ATRA for the Treatment of Auto-Immune AnemiaWithdrawnNCT04324411Phase 4
• Testing SIROLIMUS in Beta-thalassemia Transfusion Dependent Patients (THALA-RAP)Status unknownNCT04247750Phase 2
• TOPical Sirolimus in linGUal Microcystic Lymphatic Malformation -TOPGUNCompletedNCT04128722Phase 2
• Liposomal Sirolimus in Dry Eye DiseaseCompletedNCT04115800Early Phase 1
• Sirolimus for Cowden Syndrome With Colon PolyposisCompletedNCT04094675Phase 2
• Safety and Efficacy of Low-dose Sirolimus to Kaposiform HemangioendotheliomaCompletedNCT04077515Phase 4
• Study of Sirolimus in Idiopathic Retroperitoneal FibrosisCompletedNCT04047576Phase 2/3
• Treatment of Congenital Vascular Malformations Using Sirolimus: Improving Quality of LifeStatus unknownNCT03987152Phase 3
• NPC-12G Gel 0.2% Sirolimus PK Bridging StudyCompletedNCT03972462Phase 1
• The Efficacy and Safety of Sirolimus for Plastic BronchitisStatus unknownNCT03942926Phase 2
• Adjunctive Sirolimus and Oseltamivir Versus Oseltamivir Alone for Treatment of InfluenzaActive, not recruitingNCT03901001Phase 3
• Serial Measurements of Molecular and Architectural Responses to Therapy (SMMART) PRIME TrialTerminatedNCT03878524Phase 1
• Testing SIROLIMUS in Beta-thalassemia Transfusion Dependent PatientsCompletedNCT03877809Phase 2
• Umbilical Cord Blood Transfusion in Progeria SyndromeCompletedNCT03871972Phase 1/2
• Sirolimus Combined With Low-dose Warfarin for the Treatment of Refractory PNHStatus unknownNCT03866681Phase 4
• Efficacy of Rapamycin (Sirolimus) in the Treatment of Peutz-Jeghers SyndromeStatus unknownNCT03781050Phase 4

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