Histone Deacetylase Inhibitors: all 1,242 studies that test it

Page 9 of 13. Open to participants first (144), then studies with results posted, then the rest; newest registration first within each.

• Dose-Seeking Study of MPT0E028 in Subjects With Advanced Solid Malignancies Without Standard TreatmentCompletedNCT02350868Phase 1
• Neoadjuvant Chemotherapy Followed by Radiation Therapy and Gemcitabine/Sorafenib/Vorinostat in Pancreatic CancerCompletedNCT02349867Phase 1
• Open Label, Multi-center Study to Assess the Safety, Tolerability and Pharmacokinetics of CUDC-907 in Subjects With Advanced/Relapsed Solid TumorsCompletedNCT02307240Phase 1
• Rituximab, Romidepsin, and Lenalidomide in Treating Patients With Recurrent or Refractory B-cell Non-Hodgkin LymphomaWithdrawnNCT02281279Phase 1/2
• Effect of a Butyrate Enema on the Systemic Concentration of Short Chain Fatty AcidsCompletedNCT02271802Not applicable
• Study of Mocetinostat in Patients With Urothelial Carcinoma Having Inactivating Alterations of Specific GenesCompletedNCT02236195Phase 2
• Ro Plus CHOEP as First Line Treatment Before HSCT in Young Patients With Nodal Peripheral T-cell LymphomasCompletedNCT02223208Phase 1/2
• Efficacy, Safety and Tolerability Study of SHAPE in IA, IB or IIA Cutaneous T-cell LymphomaStatus unknownNCT02213861Phase 2
• Phase I Study of Romidepsin, Gemcitabine, Oxaliplatin, and Dexamethasone in Patients With Relapsed/Refractory Aggressive LymphomasCompletedNCT02181218Phase 1
• Divalproex Sodium in the Treatment of the Cutaneous Manifestations of SclerodermaWithdrawnNCT02166229Phase 1/2
• Phase I of Vorinostat-Iressa Combined Therapy on Resistance by BIM Polymorphysim in EGFR Mutant Lung CancerStatus unknownNCT02151721Phase 1
• Velcade, Thalidomide, Dexamethasone and Panobinostat Treatment and Panobinostat Maintenance in Multiple MyelomaStatus unknownNCT02145715Phase 1/2
• Pretreatment With Valproate Prior to Immunotherapy Targeting Cluster of Differentiation Antigen 20 in Chronic Lymphocytic LeukemiaCompletedNCT02144623Early Phase 1
• Carfilzomib Plus Belinostat in Relapsed/Refractory NHLCompletedNCT02142530Phase 1
• MRSI to Predict Response to RT/TMZ ± Belinostat in GBMActive, not recruitingNCT02137759Phase 2
• Vidaza and Valproic Acid Post Allogeneic Transplant for High Risk AML and MDSStatus unknownNCT02124174Phase 2
• Phase 2 Study of Fulvestrant With and Without Entinostat in Postmenopausal Women With ER+ Advanced Breast CancerWithdrawnNCT02115594Phase 2
• Carfilzomib/SAHA Combined With High-Dose Gemcitabine/Busulfan/Melphalan With Autologous Stem Cell Transplant in MyelomaWithdrawnNCT02114502Phase 2
• Effect of Vorinostat on Nervous System Hemangioblastomas in Von Hippel-Lindau Disease (Missense Mutation Only)CompletedNCT02108002Phase 1
• Treatment of Children With Autism Spectrum Disorders and Epileptiform EEG With Divalproex SodiumWithdrawnNCT02094651Phase 2
• Alternative 10 mg/mL Liquid Formulation of ACY 1215 (Ricolinostat) in Healthy SubjectsCompletedNCT02088398Phase 1
• Fludarabine Phosphate, Clofarabine, and Busulfan With Vorinostat in Treating Patients With Acute Leukemia in Remission or Relapse Undergoing Donor Stem Cell TransplantCompletedNCT02083250Phase 1
• Depakote (Divalproex Sodium) for Children With Temper Dysregulation and Severe Mood SwingsCompletedNCT02078596Phase 4
