Hypnotics and Sedatives: all 2,749 studies that test it

Page 11 of 28. Open to participants first (425), then studies with results posted, then the rest; newest registration first within each.

• A Study of Calderasib (MK-1084) With Midazolam and Digoxin in Healthy Participants (MK-1084-009)CompletedNCT06575933Phase 1
• Comparison of the Effects of Dexmedetomidine and Lidocaine on Blood Pressure and Heart Rate ResponseCompletedNCT06573957Not applicable
• Mini-dose Dexmedetomidine-Esketamine Supplemented Analgesia in Patients at High-risk of OSACompletedNCT06566482Phase 4
• Dexmedetomidine-esketamine Combined Nasal Administration and Emergence DeliriumCompletedNCT06566469Phase 4
• Oropharyngeoesophageal Topical Anesthesia Versus Propofol - Ketamine Sedation for Upper Gastrointestinal EndoscopyCompletedNCT06566326Not applicable
• A Study to Test Whether BI 456906 (Survodutide) Influences the Amount of Bupropion, Caffeine and Midazolam in the Blood in People With Overweight or ObesityCompletedNCT06564441Phase 1
• The Effect of Sedation on Rebound Pain in Knee ArthroplastyCompletedNCT06555458Not applicable
• Effect of Dexmedetomidine on Central Nervous System Complications in Patients Undergoing Cardiac SurgeryCompletedNCT06551259Phase 4
• Dexmedetomidine As An Adjuvant To Bupivacaine 0.1% in Labor AnalgesiaCompletedNCT06550414Not applicable
• A Study to Investigate the Pharmacokinetics of Midazolam After Repeated Doses of Camizestrant (AZD9833) and to Investigate the Pharmacokinetics of Camizestrant When Administered Alone and in Combination With Carbamazepine in Healthy Post-Menopausal Female ParticipantsCompletedNCT06547164Phase 1
• Compare Intraperitoneal Instillation of Bupivacaine+dexmedetomidine Versus Bupivacaine+dexamethasone on Postoperative Pain After Lap CholecystectomyCompletedNCT06535256Not applicable
• Dexamethasone Versus Demedetomidine Addition for Adductor Canal BlockCompletedNCT06527976Not applicable
• Nebulized Dexmedetomidine Versus Oral Sumatriptan in Treatment of Post Dural Puncture Headache in Cesarean SectionCompletedNCT06514040Not applicable
• Comparison of Remimazolam and Propofol on Emergence in Elderly Orthopedic Patients Under General AnesthesiaCompletedNCT06513923Phase 4
• Dexmedetomidine Improved Oxygenation and Reduced Shunt in One-Lung Ventilation at High-Risk Pediatric Thoracic SurgeryCompletedNCT06505772Not applicable
• A Drug-drug Interaction Study Evaluating the Perpetrator Potential of LY4100511 (DC-853) on Midazolam, Repaglinide, Digoxin, Rosuvastatin in Healthy ParticipantsCompletedNCT06503679Phase 1
• A Comparative Study of Intrathecal Dexmedetomidine and Fentanyl As Additives to Bupivacaine in Pott's FractureCompletedNCT06502262Phase 1
• Dexmedetomidine Infusion and Postoperative Lung Aeration After Thoracic SurgeryCompletedNCT06502002Not applicable
• Comparative Study Between Dexmedetomidine & Neostigmine as an Adjuvant to Local Anesthetic Mixture in Peribulbar Block in Vitreoretinal SurgeriesCompletedNCT06501352Early Phase 1
• Prescribing Lorazepam for IUD Insertion: Pilot Feasibility StudyWithdrawnNCT06496854Phase 2
• The Effects of Propofol and Thiopental on Nitric Oxide Production and Release in ErythrocytesCompletedNCT06485388Not applicable
