Simvastatin: all 386 studies that test it

Page 2 of 4. Open to participants first (27), then studies with results posted, then the rest; newest registration first within each.

• Evaluating Simvastatin's Potential Role in TherapyCompletedNCT00486044Phase 2Results posted
• Effects of Statin and Ezetimibe Association on Kinetics of Artificial ChilomicronsCompletedNCT00481351Phase 4Results posted
• MK-0524B Lipid Study (MK-0524B-063)CompletedNCT00479882Phase 3Results posted
• A Study to Assess the Cholesterol Lowering Effect of an Ezetimibe/Simvastatin Combination Tablet Compared to Another Cholesterol Lowering Drug in Patients With High Cholesterol and With High Cardiovascular Risk (0653A-809)(COMPLETED)CompletedNCT00479713Phase 3Results posted
• Study of Extended Release Niacin/Laropiprant on Lipids (0524A-067)CompletedNCT00479388Phase 3Results posted
• Clinical Trial of Zocor (Simvastatin) and Vytorin (Ezetimibe/Simvastatin) in Adolescents With Type 1 DiabetesCompletedNCT00477204Phase 2Results posted
• Antiplatelet and Anti-inflammatory Effects of Statins and EzetimibeCompletedNCT00474123Not applicableResults posted
• An Open-Label Study to Compare the Lipid Effects of Niacin ER and Simvastatin (NS) to Atorvastatin in Subjects With Hyperlipidemia or Mixed Dyslipidemia (SUPREME)CompletedNCT00465088Phase 3Results posted
• A Study to Determine the Number of Patients Who Reach Optimal Cholesterol Levels on Each of Three Different Treatments (0653A-121)CompletedNCT00462748Phase 3Results posted
• Vytorin (10/20 Or 10/40) Compared to Atorvastatin (10 mg or 20 mg) in Patients With Coronary Artery Disease (0653A-126)(COMPLETED)CompletedNCT00442897Phase 4Results posted
• Effects of Vytorin Versus Placebo in Subjects With Primary Hypercholesterolemia (Study P04420)CompletedNCT00413972Phase 3Results posted
• Ezetimibe/Simvastatin in Patients With Metabolic Syndrome (0653A-107)(COMPLETED)CompletedNCT00409773Phase 3Results posted
• A Study of Aspirin and Simvastatin in Pulmonary Arterial HypertensionTerminatedNCT00384865Phase 2Results posted
• Simvastatin and Anastrozole in Treating Postmenopausal Women With Ductal Carcinoma In Situ or Invasive Breast CancerCompletedNCT00354640Phase 2Results posted
• Simvastatin in Preventing a New Breast Cancer in Women at High Risk for a New Breast CancerCompletedNCT00334542Phase 2Results posted
• Study to Evaluate the Long-Term Safety and Efficacy of ABT-335, in Combination With Three Different Statins in Subjects With Mixed Dyslipidemia.CompletedNCT00300430Phase 3Results posted
• Lipid Efficacy and Safety in Participants With Mixed Hyperlipidemia (MK-0524B-024)CompletedNCT00289900Phase 3Results posted
• To Evaluate Ezetimibe/Simvastatin and Niacin (Extended Release Tablet) in Patients With Type IIa or Type IIb Hyperlipidemia (0653A-091)(COMPLETED)CompletedNCT00271817Phase 3Results posted
• Simvastatin as a Treatment for Pulmonary HypertensionCompletedNCT00180713Phase 1/2Results posted
• Ezetimibe Plus (+) Simvastatin Versus Atorvastatin Comparative Study (0653A-092)(COMPLETED)CompletedNCT00166504Phase 4Results posted
• Effects of Ezetimibe With Simvastatin in the Therapy of Adolescents With HeFH (Study P02579)CompletedNCT00129402Phase 3Results posted
• Study of Heart and Renal ProtectionCompletedNCT00125593Phase 4Results posted
