Histone Deacetylase Inhibitors: all 1,242 studies that test it

Page 7 of 13. Open to participants first (144), then studies with results posted, then the rest; newest registration first within each.

• Sintilimab in Combination With Chidamide in Refractory and Relapsed AITLStatus unknownNCT04831710Phase 2
• Romidepsin and Parsaclisib for the Treatment of Relapsed or Refractory T-Cell LymphomasCompletedNCT04774068Phase 1
• Effects of Butyrate on Affective ProcessesCompletedNCT04722549Not applicable
• Talazoparib in Combination With Belinostat for Metastatic Breast Cancer, Metastatic Castration Resistant Prostate Cancer, and Metastatic Ovarian CancerCompletedNCT04703920Phase 1
• Maintenance Therapy of Chidamide in Patients With HBV Positive Diffuse Large B-cell LymphomaCompletedNCT04661943Phase 2
• Anti-PD-1 Antibody Combined With Histone Deacetylase Inhibitor in Patients With Advanced Cervical CancerTerminatedNCT04651127Phase 1/2
• Doxorubicin, CC-(486) (5-azacitidine), Romidepsin, and Duvelisib (hARD) for T-cell LymphomaWithdrawnNCT04639843Phase 1
• Effects of Butyrate Against Pediatric ObesityCompletedNCT04620057Not applicable
• Chidamide With Immunotherapy for Patients With Locally Advanced or Metastatic Urothelial CarcinomaCompletedNCT04562311Phase 2
• Decitabine-primed Tandem CD19/CD20 CAR T Cells Plus Epigenetic Agents in Aggressive r/r B-NHL With Huge Tumor BurdenStatus unknownNCT04553393Phase 1/2
• BSEP Function Rescue During Childhood Inhereditary Cholestatic DiseasesWithdrawnNCT04531878Phase 2/3
• Valproic Acid (VPA) for Acute Kidney Injury (AKI) in Liver Transplant PatientsWithdrawnNCT04531592Phase 2
• Valproic Acid (VPA) for Acute Kidney Injury (AKI) in Trauma PatientsWithdrawnNCT04531579Phase 2
• Valproate Alone or in Combination With Quetiapine for Severe COVID-19 Pneumonia With Agitated DeliriumWithdrawnNCT04513314Phase 4
• Radiotherapy Combined With GDP With or Without Chidamide in Stage I/II Extranodal Nasal NK/T-cell LymphomaStatus unknownNCT04511351Not applicable
• Abexinostat, Palbociclib, and Fulvestrant for the Treatment of Breast or Gynecologic CancerWithdrawnNCT04498520Phase 1
• A Clinical Trial of Chidamide Combined With Etoposide in Relapsed or Refractory NK/T-cell LymphomaStatus unknownNCT04490590Phase 4
• Mood Stabilizer-induced Metabolic Abnormalities in Bipolar DisorderStatus unknownNCT04486092Not applicable
• Valproic Acid in Treating Cyanotic Breath Holding SpellsCompletedNCT04482764Phase 1
• Azacitidine Combined With Chidamide in the Treatment of Newly Diagnosed PTCL Unfit for Conventional ChemotherapyStatus unknownNCT04480125Phase 2
• Neoadjuvant Tucidinostat and Exemestane in Early Breast CancerCompletedNCT04465097Phase 2
• Safety and Tolerability of Phenylbutyrate in Inclusion Body MyositisCompletedNCT04421677Phase 1
• Efficacy of Immunotherapy Plus a Drug in Patients With Progressive Advanced Mucosal Cancer of Different LocationsCompletedNCT04357873Phase 2
• Phase I Study of Marizomib + Panobinostat for Children With DIPGTerminatedNCT04341311Phase 1
• Effect of Vorinostat on ACTH Producing Pituitary Adenomas in Cushing s DiseaseWithdrawnNCT04339751Phase 2
• Panobinostat Maintenance After HSCT fo High-risk AML and MDSTerminatedNCT04326764Phase 3
