An interventional study of High-dose oral omeprazole and Standard IV PPI in GI Bleeding, sponsored by King Chulalongkorn Memorial Hospital. Recruiting at 2 sites in Thailand. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-09-18.
Sponsored by King Chulalongkorn Memorial Hospital · Not applicable, Interventional, and Treatment
Peptic ulcer bleeding is the most common etiology in upper gastrointestinal bleeding all over the world. After endoscopic treatment, proton pump inhibitor (PPI) is recommended to prevent re-bleeding. Intravenous PPI is recommended as a standard treatment. In the past, there were many trials showing the efficacy of high-dose oral PPI after endoscopic hemostasis but most were industrial sponsor which assessing an expensive PPI. Moreover, the number of patients in those studies were insufficient to confirm a non-inferiority outcome in term of rebleeding by using oral PPI. This study will evaluate a high-dose, local-made PPI (omeprazole) in peptic ulcer treatment after successful endoscopic hemostasis compared to standard IV PPI continuous drip in term of rebleeding, as well as 24-hour gastric pH monitoring.
338 studies on the registry are indexed under Gastrointestinal Hemorrhage; 77 are open to participants now.
This study's planned enrollment of 128 is above the median of 98 across 210 interventional studies indexed under Gastrointestinal Hemorrhage.
Browse Gastrointestinal Hemorrhage studies →King Chulalongkorn Memorial Hospital is the lead sponsor of 43 studies on the registry; 11 are open to participants now.
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Exclusion Criteria:
Omeprazole 80 mg/day (40 mg twice a day) per oral route for 72 hours
Drug: High-dose oral omeprazole
Pantoprazole 8 mg/hour IV continuous drip for 72 hours
Drug: Standard IV PPI
Local made oral omeprazole 40 mg twice daily will be prescribed for 72 hours after randomization.
Pantoprazole 8mg/hour IV continuous drip will be prescribed for 72 hours after randomization
Rate of 3-day peptic ulcer rebleeding
Time frame: 3 days
Percentage of 24-hour gastric pH above 6
Time frame: 3 days
Rate of 30-day peptic ulcer rebleeding
Time frame: 30 days
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Studies of the drug tested here: Omeprazole
King Chulalongkorn Memorial Hospital