• Study of the Effectiveness of Additional Reductions in Cholesterol and HomocysteineCompletedNCT00124072Phase 3Results posted
• Detection of Plaque Inflammation by Positron Emission Tomography (PET)-Effects of Simvastatin on Plaque InflammationCompletedNCT00114504Not applicableResults posted
• An Investigational Drug on Clinical Outcomes in Patients With Aortic Stenosis (Narrowing of the Major Blood Vessel of the Heart)(MK-0653A-043 AM4)(COMPLETED)CompletedNCT00092677Phase 3Results posted
• The Role of Bisphosphonate and Simvastatin Combination on Therapeutic Response in Breast Cancer With Bone Metastasis Via Dicckopf-1 PathwayCompletedNCT07823751Not applicable
• Alveolar Ridge Splitting With Simvastatin/PRF Composite and Simultaneous Implant PlacementCompletedNCT07692620Not applicable
• Clinical Evaluation of Simcyp-Guided Simvastatin Dosing in Patients With Liver CirrhosisCompletedNCT07459972Phase 4
• Effect of Locally Applied Simvastatin Gel on Dental Implant Stability and Marginal Bone LevelCompletedNCT07194447Not applicable
• Remedial Mechanism of Simvastatin and Ursodeoxycholic Acid in Liver Cirrhosis: Crosstalk of Bile Secretion, Gut Microbiome, and Host Immune ResponseTerminatedNCT07102979Not applicable
• A Study to Investigate the Effect of AZD5004 on Rosuvastatin, Atorvastatin, Simvastatin, Repaglinide and the Effect of Erythromycin on AZD5004 in Healthy ParticipantsCompletedNCT06948747Phase 1
• Effect of Repeated Oral Doses of Avacopan on the Pharmacokinetics (PK) of a Single Dose of SimvastatinCompletedNCT06207682Phase 1
• Effect of Local Application of Simvastatin Versus Bone Powder on Implant Bone ChangesCompletedNCT06016218Phase 1/2
• Efficacy of Combination of Biodentine and Simvastatin as a Pulp Capping Materials in Vital Pulpotomy of Primary MolarsCompletedNCT05582317Not applicable
• A Study of LY3526318 in Healthy Male Japanese ParticipantsWithdrawnNCT05580250Phase 1
• Effects of Usage of Simvastatin in Mild to Moderate Traumatic Brain Injury (TBI) Patients. Could it Make a Difference?Status unknownNCT05551871Not applicable
• Simvastatin Nasal Rinses for the Treatment of COVID-19 Mediated DysomsiaWithdrawnNCT05542095Phase 1
• Effect of Simvastatin Versus Calcium Hydroxide Intracanal Medications on Post-operative Pain and Interleukin 6 and 8CompletedNCT05525013Not applicable
• Salivary Bmp-2 Levels & Radiographic Measurement Of Bone Density at Extracted ToothCompletedNCT05369091Phase 4
• Drug-Drug Interaction Study to Investigate Effects of Voclosporin on Pharmacokinetics of SimvastatinCompletedNCT05306379Phase 1
• Effect of Statin Therapy on Mortality in Patients With Ventilator Associated PneumoniaCompletedNCT05230472Phase 4
• To Study the Safety and Efficacy of Simvastatin in Patients With Hepatopulmonary Syndrome in Cirrhosis.Status unknownNCT05187715Not applicable
• Effect of Simvastatin on Sepsis and Febrile Neutropenia in Patients With Acute Lymphoblastic LeukemiaStatus unknownNCT05133310Phase 4
• The Interaction of Herbs and StatinsCompletedNCT05072405Phase 4
• Effect of Local Application of Platelet-rich Fibrin Scaffold Loaded With Simvastatin on Peri-implant Bone ChangesCompletedNCT05008068Phase 1
• Combined Simvastatin and Irinotecan in Treating ES-SCLC Patients Relapsed From 1st ChemotherapyStatus unknownNCT04985201Phase 2
