Histone Deacetylase Inhibitors: all 1,242 studies that test it

Page 4 of 13. Open to participants first (144), then studies with results posted, then the rest; newest registration first within each.

• Panobinostat With Rituximab for Relapsed/Refractory Diffuse Large B Cell LymphomaTerminatedNCT01282476Phase 2Results posted
• Belinostat for Solid Tumors and Lymphomas in Patients With Varying Degrees of Hepatic DysfunctionCompletedNCT01273155Phase 1Results posted
• Valproate Versus Ketorolac Versus MetoclopramideCompletedNCT01267864Phase 4Results posted
• Capecitabine and Vorinostat in Treating Patients With Recurrent and/or Metastatic Head and Neck CancerTerminatedNCT01267240Phase 2Results posted
• Phase I/II Adaptive Randomized Trial of Bevacizumab Versus Bevacizumab Plus Vorinostat in Adults With Recurrent GlioblastomaCompletedNCT01266031Phase 1/2Results posted
• Efficacy and Safety Dose Finding Study of Givinostat to Treat Polyarticular Course Juvenile Idiopathic ArthritisTerminatedNCT01261624Phase 2Results posted
• Panobinostat in Treating Patients With Relapsed or Refractory Non-Hodgkin LymphomaCompletedNCT01261247Phase 2Results posted
• Vorinostat, Temozolomide, or Bevacizumab in Combination With Radiation Therapy Followed by Bevacizumab and Temozolomide in Young Patients With Newly Diagnosed High-Grade GliomaCompletedNCT01236560Phase 2/3Results posted
• Entinostat and Anastrozole in Treating Postmenopausal Women With TNBC That Can Be Removed by SurgeryTerminatedNCT01234532Phase 2Results posted
• Trial of Oral Valproic Acid for Retinitis PigmentosaCompletedNCT01233609Phase 2Results posted
• Azacitidine and Entinostat in Treating Patients With Stage I Non-Small Cell Lung Cancer That Has Been Removed By SurgeryTerminatedNCT01207726Phase 2Results posted
• Study of SB939 in Subjects With MyelofibrosisCompletedNCT01200498Phase 2Results posted
• Re-expression of ER in Triple Negative Breast CancersTerminatedNCT01194908Phase 1/2Results posted
• A Study of Vorinostat and Tamoxifen in Newly Diagnosed Breast CancerTerminatedNCT01194427Phase 2Results posted
• Vorinostat and Combination Chemotherapy With Rituximab in Treating Patients With HIV-Related Diffuse Large B-Cell Non-Hodgkin Lymphoma or Other Aggressive B-Cell LymphomasCompletedNCT01193842Phase 1/2Results posted
• Vorinostat and Radiation Therapy Followed by Maintenance Therapy With Vorinostat in Treating Younger Patients With Newly Diagnosed Diffuse Intrinsic Pontine GliomaCompletedNCT01189266Phase 1/2Results posted
• Low-dose (12 Gy) TSEBT+Vorinostat Versus Low-dose TSEBT Monotherapy in Mycosis FungoidesTerminatedNCT01187446Phase 1/2Results posted
• Vorinostat in Treating Patients With Locally Advanced, Recurrent, or Metastatic Adenoid Cystic CarcinomaCompletedNCT01175980Phase 2Results posted
• A Phase Ib Expansion Study Investigating the Safety, Efficacy, and Pharmacokinetics of Intravenous CUDC-101 in Subjects With Advanced Head and Neck, Gastric, Breast, Liver and Non-small Cell Lung Cancer TumorsCompletedNCT01171924Phase 1Results posted
• Panobinostat Plus Ifosfamide, Carboplatin, and Etoposide (ICE) Compared With ICE For Relapsed Hodgkin LymphomaCompletedNCT01169636Phase 1/2Results posted
• Ridaforolimus and Vorinostat in Treating Patients With Advanced Solid Tumors or LymphomaCompletedNCT01169532Phase 1Results posted
• Vorinostat in Treating Patients With Stage IV Breast Cancer Receiving Aromatase Inhibitor TherapyCompletedNCT01153672Not applicableResults posted
• Study of 5-azacitidine in Combination With Vorinostat in Patients With Relapsed or Refractory Diffuse Large b Cell Lymphoma (DLBCL)CompletedNCT01120834Phase 1/2Results posted
• GCC 0845:Vorinostat and Lapatinib in Advanced Solid Tumors and Advanced Breast Cancer to Evaluate Response and BiomarkersTerminatedNCT01118975Phase 1/2Results posted