• Infusion of Panobinostat (MTX110) Into the Fourth Ventricle in Children and Adults with Recurrent MedulloblastomaCompletedNCT04315064Early Phase 1
• Valproic Acid in Combination With Bevacizumab and Oxaliplatin/Fluoropyrimidine Regimens in Patients With Ras-mutated Metastatic Colorectal CancerStatus unknownNCT04310176Phase 2
• Mocetinostat With Vinorelbine in Children, Adolescents & Young Adults With Refractory and/or Recurrent RhabdomyosarcomaActive, not recruitingNCT04299113Phase 1
• Sintilimab Plus Chidamide in the Treatment of Relapsed and Refractory Cutaneous T-cell Lymphoma: a Multicenter Phase II StudyStatus unknownNCT04296786Phase 2
• Hydroxocobalamin Approach for Reducing of Calprotectin With Butyrate for Ulcerative Colitis RemissionWithdrawnNCT04259060Phase 2
• Copanlisib in Combination With Romidepsin in Patients With Relapsed or Refractory Mature T-cell LymphomaWithdrawnNCT04233697Phase 1
• Phase III Study of Tucidinostat in Combination With R-CHOP in Patients With Newly Diagnosed Double-Expressor DLBCLCompletedNCT04231448Phase 3
• Vorinostat and Combination Chemotherapy Before Donor Stem Cell Transplantation for the Treatment of Relapsed Aggressive B-cell or T-cell Non-Hodgkin LymphomaWithdrawnNCT04220008Phase 2
• A Study Evaluating the Efficacy and Safety of CKD-506 in Adult Subjects With Moderate-to-Severe Rheumatoid Arthritis and Inadequate Response to MethotrexateCompletedNCT04204603Phase 2
• A Study of Selective HDAC6 Inhibition With KA2507 in Advanced Biliary Tract CancerWithdrawnNCT04186156Phase 2
• Multicenter Phase 1b Trial Testing the Neoadjuvant Combination of Domatinostat, Nivolumab and Ipilimumab in IFN-gamma Signature-low and IFN-gamma Signature-high RECIST 1.1-measurable Stage III Cutaneous or Unknown Primary MelanomaCompletedNCT04133948Phase 1/2
• Effect of Butyrate on Inflammation and Albuminuria in Patients With Albuminuria, Type 1 Diabetes and Intestinal InflammationStatus unknownNCT04073927Not applicable
• PBA Use for Treatment of ATF6-/- PatientsSuspendedNCT04041232Early Phase 1
• Chidamide Combined With Toripalimab in SarcomaCompletedNCT04025931Phase 2
• Biomarker Guided Treatment in DLBCLStatus unknownNCT04025593Phase 2
• A Clinical Study to Evaluate Pharmacokinetics, Safety, and Tolerability of Abexinostat in Chinese PatientsActive, not recruitingNCT04024696Phase 1/2
• Chidamide + R-GemOx Regimen as Salvage Treatment for Transplant-ineligible Patients With Relapsed/Refractory DLBCLCompletedNCT04022005Phase 2
• PDR001 + Panobinostat for Melanoma and NSCLCWithdrawnNCT03982134Phase 1
• Chiauranib in Combination With Chidamide in Patients With Relapsed/Refractory Non-Hodgkin's LymphomaCompletedNCT03974243Phase 1/2
• Abexinostat and Ibrutinib in Diffuse Large B-cell Lymphoma and Mantle Cell LymphomaCompletedNCT03939182Phase 1
• A Multi-Center Phase 2 Study to Evaluate Efficacy and Safety of Oral Abexinostat as Monotherapy in Patients With Relapsed or Refractory Follicular LymphomaActive, not recruitingNCT03934567Phase 2
• A Study of OKI-179 in Patients With Solid TumorsCompletedNCT03931681Phase 1
• Testing a New Anti-cancer Drug Combination, Entinostat and GSK525762C, for Advanced and Refractory Solid Tumors and LymphomasWithdrawnNCT03925428Phase 1
