Histone Deacetylase Inhibitors: all 1,242 studies that test it

Page 3 of 13. Open to participants first (144), then studies with results posted, then the rest; newest registration first within each.

• Cost- Effectiveness and Quality of Life Assessment in Mood DisorderCompletedNCT02870283Phase 4Results posted
• Clinical Study to Evaluate the Efficacy and Safety of Givinostat in Ambulant Patients With Duchenne Muscular DystrophyCompletedNCT02851797Phase 3Results posted
• Phase 1/2 Study of Mocetinostat and Durvalumab in Patients With Advanced Solid Tumors and NSCLCTerminatedNCT02805660Phase 1/2Results posted
• Entinostat in Treating Pediatric Patients With Recurrent or Refractory Solid TumorsCompletedNCT02780804Phase 1Results posted
• Belinostat Therapy With Zidovudine for Adult T-Cell Leukemia-LymphomaCompletedNCT02737046Phase 2Results posted
• Panobinostat (LBH589): Multiple Myeloma - Autologous Hematopoietic Cell Transplantation (HCT)CompletedNCT02722941Phase 2Results posted
• A Trial Evaluating Efficacy & Safety of RVD +/- Panobinostat in Transplant Eligible, Newly Diagnosed Multiple Myeloma (NDMM)TerminatedNCT02720510Phase 2Results posted
• Trial of Panobinostat in Children With Diffuse Intrinsic Pontine GliomaCompletedNCT02717455Phase 1Results posted
• Randomized Phase 2 Study of Atezolizumab and Entinostat in Patients With aTN Breast Cancer With Phase 1b Lead InCompletedNCT02708680Phase 1/2Results posted
• Characterization of Epilepsy Patients BEEP 2bCompletedNCT02707965Phase 1Results posted
• Evaluation of the Ketogenic Potential of Different Diet SupplementsCompletedNCT02693106Not applicableResults posted
• Study to Evaluate the Efficacy and Safety of CUDC-907 in Patients With RR DLBCL, Including Patients With MYC AlterationsCompletedNCT02674750Phase 2Results posted
• Panobinostat/Bortezomib/Dexamethasone in Relapsed or Relapsed-and-refractory Multiple MyelomaCompletedNCT02654990Phase 2Results posted
• Pembro and Vorinostat for Patients With Stage IV Non-small Cell Lung Cancer (NSCLC)Active, not recruitingNCT02638090Phase 1/2Results posted
• Phase I/Ib Study of Pembrolizumab With Vorinostat for Patients With Advanced Renal or Urothelial Cell CarcinomaCompletedNCT02619253Phase 1Results posted
• Lenalidomide Combined With Vorinostat/Gemcitabine/Busulfan/Melphalan With Autologous Stem-Cell Transplantation in Diffuse Large B-Cell Lymphoma of the ABC SubtypeTerminatedNCT02589145Phase 1/2Results posted
• Panobinostat (LBH589): Acute Graft Versus Host Disease (aGVHD) PreventionCompletedNCT02588339Phase 2Results posted
• Total Therapy for Infants With Acute Lymphoblastic Leukemia (ALL) IActive, not recruitingNCT02553460Phase 1/2Results posted
• Pembrolizumab and Vorinostat in Treating Patients With Recurrent Squamous Cell Head and Neck Cancer or Salivary Gland Cancer That Is Metastatic and/or Cannot Be Removed by SurgeryCompletedNCT02538510Phase 1/2Results posted
• Re-Induction Therapy for Relapsed Pediatric T-Cell Acute Lymphoblastic Leukemia or LymphomaTerminatedNCT02518750Phase 2Results posted
• Panobinostat, Gemcitabine Hydrochloride, Busulfan, and Melphalan Before Stem Cell Transplant in Treating Patients With Refractory or Relapsed Multiple MyelomaCompletedNCT02506959Phase 2Results posted
• Reducing the Residual Reservoir of HIV-1 Infected Cells in Patients Receiving Antiretroviral TherapyCompletedNCT02471430Phase 1/2Results posted
• Ph1b/2 Dose-Escalation Study of Entinostat With Pembrolizumab in Non-small Cell Lung Cancer (NSCLC) With Expansion Cohorts in NSCLC, Melanoma, and Colorectal Cancer (CRC)CompletedNCT02437136Phase 1/2Results posted
