Opioid antagonists: all 625 studies that test it

Page 3 of 7. Open to participants first (43), then studies with results posted, then the rest; newest registration first within each.

• Assessment of Efficacy and Safety in Patients With Non-cancer-related Pain and Opioid-induced ConstipationCompletedNCT01323790Phase 3Results posted
• A Study to Evaluate Efficacy and Safety of Oxycodone/Naloxone Compared to OxyContin in Korean Cancer PatientsCompletedNCT01313780Phase 4Results posted
• Assessment of Efficacy and Safety in Patients With Non-cancer-related Pain and Opioid-induced ConstipationCompletedNCT01309841Phase 3Results posted
• Low Dose Naltrexone for Glioma PatientsCompletedNCT01303835Phase 2Results posted
• Sweet Preference and Alcohol CravingCompletedNCT01296646Phase 2Results posted
• Naltrexone for Opioid Dependent Released Human Immunodeficiency Virus Positive (HIV+) Criminal Justice PopulationsCompletedNCT01246401Phase 1/2Results posted
• Will Having Alcohol Treatment Improve Functioning?CompletedNCT01245647Phase 2Results posted
• Reducing Heavy Drinking to Optimize HIV/AIDS Treatment and PreventionCompletedNCT01227044Phase 2/3Results posted
• ALK21-006: Long-Term Study of Medisorb® Naltrexone (VIVITROL®)CompletedNCT01218997Phase 3Results posted
• ALK21-004: Single-dose Opiate Challenge of Medisorb® Naltrexone (VIVITROL®) in Adults Who Use OpioidsCompletedNCT01218984Phase 2Results posted
• ALK21-003EXT: An Extension of Study ALK21-003 (NCT01218958) to Test the Long-term Safety of Medisorb® Naltrexone (VIVITROL®)CompletedNCT01218971Phase 3Results posted
• ALK21-003: Study of Medisorb® Naltrexone (VIVITROL®) in Alcohol-Dependent AdultsCompletedNCT01218958Phase 3Results posted
• N-acetylcysteine Plus Naltrexone for the Treatment of Alcohol DependenceCompletedNCT01214083Phase 2Results posted
• A Study of Oral Methylnaltrexone (MNTX) for the Treatment of Opioid-Induced Constipation (OIC) in Participants With Chronic, Non-Malignant PainCompletedNCT01186770Phase 3Results posted
• Extended-Release Naltrexone for Opioid Relapse Prevention Following Release From JailCompletedNCT01180647Phase 3Results posted
• Pilot Study of Depot NTX in Homeless VeteransTerminatedNCT01155869Phase 4Results posted
• Alcohol Pharmacotherapy for HIV+ PrisonersCompletedNCT01077310Not applicableResults posted
• Investigation of Naltrexone for Pathological GamblingCompletedNCT01057862Phase 2Results posted
• Effect of Methylnaltrexone on GI Transit in Healthy VolunteersCompletedNCT01055704Phase 4Results posted
• Naltrexone and Hypoglycemia in Type 1 DiabetesCompletedNCT01053078Phase 1/2Results posted
• Naltrexone for Impulse Control Disorders in Parkinson's DiseaseCompletedNCT01052831Phase 4Results posted
• Methylnaltrexone for Opioid-induced Constipation in Cancer PatientsCompletedNCT01004393Phase 2Results posted
• Naloxone SR Capsules in Patients With Opioid Induced ConstipationCompletedNCT00984334Phase 2Results posted
• Role of Endorphins in Perception of Dyspnea With Resistive Loading in Chronic Obstructive Pulmonary Disease (COPD)CompletedNCT00958919Not applicableResults posted
• Effect of Nalbuphine and Naloxone on Experimentally Induced Skin SensitivityTerminatedNCT00947284Not applicableResults posted
• Naltrexone for At-Risk and Problem Drinking in Smoking Cessation TreatmentCompletedNCT00938886Phase 2Results posted
• Study Evaluating the Efficacy and Safety of Subcutaneous Methylnaltrexone (MOA-728) for the Treatment of Opioid-Induced-ConstipationCompletedNCT00936884Phase 3Results posted
• Genetic and Brain Mechanisms of Naltrexone's Treatment Efficacy for AlcoholismCompletedNCT00920829Phase 4Results posted
• Buprenorphine and Methadone for Opioid Dependent Chronic Pain PatientsCompletedNCT00879996Phase 4Results posted
• ALK21-021: A Safety Study of Medisorb® Naltrexone (VIVITROL®) Administered to Health Care ProfessionalsCompletedNCT00834080Phase 3Results posted
• Pharmacogenetic Response to Naltrexone For Alcohol DependenceCompletedNCT00831272Phase 4Results posted
• Understanding Treatment Response With Naltrexone Among White AlcoholicsCompletedNCT00817089Phase 4Results posted
• Efficacy of Nalmefene in Patients With Alcohol DependenceCompletedNCT00812461Phase 3Results posted
• Safety and Efficacy of Nalmefene in Patients With Alcohol DependenceCompletedNCT00811941Phase 3Results posted