• Olaparib and Entinostat in Patients With Recurrent, Platinum-Refractory, Resistant Ovarian, Primary Peritoneal, Fallopian Tube CancersTerminatedNCT03924245Phase 1
• Neratinib + Valproate in Advanced Solid Tumors, w/Expansion Cohort in Ras-Mutated CaSuspendedNCT03919292Phase 1/2
• Bioequivalence Study of Sodium Divalproate Tablets 500 mgCompletedNCT03914534Phase 4
• Tinostamustine and Nivolumab in Advanced MelanomaStatus unknownNCT03903458Phase 1
• Voronistat in Pediatric Patients With Drug Resistant EpilepsyStatus unknownNCT03894826Phase 2
• Fimepinostat in Treating Brain Tumors in Children and Young AdultsActive, not recruitingNCT03893487Early Phase 1
• VPA Expanded UCB Transplantation for Treatment of Patients With Hematological MalignanciesCompletedNCT03885947Phase 1
• Serial Measurements of Molecular and Architectural Responses to Therapy (SMMART) PRIME TrialTerminatedNCT03878524Phase 1
• A Study of CXD101 in Combination With Pembrolizumab for Relapsed or Refractory Diffuse Large B-Cell LymphomaWithdrawnNCT03873025Phase 1/2
• Study Evaluating the Safety and Efficacy of C-CHOP in Untreated Subjects With Angioimmunoblastic T Cell LymphomaStatus unknownNCT03853044Phase 2
• Pracinostat and Gemtuzumab Ozogamicin (PraGO) in Patients With Relapsed/Refractory Acute Myeloid LeukemiaCompletedNCT03848754Phase 1
• Vorinostat Dose-escalation After Allogeneic Hematopoietic Cell TransplantationActive, not recruitingNCT03843528Phase 1
• Vorinostat for Graft vs Host Disease Prevention in Children, Adolescents and Young Adults Undergoing Allogeneic Blood and Marrow TransplantationActive, not recruitingNCT03842696Phase 1/2
• A Clinical Trial of Chidamide in the Management of Refractory ITPCompletedNCT03838354Phase 1/2
• Combination of Entinostat and Enzalutamide in Advanced Prostate CancerTerminatedNCT03829930Phase 1
• The Val-CARD TrialTerminatedNCT03825250Phase 1/2
• Sintilimab in Combination With Chidamide in Refractory and Relapsed ENKTCLCompletedNCT03820596Phase 1/2
• Epigenetic Modulation of the immunE Response in GastrointEstinal Cancers (EMERGE)Status unknownNCT03812796Phase 2
• A Study of Entinostat and FOLFOX in Subjects With Pancreatic AdenocarcinomaWithdrawnNCT03760614Phase 1
• Olaparib in Combination With Vorinostat in Patients With Relapsed/Refractory and/or Metastatic Breast CancerActive, not recruitingNCT03742245Phase 1
• Use of Phenylbutyrate Therapy for Patients With Pyruvate Dehydrogenase Complex Deficiency.CompletedNCT03734263Phase 2
• Efficacy and Safety Trial of Sodium Valproate, in Paediatric and Adult Patients With Wolfram SyndromeCompletedNCT03717909Phase 2
• A Study of HG146 Capsule in Chinese Subjects with Relapsed and Refractory Multiple MyelomaTerminatedNCT03710915Phase 1
• Study of Excretion Balance and Pharmacokinetics of [14C]-Sodium Valproate (3.7 MBq) in Healthy Postmenopausal or Permanently Sterile Female SubjectsCompletedNCT03681158Phase 1
• Disturbance of Plasma Cytokine Parameters in Clozapine-Resistant Treatment-Refractory Schizophrenia (CTRS) and Their Association With Combination TherapyCompletedNCT03652974Phase 4
