Protein Kinase Inhibitors: all 15,278 studies that test it

Page 48 of 153. Open to participants first (2,556), then studies with results posted, then the rest; newest registration first within each.

• Window of Opportunity Study of VS-6063 (Defactinib) in Surgical Resectable Malignant Pleural Mesothelioma ParticipantsTerminatedNCT02004028Phase 2Results posted
• Volasertib + Decitabine in Patients With Acute Myeloid Leukemia (AML)TerminatedNCT02003573Phase 1Results posted
• Tofacitinib Ointment For Atopic Dermatitis (Atopic Eczema)CompletedNCT02001181Phase 2Results posted
• STAR Cape+BKM120 MBC With Brain MetCompletedNCT02000882Phase 2Results posted
• Progression Free Survival (PFS) Using Erlotinib for Non-Small-Cell Lung Cancer (NSCLC) in Chinese PopulationCompletedNCT02000531Phase 4Results posted
• A Phase II, Repeat Dose, Proof of Mechanism Study of Losmapimod to Reduce Proteinuria in Patients With Focal Segmental Glomerulosclerosis (FSGS)CompletedNCT02000440Phase 2Results posted
• Phase I Trial of Afatinib (BIBW 2992) and Dasatinib in Non-small Cell Lung Cancer (NSCLC)CompletedNCT01999985Phase 1Results posted
• A Phase 1b Study Of Axitinib In Combination With Crizotinib In Patients With Advanced Solid TumorsCompletedNCT01999972Phase 1Results posted
• A Study of Tarceva (Erlotinib) Monotherapy in Patients With Advanced Non-Small Cell Lung Cancer (NSCLC)CompletedNCT01996332Phase 2Results posted
• Combo of Cabozantinib With Abiraterone in Chemotherapy-Naïve Subjects With Bone-Metastatic CRPCTerminatedNCT01995058Phase 2Results posted
• Dovitinib (TKI258) and Abiraterone Acetate in Metastatic Castrate-Resistant Prostate Cancer (mCRPC)TerminatedNCT01994590Phase 2Results posted
• Phase 1/2a Dose Escalation Study in Participants With CLL, SLL, or NHLCompletedNCT01994382Phase 1/2Results posted
• Relative Bioavailability of Pimasertib in Cancer PatientsCompletedNCT01992874Phase 1Results posted
• Trametinib and Akt Inhibitor GSK2141795 in Treating Patients With Relapsed or Refractory Multiple MyelomaCompletedNCT01989598Phase 2Results posted
• Efficacy, Safety, and Pharmacokinetic of MSC2156119J in Asian Participants With Hepatocellular CarcinomaCompletedNCT01988493Phase 1/2Results posted
• A Study of the Effects of Posaconazole on Alectinib (RO5424802) Pharmacokinetics in Healthy VolunteersCompletedNCT01984229Phase 1Results posted
• Tepotinib With Gefitinib in Participants With Locally Advanced or Metastatic NSCLC (INSIGHT)CompletedNCT01982955Phase 1/2Results posted
• LGX818 for Patients With BRAFV600 Mutated TumorsTerminatedNCT01981187Phase 2Results posted
• Efficacy and Safety of Idelalisib in Combination With Bendamustine and Rituximab in Adults With Previously Untreated Chronic Lymphocytic LeukemiaTerminatedNCT01980888Phase 3Results posted
• Efficacy and Safety of Idelalisib in Combination With Obinutuzumab Compared to Chlorambucil in Combination With Obinutuzumab for Previously Untreated Chronic Lymphocytic LeukemiaTerminatedNCT01980875Phase 3Results posted
• Study of Ibrutinib in Combination With Rituximab in Previously Untreated Subjects With Follicular LymphomaCompletedNCT01980654Phase 2Results posted
• Study of the Bruton's Tyrosine Kinase Inhibitor in Subjects With Relapsed/Refractory Marginal Zone LymphomaCompletedNCT01980628Phase 2Results posted
• Nintedanib Twice Daily vs Placebo in Patients Diagnosed With Idiopathic Pulmonary Fibrosis (IPF)CompletedNCT01979952Phase 3Results posted
• Brentuximab Vedotin or Crizotinib and Combination Chemotherapy in Treating Patients With Newly Diagnosed Stage II-IV Anaplastic Large Cell LymphomaCompletedNCT01979536Phase 2Results posted
• Trametinib With or Without GSK2141795 in Treating Patients With Metastatic Uveal MelanomaActive, not recruitingNCT01979523Phase 2Results posted
