Opioid antagonists: all 625 studies that test it

Page 6 of 7. Open to participants first (43), then studies with results posted, then the rest; newest registration first within each.

• Medication and Counseling for Controlled DrinkingStatus unknownNCT01115894Phase 3
• A Comparison of Oxycodone/Naloxone and Oxycodone After Laparoscopic HysterectomyCompletedNCT01109511Phase 4
• Subjective Analgesic Effects of Naloxone and Virtual RealityStatus unknownNCT01105871Not applicable
• Adherence to HIV Therapy in Heroin Addicts: Oral vs XR-NTXCompletedNCT01101815Phase 2
• ALK33-101: A Study of RDC-0313 (ALKS 33) in Adults With Binge Eating DisorderCompletedNCT01098435Phase 2
• Naloxone for the Treatment of Opioid-Induced PruritusCompletedNCT01071057Phase 2/3
• Methylnaltrexone for Treatment of Opiate-Induced Constipation in the Intensive Care UnitStatus unknownNCT01050595Phase 3
• Phase 1 Study to Evaluate RDC-0313 Coadministered With Buprenorphine to Opioid-Experienced Healthy AdultsCompletedNCT01046539Phase 1
• Comparison of Buprenorphine/Naloxone With Naltrexone in Opioid Dependent AdolescentsWithdrawnNCT01015066Phase 4
• Opioids and Esophageal FunctionCompletedNCT01012960Phase 4
• Study of Naltrexone for Methamphetamine AddictionCompletedNCT00984360Phase 2
• ALK33-005: A Study of ALKS33 (RDC-0313) in Adults With Alcohol DependenceCompletedNCT00981617Phase 2
• Can Methylnaltrexone Safely Treat Opioid Related Constipation in the Emergency Department?WithdrawnNCT00949377Phase 4
• Reversal of Ketamine Pharmacodynamic Effects With NaloxoneTerminatedNCT00921765Phase 4
• TNF-blocking Therapy in Combination With Disease-modifying Antirheumatic Drugs in Early Rheumatoid ArthritisStatus unknownNCT00908089Phase 4
• Efficacy of Intramuscular Naloxone 0.4mg. in Prophylaxis of Intrathecal Morphine Induced Pruritus After Cesarean SectionCompletedNCT00890942Not applicable
• Comparison of Two Dosage Strengths of Transdermal Fentanyl Versus Transdermal Buprenorphine and Placebo in Acute Pain Models in Healthy Volunteers.CompletedNCT00886002Phase 1
• Study Evaluating Safety & Efficacy of Subcutaneous Methylnaltrexone on Opioid-Induced Constipation in Cancer SubjectsWithdrawnNCT00858754Phase 4
• Low Dose Naltrexone for the Treatment of Juvenile Primary Fibromyalgia SyndromeWithdrawnNCT00855972Not applicable
• Pharmacotherapy for HIV Infected Patients With Alcohol ProblemsWithdrawnNCT00854230Phase 4
• Phase IIa Safety and Efficacy Study of SRD174 Cream in Patients With AD-associated PruritusCompletedNCT00838708Phase 2
• Safety Study of Intravenous 6β-Naltrexol (AIKO-150) in Opioid-Dependent SubjectsCompletedNCT00829777Phase 1
• ALK33-001: A Study of RDC-0313 Administered to Healthy AdultsCompletedNCT00800319Phase 1
• Enteral Naloxone Versus a Traditional Bowel Regimen for the Prevention of Opioid Induced Constipation in Trauma PatientsTerminatedNCT00799201Phase 4
• Combining Medications for the Treatment of Alcohol Dependence: An Inpatient Preliminary StudyCompletedNCT00769158Phase 1
• Combined Pharmacotherapies for AlcoholismCompletedNCT00768508Phase 3
• Naltrexone SR and Fluoxetine Combination Therapy in Subjects With Obsessive-Compulsive DisorderTerminatedNCT00758966Phase 2
• Depot Naltrexone Treatment of Opioid Dependent ParoleesCompletedNCT00756990Not applicable
• Impact of Naloxone on the Analgesic Effect of Paracetamol in Healthy VolunteersCompletedNCT00750048Phase 1
• Study to Evaluate the Subjective Effects of PTI-801 in Non-Physically Dependent Subjects With a History of Drug AbuseCompletedNCT00734461Phase 2
• Pharmacokinetics of Fentanyl Following Intravenous and Oral Routes of Administration in Healthy VolunteersCompletedNCT00714558Phase 1