• Sunitinib Malate or Valproic Acid in Preventing Metastasis in Patients With High-Risk Uveal MelanomaActive, not recruitingNCT02068586Phase 2
• Poly ICLC, Radiation, and Romidepsin for Advanced Cutaneous T Cell LymphomaTerminatedNCT02061449Phase 1
• Study to Evaluate the Food Effect of Single-dose Bioavailability of Pracinostat in Healthy Adult SubjectsCompletedNCT02058784Early Phase 1
• MLN9708 and Vorinostat in Patients With Advanced p53 Mutant MalignanciesCompletedNCT02042989Phase 1
• Traumatic Neuroprotection and Epilepsy Prevention of Valproate AcidStatus unknownNCT02027987Phase 1
• Safety Study of Mocetinostat in Combination With Azacitidine in Subjects With MDSCompletedNCT02018926Phase 1/2
• Pilot Trial of Valproate as Adjunctive Treatment for Toxoplasma Gondii Infection in Early Course SchizophreniaCompletedNCT02011750Phase 4
• Phase 2 Study Adding Pracinostat to a Hypomethylating Agent (HMA) in Patients With MDS Who Failed to Respond to Single Agent HMACompletedNCT01993641Phase 2
• Phase 1 Trial of CXD101 in Patients With Advanced CancerCompletedNCT01977638Phase 1
• A Phase I Study Of Panobinostat/Lenalidomide/Bortezomib/Dex for Relapsed And Relapsed/Refractory Multiple MyelomaCompletedNCT01965353Phase 1
• A Study to Evaluate the Safety and Tolerability of Valproic Acid in Healthy Volunteers (Part 1)CompletedNCT01951560Phase 1
• A Pilot Study of Romidepsin in Relapsed or Refractory Extranodal NK/T-cell LymphomaCompletedNCT01913119Early Phase 1
• Phase I Dose-finding and Preliminary Efficacy Study of the Istodax® in Combination With Doxil® for the Treatment of Adults With Relapsed or Refractory Cutaneous T-cell LymphomaCompletedNCT01902225Phase 1
• A Study in Stable Epilepsy Patients Comparing Brand and Generic Divalproex Sodium Extended Release TabletsStatus unknownNCT01898676Phase 1
• Preoperative Valproic Acid and Radiation Therapy for Rectal CancerStatus unknownNCT01898104Phase 1/2
• Alisertib and Romidepsin in Treating Patients With Relapsed or Refractory B-Cell or T-Cell LymphomasCompletedNCT01897012Phase 1
• Comparative Efficacy and Acceptability of Antimanic Drugs in Acute ManiaStatus unknownNCT01893229Phase 4
• Azacitidine and Entinostat in Treating Patients With Newly Diagnosed Stage IA-IIIA Non-Small Lung Cancer Undergoing SurgeryTerminatedNCT01886573Phase 1
• Study of Combination of PIGEV Before Autologous Stem Cell Transplant in Patients With Hodgkin's LymphomaStatus unknownNCT01884428Phase 1
• Phase 2 Study of Pracinostat With Azacitidine in Patients With Previously Untreated Myelodysplastic SyndromeCompletedNCT01873703Phase 2
• Valproic Acid in Childhood Progressive Brain TumorsWithdrawnNCT01861990Phase 1
• Romidepsin, Gemcitabine, Dexamethasone and Cisplatin in the Treatment of Peripheral T-Cell and Diffuse Large B-Cell LymphomaCompletedNCT01846390Phase 1
• Phase 1 Dose Finding Study of Belinostat for Treatment of Patients With Peripheral T-cell Lymphoma (PTCL)CompletedNCT01839097Phase 1
• Chidamide in Combination With Carboplatin and Paclitaxel in Advanced Non-small Cell Lung CancerCompletedNCT01836679Phase 2
• Efficacy Study of Intravenous Sodium Valproate in Addition to First Line Anti Epileptic Treatment of Generalized Convulsive Status Epilepticus.CompletedNCT01791868Not applicable
• Long-term Study Evaluating the Effect of Givinostat in Patients With Chronic Myeloproliferative NeoplasmsActive, not recruitingNCT01761968Phase 2
• Haloperidol vs. Valproate in AgitationCompletedNCT01750541Phase 3