• Dabrafenib/Trametinib, BRAF or BRAF AND MEK Pre-op With BRAF and MEK Post-op, Phase IIB, Melanoma With Brain Mets,Biomarkers and MetabolitesTerminatedNCT01978236Phase 2Results posted
• Dose Escalation Pan-FGFR (Fibroblast Growth Factor Receptor) Inhibitor (Rogaratinib)CompletedNCT01976741Phase 1Results posted
• Comparing Everolimus and Sirolimus in Renal Transplant RecipientsCompletedNCT01976390Not applicableResults posted
• Open-Label Extension Study Of Tofacitinib In Psoriatic ArthritisCompletedNCT01976364Phase 3Results posted
• A Phase 2 Study of BGJ398 in Patients With Recurrent GBMCompletedNCT01975701Phase 2Results posted
• A Phase 1B Dose-escalation and Phase 2a Study of Carotuximab (TRC105) in Combination With Pazopanib in Patients With Advanced Soft Tissue SarcomaCompletedNCT01975519Phase 1/2Results posted
• Selumetinib (AZD6244: ARRY-142886) (Hyd-Sulfate) in Metastatic Uveal Melanoma (SUMIT)CompletedNCT01974752Phase 3Results posted
• A Study of PCI-32765 (Ibrutinib) in Combination With Either Bendamustine and Rituximab or Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone in Participants With Previously Treated Indolent Non-Hodgkin LymphomaCompletedNCT01974440Phase 3Results posted
• A Study of PCI-32765 (Ibrutinib) Versus Rituximab in Relapsed or Refractory Chronic Leukemia/LymphomaCompletedNCT01973387Phase 3Results posted
• Tivozanib As Maintenance Therapy In GYNTerminatedNCT01972516Phase 2Results posted
• Open Dose Escalating Trial to Determine the Maximum Tolerated Dose in Paediatric Patients With Advanced Cancers for Whom no Therapy is KnownCompletedNCT01971476Phase 1Results posted
• A Study Of PF-06463922 An ALK/ROS1 Inhibitor In Patients With Advanced Non Small Cell Lung Cancer With Specific Molecular AlterationsCompletedNCT01970865Phase 1/2Results posted
• Momelotinib Versus Ruxolitinib in Subjects With MyelofibrosisCompletedNCT01969838Phase 3Results posted
• A Study of Baricitinib and Ciclosporin in Healthy ParticipantsCompletedNCT01968057Phase 1Results posted
• Phase II Study of Axitinib (AG-013736) With Evaluation of the VEGF-pathway in Metastatic, Recurrent or Primary Unresectable Pheochromocytoma/ParagangliomaCompletedNCT01967576Phase 2Results posted
• Trametinib and Akt Inhibitor GSK2141795 in Treating Patients With Metastatic Triple-Negative Breast CancerCompletedNCT01964924Phase 2Results posted
• A Phase II Study of Sirolimus and Erlotinib in Recurrent/Refractory Germ Cell TumorsTerminatedNCT01962896Phase 2Results posted
• Study of BTK Inhibitor, Ibrutinib in Combination With Carfilzomib in Subjects With Relapsed and Refractory Multiple MyelomaCompletedNCT01962792Phase 1/2Results posted
• A Study Investigating the Efficacy and Safety of ABT-494 Given With Methotrexate in Subjects With Rheumatoid Arthritis Who Failed Anti-Tumor Necrosis Factor (TNF) Biologic TherapyCompletedNCT01960855Phase 2Results posted
• GSK1120212+GSK2141795 for Cervical CancerTerminatedNCT01958112Phase 2Results posted
• Study of Efficacy and Safety of LEE011 in Postmenopausal Women With Advanced Breast CancerCompletedNCT01958021Phase 3Results posted
• Phase I Dose Escalation Trial of Volasertib in Combination With Azacitidine in Patients With MDS or CMMLTerminatedNCT01957644Phase 1Results posted
• Pazopanib Paediatric Phase II Trial Children's Oncology Group (COG) in Solid TumorsCompletedNCT01956669Phase 2Results posted
• Cabozantinib (XL-184) Monotherapy for Advanced CholangiocarcinomaCompletedNCT01954745Phase 2Results posted
• Efficacy and Safety of AQX-1125 in Unstable COPDCompletedNCT01954628Phase 2Results posted
• Basket Study of Neratinib in Participants With Solid Tumors Harboring Somatic HER2 or EGFR Exon 18 MutationsTerminatedNCT01953926Phase 2Results posted