• Effect of Combined Use of Naloxone and Tramacet on Postop Analgesia in Elderly Patients Having Joint Replacement SurgeryCompletedNCT00679614Phase 3
• Randomized, Double-Blind Cross-Over Trial Of Buprenorphine and Low-Dose Naloxone Versus BuprenorphineCompletedNCT00679458Not applicable
• Effectiveness of Alcohol Interventions Among Tuberculosis (TB) Patients in Tomsk Oblast, RussiaCompletedNCT00675961Not applicable
• The Effect of Naltrexone on Alcohol Craving and on Brain Activity During Alcohol InfusionCompletedNCT00667771Early Phase 1
• A Study to Evaluate the Safety of D-TRANS Fentanyl With Naltrexone in Adult Patients With Chronic Pain and Who Are Opioid TolerantCompletedNCT00650182Phase 2
• A Study of Naltrexone SR/ Bupropion SR in Overweight or Obese Subjects With Major DepressionCompletedNCT00624858Phase 2
• Drug Discrimination in Methadone-Maintained Humans Study 1CompletedNCT00593463Phase 1
• Augmenting Zyprexa With Naltrexone to Ameliorate Metabolic Side-EffectsCompletedNCT00567034Phase 1
• A Study of Naltrexone SR/ Bupropion SR in Overweight and Obese Subjects Who Are Nicotine-DependentCompletedNCT00563563Phase 2
• Research on Individualized Treatment for AlcoholismCompletedNCT00523133Phase 2
• A Study Comparing Oxycodone to Oxycodone/Naloxone in Moderate to Severe, Chronic Cancer PainCompletedNCT00513656Phase 2
• Study Evaluating Oral MOA-728 in Subjects on Methadone TherapyWithdrawnNCT00505583Phase 1
• A Randomized Placebo-Controlled, Crossover-Design Study of the Effects of Low Dose NaltrexoneCompletedNCT00501696Phase 3
• Naltrexone in the Treatment of PyromaniaWithdrawnNCT00467454Phase 2
• Study Evaluating the Safety and Tolerability of a New Intravenous Formulation of MOA-728 in Healthy SubjectsCompletedNCT00464802Phase 1
• Long-Acting Injectable Naltrexone Treatment of Alcohol Dependence in Primary Care vs. in Specialized Chemical Dependence Treatment: A Pilot TrialTerminatedNCT00461890Phase 4
• Injectable Versus Oral Naltrexone Treatment of Alcohol Dependence In Serious Mental Illness (SMI)CompletedNCT00453804Phase 4
• Study Evaluating MOA-728 in Subjects on Stable Methadone MaintenanceCompletedNCT00447811Phase 1
• Medication and Counseling for Controlled Drinking (Project SMART)CompletedNCT00444418Phase 3
• Double-Blind, Double-Dummy, 2-Period Crossover of a 20-Minute Versus a 4-hour IV of MOA-728 in Stable Methadone SubjectsCompletedNCT00444158Phase 1
• Study Evaluating the Effects of MOA-728 on Cardiac Repolarization in Healthy SubjectsCompletedNCT00434395Phase 1
• Study Evaluating MOA-728 Administered in Healthy MenWithdrawnNCT00427258Phase 1
• Study of Bupropion Versus Bupropion + Naltrexone for Smoking CessationStatus unknownNCT00419731Phase 2/3
• Comparisons Of The Bioavailability And Pharmacodynamics Of Various Formulations Of MOA-728 In Subjects On MethadoneCompletedNCT00398502Phase 1
• HIV Risk Reduction and Drug Abuse Treatment in IranWithdrawnNCT00398008Phase 2
• Bioequivalence Study in Healthy VolunteersCompletedNCT00387985Phase 1
• Dose Ranging Study in Healthy Methadone Maintenance SubjectsCompletedNCT00387491Phase 1
• Study Evaluating IV Methylnaltrexone for the Treatment of Post Operative IleusCompletedNCT00387309Phase 3
• Targeted Naltrexone for Problem DrinkersCompletedNCT00369408Phase 4
• Study Evaluating Oral MOA-728 for the Treatment of Opioid-Induced Bowel Dysfunction (OIBD) in Subjects With Chronic Non-Malignant PainCompletedNCT00366431Phase 2
• Efficacy and Safety Study of Combination Therapy to Treat Uncomplicated ObesityCompletedNCT00364871Phase 2
• Behavioral Naltrexone Therapy: A Novel Treatment for Heroin DependenceCompletedNCT00332228Phase 2
• Naltrexone in the Treatment of Concurrent Alcohol Dependence and Pathological GamblingCompletedNCT00326807Not applicable