• Mocetinostat (MGCD0103) Plus Brentuximab Vedotin (SGN-35) in Patients With Relapsed or Refractory Hodgkin LymphomaCompletedNCT02429375Phase 1/2Results posted
• Valproic Acid for Treatment of Hyperactive or Mixed Delirium in ICUTerminatedNCT02343575Phase 4Results posted
• Combination Therapy With Carfilzomib, Romidepsin, Lenalidomide in Patients With Relapsed or Refractory B- and T-cell LymphomasCompletedNCT02341014Phase 1/2Results posted
• Research In Viral Eradication of HIV ReservoirsCompletedNCT02336074Phase 2Results posted
• Vorinostat Plus Hydroxychloroquine Versus Regorafenib in Colorectal CancerCompletedNCT02316340Phase 2Results posted
• SARC018: A Study of Mocetinostat and Gemcitabine in Patients With Metastatic LeiomyosarcomaCompletedNCT02303262Phase 2Results posted
• Study of Panobinostat in Combination With Bortezomib and Dexamethasone in Japanese Patients With Relapsed/Refractory Multiple MyelomaCompletedNCT02290431Phase 2Results posted
• Study of Mocetinostat in Selected Patients With Mutations of Acetyltransferase Genes in Relapsed and Refractory Diffuse Large B-Cell Lymphoma and Follicular LymphomaTerminatedNCT02282358Phase 1/2Results posted
• Ruxolitinib and Pracinostat Combination Therapy for Patients With Myelofibrosis (MF)CompletedNCT02267278Phase 2Results posted
• Romidepsin and Lenalidomide in Treating Patients With Previously Untreated Peripheral T-Cell LymphomaCompletedNCT02232516Phase 2Results posted
• Romidepsin in Treating Patients With Steroid-Refractory Graft-versus-Host DiseaseTerminatedNCT02203578Not applicableResults posted
• Phase 1/2 Study of Vorinostat Therapy in Niemann-Pick Disease, Type C1CompletedNCT02124083Phase 1/2Results posted
• Exemestane With or Without Entinostat in Treating Patients With Recurrent Hormone Receptor-Positive Breast Cancer That is Locally Advanced or MetastaticActive, not recruitingNCT02115282Phase 3Results posted
• Comparative Efficacy of Phenylbutyrate (PBA) vs. Benzoate in Urea Cycle DisordersCompletedNCT02111200Not applicableResults posted
• ACY-1215 for Relapsed/Refractory Lymphoid MalignanciesTerminatedNCT02091063Phase 1/2Results posted
• MLN9708 (Ixazomib) in Combination With Panobinostat and Dexamethasone in Multiple MyelomaCompletedNCT02057640Phase 1/2Results posted
• 131I-MIBG Alone VS. 131I-MIBG With Vincristine and Irinotecan VS131I-MIBG With VorinostatCompletedNCT02035137Phase 2Results posted
• Phase I of Histone Deacetylase (HDAC) Inhibitor Panobinostat With Ipilimumab With Unresectable III/IV MelanomaCompletedNCT02032810Phase 1Results posted
• Romidepsin Plus Oral 5-Azacitidine in Relapsed/Refractory Lymphoid MalignanciesTerminatedNCT01998035Phase 1/2Results posted
• ACY-1215 (Ricolinostat) in Combination With Pomalidomide and Low-dose Dex in Relapsed-and-Refractory Multiple MyelomaTerminatedNCT01997840Phase 1/2Results posted
• Aza-SAHA-GBM With AutoSCT for Refractory LymphomaCompletedNCT01983969Phase 1/2Results posted
• Study of Pomalidomide, Dexamethasone, and Romidepsin for Rel/Ref MyelomaTerminatedNCT01979276Phase 1/2Results posted
• Established Status Epilepticus Treatment TrialCompletedNCT01960075Phase 3Results posted
• Pralatrexate + Romidepsin in Relapsed/Refractory Lymphoid MalignanciesTerminatedNCT01947140Phase 1/2Results posted
• Romidepsin and Abraxane in Treating Patients With Metastatic Inflammatory Breast CancerTerminatedNCT01938833Phase 1/2Results posted
• Azacitidine and Entinostat Before Chemotherapy in Treating Patients With Advanced Non-small Cell Lung CancerTerminatedNCT01935947Phase 2Results posted
• Evaluating the Safety and Efficacy of Romidepsin in Combination With Antiretroviral Therapy in HIV-Infected Adults With Suppressed Viral LoadCompletedNCT01933594Phase 1/2Results posted