• Afatinib (BIBW 2992) in Advanced Non-Small Cell Lung Cancer Patients With EGFR MutationCompletedNCT01953913Phase 3Results posted
• Pilot Study to Evaluate the Efficacy of Ruxolitinib in Alopecia AreataCompletedNCT01950780Phase 2Results posted
• Selumetinib (AZD6244, ARRY-142886) J-BTC Phase 1 StudyTerminatedNCT01949870Phase 1Results posted
• Nintedanib in Treating Patients With Advanced Non-Small Cell Lung Cancer Who Have Failed Up to Two Previous Chemotherapy RegimensCompletedNCT01948141Phase 2Results posted
• Therapeutic Trial for Patients With Ewing Sarcoma Family of Tumor and Desmoplastic Small Round Cell TumorsCompletedNCT01946529Phase 2Results posted
• Phase II Safety and Efficacy Study of Crizotinib in East Asian Patients With ROS1 Positive, ALK Negative Advanced NSCLCCompletedNCT01945021Phase 2Results posted
• A Phase IIa Study of the MEK Inhibitor Trametinib Monotherapy in the Treatment of Biliary Tract CancersCompletedNCT01943864Phase 2Results posted
• Phase I Dose Escalation Study of VS-6063 in Japanese Subjects With Non-Hematologic MalignanciesCompletedNCT01943292Phase 1Results posted
• The Effects of Treatment With Vemurafenib on the Immune System in Advanced MelanomaTerminatedNCT01942993Phase 2Results posted
• Palbociclib (PD-0332991) Combined With Fulvestrant In Hormone Receptor+ HER2-Negative Metastatic Breast Cancer After Endocrine Failure (PALOMA-3)CompletedNCT01942135Phase 3Results posted
• Trametinib With GSK2141795 in BRAF Wild-type MelanomaCompletedNCT01941927Phase 2Results posted
• A Study of the Effect of Multiple Doses of Rifampin on the Single Dose Pharmacokinetics of RO5424802CompletedNCT01940510Phase 1Results posted
• Colorectal Cancer Treated With Adjuvant Regorafenib Versus Placebo After Curative Treatment of Liver Metastases in a Randomized, Double-blind, Placebo-Controlled Phase-III STudyTerminatedNCT01939223Phase 3Results posted
• Sirolimus, Cisplatin, and Gemcitabine Hydrochloride in Treating Patients With Bladder CancerCompletedNCT01938573Phase 1/2Results posted
• A Study Of PF-05212384 Plus FOLFIRI Versus Bevacizumab Plus FOLFIRI In Metastatic Colorectal CancerTerminatedNCT01937715Phase 1/2Results posted
• A Study of Baricitinib and Probenecid in Healthy ParticipantsCompletedNCT01937026Phase 1Results posted
• Conversion to Everolimus From Calcineurin Inhibitor With Mycophenolic Acid: Impact on Long Term Renal Function in Liver Transplantation.CompletedNCT01936519Not applicableResults posted
• A Prospective Study to Assess the Hypotensive Efficacy of Rho-Kinase Inhibitor AR-12286 Ophthalmic Solution 0.5% and 0.7% in Patients With Exfoliation Syndrome and Ocular Hypertension or GlaucomaCompletedNCT01936389Phase 2Results posted
• Trial of Pimasertib With SAR245409 or Placebo in Ovarian CancerCompletedNCT01936363Phase 2Results posted
• Cabozantinib S-Malate in Treating Patients With Recurrent or Metastatic Endometrial CancerCompletedNCT01935934Phase 2Results posted
• Study of Ponatinib in Patients With Lung Cancer Preselected Using Different Candidate Predictive BiomarkersCompletedNCT01935336Phase 2Results posted
• Evaluation of Calcineurin-inhibitor Reduction With Conversion at 2 Months to Everolimus/Reduced Tacrolimus in Renal Transplant Recipients Following Campath® InductionCompletedNCT01935128Phase 4Results posted
• Cabazitaxel Plus Lapatinib as Therapy for HER2-Positive Metastatic Breast Cancer Patients With Intracranial MetastasesTerminatedNCT01934894Phase 2Results posted
• Effect of Vandetanib on Cellular Markers in Invasive Breast CancerTerminatedNCT01934335Phase 2Results posted
