A Phase 4 interventional study of 0.9% Sodium Chloride Injection and Dexamethasone 4 Mg/mL Injectable Solution in Spinal Fusion, Spine Disease and Spinal Stenosis, sponsored by Poznan University of Medical Sciences. Completed at 1 site in Poland. Open to participants aged 18 Years to 100 Years. Per ClinicalTrials.gov, last updated 2026-05-11.
Sponsored by Poznan University of Medical Sciences · Phase 4, Interventional, and Treatment
Effect of perineurial dexamethasone and dexmedetomidine on erector spinal plane block duration for spine surgery.
This study is proposed to explore the effect of perineurial Dexamethasone and Dexmedetomidine on erector spinal plane block duration for spine surgery.
After spine surgery, patients need good analgesia. Peripheral nerve blocks have provided a safe, effective method to control early postoperative pain when symptoms are most severe.
The safety of local anaesthesia is essential due to the much lower toxicity threshold of local anaesthetics. An effective adjuvant, such as Dexamethasone or Dexmedetomidine, could allow for a higher dilution of local anaesthetics while maintaining and enhancing their analgesic effect.
There is considerable research where intravenous and perineural dexamethasone and Dexmedetomidine use have been compared in adults. However, there is a massive lack of research regarding spine surgery and the Erector Spinae Plane Block.
In this study, investigators compare perineural Dexamethasone and Dexmedetomidine.
The investigator aims to find a dexamethasone or dexmedetomidine that covers the need for good pain relief and fast recovery postoperatively.
267 studies on the registry are indexed under Spinal Diseases; 54 are open to participants now.
This study's enrollment of 90 is above the median of 52 across 166 interventional studies indexed under Spinal Diseases.
Browse Spinal Diseases studies →Poznan University of Medical Sciences is the lead sponsor of 143 studies on the registry; 46 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
0.2% ropivacaine for erector spinae plane block
Drug: 0.9% Sodium Chloride Injection
0.2% ropivacaine + 4mg Dexamethasone for erector spinae plane block
Drug: Dexamethasone 4 Mg/mL Injectable Solution
0.2% ropivacaine + 50ug Dexmedetomidine for erector spinae plane block
Drug: Dexmedetomidine injection
biliteral administration of 20ml of 0,2% ropivacaine + 2ml 0.9% sodium chloride for the erector spine plane block
Also known as: 0.9% Sodium Chloride iv.
biliteral administration of 20ml of 0,2% ropivacaine with 4mg Dexamethasone for the erector spine plane block
Also known as: 0,2% ropivacaine with 4mg Dexamethasone iv
biliteral administration of 20ml of 0,2% ropivacaine with 50ug Dexmedetomidine for the erector spine plane block
Also known as: 0,2% ropivacaine with 50ug Dexmedetomidine
first need of opiate
Time after surgery when the patient needs opiate for the first time
Time frame: 48 hours
Opioid consumption
Total opiate consumption after surgery
Time frame: 48 hours
Numerical Rating Scale [range 0:10]
NRS (Numerical Rating Scale; 0 - no pain; 10 - the worst pain ever)
Time frame: Time Frame: 4 hours after surgery
Numerical Rating Scale [range 0:10]
NRS (Numerical Rating Scale; 0 - no pain; 10 - the worst pain ever)
Time frame: Time Frame: 8 hours after surgery
Numerical Rating Scale [range 0:10]
NRS (Numerical Rating Scale; 0 - no pain; 10 - the worst pain ever)
Time frame: Time Frame: 12 hours after surgery
Numerical Rating Scale [range 0:10]
NRS (Numerical Rating Scale; 0 - no pain; 10 - the worst pain ever)
Time frame: Time Frame: 16 hours after surgery
Numerical Rating Scale [range 0:10]
NRS (Numerical Rating Scale; 0 - no pain; 10 - the worst pain ever)
Time frame: Time Frame: 20 hours after surgery
Numerical Rating Scale [range 0:10]
NRS (Numerical Rating Scale; 0 - no pain; 10 - the worst pain ever)
Time frame: Time Frame: 24 hours after surgery
NLR
Neutrophil-to-lymphocyte ratio
Time frame: 48 hours after surgery
PLR
Platelet-to-lymphocyte ratio
Time frame: 48 hours after surgery
Plan to share: No
This study is completed, as verified in Apr 2024. You cannot join it, but the record below documents what was studied.
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Poznan University of Medical Sciences