• Valproic Acid for the Prevention of Post-Amputation PainCompletedNCT01928849Phase 2Results posted
• Phase II Anti-PD1 Epigenetic Therapy Study in NSCLC.CompletedNCT01928576Phase 2Results posted
• Safety and Efficacy Study of Pracinostat With Azacitadine in Elderly Patients With Newly Diagnosed Acute Myeloid Leukemia (AML)CompletedNCT01912274Phase 2Results posted
• A Two-part Study to Assess the Safety and Preliminary Efficacy of Givinostat in Patients With Polycythemia VeraCompletedNCT01901432Phase 1/2Results posted
• Study of Valproic Acid (VPA) vs Placebo to Shorten Time of Indwelling Pleural CatheterTerminatedNCT01900730Phase 2Results posted
• Study of Vorinostat in Combination With Gemcitabine and Docetaxel in Advanced SarcomaCompletedNCT01879085Phase 1/2Results posted
• Phase II Study of Gemcitabine+Romidepsin in the Relapsed/Refractory Peripheral T-cell Lymphoma PatientsCompletedNCT01822886Phase 2Results posted
• Sorafenib, Valproic Acid, and Sildenafil in Treating Patients With Recurrent High-Grade GliomaCompletedNCT01817751Phase 2Results posted
• Study to Allow Access to Single Agent Panobinostat for Patients Who Are on s.a. Panobinostat Treatment in a Novartis-sponsored Study and Continue to Benefit From the Treatment as Judged by the InvestigatorCompletedNCT01802879Phase 2Results posted
• Cytarabine and Daunorubicin Hydrochloride or Idarubicin and Cytarabine With or Without Vorinostat in Treating Younger Patients With Previously Untreated Acute Myeloid LeukemiaCompletedNCT01802333Phase 3Results posted
• Vorinostat Plus Tacrolimus & Methotrexate to Prevent Graft vs Host Disease Following Unrelated Stem Cell TransplantCompletedNCT01790568Phase 2Results posted
• Vorinostat, Tacrolimus, and Methotrexate in Preventing GVHD After Stem Cell Transplant in Patients With Hematological MalignanciesCompletedNCT01789255Phase 2Results posted
• A Study to Assess Safety/Tolerability, pk, Effects on Histology, Clinical Parameters of Givinostat in Children With DMDCompletedNCT01761292Phase 1/2Results posted
• Valproate for Mood Swings and Alcohol Use Following Head InjuryCompletedNCT01760785Not applicableResults posted
• Romidepsin in Combination With Lenalidomide in Adults With Relapsed or Refractory Lymphomas and MyelomaCompletedNCT01755975Phase 1/2Results posted
• Addition of Vorinostat to Azacitidine in Higher Risk MDS a Phase II add-on Study in Patients With Azacitidine FailureTerminatedNCT01748240Phase 2Results posted
• Ph II SAHA and Bevacizumab for Recurrent Malignant Glioma PatientsCompletedNCT01738646Phase 2Results posted
• Dose-Escalation Trial of Carfilzomib With and Without Romidepsin in Cutaneous T-Cell LymphomaTerminatedNCT01738594Phase 1Results posted
• Valproic Acid in Subjects With Intact Cognition - Proof of Concept StudyCompletedNCT01729598Early Phase 1Results posted
• Vorinostat in Treating Patients With Stage IV Breast Cancer Receiving Hormone TherapyCompletedNCT01720602Not applicableResults posted
• Panobinostat and Ruxolitinib In MyElofibrosis (PRIME Trial)CompletedNCT01693601Phase 1/2Results posted
• Belinostat and Yttrium Y 90 Ibritumomab Tiuxetan in Patients W/Relapsed Aggressive B-Cell NHLCompletedNCT01686165Phase 2Results posted
• Phase II, Single-Center, Oral Panobinostat in Combination With Lenalidomide and Dexamethasone in Multiple Myeloma (MM)CompletedNCT01651039Phase 2Results posted
• Decitabine and Vorinostat Conditioning Followed by CD3-/CD19- NK Cells Infusion for High Risk Myelodysplastic SyndromesCompletedNCT01593670Phase 2Results posted
