Levonorgestrel clinical trials
Also written Mirena, Plan B and LNG.
Counted the way a researcher would: Levonorgestrel with its salts, dosage forms, brands and biosimilars. Looking for a trial to join? Including related medicines shows more you could take part in.
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How each study uses Levonorgestrel is sorted by a rule, right about nine times in ten. Readers can ask us to read every study one by one.Ask us to read each study
Get an email when these change. Save the Levonorgestrel studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Approvals
The first approval found in each region, with its record
- United States
- 26 Jul 1979 · LO/OVRAL FE · NDA 018206 (FDA, Drugs@FDA; in a combination)
- European Union
- Not in EMA's list of EU-wide authorisations
From FDA's Drugs@FDA and Purple Book (through openFDA) and the European Medicines Agency, files of Sept 2026 and 27 Oct 2026. National approvals in Europe and other countries are not included. How this is worked out
How studies write it
Studies that test it under each name
Other names
- LNG
- 2
Studies by the year they started
97 studies that test it; most in 2005 (7); 1 more planned to start later
| Year | Studies |
|---|---|
| 1994 | 1 |
| 1999 | 1 |
| 2002 | 1 |
| 2003 | 2 |
| 2004 | 1 |
| 2005 | 7 |
| 2006 | 6 |
| 2007 | 4 |
| 2008 | 2 |
| 2009 | 3 |
| 2010 | 3 |
| 2011 | 7 |
| 2012 | 5 |
| 2013 | 1 |
| 2014 | 4 |
| 2015 | 4 |
| 2016 | 5 |
| 2017 | 4 |
| 2018 | 6 |
| 2019 | 3 |
| 2020 | 3 |
| 2021 | 5 |
| 2022 | 4 |
| 2023 | 2 |
| 2024 | 4 |
| 2025 | 3 |
| 2026 | 6 |
By phase
A phase 1/2 study counts in both.
What it is tested for
Each study’s main condition, where its own words name it, so a study counts once.
Who runs them
Industry 50 · Other 49
Bayer (13) · Wyeth is now a wholly owned subsidiary of Pfizer (8) · University of Utah (4) · FHI 360 (4) · Duramed Research (4) · Laboratorios Andromaco S.A. (3) · InnovaGyn, Inc. (2) · AbbVie (2)
Often tested with
Tested in the same studies.
Ethinyl Estradiol (36) · Etonogestrel (4) · Medroxyprogesterone Acetate (3) · Medroxyprogesterone (3) · Meloxicam (2) · Anastrozole (2) · Ulipristal acetate (2) · Ulipristal (2)
Related medicines
As reviewed, each with the page that says it.
- An enantiomer of Norgestrel source
- One of Hormonal contraceptives source
Coming up
From the study records. Dates are the sponsors’ own estimates and often move.
Reaching primary completion within a year · 5, 1 in phase 3
Studies that test Levonorgestrel, phase 3 first.
- Sep 2027Levonorgestrel-piroxicam Versus Ulipristal Acetate for Emergency ContraceptionPhase 3 · The University of Hong Kong
- Mar 2027Levonorgestrel 52 mg IUD for Emergency Contraception and Same-Day StartPhase 4 · University of Utah
- Mar 2027Kuwa Free! - Live Free!Not applicable · University of Alabama at Birmingham
- Mar 2027Contraceptive Hormone and Reward Measurement (CHARM Study)Phase 4 · University of Colorado, Denver
- Jun 2027The Influence of Plan B® on Cardiovascular Health.Not applicable · McMaster University
Studies
Open first, then newest update. How each study uses Levonorgestrel is read from its arms, and is right about nine times in ten. Ask us to read each study. These are the studies that list it as an intervention; a search of ClinicalTrials.gov also finds studies that mention it only in a description, such as earlier treatment.
