Simvastatin: all 386 studies that test it

Page 3 of 4. Open to participants first (27), then studies with results posted, then the rest; newest registration first within each.

• Effect of Simvastatin Withdrawal on Ocular Endothelial FunctionWithdrawnNCT02533141Phase 4
• Renal Hemodynamic Effects of the HMG-CoA Reductase Inhibitors in Normal Volunteers and in Patients With Chronic Renal FailureCompletedNCT02511418Not applicable
• To Compare the Efficacy and Safety of Carvedilol With or Without Simvastatin in Patients With Portal Hypertension and Esophageal Varices.CompletedNCT02465645Not applicable
• Evaluate the Pharmacokinetics of Simvastatin When Coadministered With PEX168 in Healthy Adult SubjectsCompletedNCT02447601Phase 1
• Trial of Simvastatin for the Treatment of Severe AsthmaWithdrawnNCT02433535Phase 2
• Cilostazol-Simvastatin Drug Interaction StudyStatus unknownNCT02431013Phase 1
• Role of Immune Responses After Acute Myocardial InfarctionStatus unknownNCT02428374Phase 4
• Trial to Evaluate the Efficacy of Simvastatin for Smoking CessationCompletedNCT02399709Phase 2
• Simvastatin With Topotecan and Cyclophosphamide in Relapsed and/or Refractory Pediatric Solid and CNS TumorsCompletedNCT02390843Phase 1
• Simvastatin and Metformin in Chronic PeriodontitisCompletedNCT02372656Phase 2/3
• Statin DistributionCompletedNCT02360826Phase 1
• Metformin and Simvastatin Use in Bladder CancerStatus unknownNCT02360618Phase 2
• Anti-Platelet and Statin Therapy to Prevent Cancer-Associated ThrombosisCompletedNCT02285738Early Phase 1
• SIMOX - Induction of Oxidative StressCompletedNCT02256254Phase 2
• Use of Simvastatin as a Steroid Sparing Agent for Uveitis PatientsStatus unknownNCT02252328Phase 2/3
• Pharmacokinetics of Simvastatin and Its Metabolite Simvastatin Acid With and Without Concomitant Administration of Telmisartan in Healthy SubjectsCompletedNCT02187536Phase 1
• The Effect of Multiple Oral Doses of BI 1356 BS on Pharmacokinetics, Safety and Tolerability of Multiple Oral Doses of Simvastatin and on the Pharmacokinetics of Its Metabolite Simvastatin Acid in Healthy Male VolunteersCompletedNCT02183623Phase 1
• Capecitabine Plus Simvastatin in Locally Advanced Rectal Cancer PatientsStatus unknownNCT02161822Phase 2
• Simvastatin Effect on Portal HypertensionCompletedNCT02134626Phase 3
• Platelet Rich Fibrin Combined With Simvastatin for Treatment of Intrabony Defect in Chronic PeriodontitisCompletedNCT02120872Phase 2
• Efficacy of Simvastatin for the Treatment of COPDCompletedNCT02070133Phase 3
• Clinical and Economic Outcome of Simvastatin in Critically Ill Septic PatientCompletedNCT02067949Phase 3
• A Single Arm, Phase II Study of Simvastatin Plus XELOX and Bevacizumab as First-line Chemotherapy in Metastatic Colorectal Cancer PatientsCompletedNCT02026583Phase 2
• Sarilumab Effect on the Pharmacokinetics of SimvastatinCompletedNCT02017639Phase 1
• Simvastatin Addition for Patients With Recent-onset SchizophreniaCompletedNCT01999309Phase 3
• A Two-part Study to Investigate the Interaction and Pharmacokinetics of GSK2586184CompletedNCT01953835Phase 1
• A Study to Assess the Effects of Canagliflozin (JNJ-28431754) on the Pharmacokinetics, Pharmacodynamics, and Safety of Simvastatin in Healthy VolunteersCompletedNCT01821027Phase 1
• Efficacy Study of SIMVASTATIN to Treat Chronic Rhinosinusitis After Failure of Optimal TreatmentTerminatedNCT01771198Phase 2
• Permeability MRI in Cerebral Cavernous Malformations Type 1 in New Mexico: Effects of StatinsTerminatedNCT01764451Early Phase 1
• Assess the Pharmacokinetics of Rosuvastatin and Simvastatin When Administered Alone or in Combination With FostamatinibCompletedNCT01725230Phase 1
• Statin Recapture Therapy Before Coronary Artery Bypass GraftingCompletedNCT01715714Phase 4
• A Pharmacokinetic Interaction Study Between TMC435, Atorvastatin and Simvastatin in Healthy ParticipantsCompletedNCT01689623Phase 1
