Protein Kinase Inhibitors: all 15,278 studies that test it

Page 50 of 153. Open to participants first (2,556), then studies with results posted, then the rest; newest registration first within each.

• ADAM-Afatinib Diarrhea Assessment and ManagementCompletedNCT01814553Phase 3Results posted
• Ponatinib in Advanced NSCLC w/ RET TranslocationsCompletedNCT01813734Phase 2Results posted
• The Effects of Vemurafenib + Cobimetinib on Immunity in Patients With MelanomaTerminatedNCT01813214Phase 2Results posted
• Cabozantinib-S-Malate in Treating Patients With Hormone-Resistant Metastatic Prostate CancerCompletedNCT01812668Not applicableResults posted
• Alisertib With and Without Rituximab in Treating Patients With Relapsed or Refractory B-Cell Non-Hodgkin LymphomaTerminatedNCT01812005Phase 2Results posted
• Cabozantinib-S-Malate in Treating Patients With Refractory Thyroid CancerCompletedNCT01811212Phase 2Results posted
• Assess Safety & Efficacy of Selumetinib When Given in Combination With Standard First Line Treatment for Advanced Non-small Cell Lung CancerCompletedNCT01809210Phase 1Results posted
• A Study of Neratinib Plus Capecitabine Versus Lapatinib Plus Capecitabine in Patients With HER2+ Metastatic Breast Cancer Who Have Received Two or More Prior HER2 Directed Regimens in the Metastatic SettingCompletedNCT01808573Phase 3Results posted
• Phase II Trial of Tivozanib in Advanced Hepatocellular CancerTerminatedNCT01807156Phase 2Results posted
• Daunorubicin Hydrochloride, Cytarabine, and Nilotinib in Treating Patients With Newly Diagnosed Acute Myeloid LeukemiaCompletedNCT01806571Phase 2Results posted
• Randomized Phase 2 Trial of Axitinib and TRC105 Versus Axitinib Alone in Patients Renal Cell CarcinomaTerminatedNCT01806064Phase 1/2Results posted
• AZD9291 First Time In Patients Ascending Dose StudyCompletedNCT01802632Phase 1/2Results posted
• Akt Inhibitor MK2206 in Treating Patients With Previously Treated Colon or Rectal Cancer That is Metastatic or Locally Advanced and Cannot Be Removed by SurgeryCompletedNCT01802320Phase 2Results posted
• A Phase Ib/II Study of AEB071 and MEK162 in Adult Patients With Metastatic Uveal MelanomaTerminatedNCT01801358Phase 1/2Results posted
• A Study of Alectinib (RO5424802) in Participants With Non-Small Cell Lung Cancer Who Have Anaplastic Lymphoma Kinase (ALK) Mutation and Failed Crizotinib TreatmentCompletedNCT01801111Phase 1/2Results posted
• A Phase II Trial of MLN8237 in Patients With Metastatic Castrate Resistant and Neuroendocrine Prostate CancerCompletedNCT01799278Phase 2Results posted
• A Phase II, Single-Arm Study of RAD001 (Everolimus), Letrozole, and Metformin in Patients With Advanced or Recurrent Endometrial CarcinomaCompletedNCT01797523Phase 2Results posted
• Study of Fulvestrant +/- Everolimus in Post-Menopausal, Hormone-Receptor + Metastatic Breast Ca Resistant to AICompletedNCT01797120Phase 2Results posted
• Entospletinib in Combination With Idelalisib in Adults With Relapsed or Refractory Hematologic MalignanciesTerminatedNCT01796470Phase 2Results posted
• BKM120 For Triple Negative Breast CancerCompletedNCT01790932Phase 2Results posted
• A Phase 1b/2 Study of PLX3397 + Radiation Therapy + Temozolomide in Patients With Newly Diagnosed GlioblastomaCompletedNCT01790503Phase 1/2Results posted
• Ruxolitinib Prior to Transplant in Patients With MyelofibrosisTerminatedNCT01790295Phase 2Results posted
• Everolimus Roll-over Protocol for Patients Who Have Completed a Previous Novartis-sponsored Everolimus Study.CompletedNCT01789281Phase 4Results posted
• A Phase Ib/II Dose-finding Study to Assess the Safety and Efficacy of LDE225 + INC424 in Patients With MFCompletedNCT01787552Phase 1/2Results posted