• Impact of Valproate on Angiogenesis and Histone Deacetylation in Bladder CancerCompletedNCT01738815Early Phase 1
• Treatment of Nodding Syndrome - A Randomized Blinded Placebo-Controlled Crossover Trial of Oral Pyridoxine and Conventional Anti-Epileptic Therapy, in Northern Uganda - 2012WithdrawnNCT01730313Phase 2
• Phase I Study to Assess the Safety, Tolerability, and Pharmacokinetics of Orally Administered CUDC-101 in Cancer PatientsTerminatedNCT01702285Phase 1
• Valproic Acid and Platinum-based Chemoradiation in Locally Advanced Head and Neck Squamous Cell CarcinomaCompletedNCT01695122Phase 2
• Vorinostat Before Surgery in Treating Patients With Triple-Negative Breast CancerWithdrawnNCT01695057Not applicable
• Safety and Effect of The HDAC Inhibitor Panobinostat on HIV-1 Expression in Patients on Suppressive HAARTCompletedNCT01680094Phase 1/2
• Valproate and Levocarnitine in Children With Spinal Muscular AtrophyStatus unknownNCT01671384Phase 3
• Panobinostat Biological Correlates StudyCompletedNCT01658241Phase 2
• SHP-141C in Plaque Type PsoriasisCompletedNCT01646567Phase 1
• Romidepsin in Treating Patients With Lymphoma, Chronic Lymphocytic Leukemia, or Solid Tumors With Liver DysfunctionCompletedNCT01638533Phase 1
• Valproate as First Line Therapy in Combination With Rituximab and CHOP in Diffuse Large B-cell LymphomaCompletedNCT01622439Phase 1/2
• Rubinstein-Taybi Syndrome: Functional Imaging and Therapeutic TrialCompletedNCT01619644Phase 2
• Randomised Study of Azacitidine Versus Azacitidine With Vorinostat in Patients With AML or High Risk MDSCompletedNCT01617226Phase 2
• A Phase Ib Study of Panobinostat (LBH589) in Combination With 5-Azacitidine for Myelodysplastic Syndromes (MDS), Chronic Myelomonocytic Leukemia (CMML) or Acute Myeloid Leukemia (AML) PatientsCompletedNCT01613976Phase 1
• Study of Curcumin, Vorinostat, and SorafenibWithdrawnNCT01608139Phase 1
• Vorinostat and Concurrent Whole Brain Radiotherapy for Brain MetastasisTerminatedNCT01600742Phase 2
• Study to Assess Food Effect on Pharmacokinetics of Entinostat in Subjects With Breast Cancer or Non-Small Cell Lung CancerCompletedNCT01594398Phase 1
• Romidepsin, Ifosfamide, Carboplatin, and Etoposide in Treating Participants With Relapsed or Refractory Peripheral T-Cell LymphomaCompletedNCT01590732Phase 1
• Vorinostat in Treating Patients With Metastatic Melanoma of the EyeActive, not recruitingNCT01587352Phase 2
• Efficacy of Quetiapine XR Versus Divalproex on Clinical Outcome Quality of Sleep and Quality of Life in Bipolar DepressionWithdrawnNCT01587066Phase 4
• Refractory Status Epilepticus Treatment StudyCompletedNCT01586208Phase 3
• Phase I Mass Balance, PK and Safety Study of 14C-Labeled Belinostat in Patients With Advanced CancerCompletedNCT01583777Phase 1
• Study of ACY-1215 in Combination With Lenalidomide, and Dexamethasone in Multiple MyelomaCompletedNCT01583283Phase 1
• Bioequivalence Study of Divalproex Sodium ER Tablets, 500 mg Under Fed ConditionsCompletedNCT01581788Phase 1
• Bioequivalence Study of Divalproex Sodium ER Tablets 500 mg of Dr. Reddy's Under Fasting ConditionsCompletedNCT01581775Phase 1
• Safety and Pharmacokinetic Profile of CKD-581CompletedNCT01580371Phase 1
• Vorinostat Plus FND in Relapsed or Refractory Mantle Cell LymphomaTerminatedNCT01578343Phase 2