• Histone Deacetylase Inhibitor LBH589 in Addition to Corticosteroids in Patients With Acute Graft Versus Host Disease (GVHD)CompletedNCT01111526Phase 1/2Results posted
• Azacitidine and Entinostat in Treating Patients With Metastatic Colorectal CancerCompletedNCT01105377Phase 2Results posted
• Panobinostat and Letrozole in Treating Patients With Metastatic Breast CancerCompletedNCT01105312Phase 1/2Results posted
• Oral LBH589 in Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL) and Mantle Cell Lymphoma (MCL)TerminatedNCT01090973Phase 2Results posted
• Efficacy of Panobinostat in Patients With Relapsed and Bortezomib-refractory Multiple MyelomaCompletedNCT01083602Phase 2Results posted
• Panobinostat & Bortezomib in Pancreatic Cancer Progressing on Gemcitabine TherapyTerminatedNCT01056601Phase 2Results posted
• Entinostat in Combination With Aldesleukin in Treating Patients With Metastatic Kidney CancerActive, not recruitingNCT01038778Phase 1/2Results posted
• A Phase III Randomized, Double Blind, Placebo Controlled Multi-center Study of Panobinostat for Maintenance of Response in Patients With Hodgkin's Lymphoma (HL)CompletedNCT01034163Phase 3Results posted
• PCI-24781 in Combination With Doxorubicin to Treat SarcomaCompletedNCT01027910Phase 1/2Results posted
• Panobinostat or Placebo With Bortezomib and Dexamethasone in Patients With Relapsed Multiple MyelomaCompletedNCT01023308Phase 3Results posted
• Trial of LBH589 in Metastatic Thyroid CancerCompletedNCT01013597Phase 2Results posted
• Efficacy of Vorinostat to Induce Fetal Hemoglobin in Sickle Cell DiseaseTerminatedNCT01000155Phase 2Results posted
• Belinostat and Carboplatin in Treating Patients With Recurrent or Persistent Ovarian Epithelial Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer That Did Not Respond to Carboplatin or CisplatinCompletedNCT00993616Phase 2Results posted
• Efficacy and Safety of HPN-100 for the Treatment of Adults With Urea Cycle DisordersCompletedNCT00992459Phase 3Results posted
• Bortezomib and Vorinostat as Maintenance Therapy After Autologous Stem Cell Transplant in Treating Patients With Non-Hodgkin LymphomaCompletedNCT00992446Phase 2Results posted
• Study of Panobinostat in Patients With Neuroendocrine TumorsTerminatedNCT00985946Phase 2Results posted
• Epigenetic Modulation in Relapsed/Refractory Diffuse Large B-Cell Lymphoma (DLBCL)TerminatedNCT00978432Phase 2Results posted
• Paclitaxel, Carboplatin and Vorinostat for the Treatment of Advanced Stage Ovarian CarcinomaTerminatedNCT00976183Phase 1/2Results posted
• Vorinostat, Rituximab, and Combination Chemotherapy in Treating Patients With Newly Diagnosed Stage II, Stage III, or Stage IV Diffuse Large B-Cell LymphomaActive, not recruitingNCT00972478Phase 1/2Results posted
• Panobinostat (LBH589) Plus Everolimus (RAD001) in Patients With Relapsed and Refractory LymphomaCompletedNCT00967044Phase 1/2Results posted
• Vorinostat in Patients With Primary Cutaneous T-Cell LymphomaTerminatedNCT00958074Phase 2Results posted
• Vorinostat With XRT and 5-FU for Locally Advanced Adenocarcinoma of the PancreasTerminatedNCT00948688Phase 1/2Results posted
• Vorinostat in Combination With Azacitidine in Patients With Newly-Diagnosed Acute Myelogenous Leukemia (AML) or Myelodysplastic Syndrome (MDS)CompletedNCT00948064Phase 2Results posted
• A Phase Ib/IIb, Open-label, Multi-center, Study of Oral Panobinostat Administered With 5-Azacitidine (in Adult Patients With Myelodysplastic Syndromes (MDS), Chronic Myelomonocytic Leukemia (CMML), or Acute Myeloid Leukemia (AML).CompletedNCT00946647Phase 1/2Results posted
• Vorinostat, Fluorouracil, and Leucovorin Calcium in Treating Patients With Metastatic Colorectal Cancer That Has Not Responded to Previous TreatmentCompletedNCT00942266Phase 2Results posted
