5-HT3 antagonists: all 422 studies that test it

Page 3 of 5. Open to participants first (39), then studies with results posted, then the rest; newest registration first within each.

• Ramosetron OD Tablet and Postdischarge Nausea and VomitingStatus unknownNCT04297293Phase 4
• Granisteron Versus Ondansetron for Prophylaxis Against Post-Spinal Anesthesia Shivering: a Randomized Controlled StudyStatus unknownNCT04294992Not applicable
• A Pilot Trial Evaluating the Effect of Tropisetron on Postoperative Cognitive Dysfunction After Cardiac SurgeryStatus unknownNCT04195204Phase 4
• The Ondansetron Premedication Trial in Juvenile Idiopathic ArthritisCompletedNCT04169828Not applicable
• Hemodynamic Protection of Preoperative Ondansetron 15 Minutes Before Spinal Anaesthesia in Caesarean SectionCompletedNCT04140058Phase 3
• Study to Evaluate AD04 in Adults With Alcohol Use Disorder (AUD) and Selected Serotonin Transporter PolymorphismsCompletedNCT04101227Phase 3
• Granisetron Extended Release Injection (GERSC) for the Prevention of Chemotherapy-induced Nausea and VomitingWithdrawnNCT04085393Phase 2
• Post-Operative Nausea and Vomiting in Children Submitted to Strabismus SurgeryStatus unknownNCT04060771Phase 3
• The Efficacy and Safety of Tropisetron in Preventing Emergence DeliriumStatus unknownNCT04027751Phase 4
• Study to Evaluate Rate of Nausea in Healthy Premenopausal Female Subjects Treated With Single Dose of Bremelanotide Alone or With ZofranCompletedNCT03973047Phase 1
• Rolapitant Plus Olanzapine in Multiday Cisplatin ChemotherapyWithdrawnNCT03960151Phase 2
• Postoperative Nausea and Vomiting After Laparoscopic CholecystectomyCompletedNCT03933605Not applicable
• The Effect of Ondansetron on Spinal Anesthesia in Caesarean SectionStatus unknownNCT03931863Phase 3
• Adjunctive Granisetron Therapy in Patients With Sepsis or Septic ShockCompletedNCT03924518Phase 2
• NEPA to Prevent Chemotherapy Induced Nausea and Vomiting in Patients With Breast CancerCompletedNCT03862144Phase 2
• Multi-DOSE Oral Ondansetron for Pediatric Acute GastroEnteritisCompletedNCT03851835Phase 3
• Mode of Action of Ondansetron, a 5-HT Receptor 3 Antagonist, in Lactulose Induced DiarrhoeaCompletedNCT03833999Phase 4
• Comparative Effectiveness of AKYNZEO® and Standard of Care (Including EMEND®) for the Prevention of Nausea and Vomiting (CINV) in Cancer PatientsStatus unknownNCT03831633Phase 4
• Cisplatin Disposition and Kidney InjuryActive, not recruitingNCT03817970Phase 3
• Validating the Effect og Ondansetron and Mirtazapine in Treating Hyperemesis GravidarumTerminatedNCT03785691Phase 2
• Effects of Intraoperative Dexamethasone and Ondansetron on Postoperative Nausea and Vomiting in Microvascular Decompression SurgeryCompletedNCT03685032Not applicable
• Safety and Antiemetic Efficacy of Akynzeo Plus Dexamethasone During Radiotherapy and Concomitant Weekly CisplatinStatus unknownNCT03668639Phase 2/3
• Effects of Ondansetron on Hemodynamics in Cesarean Section Under Spinal AnesthesiaCompletedNCT03629522Phase 4
• Effectiveness and Quality of Life Analysis of Palonosetron Against Ondansetron Combined With Dexamethasone and Fosaprepitant in Prevention of Acute and Delayed Emesis Associated to Chemotherapy Moderate and Highly Emetogenic in Breast Cancer.Status unknownNCT03606369Phase 2/3
• Noninvasive Markers of Functional Nausea in ChildrenCompletedNCT03593811Early Phase 1
• PALONOSETRON X FOSAPREPITANT IN PONVStatus unknownNCT03586817Phase 4
• TReatment of Irritable Bowel Syndrome With Diarrhoea Using Titrated ONdansetron TrialCompletedNCT03555188Phase 3
• Anti-shivering Effect of OndansetronStatus unknownNCT03530007Phase 2/3
• Effect of Granisetron on Morphine Induced Pruritus in Cesarean SectionCompletedNCT03483870Phase 2
• Comp Granisetron Midazolam Comb in Lap ChildrenStatus unknownNCT03483350Phase 3
• Effect of Ramosetron on Post-discharge Nausea and VomitingStatus unknownNCT03409835Not applicable
• Ramosetron Pre-treatment for PONV and QT ProlongationCompletedNCT03278522Phase 4
• Effect of Ramosetron on Heart Rate-corrected QT Interval During Robot-assisted Laparoscopic Prostatectomy With Steep Trendelenburg PositionCompletedNCT03232125Not applicable