• Efficacy of Nalmefene in Patients With Alcohol DependenceCompletedNCT00811720Phase 3Results posted
• Study Evaluating Long-Term Safety of MOA-728 in Participants With Opioid-Induced ConstipationCompletedNCT00804141Phase 3Results posted
• Pilot Trial of Naltrexone for Obesity in Women With SchizophreniaCompletedNCT00793780Not applicableResults posted
• A Study to Compare Oxycodone/Naloxone Prolonged Release Against Codeine/Paracetamol in the Treatment of Moderate to Severe Chronic Low Back Pain or Pain Due to OsteoarthritisCompletedNCT00784810Phase 4Results posted
• Treatment Study Using Depot Naltrexone (1/6) Philadelphia Coord/Data Mgmt SiteCompletedNCT00781898Phase 2/3Results posted
• VIVITROL as a Treatment for Cocaine and Alcohol DependenceCompletedNCT00777062Phase 2Results posted
• Naltrexone in the Treatment of TrichotillomaniaCompletedNCT00775229Phase 2Results posted
• The Effect of Naltrexone and Varenicline on Alcohol-Mediated Smoking LapseCompletedNCT00773422Phase 2Results posted
• Effects of Low-dose Naltrexone in Combination With a Range of Smoked MarijuanaCompletedNCT00743145Phase 2Results posted
• Efficacy of Nalbuphine and Naloxone Administered as Nose Sprays in the Treatment of Orofacial PainTerminatedNCT00716807Not applicableResults posted
• The Efficacy of Low Dose Naltrexone Therapy in Children With Crohn's DiseaseCompletedNCT00715117Phase 2Results posted
• A Study Using Functional Magnetic Resonance Imaging (fMRI) to Assess the Effects of Naltrexone SR/ Bupropion SR Therapy in Overweight or Obese SubjectsCompletedNCT00711477Phase 2Results posted
• Preference for Subutex® (Buprenorphine) Versus Suboxone® (Buprenorphine/Naloxone) in Opioid Dependent Patients on Subutex® (Study P05094)(COMPLETED)CompletedNCT00684073Phase 4Results posted
• ALK21-013: Efficacy and Safety of Medisorb® Naltrexone (VIVITROL®) in Adults With Opioid DependenceCompletedNCT00678418Phase 3Results posted
• Mechanisms of Hypoglycemia Associated Autonomic FailureTerminatedNCT00678145Phase 2Results posted
• Study Evaluating Subcutaneous Methylnaltrexone For Treatment Of Opioid-Induced Constipation In Patients With Advanced IllnessCompletedNCT00672477Phase 4Results posted
• Safety of Subcutaneous Methylnaltrexone for Opioid-Induced Constipation in Patients With Advanced IllnessCompletedNCT00672139Phase 4Results posted
• An Exploratory Study of Naltrexone Plus Aripiprazole for Alcohol DependenceCompletedNCT00667875Phase 2Results posted
• The Effects of Naltrexone on Active Crohn's DiseaseCompletedNCT00663117Phase 2Results posted
• Medication Development in Alcoholism: Acamprosate Versus NaltrexoneCompletedNCT00656630Phase 2Results posted
• Study of Subcutaneous Methylnaltrexone (MNTX) in the Treatment of Opioid-Induced Constipation During Rehabilitation After Orthopedic ProceduresCompletedNCT00640146Phase 2Results posted
• Extended-release Naltrexone for Alcohol Dependence in Primary CareCompletedNCT00620750Phase 4Results posted
• Study Evaluating MOA-728 Oral for the Treatment of OIBD in Subjects With Chronic Non-Malignant PainCompletedNCT00605644Phase 2Results posted
• A Phase 2, Double-Blind, Multiple-Dose Escalation Study to Evaluate NKTR-118 (Oral PEG-Naloxol) in Patients With Opioid-Induced Constipation (OIC)CompletedNCT00600119Phase 2Results posted
• Behavioral Naltrexone Therapy for Promoting Adherence to Oral Naltrexone vs Extended Release Injectable Depot NaltrexoneCompletedNCT00577408Phase 3Results posted
• Naltrexone for Heavy Drinking in Young AdultsCompletedNCT00568958Phase 4Results posted
• Effects of Low Dose Naltrexone in FibromyalgiaCompletedNCT00568555Not applicableResults posted
• A Safety and Efficacy Study of Naltrexone SR/Bupropion SR in Overweight and Obese SubjectsCompletedNCT00567255Phase 3Results posted
• Buprenorphine as a Treatment in Opiate Dependent Pain PatientsTerminatedNCT00552578Phase 4Results posted
• Study Evaluating Oral MOA-728 For The Treatment Of OIBD In Subjects With Chronic Non-Malignant PainCompletedNCT00547586Phase 2Results posted
• Vivitrol for Reducing Driving While Impaired Behavior Among Repeat OffendersCompletedNCT00537745Phase 4Results posted
• A Study of the Safety and Efficacy of Two Doses of Naltrexone SR/Bupropion SR and Placebo in Overweight and Obese SubjectsCompletedNCT00532779Phase 3Results posted