• Dose-Ranging Study Of Tofacitinib In Adults With Active Ankylosing SpondylitisCompletedNCT01786668Phase 2Results posted
• Nilotinib Treatment-free Remission Study in CML (Chronic Myeloid Leukemia) PatientsCompletedNCT01784068Phase 2Results posted
• A Phase II Study of Everolimus in Combination With Exemestane Versus Everolimus Alone Versus Capecitabine in Advance Breast Cancer.CompletedNCT01783444Phase 2Results posted
• A Dose Ranging Study to Evaluate the Safety and Efficacy of GSK2586184 in Patients With Chronic Plaque PsoriasisCompletedNCT01782664Phase 2Results posted
• A Phase II Study of Tivozanib in Patients With Metastatic and Non-resectable Soft Tissue SarcomasCompletedNCT01782313Phase 2Results posted
• Imatinib Treatment in Recent Onset Type 1 Diabetes MellitusCompletedNCT01781975Phase 2Results posted
• A Phase Ib/II Study of LEE011 in Combination With MEK162 in Patients With NRAS Mutant MelanomaCompletedNCT01781572Phase 1/2Results posted
• Phase I Dose-Escalation, Safety, Pharmacokinetic and Pharmacodynamic Study of BVD-523 in Patients With Advanced MalignanciesCompletedNCT01781429Phase 1/2Results posted
• Phase 2 Study of Neoadjuvant Vemurafenib in Melanoma Patients With Untreated Brain MetastasesCompletedNCT01781026Phase 2Results posted
• Safety and Efficacy of LEE011 and LGX818 in Patients With BRAF Mutant Melanoma.TerminatedNCT01777776Phase 1/2Results posted
• A Study of the Bruton's Tyrosine Kinase Inhibitor Ibrutinib Given in Combination With Bendamustine and Rituximab in Patients With Newly Diagnosed Mantle Cell LymphomaCompletedNCT01776840Phase 3Results posted
• A Sequential Two-Stage Dose Escalation Study to Evaluate the Safety and Efficacy of RuxolitinibCompletedNCT01776723Phase 1/2Results posted
• Akt Inhibitor MK-2206 and Anastrozole With or Without Goserelin Acetate in Treating Patients With Stage II-III Breast CancerTerminatedNCT01776008Phase 2Results posted
• Sorafenib + mFOLFOX for Hepatocellular CarcinomaCompletedNCT01775501Phase 2Results posted
• ARCHER1050: A Study of Dacomitinib vs. Gefitinib in 1st-Line Treatment Of Advanced NSCLC.CompletedNCT01774721Phase 3Results posted
• Study of Regorafenib After Sorafenib in Patients With Hepatocellular CarcinomaCompletedNCT01774344Phase 3Results posted
• Pacritinib Versus Best Available Therapy to Treat MyelofibrosisTerminatedNCT01773187Phase 3Results posted
• Investigation of Potential Drug-drug Interaction of Volasertib With Itraconazole in Patients With Various TumoursCompletedNCT01772563Phase 1Results posted
• Relative Bioavailability of a Single Dose of Nintedanib Given Alone and in Combination With Multiple Doses of RifampicinCompletedNCT01770392Phase 1Results posted
• Study of 5-FU, Oxaliplatin, & Lapatinib Combined With Radiation Therapy to Treat HER2 Positive Esophagogastric CancerTerminatedNCT01769508Phase 2Results posted
• Pazopanib Hydrochloride in Treating Patients With Metastatic Kidney CancerCompletedNCT01767636Phase 2Results posted
• Irinotecan Hydrochloride and Temozolomide With Temsirolimus or Dinutuximab in Treating Younger Patients With Refractory or Relapsed NeuroblastomaCompletedNCT01767194Phase 2Results posted
• A Pharmacokinetics Study to Investigate the Effect of Vemurafenib on Digoxin in Patients With BRAFV600 Mutation-Positive Metastatic MelanomaCompletedNCT01765569Phase 1Results posted
• A Pharmacokinetics (PK) Study to Investigate the Effect of Rifampin on PK of Vemurafenib (Zelboraf)CompletedNCT01765543Phase 1Results posted
• Sirolimus in Kidney Transplant Patients With Squamous Cell Skin CarcinomaTerminatedNCT01764607Phase 2Results posted