• Efficacy of Ondansetron in LARS TreatmentCompletedNCT03182179Not applicable
• Granisetron Effect on Hemodynamic Changes in Laparoscopic CholecystectomyCompletedNCT03180229Phase 4
• Comparison Between Ondansetron 8 mg and Lidocain 40 mg in Preventing Pain Due to Propofol InjectionCompletedNCT03134612Phase 2
• Value of Ondansetron Medication vs Inhaled Isopropyl Therapy in the Emergency Department (VOMIITED)CompletedNCT03125811Early Phase 1
• Granisetron in Diabetic Parturients Decrease Spinal Induced HypotensionCompletedNCT03091881Phase 4
• Olanzapine for the Prevention of Chemotherapy-Induced Nausea and Vomiting in Chinese Breast Cancer PatientsCompletedNCT03079219Phase 3
• A Study of SENS 401 in Healthy SubjectsCompletedNCT03071003Phase 1
• Triage Administration of Ondansetron for Gastroenteritis in ChildrenTerminatedNCT03052361Phase 2/3
• Efficacy of an Anterior Quadratus Lumborum Block vs. a TAP-block for Inguinal Hernia RepairCompletedNCT03023462Not applicable
• Treatment Algorithm for Nausea and Vomiting in the Palliative PhaseStatus unknownNCT03017391Phase 4
• Therapeutic Efficacy of Ramosetron for Treatment of Established PONV After Laparoscopic SurgeryCompletedNCT03017222Not applicable
• Proof-of-Concept Trial of Palonosetron and Olanzapine Without Dexamethasone for the Prevention of CINStatus unknownNCT02970643Not applicable
• Prophylactic Ondansetron in Post-op Cardiac Surgery Patients to Prevent Post-operative Nausea and VomitingCompletedNCT02966041Not applicable
• Compare Between Two Doses of Palonosetron on the Prevention of Postoperative Nausea and Vomiting in Obese PatientsCompletedNCT02941913Phase 4
• Aprepitant for the Prevention of Chemotherapy-induced Nausea and VomitingStatus unknownNCT02933099Phase 3
• Norepinephrine Consumption After Prophylactic OndansetronCompletedNCT02928601Phase 4
• Reduction in Spinal-induced Hypotension With Ondansetron in Parturients Undergoing Caesarean SectionCompletedNCT02913768Phase 4
• Aprepitant Without Steroid in Preventing Chemotherapy-induced Nausea and Vomiting in Patients With Colorectal CancerCompletedNCT02909478Phase 3
• The Effect of Preventive Use of Ondansetron in the Cesarean Section Under Spinal AnesthesiaStatus unknownNCT02883192Not applicable
• Clinical Trial Assessing 5-HT3 Receptor Antagonist (Ramosetron) for the Treatment of Anterior Resection SyndromeStatus unknownNCT02869984Early Phase 1
• Interest of Intravenous Ondansetron in the Prevention of Spinal Anaesthesia-induced Hypotension in Caesarean SectionTerminatedNCT02862873Not applicable
• Effect of Ramosetron on Bowel Motility After Gynecological SurgeryStatus unknownNCT02849483Phase 4
• Effect of Ramosetron in Prevention of Intrathecal Morphine Induced Nausea and VomitingCompletedNCT02830906Phase 3
• The Effects of Anesthetic Techniques and Palonosetron Administration on the Incidence of PONVCompletedNCT02809378Phase 4
• Post-operative Nausea Vomiting in Laparoscopic CholecystectomyStatus unknownNCT02803788Phase 4
• Comparison of Palonosetron Versus Combination of Palonosetron and Dexamethasone for Preventing Postoperative Vomiting in Patients Receiving Fentanyl by Patient-controlled Analgesia After Minor Orthopedic SurgeryCompletedNCT02744508Not applicable
• Antiemetic Efficacy of Ondansetron Versus MetoclopramideStatus unknownNCT02619201Phase 3
• The Effects of Gabapentin and Ramosetron on Postoperative Nausea and Vomiting in Laparoscopic Gynecological SurgeryStatus unknownNCT02617121Not applicable
• Prevention of Spinal Induced Shivering During CSCompletedNCT02588547Phase 2
• Prophylactic Antiemetic Efficacy of Palonosetron Versus Ondansetron for the Prophylaxis of Postoperative Nausea and Vomiting (PONV) in Women Over 60 Years Undergoing Laparoscopic CholecystectomyCompletedNCT02541019Phase 4
• Ramosetron, Aprepitant, and Dexamethasone Versus Palonosetron, Aprepitant, and DexamethasoneCompletedNCT02532634Phase 4
• Comparison of Palonosetron and Ramosetron for Preventing Patient-controlled Analgesia Related Nausea and Vomiting Following Spine Surgery; Association With ABCB1 PolymorphismCompletedNCT02480088Phase 4
• Flavored Intravenous Ondansetron Administered Orally for the Treatment of Persistent VomitingCompletedNCT02473887Phase 1