• The Effect of Nocturnal Dexmedetomidine on Postoperative Sleep Quality and Fatigue After Major Surgery in Elderly Patients: DEXSLEEP StudyCompletedNCT06480539Phase 4
• Opioid-based Versus Opioid-free Anaesthesia for Laparoscopic CholecystectomyCompletedNCT06476600Not applicable
• Effect of Nebulized Dexmedetomidine on Post-dural Puncture HeadacheCompletedNCT06470854Not applicable
• Dexamethasone vs. Dexmedetomidine for ESPB in Pain Management After Knee ArthroplastyCompletedNCT06470100Phase 4
• Propofol vs. Nasal Dexmedetomidine in Pediatric Agitation and DeliriumCompletedNCT06466915Phase 4
• Dexmedetomidine as an Adjuvant to Bupivacaine in Bilateral PECs for Pain Control After Cardiac SurgeriesCompletedNCT06453681Phase 4
• Patient-controlled Sedation With Propofol Versus Anesthesiologist-administered Sedation for Orthopedic SurgeryCompletedNCT06451380Not applicable
• Comparison of Intravenous V/S Nasal Atomizer Delivery of Midazolam for Conscious Sedation for No-scalpel VasectomyCompletedNCT06449365Phase 4
• Ketamine for Sedation in Severe Traumatic Brain InjurySuspendedNCT06429657Phase 4
• Intrathecal Dexmedetomidine vs EpinephrineCompletedNCT06418308Phase 4
• Intranasal Dexmedetomidine Versus Oral Midazolam Premedication for Postoperative Negative Behavior Changes in ChildrenCompletedNCT06417125Phase 4
• Effect of Dexmedetomidine on Improving Intubating Conditions Without the Use of Muscle RelaxantCompletedNCT06409377Phase 4
• Propofol Versus Dexmedetomidine for Sedation of Cancer Patients Undergoing ERCPCompletedNCT06409104Not applicable
• Dexmedetomidine and Remifentanil in NORACompletedNCT06403670Phase 4
• Opioid Free Anesthesia in Abdominal Laparoscopic SurgeryCompletedNCT06394375Phase 2/3
• Dexmedetomidine vs Fentanyl in Controlling Labor PainCompletedNCT06392321Not applicable
• Postoperative Dexmedetomidine in Prevention of Postoperative DeliriumCompletedNCT06382961Not applicable
• The Efficacy of Thoracic Erector Spinae Plane Block For Perioperative Analgesia in Laparoscopic Bariatric Surgery for Super Obese Patients.CompletedNCT06377605Not applicable
• Dexmedetomidine and Postoperative Cognitive Dysfunction (POCD)CompletedNCT06371638Phase 4
• Different Doses of Dexmedetomidine in External Oblique Intercostal Plane Block in SplenectomyCompletedNCT06363578Not applicable
• Detoxification From the Lipid TractCompletedNCT06357104Phase 4
• Infraclavicular Brachial Plexus Block With Bupivacaine Alone or With Both Dexmedetomidine and DexamethasoneStatus unknownNCT06356415Not applicable
• Stellate Ganglion Block Combined With Dexmedetomidine or Subanesthetic Ketamine Infusion for Treatment of Neurostorm.CompletedNCT06354673Not applicable
• IV Dexmedetomidine vs Oral Gabapentin and Their Combination for Postoperative Analgesia in Cancer Patients Undergoing Modified Radical MastectomyCompletedNCT06354478Not applicable
• The Effect of Intravenous Versus Volatile Anesthesia on Postoperative Cognitive Dysfunction in Elderly PatientsCompletedNCT06353516Not applicable
• ED90 of Fospropofol Disodium in Induction and Maintenance of AnesthesiaCompletedNCT06344325Phase 4
• Quality of Recovery After Laparoscopic Cholecystectomy Comparing Opioid Free Analgesia Versus Opioid Free AnesthesiaCompletedNCT06343753Not applicable
• Dexmedetomidine and Ketamine as an Adjuvant in External Oblique Intercostal Plane Block for Post Thoracotomy PainCompletedNCT06331182Not applicable