• Alisertib in Combination With Vorinostat in Treating Patients With Relapsed or Recurrent Hodgkin Lymphoma, B-Cell Non-Hodgkin Lymphoma, or Peripheral T-Cell LymphomaCompletedNCT01567709Phase 1
• Bevacizumab and Temsirolimus Alone or in Combination With Valproic Acid or Cetuximab in Treating Patients With Advanced or Metastatic Malignancy or Other Benign DiseaseTerminatedNCT01552434Phase 1
• Study of the Combination of Panobinostat & Carfilzomib in Patients With Relapsed &/or Refractory Multiple MyelomaCompletedNCT01549431Phase 1
• The Efficacy and Safety of Topical Valproic Acid in Preventing Hair LossCompletedNCT01548066Phase 2
• Pazopanib in Combination With PCI-24781 in Patients With Metastatic Solid TumorsCompletedNCT01543763Phase 1
• Cytidine- and Creatine-Containing Drug in Treating Bipolar DepressionWithdrawnNCT01543139Phase 2
• Histone Deacetylases - Gastric Cancer (HDAC-GaCa-2008)TerminatedNCT01528501Phase 2
• Phase I Study of Panobinostat + Bortezomib for Relapsed and/or Refractory Mantle Cell Lymphoma (MCL)CompletedNCT01504776Phase 1
• Vorinostat Plus Lenalidomide and Dexamethasone or Lenalidomide Plus Dexamethasone in Multiple Myeloma Patients Who Experience Biochemical Relapse During Lenalidomide Maintenance TherapyWithdrawnNCT01501370Phase 2
• A Pilot Study of Oral Vorinostat Plus Oral Eltrombopag Support in Patients With Lymphoma (VEIL)TerminatedNCT01500538Phase 2
• A Study on the Effects of Valproate on the Pharmacokinetics of RO4917838 in Healthy VolunteersCompletedNCT01495104Phase 1
• Study of Vorinostat With Doxil and Bortezomib for Patients With Relapsed/Refractory Multiple MyelomaWithdrawnNCT01492881Phase 2
• A Study of the Histone Deacetylase Inhibitor (HDACi) Quisinostat (JNJ-26481585) in Patients With Previously Treated Stage Ib-IVa Cutaneous T-cell LymphomaCompletedNCT01486277Phase 2
• Phase I Dose Finding and Proof-of-concept Study of Panobinostat With Standard Dose Cytarabine and Daunorubicin for Untreated Acute Myeloid Leukemia or Advanced Myelodysplastic SyndromeCompletedNCT01463046Phase 1
• Phase I/II Study With Oral Panobinostat Maintenance Therapy Following Allogeneic Stem Cell Transplantation in Patients With High Risk Myelodysplastic Syndrome (MDS) or Acute Myeloid Leukemia (AML)Status unknownNCT01451268Phase 1/2
• Topical Romidepsin to Treat Early-Stage Cutaneous T-Cell LymphomaTerminatedNCT01445340Phase 1
• Combination Therapy of Lenalidomide/Bortezomib/Dexamethasone and Panobinostat in Transplant Eligible New Diagnosed Multiple Myeloma (MM) PatientsCompletedNCT01440582Phase 1
• Entinostat, Lapatinib Ditosylate and Trastuzumab in Treating Patients With Locally Recurrent or Distant Relapsed Metastatic Breast Cancer Previously Treated With Trastuzumab OnlyCompletedNCT01434303Phase 1
• Panobinostat and Ruxolitinib in Primary Myelofibrosis, Post-polycythemia Vera-myelofibrosis or Post-essential Thrombocythemia-myelofibrosisCompletedNCT01433445Phase 1
• Vorinostat in ChildrenCompletedNCT01422499Phase 1/2
• Vorinostat With Gemcitabine, Busulfan, and Melphalan With Stem Cell Transplant (SCT) in Relapsed or Refractory Lymphoid MalignanciesCompletedNCT01421173Phase 1
• Efficacy and Safety of Oral Valproic Acid for Retinitis PigmentosaCompletedNCT01399515Phase 2
• Vorinostat in Combination With Bortezomib, Doxorubicin and Dexamethasone (VBDD) in Patients With Refractory or Relapsed Multiple Myeloma (MM)CompletedNCT01394354Phase 1/2

← Histone Deacetylase Inhibitors overview