• Vascular and Metabolic Effects of Vytorin vs SimvastatinCompletedNCT01666067Phase 4
• The Short-term Effects of Simvastatin on the Vision of Males Affected by ChoroideremiaTerminatedNCT01654562Phase 1/2
• Effect of Simvastatin on Pneumonia Prognosis in Elderly PatientsStatus unknownNCT01651728Phase 3
• Study for Identifying Optimal Simvastatin Formulation for Uniform Time to Maximum Plasma ConcentrationTerminatedNCT01642862Phase 1
• Randomized Double Blind Placebo Control Study in Patients with SchizophreniaCompletedNCT01602029Phase 2
• Study of Metformin With Simvastatin for Men With Prostate CarcinomaWithdrawnNCT01561482Phase 2
• A Prevention Trial in Subjects at High Risk for Breast CancerCompletedNCT01500577Phase 2
• A Study To Estimate The Effect Of Repeated Dosing of PF-05175157 On The Pharmacokinetics Of A Single Dose Of Simvastatin In Healthy Adult SubjectsCompletedNCT01469468Phase 1
• Drug-Drug Interaction Study Of Effect Of PF-03882845 On Simvastatin PharmacokineticsCompletedNCT01445860Phase 1
• Effects on NF-κB Activity: High Dose Simvastatin Versus Combination Therapy With EzetimibeCompletedNCT01424891Not applicable
• Effect of Ezetimibe or Simvastatin or Both on Low Densitiy Lipoprotein -Subfractions in Patients With Type 2 DiabetesCompletedNCT01384058Phase 4
• Effect of Cilostazol on the Pharmacokinetics of SimvastatinCompletedNCT01383395Phase 1
• Simvastatin Treatment of Pachyonychia CongenitaStatus unknownNCT01382511Not applicable
• Primary Prevention of Cardiovascular Disease (CVD) in Pre-diabetic & Pre-hypertensive SubjectsStatus unknownNCT01364675Not applicable
• Protocol for Correlating Enteropathic Severity and Small Intestinal CYP3A4 Activity in Patients With Celiac DiseaseCompletedNCT01338324Phase 2/3
• Phase II Study of Simvastatin for Relapsed/Refractory MyelomaWithdrawnNCT01332617Phase 2
• A Single-centre Open Label Study to Investigate the Effect of Repeat Doses of SB-649868 on the Pharmacokinetics of Simvastatin and Atorvastatin in Healthy Male Volunteers.CompletedNCT01299597Phase 1
• Study About Simvastatin in Portal Hypertension in Compensated CirrhosisStatus unknownNCT01282398Phase 4
• Hemodynamic Effect of Simvastatin With Beta Blockers in Clinical Portal HypertensionStatus unknownNCT01282385Phase 4
• Simvastatin + Cetuximab/Irinotecan in K-ras Mutant Colorectal Cancer (CRC)CompletedNCT01281761Phase 2
• Trial of XELIRI/FOLFIRI + Simvastatin Followed by Simvastatin Maintenance in Metastatic Colorectal CancerStatus unknownNCT01238094Phase 3
• Effect of Statin Treatment on Insulin Sensitivity During Myocardial InfarctionCompletedNCT01205347Phase 4
• Simvastatin Effect on the Incidence of Acute Lung Injury/Adult Respiratory Distress Syndrome (ALI/ARDS)WithdrawnNCT01195428Not applicable
• Cetuximab and Simvastatin in Treating Patients With Advanced or Metastatic Colorectal CancerStatus unknownNCT01190462Phase 2
• Study to Compare the Effect of Vytorin (Simvastatin/Ezetimibe) 10/20mg Versus Atorvastatin 20mg on ApoB/ApoA1 Ratio in Subjects With DiabetesStatus unknownNCT01185236Phase 4
• Effect of Aminobiphosphonates and Statins on Circulating Vgamma9Vdelta2-T CellsCompletedNCT01179464Not applicable
• Effect of Simvastatin on Cardiac FunctionCompletedNCT01178710Not applicable
• Bioequivalence Study of Simvastatin Tablets, 80 mg of Dr. Reddy's Under Fed ConditionsCompletedNCT01167933Phase 1
• Bioequivalence Study of Simvastatin Tablets 80 mg of Dr. Reddy's Under Fasting ConditionCompletedNCT01167894Phase 1
• BIBW 2992 Plus Simvastatin vs. BIBW 2992 in Previously Treated Patients With Advanced Non-adenocarcinomatous NSCLCCompletedNCT01156545Phase 2
• The Effect of Statins in Patients With Chronic Obstructive Pulmonary Disease (COPD)CompletedNCT01151306Phase 4
• A Drug Interaction Study of Simvastatin and AlbiglutideCompletedNCT01147692Phase 1
• A Drug Interaction Study Between Simvastatin, Atorvastatin, Rosuvastatin, and GSK2248761 in Healthy Subjects.CompletedNCT01138072Phase 1