• Study of LBH589 for Patients With Low or Intermediate-1 Risk Myelodysplastic Syndrome (MDS)TerminatedNCT00939159Phase 2Results posted
• Vorinostat and Bortezomib in Treating Patients With Advanced Soft Tissue SarcomaCompletedNCT00937495Phase 2Results posted
• LBH589 in Relapsed or Relapsed and Refractory Waldenstrom's MacroglobulinemiaCompletedNCT00936611Phase 2Results posted
• A Study to Evaluate Safety and Efficacy of Panobinostat in Participants With Primary MyelofibrosisTerminatedNCT00931762Phase 2Results posted
• Phase II Study of GIVINOSTAT (ITF2357) in Combination With Hydroxyurea in Polycythemia VeraCompletedNCT00928707Phase 2Results posted
• Treatment of Resistant Metastatic Melanoma Using Decitabine, Temozolomide and PanobinostatTerminatedNCT00925132Phase 1/2Results posted
• Vorinostat, Fludarabine Phosphate, Cyclophosphamide, and Rituximab in Treating Patients With Previously Untreated Chronic Lymphocytic Leukemia or Small Lymphocytic LymphomaCompletedNCT00918723Phase 1/2Results posted
• Panobinostat and Everolimus in Treating Patients With Recurrent Multiple Myeloma, Non-Hodgkin Lymphoma, or Hodgkin LymphomaCompletedNCT00918333Phase 1/2Results posted
• Vorinostat, Carboplatin and Gemcitabine in Women With Recurrent, Platinum-Sensitive Ovarian CancerTerminatedNCT00910000Phase 1/2Results posted
• A Continuation Clinical Trial of Oral Vorinostat (MK-0683) in Advanced Cancers (MK-0683-007)CompletedNCT00907738Phase 2Results posted
• Vorinostat, Azacitidine, and Gemtuzumab Ozogamicin for Older Patients With Relapsed or Refractory AMLCompletedNCT00895934Phase 1/2Results posted
• Pre-reinductive Decitabine and Vorinostat in Relapsed Lymphoblastic Lymphoma or Acute Lymphoblastic LeukemiaTerminatedNCT00882206Phase 2Results posted
• Efficacy and Safety of Panobinostat (LBH589) in Patients With Refractory de Novo or Secondary Acute Myelogenous Leukemia (AML)CompletedNCT00880269Phase 2Results posted
• Valproic Acid, Radiation, and Bevacizumab in Children With High Grade Gliomas or Diffuse Intrinsic Pontine GliomaCompletedNCT00879437Phase 2Results posted
• A Phase I/II Clinical Trial of PXD101 in Combination With Doxorubicin in Patients With Soft Tissue SarcomasCompletedNCT00878800Phase 1/2Results posted
• Trial of PXD101 (Belinostat) in Combination With Idarubicin to Treat AML Not Suitable for Standard Intensive TherapyCompletedNCT00878722Phase 1/2Results posted
• Safety and Efficacy Studies of Panobinostat and Bicalutamide in Patients With Recurrent Prostate Cancer After CastrationCompletedNCT00878436Phase 1/2Results posted
• Study of Vorinostat (MK-0683) With Follicular Lymphoma (FL), Other Indolent B-cell Non-Hodgkin's Lymphoma (B-NHL), or Mantle Cell Lymphoma (MCL) Participants (MK-0683-103)CompletedNCT00875056Phase 2Results posted
• Belinostat, Carboplatin and Paclitaxel (BelCaP) Compared to Carboplatin and Paclitaxel in Patients With Cancer of Unknown PrimaryCompletedNCT00873119Phase 2Results posted
• A Phase 2 Multi-Center Study of Entinostat (SNDX-275) in Patient With Relapsed or Refractory Hodgkin's LymphomaTerminatedNCT00866333Phase 2Results posted
• Belinostat in Relapsed or Refractory Peripheral T-Cell LymphomaCompletedNCT00865969Phase 2Results posted
• LBH589 and Bevacizumab in Patients With Recurrent High Grade GliomaCompletedNCT00859222Phase 1/2Results posted
• Phase I Study of MK-0683 in Combination With Bortezomib in Participants With Multiple Myeloma (MK-0683-098)CompletedNCT00858234Phase 1Results posted
• Bortezomib and Vorinostat in Treating Patients With Multiple Myeloma Who Have Undergone Autologous Stem Cell TransplantCompletedNCT00839956Phase 2Results posted
• Study of the Combination of Vorinostat and Radiation Therapy for the Treatment of Patients With Brain MetastasesCompletedNCT00838929Phase 1Results posted
