Opioid antagonists: all 625 studies that test it
Page 4 of 7. Open to participants first (43), then studies with results posted, then the rest; newest registration first within each.
- Targeted Naltrexone to Support Individuals Participating in Dry JanuaryCompletedNCT07132177Phase 2
- A Randomized, Double-Blind, Single-Center Clinical Study on the Efficacy of Naltrexone Implant in Antagonizing Opioid Agonist HydromorphoneCompletedNCT07014644Phase 2
- A Study of Aticaprant 10 mg as Adjunctive Therapy in Adult Participants With Major Depressive Disorder (MDD) With Moderate-to-severe Anhedonia and Inadequate Response to Current Antidepressant Therapy and Long-term Extension Treatment With AticaprantTerminatedNCT06514742Phase 3
- Nalmefene vs Naloxone for the Treatment of Recurrent Respiratory Depression After Opioid OverdoseWithdrawnNCT06408714Phase 3
- Drug-Drug Interaction and Safety of AZD4041 Study (Part 1) and Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of AZD4041 Study in Opioid Use Disorder (Part 2).TerminatedNCT06406400Phase 1
- Study of Injectable Naltrexone and Oral Bupropion Among Cigarette Smokers With SchizophreniaTerminatedNCT06374290Phase 1
- An Acute Migraine Factorial StudyCompletedNCT06245902Phase 2
- Trial of Naltrexone/Bupropion for the Treatment of Methamphetamine Use DisorderActive, not recruitingNCT06233799Phase 3
- An Evaluation of The Absolute Bioavailability of TH104CompletedNCT06198686Phase 1
- Behavioral Pharmacological Examination of a Novel Buprenorphine Induction Method Among Individuals Who Use FentanylActive, not recruitingNCT06089707Phase 3
- Low-dose Versus a High-dose Sublingual Buprenorphine InductionActive, not recruitingNCT05944952Phase 4
- The Use of Naltrexone Hydrochloride to Promote Healing in Patients With Resistant Non-infectious Corneal UlcerCompletedNCT05924893Not applicable
- Clinical Outcomes From NalmefeneWithdrawnNCT05808881Phase 4
- Colonic Motor Patterns in Healthy VolunteersCompletedNCT05770960Phase 4
- Single-Site Study of Naltrexone/Acetaminophen for the Acute Treatment of Migraine: A Phase 2 Randomized TrialWithdrawnNCT05685225Phase 2
- Novel Induction to Buprenorphine/NaloxoneTerminatedNCT05644587Phase 4
- Naltrexone Neuroimaging in Teens With Eating DisordersActive, not recruitingNCT05509257Early Phase 1
- Low-dose Naltrexone for Post-COVID Fatigue SyndromeCompletedNCT05430152Phase 2
- A Thorough QT Study of Aticaprant (JNJ-67953964) in Healthy Adult ParticipantsCompletedNCT05387759Phase 1
- Reversal of Opioid-induced Respiratory Depression With Opioid AntagonistsTerminatedNCT05338632Phase 1
- Safety, Tolerability, and Pharmacokinetics of Naltrexone Implant (DLP-160)CompletedNCT05304364Phase 1
- A Phase 4 Clinical Study to Investigate the Efficacy and Safety of Naloxone HCI IV in Patients With StrokeCompletedNCT05301712Phase 4
- Extended-Release Naltrexone and Monthly Extended-Release Buprenorphine for Cocaine Use Disorder (CURB-2)CompletedNCT05262270Phase 2
- A Study of 14C JNJ-67953964 in Healthy Adult Male ParticipantsCompletedNCT05197062Phase 1
- Pharmacological and Behavioral Treatment After Bariatric SurgeryCompletedNCT05157698Phase 3
- Stress and Opioid Misuse Risk: The Role of Endogenous Opioid and Endocannabinoid MechanismsCompletedNCT05142267Phase 4
- In Hospital IM Naltrexone: A Pilot StudyWithdrawnNCT05087771Phase 4
- Effects of Naltrexone on Nocturnal Breathing Patterns at AltitudeCompletedNCT05037032Phase 4
- The NIPA Study Naloxegol Administration to Prevent Opioids Induced Gastrointestinal Motility Disturbance in Brain Injured PAtientsSuspendedNCT05008926Phase 3
- Understanding How Opioids Affect the Experiential and Neural Signatures of Social ExperiencesCompletedNCT05007561Early Phase 1
- Opioid Antagonism in Individuals Ascertained Through the Partners HealthCare BiobankCompletedNCT04975347Phase 1
- Neural Mechanisms of Immersive Virtual Reality in Chronic PainActive, not recruitingNCT04851301Phase 1/2