• Assess Efficacy & Safety of Selumetinib in Combination With Docetaxel in Patients Receiving 2nd Line Treatment for v-Ki-ras2 Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) Positive NSCLCActive, not recruitingNCT01933932Phase 3Results posted
• NECTAR Everolimus Plus Cisplatin in Triple (-) Breast CancerCompletedNCT01931163Phase 2Results posted
• Oral Pazopanib Plus Oral Topotecan Metronomic Antiangiogenic Therapy for Recurrent Glioblastoma Multiforme (A) Without Prior Bevacizumab Exposure and (B) After Failing Prior BevacizumabCompletedNCT01931098Phase 2Results posted
• A Study to Evaluate Effect of Itraconazole on the Pharmacokinetics of Cobimetinib in Healthy ParticipantsCompletedNCT01929876Phase 1Results posted
• Rapalogues for Autism Phenotype in TSC: A Feasibility StudyCompletedNCT01929642Phase 2Results posted
• Japan PhI/II of GSK2118436 and GSK1120212 Combination in Subjects With BRAF V600E/K Mutation Positive Advanced Solid Tumors (Phase I Part) or Cutaneous Melanoma (Phase II Part)CompletedNCT01928940Phase 2Results posted
• Study of Chemotherapy With Cisplatin/Carboplatin, and Docetaxel With or Without Erlotinib in Patients With Head and Neck Squamous Cell Carcinomas Amenable for Surgical ResectionCompletedNCT01927744Phase 2Results posted
• Phase Ib/II Study of Efficacy and Safety of MEK162 and Panitumumab, in Adult mCRC Patients With Mutant or Wild-type RAS TumorsCompletedNCT01927341Phase 1/2Results posted
• In Vivo Treg Expansion and Graft-Versus-Host Disease ProphylaxisCompletedNCT01927120Phase 2Results posted
• A Study Of PF-05212384 Plus Irinotecan Vs Cetuximab Plus Irinotecan In Patients With KRAS And NRAS Wild Type Metastatic Colorectal CancerTerminatedNCT01925274Phase 2Results posted
• A Study of Baricitinib and Omeprazole in Healthy ParticipantsCompletedNCT01925144Phase 1Results posted
• A Study of Baricitinib When Administered With Ketoconazole or Fluconazole in Healthy ParticipantsCompletedNCT01924299Phase 1Results posted
• Study of Letrozole With or Without BYL719 or Buparlisib, for the Neoadjuvant Treatment of Postmenopausal WomenCompletedNCT01923168Phase 2Results posted
• Adavosertib and Local Radiation Therapy in Treating Children With Newly Diagnosed Diffuse Intrinsic Pontine GliomasCompletedNCT01922076Phase 1Results posted
• A Pharmacodynamics Pre-surgical Study of LEE011 in Early Breast Cancer Patients (MONALEESA-1)TerminatedNCT01919229Phase 2Results posted
• Dacomitinib + Pemetrexed for Patients With Advanced Non-squamous Non-small Cell Lung Cancer (NSCLC)TerminatedNCT01918761Phase 1Results posted
• GDC-0941 and Cisplatin in Treating Patients With Androgen Receptor-Negative Triple Negative Metastatic Breast CancerTerminatedNCT01918306Phase 1/2Results posted
• A Study of ENMD-2076 in Ovarian Clear Cell CancersCompletedNCT01914510Phase 2Results posted
• FOLFOX Plus Regorafenib in Patients With Unresectable or Metastatic Esophagogastric CancerCompletedNCT01913639Phase 2Results posted
• A Study of Carbon-14-Labeled LY2835219 ([^14C]-LY2835219) in Healthy ParticipantsCompletedNCT01913314Phase 1Results posted
• Role of Everolimus in Highly Sensitized PatientsCompletedNCT01911546Phase 2Results posted
• A Study of Baricitinib and Rifampicin in Healthy ParticipantsCompletedNCT01910311Phase 1Results posted
• A Study of Vemurafenib (Zelboraf) in Chinese Participants With BRAF V600 Mutation-Positive Unresectable or Metastatic MelanomaCompletedNCT01910181Phase 1Results posted
• Study Comparing Combination of LGX818 Plus MEK162 Versus Vemurafenib and LGX818 Monotherapy in BRAF Mutant MelanomaCompletedNCT01909453Phase 3Results posted
• Study of Cabozantinib (XL184) vs Placebo in Subjects With Hepatocellular Carcinoma Who Have Received Prior SorafenibCompletedNCT01908426Phase 3Results posted

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