• Prophylactic Antiemetic Efficacy of Palonosetron Versus Ondansetron for Cesarean Sections Under Regional AnesthesiaCompletedNCT02468323Phase 4
• The Effects of Ondansetron on Brain FunctionCompletedNCT02460341Phase 1
• Anti Emetic Efficacy of Combination of Ramosetron and Premixture of Naloxone With Patient-controlled AnalgesiaCompletedNCT02416115Not applicable
• Prospective Study of Palonosetron in Radiation Induced Nausea and Vomiting (RINV)CompletedNCT02388750Phase 2
• Prevention of Postoperative Nausea and Vomiting in Patients Undergoing Vitrectomy Under Local AnesthesiaStatus unknownNCT02386059Phase 4
• Ondansetron's Opposite Effect on Postoperative Analgesia of AcetaminophenCompletedNCT02296333Phase 4
• Effects of Food on the Bioavailability and Pharmacokinetic Profile of Itasetron After a Single Oral Dose in Healthy Male SubjectsCompletedNCT02259985Phase 1
• Study on the Effect of Granisetron on Myofascial Pain in the Orofacial MusclesCompletedNCT02230371Phase 4
• Palonosetron Plus Aprepitant Versus Palonosetron in Preventing Nausea and Vomiting in Leukemic PatientsStatus unknownNCT02205164Phase 2
• The Efficacy and Safety of Ramosetron in Patients Undergoing Off Pump Coronary Artery Bypass SurgeryCompletedNCT02139241Not applicable
• MEtoclopramide, DExamethasone or Axoli to Prevent or Delay Chemotherapy-induced Nausea and Vomiting in Moderately Emetogenic Non-AC-based ChemotherapyCompletedNCT02135510Phase 3
• Decreasing Narcotics in Advanced Pelvic SurgeryCompletedNCT02110719Phase 4
• Phamacokinetic and Pharmacodynamic Study of Ramosetron in Chemotherapy Induced Nasea and VomitingCompletedNCT02076529Not applicable
• Efficacy of Ondansetron on Vomiting Due to Acute Gastroenteritis in Pediatric During WinterTerminatedNCT02028910Phase 3
• Long Term Prevention of Nausea and Vomiting in Gynecologic LaparoscopyStatus unknownNCT02011659Phase 3
• Patient Satisfaction, Efficacy and Compliance of Antiemetic Patch vs Pill in Malignant Glioma PatientsWithdrawnNCT01952886Phase 2
• Prevention of Intrathecal Morphine Induced Pruritus: Comparison of Ondansetron and PalonosetronCompletedNCT01952626Not applicable
• Prevention of Chemotherapy Induced Nausea and Vomiting in Breast Cancer Patients.Status unknownNCT01913990Phase 4
• The Efficacy and Safety of Palonosetron in Preventing the Gastrointestinal Reactions Induced by 3-day Highly Emetogenic ChemotherapyCompletedNCT01909856Phase 2
• Heart Safety Study of Ondansetron in Children Receiving ChemotherapyWithdrawnNCT01896440Phase 4
• Dexamethasone and Ondansetron Versus Placebo for Postoperative Nausea and VomitingCompletedNCT01876290Phase 4
• A Study to Assess the Efficacy and Safety of YM060 in Female Patients With Diarrhea-predominant Irritable Bowel Syndrome (IBS)CompletedNCT01870895Phase 3
• Ondansetron Administration to Children With Gastroenteritis, Vomiting and SOME Dehydration in EDs in PakistanCompletedNCT01870648Phase 4
• Ondansetron Administration to WELL Children With Gastroenteritis Associated Vomiting in EDs in PakistanCompletedNCT01870635Phase 4
• Safety and Efficacy Study of GR68755 (Alosetron Hydrochloride) to Treat Severe Diarrhea-Predominant Irritable Bowel Syndrome (IBS)CompletedNCT01855711Phase 2
• Inhaled Ondansetron & DyspneaCompletedNCT01851993Early Phase 1
• Comparison of Palonosetron and Ramosetron for Preventing Patient-controlled Analgesia Related Nausea and Vomiting Following Spine SurgeryCompletedNCT01825733Not applicable
• Droperidol and Cardiac RepolarizationCompletedNCT01819857Phase 4
• Ondansetron for Pediatric Mild Traumatic Brain InjuryCompletedNCT01815125Phase 1
• Efficacy Study of Antiemetics to Reduce Postoperative Nausea and VomitingCompletedNCT01806948Phase 2
• Efficacy Study of Ramosetron in the Setting of Hematopoietic Stem Cell TransplantationStatus unknownNCT01788605Phase 2
• Postoperative Vomiting in Children: Comparison Tri - Versus bi -ProphylaxisCompletedNCT01739985Not applicable
• A Long Term Study of YM060 in Female Patients With Diarrhea-predominant Irritable Bowel SyndromeCompletedNCT01736423Phase 3
• Improving Tolerance of Treatment of Pulmonary MAC InfectionsWithdrawnNCT01719042Phase 2

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