- Buprenorphine Induction for Fentanyl Dependent Opioid UsersWithdrawnNCT04794790Early Phase 1
- A Study of JNJ-67953964 in Healthy Japanese Adult Male ParticipantsCompletedNCT04791332Phase 1
- Buprenorphine/Naloxone Micro-Dosing for Postoperative Pain Management in Opioid-Tolerant PatientsWithdrawnNCT04771689Phase 4
- Phase III Trial Assessing the Efficacy and Safety of PXT3003 in CMT1A PatientsActive, not recruitingNCT04762758Phase 3
- An Investigation of the Effects of Opioid Receptor Blockade on Changes in Self-esteem and Social AttentionCompletedNCT04757506Not applicable
- Cost-utility and Physiological Effects of LDN in Patients With FibromyalgiaActive, not recruitingNCT04739995Phase 4
- RCT for Gambling and Naltrexone, Using Use Eye-tracking Analysis to Predict Treatment ResponseStatus unknownNCT04738773Phase 2
- A Single-Dose, Bioequivalence Study of FMXIN001 4 mg Microspheres PowderCompletedNCT04713709Phase 1
- Effect of Nalmefene on the Quality of Resuscitation in Patients Under General AnesthesiaCompletedNCT04713358Phase 4
- Pilot Study Into LDN and NAD+ for Treatment of Patients With Post-COVID-19 SyndromeCompletedNCT04604704Phase 2
- Pilot Study Into the Use of Metformin and LDN for Patients With COVID-19WithdrawnNCT04604678Phase 2
- Optimizing Retention, Duration and Discontinuation Strategies for Opioid Use Disorder Pharmacotherapy (RDD)Active, not recruitingNCT04464980Phase 2
- Topical Naloxone to Diagnose Ocular PainCompletedNCT04454281Phase 1
- Effect of Naloxegol on Postoperative Ileus in Patients Undergoing Cardiac SurgeryCompletedNCT04433390Phase 3
- Naltrexone/Bupropion (Mysimba) to Optimize Weight Outcomes After Obesity SurgeryWithdrawnNCT04399395Phase 4
- Effect of Naltrexone in Achieving and Maintaining Abstinence From Alcohol in Patients With Cirrhosis.CompletedNCT04391764Not applicable
- Treatment of Chronic Itch in Atopic Dermatitis With Opioid Antagonist NaltrexoneWithdrawnNCT04325802Phase 2
- Rapid Antidepressant Improvement Secondary to Excitatory Brain ResponsesCompletedNCT04276259Phase 4
- Fibromyalgia and Naltrexone: The FINAL StudyCompletedNCT04270877Phase 2
- Efficacy of Low Dose Naltrexone in PsoriasisCompletedNCT04250792Phase 1
- Long-acting Buprenorphine vs. Naltrexone Opioid Treatments in CJS-involved AdultsCompletedNCT04219540Phase 4
- Evaluation of Naloxegol in the Prevention of POI After CystectomyWithdrawnNCT04219046Phase 2
- A Study to Investigate the Effect of JNJ-67953964 on Gastric Mucosal Integrity in Healthy Male and Female ParticipantsCompletedNCT04185051Phase 1
- Treatment of Chronic Itch in Atopic Dermatitis With Topical NaltrexoneWithdrawnNCT04154033Phase 2
- An Extension Study of Methylnaltrexone Bromide (MNTX) in Participants With Advanced Pancreatic CancerWithdrawnNCT04151719Phase 3
- Low Dose Naltrexone for Chronic Pain in Osteoarthritis and Inflammatory ArthritisWithdrawnNCT04115020Phase 2
- Effect of Standard of Care Reduced Dose Versus Full Dose Buprenorphine/Naloxone in the Perioperative Period on Pain Control and Post-Operative Opioid Use Disorder SymptomsWithdrawnNCT04091009Phase 4
- A Study of Methylnaltrexone Bromide (MNTX) in Participants With Advanced Pancreatic CancerWithdrawnNCT04083651Phase 2/3
- Neural Correlates of Hypoalgesia Driven by ObservationCompletedNCT03897998Phase 2
- The Evaluation of Safety and Tolerance of Commercially Available Naltrexone Administered Daily - Assessment for CBRN OperationsCompletedNCT03879460Phase 1
- Study of the Opioid Modulation of the Effect of Alcohol on the Dopaminergic Reward SystemTerminatedNCT03854942Phase 1
- Evaluation of Intranasal Naltrexone and NaloxoneCompletedNCT03851731Phase 1
- A Study to Compare Bioavailability of Naloxone Nasal Spray, Naloxone Hydrochloride (HCl) Intravenous (IV) and Intramuscular Injection (IM) in Healthy VolunteersCompletedNCT03827642Phase 1
- A Study to Compare Bioavailability of Naloxone Nasal Spray and Naloxone Hydrochloride (HCl) Intramuscular Injection (IM) in Healthy VolunteersCompletedNCT03827629Phase 1