• Dexmedetomidine Infusion Dose Versus Rapid Bolus Dose Before Tracheal Intubation.CompletedNCT06327399Phase 2
• Opioid Sparing Anesthesia Care for Pediatric Patients Having Tonsil SurgeryCompletedNCT06326983Not applicable
• Dexmedetomidine in Spinal Anesthesia Decreasing Post Spinal Shivering in Caesarean SectionCompletedNCT06318546Phase 1
• Intrathecal Dexmedetomidine vs MidazolameCompletedNCT06315634Phase 4
• Propofol Versus Dexmedetomidine Effect on Prevention Emergence AgitationCompletedNCT06312618Phase 4
• Effect of Intravenous Dexmedetomidine Versus Dexamethasone for Management of Repound Pain After Supraclavicular Brachial Plexus BlockCompletedNCT06304909Phase 1
• Dexmedetomidine vs. Remifentanil Conscious Sedation for Stapedotomy/StapedectomyCompletedNCT06283836Not applicable
• Safety and Efficacy of Fospropofol vs Propofol During Invasive Mechanical Ventilation.CompletedNCT06261996Not applicable
• A Study to Learn If the Study Medicine Called Vepdegestrant Changes How the Body Processes the Other Study Medicine Called MidazolamCompletedNCT06256510Phase 1
• Ketamine Versus Propofol as ICU SedationCompletedNCT06243822Phase 4
• Dexamethasone vs. Dexmedetomidine for ESPB in Pain Management After Spine SurgeryCompletedNCT06233617Phase 4
• Dexamethasone vs. Dexmedetomidine for Popliteal Nerve Block in Pain Management After Pediatric Ankle and Foot SurgeryCompletedNCT06233565Phase 4
• Dexmedetomidine in Obturator Nerve Block as an Analgesic in Transurethral SurgeriesCompletedNCT06229054Early Phase 1
• Dexmedetomidine Versus Ketofol for Moderate Sedation in Endoscopic Retrograde CholangiopancreatographyCompletedNCT06212401Phase 4
• PK Effects of SHR4640 on Repaglinide and Midazolam, and the Impact of SHR4640 on QT IntervalCompletedNCT06196580Phase 1
• Investigating the Role of Diazepam on Brain Function and Chemistry in Psychosis RiskCompletedNCT06190483Not applicable
• Dexmedetomidine Versus Fentanyl on Postoperative Analgesic Profile in Laparoscopic Sleeve GastrectomyCompletedNCT06186895Not applicable
• Dexmedetomidine-ketamine Combination Versus Fentanyl-midazolam During BronchoscopyCompletedNCT06185127Phase 3
• Efficacy and Safety of Ciprofol for the Sedation in Patients Undergoing HysteroscopyCompletedNCT06172140Not applicable
• Effect of Dexmedetomidine vs Esmolol or Placebo on Cerebral Hemodynamics in Septic ShockCompletedNCT06169475Not applicable
• Comparison of Perioperative Conscious Sedation During Endovascular Thrombectomy in Acute Ischemic StrokeCompletedNCT06139692Phase 4
• Pilot Study of Dexmedetomidine Sublingual Film for the Ambulatory Treatment of Hyperadrenergic Autonomic Crisis in Patients With Familial DysautonomiaActive, not recruitingNCT06128356Phase 2
• Clinical Trial to Assess Effect of Verapamil on Systemic Exposure of EP395 and Effect of EP395 on Systemic Exposure of Midazolam and DigoxinCompletedNCT06118684Phase 1
• Dexmedetomidine and Propofol in Mechanically Ventilated Patients by Using Salivary Alpha-amylase as a Stress MarkerCompletedNCT06098209Not applicable
• Hypotensive Anesthesia for Orthognathic SurgeryCompletedNCT06093893Phase 4
• Dexamethasone Vs. Dexmedetomidine for ESPB in Pain Management After Pediatric Idiopathic Scoliosis SurgeryCompletedNCT06086431Phase 4