Testing it · 99
- The Influence of Plan B® on Cardiovascular Health.RecruitingNot applicableMcMaster UniversityNCT07759635Written as Plan B (Levonorgestrel)
- Weight-loss Drug for Fertility-Sparing Treatment of Atypical Hyperplasia and Low-grade Cancer of the EndometriumRecruitingPhase 2GynOncTrialsNCT06073184Written as Mirena
- Efficacy, Safety, and Tolerability of Levonorgestrel Vaginal SystemNot yet recruitingPhase 3Chemo ResearchNCT07734155Written as Levonorgestrel
- Weight Management Plus LNG-IUS/Megestrol Acetate in Endometrial Atypical HyperplasiaRecruitingPhase 2/3Xiaojun ChenNCT05316493Written as Levonorgestrel-Releasing Intrauterine Contraceptive System (Mirena), 52 Mg
- Levonorgestrel-piroxicam Versus Ulipristal Acetate for Emergency ContraceptionRecruitingPhase 3The University of Hong KongNCT06727734Written as Levonorgestrel
- Levonorgestrel 52 mg IUD for Emergency Contraception and Same-Day StartRecruitingPhase 4University of UtahNCT05444582Written as Levonorgestrel 52 MG Intrauterine System
- Kuwa Free! - Live Free!RecruitingNot applicableUniversity of Alabama at BirminghamNCT05044962Written as Levonorgestrel
- Rct Assessing Pregnancy - Piroxicam for Ec With LevonorgestrelNot yet recruitingPhase 3University of UtahNCT07449299Written as Levonorgestrel 1.5 mg and Piroxicam 40 mg
- Contraceptive Hormone and Reward Measurement (CHARM Study)RecruitingPhase 4University of Colorado, DenverNCT05058872Written as Levonorgestrel/ethinyl estradiol
- Comparison of Two PPOS Models for Pituitary SuppressionNot yet recruitingNot applicableNextFertilityNCT06304220Written as Cerazet
- Oral Contraceptive Pill Compared With Vitamin E in Women With MigraineRecruitingPhase 3Leiden University Medical CenterNCT04007874Written as Ethinylestradiol/levonorgestrel
- Oral Levonorgestrel Plus Meloxicam, IG-002 Delays Ovulation in Normal Menstruating Women by Seven DaysCompletedPhase 2InnovaGyn, Inc.NCT05695352Written as Levonorgestrel 1.5mg
- A Study of ABBV-295 Subcutaneous Injections to Assess Pharmacokinetics and Adverse Events in Healthy Adult Women Participants With Overweight or Obesity Taking Oral ContraceptivesCompletedPhase 1AbbVieNCT07414784Written as Levonorgestrel/Ethinyl Estradiol
- A Phase 1 Study to Assess the Effect of ABBV-722 on Ethinyl Estradiol and Levonorgestrel Drug Levels in Healthy Adult Female ParticipantsCompletedPhase 1AbbVieNCT07502417Written as Ethinyl Estradiol + Levonorgestrel
- Mirena for the Treatment of Nonatypical Endometrial Hyperplasia for 6 MonthsWithdrawnPhase 3BayerNCT06904274Written as BAY865028
- Phase II Study of Ovulation in Obese WomenCompletedPhase 2InnovaGyn, Inc.NCT06306131Written as Levonorgestrel 1.5 milligram
- A Study of Elenestinib in Healthy Adult Female ParticipantsCompletedPhase 1Blueprint Medicines CorporationNCT07388511Written as Levonorgestrel/Ethinyl Estradiol
- A Research Study Looking Into the Effect of NNC0519-0130 on Blood Levels of a Birth Control Pill and Emptying of the Stomach in Women After MenopauseCompletedPhase 1Novo Nordisk A/SNCT06513104Written as Levonorgestrel + Ethinylestradiol
- Study Comparing Emergency Contraception Effectiveness in Women Who Weight ≥ 80 kgTerminatedPhase 4Kimberly MyerNCT03537768Written as Levonorgestrel