- Medication Maintenance Therapy in Community Pharmacy SettingsCompletedNCT03766893Early Phase 1
- Rapid Reversal of CNS-Depressant Drug Effect Prior to Brain Death DeterminationWithdrawnNCT03743805Early Phase 1
- Buprenorphine vs Buprenorphine/Naloxone on the Effects of Maternal SymptomatologyWithdrawnNCT03740243Phase 4
- Naltrexone Plus Ketamine for the Rapid Treatment of Major Depressive Disorder and Alcohol Use DisorderCompletedNCT03658330Phase 2
- Long Acting Naltrexone for Opioid Addiction: Focus on Sustained Abstinence and RecoveryCompletedNCT03647774Phase 4
- Buprenorphine for Probationers and Parolees: Bridging the Gap Into TreatmentSuspendedNCT03616236Phase 3
- Effects of Mediterranean Diet and Naltrexone/Bupropion Treatment in Obese Breast Cancer PatientsCompletedNCT03581630Not applicable
- Defining the Clinical Role of Topiramate in the Treatment of Alcohol Dependence in AustraliaStatus unknownNCT03479086Phase 3
- Effects of Intranasal Naloxone on Gambling Urges and Craving in Gambling DisorderStatus unknownNCT03430180Phase 2
- Effect of Ultra-low Dose Naloxone During Supraclavicular Brachial Plexus Block on Post-operative OpioiCompletedNCT03372486Not applicable
- Naloxegol and Opioid-induced ConstipationStatus unknownNCT03316859Phase 2/3
- Opioid-Induced Swallowing Dysfunction - The Impact of Bolus VolumeStatus unknownNCT03283020Phase 4
- Patient Driven Recovery With Nalmefene and CoachingCompletedNCT03279562Phase 1
- Effect of Buprenorphine/Naloxone Continuation on Pain Control and Opioid UseStatus unknownNCT03266445Phase 4
- Treatment of Gambling Disorder With Fast Acting Opiate Antagonist, Naloxone Nasal SprayCompletedNCT03223896Phase 2
- Low-Dose Naltrexone and Acetaminophen Combination in the Treatment of Chronic Low Back Pain (ANODYNE-4)CompletedNCT03201393Phase 2
- Low-Dose Naltrexone and Acetaminophen Combination and Sumatriptan in the Acute Treatment of Migraine With NauseaCompletedNCT03185143Phase 2/3
- Pharmacokinetic Evaluation of Nalmefene Administered Intranasally to Healthy VolunteersCompletedNCT03129347Phase 1
- Low-Dose Naltrexone and Acetaminophen Combination and Its Components in the Acute Treatment of MigraineCompletedNCT03061734Phase 2
- Naloxegol for Opioid-Related GastroparesisWithdrawnNCT03036891Phase 2
- Nalmefene, Baclofen and Impulsivity in Subjects With Alcohol Use Disorder and Healthy Control SubjectsCompletedNCT03034408Phase 2
- The Effect of Naloxone and Methylnaltrexone on Esophageal Sensitivity in HealthCompletedNCT03014843Not applicable
- Movantik for Opioid-Related Esophageal DisordersTerminatedNCT02998606Phase 2
- Effect of High-dose Naloxone Following Third Molar ExtractionCompletedNCT02976337Phase 2
- Immune Effects of Low-dose Naltrexone in ME/CFSWithdrawnNCT02965768Not applicable
- Methylnaltrexone as a Method to Improve Ticagrelor Uptake in Morphine Treated STEMI PatientsCompletedNCT02942550Phase 4
- Evaluation of Nalmefene in Impulse Control Disorders in Parkinson's Disease: A Prospective Open Label StudyStatus unknownNCT02934919Phase 2
- An Insulin Sensitivity Study in Healthy SubjectsCompletedNCT02922426Phase 1
- Double-Blind Trial of Ketamine Therapy Plus or Minus Naltrexone in Treatment Resistant Depression (TRD)CompletedNCT02911597Phase 1
- The Use of Low Dose Prophylactic Naloxone Infusion to Prevent Respiratory Depression With Intrathecal Morphine.CompletedNCT02885948Phase 4
- The Effect of Ultra-low-dose Naloxone on Remifentanil-induced Postoperative Hyperalgesia - A Randomized Controlled StudyCompletedNCT02856087Not applicable
- Nalmefene in Patients With Alcoholic Compensated Cirrhosis for the Treatment of Alcohol Dependence.WithdrawnNCT02824354Phase 3
- Low Dose Naltrexone for Treatment of Pain in Patients With Fibromyalgia - Effect Via a Central Mechanism?CompletedNCT02806440Phase 4
- A Phase 1 Safety Study in Adults With SchizophreniaCompletedNCT02804568Phase 1