• Study Comparing the Efficacy of MEK162 Versus Dacarbazine in Unresectable or Metastatic NRAS Mutation-positive MelanomaCompletedNCT01763164Phase 3Results posted
• Ponatinib for Squamous Cell Lung and Head and Neck CancersTerminatedNCT01761747Phase 2/3Results posted
• A Multicenter, Open-Label, Phase 3 Trial to Compare the Efficacy and Safety of Lenvatinib (E7080) Versus Sorafenib in First-line Treatment of Participants With Unresectable Hepatocellular CarcinomaCompletedNCT01761266Phase 3Results posted
• Study of Tivantinib in Subjects With Inoperable Hepatocellular Carcinoma (HCC) Who Have Been Treated With One Prior TherapyCompletedNCT01755767Phase 3Results posted
• Cabozantinib for Adults With Advanced Soft Tissue SarcomaCompletedNCT01755195Phase 2Results posted
• A Study of Vitamin C in the Treatment of Liver Cancer to Determine if it is Safe and EffectiveCompletedNCT01754987Phase 1/2Results posted
• Combined BRAF-Targeted Therapy & Immunotherapy for MelanomaTerminatedNCT01754376Phase 2Results posted
• Dovitinib in Treating Patients With Recurrent or Progressive GlioblastomaCompletedNCT01753713Phase 2Results posted
• Pilot Study to Determine Effects of the Btk Inhibitor PCI-32765 on Leukemia Cell Kinetics and Trafficking, Using Heavy Water Labeling in Subjects With CLL and SLLCompletedNCT01752426Phase 1/2Results posted
• BRAF/MEK/EGFR Inhibitor Combination Study in Colorectal Cancer (CRC)CompletedNCT01750918Phase 1/2Results posted
• Assess Efficacy and Safety of AZD6244 in Combination With Docetaxel in Patients Receiving Second Line Non Small Cell Lung Cancer Treatment.CompletedNCT01750281Phase 2Results posted
• AZD1775 for Advanced Solid TumorsCompletedNCT01748825Phase 1Results posted
• Study of Safety and Efficacy in Patients With Malignant Rhabdoid Tumors (MRT) and NeuroblastomaTerminatedNCT01747876Phase 1Results posted
• Tivozanib in Combination With Paclitaxel in Patients With Locally Recurrent or Metastatic Triple Negative Breast CancerTerminatedNCT01745367Phase 2Results posted
• Co-Administration Of Methotrexate And CP-690,550CompletedNCT01745055Phase 1Results posted
• A Multicenter Phase 2 Study of Ibrutinib in Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL) With 17p DeletionCompletedNCT01744691Phase 2Results posted
• A Study That Switched Patients From Imatinib to Nilotinib and Then Was Followed by Treatment CessationCompletedNCT01744665Phase 2Results posted
• Sandostatin LAR and Axitinib vs Pbo in Pnts With Advanced Well-differentiated Non-pancreatic Neuroendocrine CarcinomasCompletedNCT01744249Phase 2/3Results posted
• A Randomized Phase III Study to Assess the Effect of a Longer Duration of Consolidation Treatment With Nilotinib on TFR in CP CML.CompletedNCT01743989Phase 3Results posted
• CP-690,550 Thorough QTc StudyCompletedNCT01743677Phase 1Results posted
• An Open Label Study of Postmenopausal Women With Oestrogen Receptor Positive Locally Advanced or Metastatic Breast Cancer Treated With Everolimus (RAD001) With Exemestane, With Exploratory Epigenetic Marker AnalysisCompletedNCT01743560Phase 4Results posted
• Phase I Study of LDK378 in Pediatric, Malignancies With a Genetic Alteration in Anaplastic Lymphoma Kinase (ALK)CompletedNCT01742286Phase 1Results posted
• A Study of Palbociclib (PD-0332991) + Letrozole vs. Letrozole For 1st Line Treatment Of Postmenopausal Women With ER+/HER2- Advanced Breast Cancer (PALOMA-2)CompletedNCT01740427Phase 3Results posted
• Pharmacokinetics Of CP-690,550 In Patients With Impaired Renal FunctionCompletedNCT01740362Phase 1Results posted
• Sunitinib Malate Related Fatigue in Patients With Metastatic Kidney CancerTerminatedNCT01740154Not applicableResults posted