- Study of Spermatogenesis Suppression With DMAU Alone or With LNG Versus Placebo Alone in Normal MenCompletedPhase 2Premier ResearchNCT03455075Written as Levonorgestrel 0.03 MG
See all 99 studies that test Levonorgestrel →
Given beside what is tested · 17 — Levonorgestrel is usual care or a partner of the new treatment
- A Study of LY4515100 in Healthy ParticipantsRecruitingPhase 1Eli Lilly and CompanyNCT07339722Written as Levonorgestrel
- Assessing the Efficacy and Acceptability of Two Missed Period Pills RegimensNot yet recruitingPhase 2/3Gynuity Health ProjectsNCT06492889Written as Levonorgestrel
- A Research Study Looking at How the Compound NNC0487-0111 Works With Birth Control Pills and Affects Emptying of the Stomach in Women Not Able to Become PregnantCompletedPhase 1Novo Nordisk A/SNCT06461039Written as Levonorgestrel 150 μg + Ethinylestradiol 30 μg (Oral contraceptive OC)
- A Research Study Looking at How the Compound NNC0194-0499 Works With Birth Control Pills in Women Not Able to Bear Children.CompletedPhase 1Novo Nordisk A/SNCT06188026Written as ethinylestradiol/levonorgestrel
- STUDY TO EVALUATE THE EFFECT OF PF-06882961 ON SINGLE DOSE ATORVASTATIN, MEDAZOLAM AND ORALCONTRACEPTIVE PHARMACOKINETICS IN HEALTHY ADULT PARTICIPANTSCompletedPhase 1PfizerNCT05093205Written as Levonorgestrel & Ethinyl Estradiol
- Piroxicam and Levonorgestrel Co-treatment for Emergency ContraceptionCompletedPhase 2/3Dr. Hang Wun Raymond LiNCT03614494Written as Levonorgestrel 1.5mg
- Effects of St. John's Wort on the Oral Contraceptive Hormone LevonorgestrelCompletedPhase 4University of UtahNCT00131885Written as Levonorgestrel
- A Pharmacokinetic Evaluation of Levonorgestrel Implant and Antiretroviral TherapyCompletedPhase 2University of NebraskaNCT01789879Written as Levonorgestrel
- Pharmacokinetics Study to Evaluate Drug-Drug Interactions and Safety of Elpida® in Co-Administration With Other DrugsCompletedPhase 1ViriomNCT03709355Written as Levonorgestrel+Ethinylestradiol
- Assessing Use Of Mifepristone After Progestin Priming For Use As "Missed Period Pills"Status unknownPhase 2Gynuity Health ProjectsNCT04676776Written as Levonorgestrel
- Effect Of Multiple Dose PF-06700841 On The Pharmacokinetics Of Single Dose Oral Contraceptive SteroidsCompletedPhase 1PfizerNCT04267250Written as Ethinyl estradiol (EE) and levonorgestrel (LN)
- Drug-drug Interaction Between Rifampicin and Progestins/Ethinylestradiol and MidazolamCompletedPhase 1BayerNCT03353857Written as levonorgestrel/ Microlut
- A Study to Assess CYP3A4 Modulator, Oral Contraceptive, and pH Modifier Drug Interactions for ABI-H2158 in Healthy AdultsCompletedPhase 1Assembly BiosciencesNCT04142762Written as Ethinyl Estradiol / Levonorgestrel
- Effect of PF-06651600 on the Pharmacokinetics of Oral Contraceptive SteroidsCompletedPhase 1PfizerNCT04018274Written as Ethinyl estradiol (EE) and levonorgestrel(LN)
- Mirena and Estrogen for Control of Perimenopause Symptoms and Ovulation SuppressionCompletedNot applicableUniversity of Colorado, DenverNCT01613131Written as Mirena
- Study to Evaluate the Pharmacokinetics of an Oral Contraceptive Containing Levonorgestrel and Ethinyl Estradiol When Co-administered With GSK1265744 in Healthy Adult Female SubjectsCompletedPhase 1ViiV HealthcareNCT02159131Written as Levonorgestrel