• Trial of Low-Dose Naltrexone for Children With Pervasive Developmental Disorder (PDD)Status unknownNCT00318162Phase 1/2
• Study Evaluating the Safety of MOA-728 Administered Orally to Healthy SubjectsCompletedNCT00311350Phase 1
• Impact of Low Dose Naloxone on Fentanyl Requirements in Pediatric ICU PatientsCompletedNCT00286052Phase 3
• Naltrexone Effects on Alcohol IntakeCompletedNCT00254670Not applicable
• Bridging Active Heroin Users to Hepatitis C Treatment Using Buprenorphine - 1CompletedNCT00249574Not applicable
• Efficacy of Naltrexone Treatment as Augmentation to SSRI in OCD PatientsCompletedNCT00234689Not applicable
• Naltrexone for Bipolar Disorder and Alcohol DependenceCompletedNCT00223275Phase 4
• Naltrexone in Two Models of Psychosocial Treatments for Cocaine and Alcohol Dependence - 1CompletedNCT00218660Phase 3
• Combined Treatment for Cocaine-Alcohol Dependence - 1CompletedNCT00218569Phase 2
• Naltrexone Augmentation of Nicotine Patch Therapy - 1CompletedNCT00218153Phase 3
• Naltrexone Implants vs. MMT Among Inmates in the Norwegian Correctional ServicesCompletedNCT00204243Phase 2
• Nalmefene Smoking Cessation StudyCompletedNCT00202696Phase 2
• Naltrexone in Two Models of Psychosocial Treatments for Cocaine and Alcohol DependenceCompletedNCT00167232Phase 3
• Abuse Potential of Buprenorphine and Naloxone in Non-Dependent Opioid UsersCompletedNCT00158236Not applicable
• Abuse Potential of Buprenorphine/NaloxoneTerminatedNCT00149539Phase 2
• Naltrexone and Adrenergic Agents to Reduce Heroin Use in Heroin AddictsCompletedNCT00142948Phase 2
• Combination of Disulfiram Plus Naltrexone to Treat Both Cocaine- and Alcohol-dependent Individuals - 1CompletedNCT00142844Phase 2
• Addition of Naltrexone to Methadone TaperCompletedNCT00135759Phase 2
• Blockade Efficacy of Buprenorphine/Naloxone For Opioid DependenceCompletedNCT00134888Not applicable
• Assessing Abuse Potential of Parenteral Buprenorphine/Naloxone in Non-Dependent Opioid AbusersTerminatedNCT00134875Not applicable
• Nalmefene Gambling Study: Study of Nalmefene HCl in the Treatment of Pathological GamblingCompletedNCT00132119Phase 2/3
• Naltrexone in Borderline Personality DisorderTerminatedNCT00124839Phase 3
• Buprenorphine/Naloxone - Facilitated Rehabilitation for Opioid Dependent Adolescents - 1CompletedNCT00078130Phase 3
• Self-Injury: Diagnosis and TreatmentStatus unknownNCT00065936Phase 3
• Buprenorphine/Naloxone Versus Clonidine for Outpatient Opiate Detoxification - 1CompletedNCT00032968Phase 3
• Buprenorphine/Naloxone Versus Clonidine for Inpatient Opiate Detoxification - 1CompletedNCT00032955Phase 3
• Combined Pharmacotherapies for Alcoholism (Naltrexone/Ondansetron)CompletedNCT00027079Phase 2
• Naloxone in Treating Constipation in Patients Who Are Receiving Opioids for Chronic PainStatus unknownNCT00020605Phase 3
• Treating Alcohol Use In Older Adults With DepressionCompletedNCT00018824Phase 4
• Naltrexone and Patch for SmokersCompletedNCT00018213Not applicable
• Buprenorphine/Naloxone in the Treatment of Heroin Dependence - 14CompletedNCT00015340Phase 4
• Buprenorphine and Naloxone Combination Study - 10CompletedNCT00015288Phase 1
• Buprenorphine and Naloxone for the Treatment of Opiate Dependence - 1CompletedNCT00015171Phase 3
• Naltrexone in Treatment of Cocaine Dependence - 5CompletedNCT00015080Phase 2
• Buprenorphine/Naloxone for Opiate-Dependence Treatment - 1CompletedNCT00015028Phase 2
• Determine the Safety of a Sublingual Tablet Formulation of Buprenorphine and Naloxone by Extending the Combination Tablet Availability to Physicians in Office-Based PracticeCompletedNCT00007527Phase 4

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