• An Extension (Rollover) Study of Vemurafenib in Participants With BRAF V600 Mutation-Positive Malignancies Previously Enrolled in an Antecedent Vemurafenib ProtocolCompletedNCT01739764Phase 4Results posted
• Study of LY2835219 for Mantle Cell LymphomaCompletedNCT01739309Phase 2Results posted
• Cabozantinib for Metastatic Triple Negative BrCaCompletedNCT01738438Phase 2Results posted
• Study Efficacy and Safety of INC280 in Patients With Advanced Hepatocellular Carcinoma.TerminatedNCT01737827Phase 2Results posted
• Sirolimus and Auranofin in Treating Patients With Advanced or Recurrent Non-Small Cell Lung Cancer or Small Cell Lung CancerCompletedNCT01737502Phase 1/2Results posted
• Multiple Dose Escalation Study In Medically Stable Subjects With PsoriasisCompletedNCT01736696Phase 1Results posted
• Study to Allow Access to Nilotinib for Patients Who Are on Nilotinib Treatment in a Novartis-sponsored StudyCompletedNCT01735955Phase 4Results posted
• PNOC 001: Phase II Study of Everolimus for Recurrent or Progressive Low-grade Gliomas in ChildrenCompletedNCT01734512Phase 2Results posted
• Efficacy and Safety of Idelalisib (GS-1101) in Combination With Bendamustine and Rituximab for Previously Treated Indolent Non-Hodgkin LymphomasTerminatedNCT01732926Phase 3Results posted
• Efficacy and Safety of Idelalisib (GS-1101) in Combination With Rituximab for Previously Treated Indolent Non-Hodgkin LymphomasTerminatedNCT01732913Phase 3Results posted
• A Phase I/II Study Afatinib/Carboplatin/Paclitaxel Induction Chemotherapy In HPV-Negative HNSCC.TerminatedNCT01732640Phase 1/2Results posted
• Ruxolitinib Phosphate and Danazol in Treating Anemia in Patients With MyelofibrosisCompletedNCT01732445Phase 2Results posted
• Dovitinib in BCG Refractory Urothelial Carcinoma With FGFR3 Mutations or Over-expressionTerminatedNCT01732107Phase 2Results posted
• A Study of E7080 in Subjects With Advanced Thyroid CancerCompletedNCT01728623Phase 2Results posted
• Study of Dalantercept and Axitinib in Patients With Advanced Renal Cell CarcinomaTerminatedNCT01727336Phase 2Results posted
• Open-label Extension Study in Patients 65 Years or Older With Chronic Lymphocytic Leukemia or Small Lymphocytic LymphomaCompletedNCT01724346Phase 3Results posted
• PD 0332991 and Anastrozole for Stage 2 or 3 Estrogen Receptor Positive and HER2 Negative Breast CancerActive, not recruitingNCT01723774Phase 2Results posted
• Dabrafenib With or Without Trametinib in Treating Patients With Advanced Differentiated Thyroid CancerCompletedNCT01723202Phase 2Results posted
• Open-label Phase 3 BTK Inhibitor Ibrutinib vs Chlorambucil Patients 65 Years or Older With Treatment-naive CLL or SLLCompletedNCT01722487Phase 3Results posted
• Volasertib in Combination With Low-dose Cytarabine in Patients Aged 65 Years and Above With Previously Untreated Acute Myeloid Leukaemia, Who Are Ineligible for Intensive Remission Induction Therapy (POLO-AML-2)CompletedNCT01721876Phase 3Results posted
• Dabrafenib and Trametinib With Radiosurgery in Melanoma Brain MetsTerminatedNCT01721603Phase 2Results posted
• Phase I/II Trial of AXL1717 in the Treatment of Recurrent Malignant AstrocytomasTerminatedNCT01721577Phase 1/2Results posted
• A Study in Moderate to Severe Rheumatoid Arthritis ParticipantsCompletedNCT01721057Phase 3Results posted
• A Moderate to Severe Rheumatoid Arthritis StudyCompletedNCT01721044Phase 3Results posted
• Study of ENMD-2076 in Patients With Advanced/Metastatic Soft Tissue SarcomaCompletedNCT01719744Phase 2Results posted
• Study of LGX818 and Cetuximab or LGX818, BYL719, and Cetuximab in BRAF Mutant Metastatic Colorectal CancerCompletedNCT01719380Phase 2Results posted

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