• Simvastatin and Panitumumab in Treating Patients With Advanced or Metastatic Colorectal CancerStatus unknownNCT01110785Phase 2
• To Explore The Potential For PF-04531083 To Effect The Blood Concentrations Of Simvastatin And Its Main Acid Metabolite Following Co-Administration Of Both MedicationsCompletedNCT01103739Phase 1
• Effect of Simvastatin and Ezetimibe on Lipid and InflammationCompletedNCT01103648Not applicable
• A Study to Investigate the Interaction of GSK1292263 With Rosuvastatin and Simvastatin in Healthy SubjectsCompletedNCT01101568Phase 1
• Trial of XP (Capecitabine/CDDP) Simvastatin in Advanced Gastric Cancer PatientsCompletedNCT01099085Phase 3
• Study To Assess the Pharmacokinetics of AZD1656 During Coadministration With SimvastatinCompletedNCT01096940Phase 1
• Efficacy of Statin Association With Standard Treatment in Prevention of Recurrent Hemorrhage in Patient With Cirrhosis and Variceal BleedingCompletedNCT01095185Phase 3
• Statins To Treat Adult Cystic FibrosisWithdrawnNCT01092572Phase 1/2
• The Effect Of Simvastatin On Bone Remodeling In Socket Of Mandibular TeethStatus unknownNCT01085149Not applicable
• High-dose Simvastatin for Aneurysmal Subarachnoid HaemorrhageCompletedNCT01077206Phase 2/3
• Stroke Treatment With Acute Reperfusion and SimvastatinCompletedNCT01073007Phase 4
• Simvastatin and Diastolic DysfunctionCompletedNCT01061450Phase 4
• STATIN-VAP STATIN-VAP - STATINs and Ventilator-Associated PneumoniaTerminatedNCT01057758Phase 3
• Targeting Microvascular Dysfunction in Young Hypertensive PatientsWithdrawnNCT01047423Phase 4
• Simvastatin in Colorectal SurgeryCompletedNCT00994903Phase 3
• Muscle Characteristics Associated With Statin TherapyWithdrawnNCT00990834Not applicable
• Acetyl-L-Carnitine in Type 2 DiabetesCompletedNCT00984750Phase 3
• Simvastatin for Treating Erectile DysfunctionCompletedNCT00947323Phase 3
• Impact of Statins on Cytokine Expression in PneumoniaWithdrawnNCT00946166Phase 4
• Trial of Simvastatin and Gemcitabine in Pancreatic Cancer PatientsCompletedNCT00944463Phase 2
• Role of Anti-Inflammatory Agents in Patients With SchizophreniaCompletedNCT00929955Phase 1
• Simvastatin Effect on Inflammation and Endothelial Function After Myocardial InfarctionCompletedNCT00906451Phase 4
• Influence of Simvastatin on Apolipoprotein B-100 (apoB-100) SecretionCompletedNCT00905541Not applicable
• Efficacy and Adverse Effect of Simvastatin Compare to Rosuvastatin in Systemic Lupus Erythematosus (SLE) Patients With Corticosteroid Therapy and High Low-Density Lipoprotein (LDL) Cholesterol LevelStatus unknownNCT00866229Phase 4
• Ezetimibe/Simvastatin Combination in Proteinuric NephropathyStatus unknownNCT00861731Phase 4
• Metabolic and Vascular Effects of Statins in Untreated Dyslipidemic Diabetic PatientsCompletedNCT00854503Phase 3
• Trial of Simvastatin in Amnestic Mild Cognitive Impairment (MCI) PatientsStatus unknownNCT00842920Phase 4
• Pharmacokinetic Drug Interaction Study of Dapagliflozin and Valsartan or Simvastatin in Healthy SubjectsCompletedNCT00839683Phase 1
• High-dose HMG-CoA Inhibitor Simvastatin Relapsed CLLCompletedNCT00828282Phase 1
• Phase II Study of Simvastatin in Primary Breast Cancer; Test of Its Potential Selectivity on Basal Subtype Breast CancerStatus unknownNCT00807950Phase 2
• The Additive Anti-inflammatory Effect of Simvastatin in Combination With Inhaled Corticosteroids in AsthmaCompletedNCT00792337Phase 3
• The Effect of Simvastatin Therapy on the Expression of Procoagulant and Inflammatory Markers in Heart FailureCompletedNCT00769210Early Phase 1
• Vytorin on Carotid Intima-media Thickness and Overall RigidityCompletedNCT00738296Phase 4
• A Study to Assess Co-Administered AZD9056 (Steady State) and Simvastatin (Single Dose) in Healthy VolunteersCompletedNCT00736606Phase 1
• Crossover of Higher Dose Statins in Patients With Low High-density Lipoproteins Cholesterol (HDLc)Status unknownNCT00736463Phase 4

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