• Study Evaluating Subcutaneous MOA-728 for the Treatment of Opioid-Induced Constipation (OIC) in Subjects With Chronic Non-Malignant PainCompletedNCT00529087Phase 3Results posted
• A Study Evaluating Intravenous (IV) MOA-728 for the Treatment of Postoperative Ileus (POI) in Participants After Ventral Hernia RepairCompletedNCT00528970Phase 3Results posted
• ALK21-018: Effects of Medisorb® Naltrexone (VIVITROL®) on Alcohol Craving in Treatment-seeking, Alcohol-dependent AdultsCompletedNCT00511836Phase 4Results posted
• Naltrexone and Varenicline: Weight Gain and Tolerability in Cigarette SmokersCompletedNCT00502216Phase 1/2Results posted
• ALK21-014: Efficacy and Safety of Medisorb® Naltrexone (VIVITROL®) After Enforced AbstinenceCompletedNCT00501631Phase 3Results posted
• A Safety and Efficacy Study Comparing Naltrexone SR/Bupropion SR and Placebo in Obese Subjects With Type 2 DiabetesCompletedNCT00474630Phase 3Results posted
• Double-Blind Naltrexone in Compulsive Sexual BehaviorCompletedNCT00467558Phase 2Results posted
• A Safety and Efficacy Study of Naltrexone SR/Bupropion SR and Placebo in Overweight and Obese Subjects Participating in an Intensive Behavior Modification ProgramCompletedNCT00456521Phase 3Results posted
• Effects of a Range of Naltrexone Doses in Combination With Smoked MarijuanaCompletedNCT00403117Phase 2Results posted
• Study of Intravenous (IV) Methylnaltrexone Bromide (MNTX) in the Treatment of Post-Operative Ileus (POI)CompletedNCT00401375Phase 3Results posted
• Phase II of Naltrexone in Hormone-Refractory Metastatic Breast CancerTerminatedNCT00379197Phase 2Results posted
• Effectiveness of Naltrexone Versus Placebo to Reduce Craving for Alcohol With Evaluation of Genetic Variability.CompletedNCT00366626Phase 4Results posted
• Naltrexone & SSRI in Alcoholics With Depression/PTSDCompletedNCT00338962Phase 3Results posted
• N-Acetyl Cysteine Plus Naltrexone in Methamphetamine DependenceCompletedNCT00332605Phase 2Results posted
• Double-Blind Naltrexone in KleptomaniaCompletedNCT00332579Phase 2Results posted
• Optimal Dose of Prophylactic Naloxone in Reducing Opioid-Induced Side Effects in Children/AdolescentsCompletedNCT00330343Phase 2Results posted
• Starting Treatment With Agonist Replacement Therapies (START)CompletedNCT00315341Phase 4Results posted
• Optimizing Pharmacotherapy for Bipolar AlcoholicsCompletedNCT00302133Phase 1/2Results posted
• Efficacy of Naltrexone in Women's Smoking CessationCompletedNCT00271024Phase 2Results posted
• Drug Treatment Combined With Drug and Risk Reduction Counseling to Prevent of HIV Infection and Death Among Injection Drug UsersTerminatedNCT00270257Phase 3Results posted
• Effects of Naltrexone on Nicotine ReinforcementCompletedNCT00270231Phase 2Results posted
• Endophenotype for Alcohol Misuse in Healthy Minority PopulationsCompletedNCT00256451Phase 4Results posted
• Addiction Treatment in Russia: Oral vs. Naltrexone ImplantCompletedNCT00218426Phase 2/3Results posted
• Medications for Stopping Cocaine Dependence and Preventing RelapseCompletedNCT00218023Phase 2Results posted
• Effectiveness of Gabapentin When Used With Naltrexone to Treat Alcohol Dependence Compared to Placebo and Naltrexone AloneCompletedNCT00183196Phase 3Results posted
• ALK21-006EXT: Long-term Safety of Medisorb® Naltrexone (VIVITROL®) in Alcohol- or Opioid-dependent Adults (Extension of Study ALK21-006 [NCT01218997])TerminatedNCT00156936Phase 3Results posted
• ALK21-010: Long-term Safety of Medisorb® Naltrexone (VIVITROL®) in Alcohol-dependent AdultsCompletedNCT00156923Phase 3Results posted
• Modafinil and Naltrexone to Reduce Cocaine and Alcohol DependenceCompletedNCT00142818Phase 2Results posted
• Low-Dose Naltrexone Combined With Bupropion to Stop Smoking With Less Weight GainCompletedNCT00129246Phase 1/2Results posted
• Managing Alcoholism in People Who Do Not Respond to NaltrexoneCompletedNCT00115037Phase 4Results posted
• Targeted Interventions for Weight-Concerned SmokersCompletedNCT00105482Phase 2Results posted
• Treatment for Alcoholism and Post-Traumatic Stress Disorder (Naltrexone)CompletedNCT00006489Phase 4Results posted
• Pharmacokinetic (PK) Evaluation of Nalmefene FormulationsCompletedNCT07543276Phase 1
• Phase II Clinical Study on the Efficacy and Safety of Naltrexone Implant in Patients With Alcohol Use DisorderCompletedNCT07333638Phase 2

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