• Intranasal Dexmedetomidine Versus Intravenous Dexmedetomidine for Improving Quality of Endoscopic Sinus SurgeryStatus unknownNCT06081933Phase 4
• Optimization of Sedation Protocol for Endoscopic Procedures Using Impedance Ventilation Monitor.CompletedNCT06060626Not applicable
• Regional AnaesthesiaCompletedNCT06055101Not applicable
• An Open-label Trial to Evaluate the Safety and Efficacy of Chloral Hydrate in Patients with Severe InsomniaCompletedNCT06053840Phase 4
• Dexmedetomidine Infusion During Laparoscopic AdrenalectomyCompletedNCT06037135Not applicable
• Ultrasound Guided Pericapsular Nerve Block Versus iv Sedation Analgesia in Reduction of Shoulder DislocationCompletedNCT06034873Phase 2
• Drug-durg Interaction of Leritrelvir(RAY1216) With Midazolam, Omeprazole, Rosuvastatin, Verapamil, and RifampinCompletedNCT06031454Phase 1
• ED50 of Midazolam Oral Solution for Preoperative Hypnosis in Adults : An Up-and-Down Sequential Allocation TrialCompletedNCT06018207Not applicable
• Effect of Eszopiclone on Adherence to CPAP and Severity of Insomnia in Patients With COMISACompletedNCT06017921Phase 4
• A Study to Test How Well Different Doses of BI 1584862 Are Tolerated by Healthy MenCompletedNCT06006598Phase 1
• Efficacy and Safety of Remimazolam Compared With Midazolam During Bronchoscopy:Randomised Controlled TrialCompletedNCT05994547Phase 4
• Effects of Intrathecal Dexmedetomidine as an Adjuvant to Low Dose Hyperbaric 0.5% BupivacaineCompletedNCT05993975Phase 4
• Effect of Dexmedetomidine on the Quality of Recovery in Parturients Undergoing Elective Caesarean SectionsCompletedNCT05991466Phase 4
• Comparison of Efficacy of Bupivacaine in Supraclavicular Block With or Without DexmedetomidineCompletedNCT05991375Phase 4
• Intraperitoneal Dexamethasone, Dexmedetomidine, and Dexamethasone-Dexmedetomidine Combination on Postoperative Nausea and Vomiting After Laparoscopic CholecystectomyCompletedNCT05988671Phase 3
• Caudal Ropivacaine With or Without Dexmedetomidine for Post Operative AnalgesiaCompletedNCT05979558Not applicable
• Effect of Ketanserin, Olanzapine, and Lorazepam After LSD Administration on the Acute Response to LSD in Healthy SubjectsCompletedNCT05964647Phase 1
• A Study to Assess the Effect of Danicamtiv on the Drug Levels of Midazolam in Participants With Stable Heart FailureCompletedNCT05952089Phase 1
• The Effect of Anesthetic Methods on Gastrointestinal MotilityCompletedNCT05951686Not applicable
• Esketamine and Propofol for Children With Autism Spectrum Disorder Undergoing ColonoscopyCompletedNCT05951465Not applicable
• Dexmedetomidine Versus Dexmedetomidine with Ketamine in Mechanically Ventilated ARDS PatientsCompletedNCT05951387Phase 4
• Endotype-Targeted Therapy to Rescue OSA Patients Struggling With CPAP Adherence (TOP-CPAP)CompletedNCT05951023Phase 2
• Mini-dose Dexmedetomidine-Esketamine Infusion and Perioperative Sleep QualityCompletedNCT05950646Phase 4
• The Effect of Ketamine - Dexmedetomidine Admixture (Ketodex) on Hemodynamic Stability During Anesthesia Induction in Adults.CompletedNCT05948267Phase 4
• Dexmedetomidine or Lidocaine for Lessening the Hemodynamic Responses to Laryngoscopy and IntubationCompletedNCT05941767Not applicable

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