An interventional study of dexmedetomidine and 0.9% normal saline in Pheochromocytoma, sponsored by Yonsei University. Completed at 1 site in Korea, Republic of. Open to participants aged 20 Years to 70 Years. Per ClinicalTrials.gov, last updated 2023-10-06.
Sponsored by Yonsei University · Not applicable, Interventional, and Supportive care
The investigators planned this study to investigate the effects of dexmedetomidine administration on intraoperative hemodynamic stability in patients with pheochromocytoma.
149 studies on the registry are indexed under Pheochromocytoma; 56 are open to participants now.
This study's enrollment of 40 is above the median of 33 across 81 interventional studies indexed under Pheochromocytoma.
Browse Pheochromocytoma studies →Yonsei University is the lead sponsor of 1,387 studies on the registry; 232 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
In the dexmedetomidine group, dexmedetomidine is administered at a rate of 0.5 μg/kg/h immediately after anesthesia induction and continued until the completion of the surgery.
Drug: dexmedetomidine
In the control group, a 0.9% normal saline infusion is initiated at the same rate immediately after anesthesia induction and continued until the end of the operation.
Drug: 0.9% normal saline
In the dexmedetomidine group, dexmedetomidine is administered at a rate of 0.5 μg/kg/h immediately after anesthesia induction and continued until the completion of the surgery. The research nurse, who did not participate in the study other than the management and preparation of the study medication, prepared 50mL of 0.9% normal saline for the control group and a mixture of dexmedetomidine 2 mL and 0.9% normal saline 48 mL (at a concentration of 4 μg/mL) for the dexmedetomidine group.
In the control group, a 0.9% normal saline infusion is initiated at the same rate immediately after anesthesia induction and continued until the end of the operation.
Intraoperative hemodynamic stability ( maximum blood pressure during surgery (systolic blood pressure (SBP), diastolic blood pressure (DBP), mean blood pressure (MBP))
Time frame: during operation
Intraoperative hemodynamic stability (duration of SBP increase by 30% or more from baseline (in minutes)
Time frame: during operation
Intraoperative hemodynamic stability (duration of SBP exceeding 200 mmHg)
Time frame: during operation
Intraoperative hemodynamic stability (maximum HR during surgery)
Time frame: during operation
Intraoperative hemodynamic stability (duration of HR exceeding 110 beats per minute during surgery)
Time frame: during operation
Intraoperative hemodynamic stability (comparison of the quantity of vasoactive drugs (nitroprusside, esmolol, norepinephrine) used during surgery)
Time frame: during operation
levels of catecholamines
the actual secretion levels of catecholamines, specifically epinephrine and norepinephrine, were measured at different time points
Time frame: immediately after anesthesia induction
levels of catecholamines
the actual secretion levels of catecholamines, specifically epinephrine and norepinephrine, were measured at different time points
Time frame: immediately after removal of the pheochromocytoma
levels of catecholamines
the actual secretion levels of catecholamines, specifically epinephrine and norepinephrine, were measured at different time points
Time frame: immediately after the completion of surgery
This study is completed, as verified in Oct 2023. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Yonsei University