• A Study of Panobinostat in Combination With Everolimus for Children and Young Adults With GliomasWithdrawnNCT03632317Phase 2
• Maintenance Treatment of Chidamide in Stage IV or Relapsed/Refractory Extranodal NK/T-cell LymphomaStatus unknownNCT03630731Phase 2
• Efficacy and Safety of Chi-BEAC Combining With Auto-HSCT to Treat Aggressive Lymphoma SubjectsStatus unknownNCT03629873Phase 2
• Safety, Pharmacokinetics and Efficacy Study of Bisthianostat in Refractory or Recurrent Multiple Myeloma PatientsStatus unknownNCT03618602Phase 1
• Chidamide Combined With CHOPE Regimen for Peripheral T-cell Lymphoma PatientsStatus unknownNCT03617432Phase 2
• Chidamide Maintenance After Autologous Hematopoietic Stem Cell Transplantation for Relapsed, Refractory or High-risk LymphomaStatus unknownNCT03611231Phase 2
• Phase 2 Trial of Chidamide-Lenalidomide-Dexamethasone(CRD) Regimen in R/R MMStatus unknownNCT03605056Phase 2
• Chidamide Combined With Clad/Gem/Bu With AutoSCT in High Risk Hodgkin & Non-Hodgkin LymphomaStatus unknownNCT03602131Phase 2
• Study of Abexinostat in Patients With Relapsed or Refractory Follicular LymphomaActive, not recruitingNCT03600441Phase 2
• Tofacitinib Combined With Chidamide in R/R ENKTCLStatus unknownNCT03598959Phase 2
• Abexinostat in Combination With Pembrolizumab in Patients With Advanced Solid Tumor MalignanciesCompletedNCT03590054Phase 1
• Phase II Umbrella Study Directed by Next Generation SequencingStatus unknownNCT03574402Phase 2
• Precision Diagnosis Directing HDACi Chidamide Target Therapy for Adult T-LBL/ALLStatus unknownNCT03564704Phase 2/3
• Precision Diagnosis Directing HDACi and TKI Target Therapy for Adult Ph-like ALLStatus unknownNCT03564470Phase 2/3
• Precision Diagnosis Directing HDACi Chidamide Target Therapy for Adult ETP-ALLStatus unknownNCT03553238Phase 2/3
• Ph3 Study of Exemestane With or Without Entinostat in Chinese Patients With Hormone Receptor-Positive, Locally Advanced or Metastatic Breast CancerStatus unknownNCT03538171Phase 3
• LRAs United as a Novel Anti-HIV Strategy.CompletedNCT03525730Phase 1/2
• High Dose IL 2 and Entinostat in RCCActive, not recruitingNCT03501381Phase 2
• A Study In Healthy Male Volunteers Designed To Investigate How A Radiolabelled Medicine Is Broken Down And Removed From The BodyCompletedNCT03495934Phase 1
• Chidamide for Patients With Recurrent and Metastatic Epstein-Barr Virus (EBV)-Associated Solid TumorsStatus unknownNCT03494634Phase 2
• A Pilot Study of the Combination of Entinostat With Capecitabine in High Risk Breast Cancer After Neo-adjuvant TherapyCompletedNCT03473639Phase 1
• Chidamide for Patients With Relapse or Refractory Diffuse Large B-Cell Lymphoma and Follicular LymphomaStatus unknownNCT03410004Phase 2
• Study to Evaluate the Effect of UGT Inhibition by Valproic Acid on the Pharmacokinetics of BIIB074CompletedNCT03385525Phase 1
• Window of Opportunity Trial of Entinostat in Patients With Newly Diagnosed Stage I-IIIC,TNBCTerminatedNCT03361800Early Phase 1
• Avelumab With Valproic Acid in Virus-associated CancerCompletedNCT03357757Phase 2
• Chidamide Plus PTCy/Cyclosporine to Prevent GVHD After Myeloablative Conditioning, Matched PBSCTStatus unknownNCT03336632Phase 2

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