- Management of Initial Bleeding/Spotting Associated With the Levonorgestrel-releasing Intrauterine System (MIRENA)CompletedPhase 4BayerNCT01295294Written as Mirena (Levonorgestrel IUS, BAY86-5028)
As the comparator · 12 — what is tested is compared with Levonorgestrel
- A Study of a Levonorgestrel-Releasing Intrauterine System for Long-Term, Reversible ContraceptionTerminatedPhase 3Medicines360NCT00995150Written as Mirena
- Safety and Efficacy of CDB-2914 in Comparison to Levonorgestrel for Emergency ContraceptionCompletedPhase 3HRA PharmaNCT00551616Written as Levonorgestrel
- Effects on Hemostasis, Lipids, Carbohydrate Metabolism, Adrenal & Thyroid Function of the Combined Oral Contraceptive NOMAC-E2 Compared to a COC Containing LNG-EE (292004)(COMPLETED)(P05764)CompletedPhase 3Organon and CoNCT00511355Written as Levonorgestrel and Ethinyl Estradiol
- To Investigate the Pharmacological Effects, Drug Blood Levels and Safety of an Intrauterine System Releasing the Study Drug BAY1007626 in Comparison to Mirena and Jaydess in Healthy Young Women Treated for 90 Days to Determine the Drug Dose for Further DevelopmentTerminatedPhase 2BayerNCT02490774Written as Mirena
- Impact vs. Dienogest: A Combined Oral Contraceptive in the Size of EndometriomasSuspendedPhase 2/3Fundación Santa Fe de BogotaNCT02599077Written as Levonorgestrel
- Effect on Primary DysmenorrheaCompletedPhase 3BayerNCT00909857Written as Ethinyl estradiol, Levonorgestrel (Miranova)
- Dose-finding Study for the Ultralow-dose Levonorgestrel Intrauterine Contraceptive System (LCS)CompletedPhase 2BayerNCT00185380Written as Levonorgestrel IUS (Mirena, BAY86-5028)
- Copper T380 IUD Versus Oral Levonorgestrel for Emergency Contraception vs. Plan B for Emergency ContraceptionCompletedNot applicableUniversity of UtahNCT00669396Written as levonorgestrel
- FC Patch Low: Metabolism StudyCompletedPhase 2BayerNCT00933179Written as EE/Levonorgestrel (Microgynon, BAY86-4977)
- Cross-over Study to Prove Bioequivalence Between Two Oral Formulations of LevonorgestrelCompletedPhase 1BayerNCT01096485Written as Levonorgestrel (Postday)
- Cross -Over Study to Prove Bioequivalence Between Two Oral Formulations of LevonorgestrelCompletedPhase 1BayerNCT01096498Written as Levonorgestrel (Postday)
- Therapeutic Equivalence Trial of Two Hormonal-IUDs in Patients With Heavy Menstrual BleedingCompletedPhase 3Uteron Pharma S.A.NCT01695902Written as Mirena
Codes
What other systems call Levonorgestrel · ClinicalTrials.gg INT008553
- MeSH (NLM) D016912LevonorgestrelConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) 5W7SIA7YZWLEVONORGESTRELConfirmed FDA, NLM, Wikidata
- RxNorm 6373Confirmed FDA, Wikidata
- NCI Thesaurus C47585LevonorgestrelConfirmed FDA, Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D016912 | Levonorgestrel | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | 5W7SIA7YZW | LEVONORGESTREL | Confirmed FDA, NLM, Wikidata |
| RxNorm | 6373 | — | Confirmed FDA, Wikidata |
| NCI Thesaurus | C47585 | Levonorgestrel | Confirmed FDA, Wikidata |
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.