• Simvastatin and Emotional Processing (OxSTEP)CompletedNCT04973800Not applicable
• A Study to Evaluate the DDI of DBPR108 With Metformin,Glibenclamide,Valsartan, or Simvastatin in Healthy SubjectsCompletedNCT04859452Phase 1
• The Use of Injectable Plasma Versus the Use of Simvastatin Gel in Surgical Management of Bony Defect in DentistryStatus unknownNCT04824898Phase 1
• Simvastatin Around Immediate ImplantCompletedNCT04803500Phase 2
• Combined Simvastatin and Albumin Paclitaxel in Treating ES-SCLC Patients Relapsed From 1st ChemotherapyStatus unknownNCT04698941Phase 2
• 7-day Simvastatin and Emotional ProcessingCompletedNCT04652089Phase 1/2
• Neurotoxicity Prophylaxis With Intrathecal Dexamethasone and Simvastatin Post Axi-CelActive, not recruitingNCT04514029Early Phase 1
• Statin Therapy to Reduce Progression in Women With Platinum Sensitive Ovarian CancerCompletedNCT04457089Early Phase 1
• Simvastatin Effect in Combination With Neoadjuvant Chemotherapy to Clinical Response and Tumor-Free Margin in Locally Advanced Breast CancerCompletedNCT04418089Phase 2
• Study of Ruxolitinib Plus Simvastatin in the Prevention and Treatment of Respiratory Failure of COVID-19.CompletedNCT04348695Phase 2
• Coronavirus Response - Active Support for Hospitalised Covid-19 PatientsWithdrawnNCT04343001Phase 3
• Simvastatin add-on Treatment to Standard Antidepressant Therapy in Patients With Comorbid Obesity and Major DepressionCompletedNCT04301271Phase 2
• Simvastatin in UveitisCompletedNCT04183387Phase 2
• Effect of Lipid Lowering Agents on Diabetic Retinopathy and Cardiovascular Risk of Diabetic PatientsStatus unknownNCT04140201Phase 4
• Effect of Simvastatin on the Prognosis of Primary Primary Sclerosing Cholangitis (PSC)Active, not recruitingNCT04133792Phase 3
• Impact of Bariatric Surgery on Pharmacokinetic Study of Simvastatin and CarvedilolStatus unknownNCT04049786Phase 4
• Simvastatin in the Prevention of Recurrent PancreatitisTerminatedNCT04021498Phase 3
• Phase IB Metformin, Digoxin, Simvastatin in Solid TumorsActive, not recruitingNCT03889795Phase 1
• Safety and Tolerability Study of Ezetimibe (SCH 058235/MK-0653) Plus Atorvastatin or Simvastatin in Homozygous Familial Hypercholesterolemia (P01417/MK-0653-019)CompletedNCT03885921Phase 3
• Ezetimibe (SCH 58235) Taken With Either Atorvastatin or Simvastatin in Participants With Familial Hypercholesterolemia (MK-0653-018)CompletedNCT03884452Phase 3
• Drug-Drug Interaction Study of Vadadustat With Rosuvastatin, Sulfasalazine, Pravastatin, Atorvastatin and SimvastatinCompletedNCT03801733Phase 1
• Efficacy of the Combination of Simvastatin Plus Rifaximin in Patients With Decompensated Cirrhosis to Prevent ACLF DevelopmentCompletedNCT03780673Phase 2/3
• Simvastatin Therapy in Patients With Dilated Cardiomyopathy.CompletedNCT03775070Phase 2
• The Effect of Simvastatin Combined With Ezetimibe in Patients With Stable Angina and DiabetesStatus unknownNCT03771053Not applicable
• Comparative Evaluation Of 1.2% Atorvastatin and 1.2% Simvastatin Gel Local Drug Delivery And Redelivery In Chronic Periodontitis Subjects With Diabetes Mellitus: A Randomized Controlled Clinical Trial.CompletedNCT03745300Phase 2/3