• Divalproex Sodium Delayed-Release Tablets Under Non-Fasting ConditionsCompletedNCT00834990Phase 1Results posted
• Divalproex Sodium Delayed-Release Tablets Under Fasting ConditionsCompletedNCT00834639Phase 1Results posted
• Vorinostat Plus Radiation Therapy in Pancreatic CancerTerminatedNCT00831493Phase 1/2Results posted
• Study of the Effect of the Addition of SNDX-275 (Entinostat) to Continued Aromatase Inhibitor (AI) Therapy in Postmenopausal Women With ER+ Breast Cancer Whose Disease is ProgressingCompletedNCT00828854Phase 2Results posted
• Vorinostat in Combination With Palliative Radiotherapy for Patients With Non-Small Cell Lung CancerCompletedNCT00821951Phase 1Results posted
• Bortezomib and Vorinostat in Treating Patients With High-Risk Myelodysplastic Syndrome or Acute Myeloid LeukemiaTerminatedNCT00818649Phase 2Results posted
• Vorinostat to Prevent Graft Versus Host Disease Following Reduced Intensity, Related Donor Stem Cell TransplantCompletedNCT00810602Phase 1/2Results posted
• Combination of Vorinostat and Bortezomib in Relapsed or Refractory T-Cell Non-Hodgkin's LymphomaTerminatedNCT00810576Phase 2Results posted
• The Efficacy and Safety of Low Dose Combination of LTG and VPA Compared to CBZ MonotherapyCompletedNCT00807989Phase 4Results posted
• Vorinostat and Bortezomib as Third-line Treatment in Advanced Non-small Cell Lung CancerCompletedNCT00798720Phase 2Results posted
• Effect of ITF2357 on Mucosal Healing in Patients With Moderate-to-severe Active Crohn's DiseaseTerminatedNCT00792740Phase 1/2Results posted
• Trial of the Histone-Deacetylase Inhibitor ITF2357 Followed by Mechlorethamine in Relapsed/Refractory Hodgkin's LymphomaCompletedNCT00792467Phase 1/2Results posted
• SAHA + CHOP in Untreated T-cell Non-Hodgkin's LymphomaCompletedNCT00787527Phase 1/2Results posted
• Vorinostat and Pegylated Liposomal Doxorubicin in Relapsed or Refractory LymphomasTerminatedNCT00785798Phase 1/2Results posted
• Study of Panobinostat Monotherapy in Women With HER2-negative Locally Recurrent or Metastatic Breast CancerCompletedNCT00777049Phase 2Results posted
• Antiepileptic Drugs and Vascular Risk MarkersTerminatedNCT00774306Not applicableResults posted
• Study of Vorinostat (MK0683), an Histone Deacetylase (HDAC) Inhibitor in Combination With Bortezomib in Patients With Relapsed or Refractory Multiple Myeloma (MK-0683-095)CompletedNCT00773838Phase 2Results posted
• Study of Vorinostat (MK-0683) or Placebo, in Combination With Bortezomib in Participants With Multiple Myeloma (MK-0683-088 AMN)CompletedNCT00773747Phase 3Results posted
• Effect of Endoplasmic Reticulum Stress on Metabolic FunctionCompletedNCT00771901Not applicableResults posted
• Vorinostat (MK-0683) Phase I Study in Cutaneous T-Cell Lymphoma (CTCL) Patients (MK-0683-089 EXT1)CompletedNCT00771472Phase 1Results posted
• Trial of Romidepsin and Bortezomib for Multiple MyelomaTerminatedNCT00765102Phase 2Results posted
• Vorinostat, Cladribine, and Rituximab in Treating Patients With Mantle Cell Lymphoma, Relapsed Chronic Lymphocytic Leukemia, or Relapsed B Cell Non-Hodgkin's LymphomaCompletedNCT00764517Phase 2Results posted
• A Phase 2 Exploratory Study of Erlotinib and SNDX-275 in Participants With Non-small Cell Lung Carcinoma Who Are Progressing on ErlotinibTerminatedNCT00750698Phase 2Results posted
• Melphalan and Panobinostat (LBH589) for the Treatment of Patients With Recurrent Multiple MyelomaCompletedNCT00743288Phase 1/2Results posted
• Phase II Study of Oral Panobinostat in Adult Participants With Relapsed/Refractory Classical Hodgkin's LymphomaCompletedNCT00742027Phase 2Results posted
• A Clinical Trial to Validate Molecular Targets of Vorinostat in Patients With Aerodigestive Tract CancerCompletedNCT00735826Not applicableResults posted

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