• Multi-Center Study of the Effects of Simvastatin on Hepatic Decompensation and Death in Subjects Presenting With High-Risk Compensated CirrhosisActive, not recruitingNCT03654053Phase 3
• NIRS to Diagnose SAMSStatus unknownNCT03653663Phase 4
• Central Nervous System Vascular Changes in Adult Sickle Cell Disease and the Effect of Treatment With SimvastatinStatus unknownNCT03599609Phase 1/2
• Lipid-lowering Therapies in Vietnamese Chronic Kidney Disease PopulationStatus unknownNCT03543774Phase 4
• Simvastatin as an Augmentation Treatment for Treatment Resistant Depression: Randomized Controlled Trial.CompletedNCT03435744Phase 3
• Efficacy of High and Low-Dose Simvastatin on Vascular Oxidative Stress and Neurological Outcome in Patients With AISCompletedNCT03402204Phase 3
• Effects of Simvastatin on Uterine Leiomyoma SizeActive, not recruitingNCT03400826Phase 2
• Multiple Sclerosis-Simvastatin Trial 2CompletedNCT03387670Phase 3
• Drug-drug Interaction Between Simvastatin and SHR3824Status unknownNCT03329118Phase 1
• Simvastatin Plus Dual Anti-HER2 Therapy for Metastatic Breast CancerActive, not recruitingNCT03324425Phase 2
• Metformin and Simvastatin in Addition to FulvestrantStatus unknownNCT03192293Phase 2
• A Drug-Drug Interaction Study Between GDC-0853 and Midazolam, Itraconazole, Rosuvastatin, and SimvastatinCompletedNCT03174041Phase 1
• Simvastatin Plus Rifaximin in Decompensated CirrhosisCompletedNCT03150459Phase 2
• A Phase I Study of High Dose Simvastatin in Patients With Gastrointestinal Tract Cancer Who Failed to Standard ChemotherapyStatus unknownNCT03086291Phase 1
• Simvastatin Metabolism as a Test for CD Activity (IRB 15-007568]CompletedNCT03011931Early Phase 1
• Evaluation Of The Portal Pressure By Doppler Ultrasound In Cirrhotic Patients Before And After SimvastatinCompletedNCT02994485Phase 4
• Simvastatin in Overcoming Chemotherapy Resistance in Patients With Relapsed or Refractory Multiple MyelomaWithdrawnNCT02971410Early Phase 1
• Simvastatin to Prevent SCI-Induced Bone LossStatus unknownNCT02946424Phase 2
• Randomized Comparative Efficacy and Safety Study of Intermittent Simvastatin and Fenofibrate in HemodialysisCompletedNCT02886299Phase 4
• Effect of Statin Use on Aldosterone SecretionCompletedNCT02871687Phase 1
• The DDI Study of SP2086 and SimvastatinStatus unknownNCT02817243Phase 1
• The Drug-drug Interaction of SP2086 and SimvastatinCompletedNCT02815722Phase 1
• Simvastatin as a Neuroprotective Treatment for Moderate Parkinson's DiseaseCompletedNCT02787590Phase 2
• Effects of Simvastatin and Micronized Trans-resveratrol Treatment on Polycystic Ovary Syndrome (PCOS) PatientsStatus unknownNCT02766803Phase 4
• Treatment With HMG-COA Reductase Inhibitor of Growth and Bone Abnormalities in Children With Noonan SyndromeCompletedNCT02713945Phase 3
• Pharmacokinetic and Safety Study of Cenicriviroc and HMG-CoA Reductase Inhibitors, Caffeine and DigoxinCompletedNCT02685462Phase 1
• A Study to Investigate the Effect of MT-8554 on the Pharmacokinetics of Simvastatin and Rosuvastatin in Healthy SubjectsCompletedNCT02675309Phase 1
• Effect of Gemcabene on the Pharmacokinetics of Simvastatin in Healthy VolunteersCompletedNCT02587390Phase 1
• Drug Interaction Study of MGL-3196 With Rosuvastatin and SimvastatinCompletedNCT02542969Phase 1

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