• Sequential Multiple Assignment Treatment for Bipolar DisorderCompletedNCT01588457Phase 4Results posted
• Panobinostat and Everolimus in Treating Patients With Metastatic or Unresectable Renal Cell Cancer That Does Not Respond to Treatment With Sunitinib Malate or Sorafenib TosylateTerminatedNCT01582009Phase 1/2Results posted
• Open-Label Extension of the Dose Finding Study (DSC/08/2357/36) in Patients With Poly Juvenile Idiopathic ArthritisTerminatedNCT01557452Not applicableResults posted
• Temozolomide Plus Vorinostat in Relapse/Refractory Acute Myeloid Leukemia (AML)CompletedNCT01550224Phase 2Results posted
• Phase I/II Study of Combination of Sorafenib, Vorinostat, and Bortezomib for the Treatment of Acute Myeloid Leukemia With Complex- or Poor-risk (Monosomy 5/7) Cytogenetics or FLT3-ITD Positive GenotypeCompletedNCT01534260Phase 1/2Results posted
• Phenylbutyrate Therapy for Maple Syrup Urine DiseaseCompletedNCT01529060Phase 2/3Results posted
• Oral Panobinostat Adult Patients DLBCL Relapsed/Refractory Stem Cell Transfusion (ASCT) or Not Eligible for ASCTCompletedNCT01523834Phase 2Results posted
• Azacitidine With or Without Lenalidomide or Vorinostat in Treating Patients With Higher-Risk Myelodysplastic Syndromes or Chronic Myelomonocytic LeukemiaActive, not recruitingNCT01522976Phase 2Results posted
• Study of the Combination of Panobinostat and Carfilzomib in Patients With Relapsed/Refractory Multiple MyelomaCompletedNCT01496118Phase 1/2Results posted
• A Pilot Study of Decitabine and Vorinostat With Chemotherapy for Relapsed ALLTerminatedNCT01483690Phase 1/2Results posted
• Decision-Making in Bipolar DisorderCompletedNCT01463111Not applicableResults posted
• A Phase II Trial of Panobinostat and Lenalidomide in Patients With Relapsed or Refractory Hodgkin's LymphomaCompletedNCT01460940Phase 2Results posted
• A Japanese Phase 1/2 Study to Assess the Efficacy, Safety and Pharmacokinetics of Romidepsin in Patients With Peripheral T-cell Lymphoma (PTCL)CompletedNCT01456039Phase 1/2Results posted
• Safety, Pharmacodynamics (PD), Pharmacokinetics (PK) Study of SHP141 in 1A, 1B, or 2A Cutaneous T-Cell Lymphoma (CTCL)CompletedNCT01433731Phase 1Results posted
• Carboplatin and Paclitaxel With or Without Vorinostat in Treating Patients With Advanced Non-Small Cell Lung CancerTerminatedNCT01413750Phase 2Results posted
• Entinostat And Imatinib Mesylate In Treating Patients With Relapsed or Refractory Philadelphia Chromosome-Positive Acute Lymphoblastic LeukemiaTerminatedNCT01383447Phase 1/2Results posted
• A Rollover Study for Patients Who Participated in Other Romidepsin ProtocolsCompletedNCT01353664Phase 2Results posted
• Azacitidine and Entinostat in Treating Patients With Advanced Breast CancerCompletedNCT01349959Phase 2Results posted
• Magnetic Resonance Spectroscopy Imaging in Predicting Response to Vorinostat and Temozolomide in Patients With Recurrent or Progressive GlioblastomaCompletedNCT01342757Not applicableResults posted
• Treatment Strategy for Alcohol Use Disorders in Veterans With TBICompletedNCT01342549Phase 3Results posted
• Influence of Rifampin on the Pharmacokinetics of Romidepsin in Patients With Advanced CancerCompletedNCT01324323Phase 1Results posted
• Influence of Ketoconazole on the Pharmacokinetics of Romidepsin in Patients With Advanced CancerCompletedNCT01324310Phase 1Results posted
• The Effect of Vorinostat on HIV RNA Expression in the Resting CD4+ T Cells of HIV+ Pts on Stable ARTCompletedNCT01319383Phase 1/2Results posted
• Bortezomib, Vorinostat and Dexamethasone for Relapsed/Refractory Acute Lymphoblastic Leukemia (ALL)TerminatedNCT01312818Phase 2Results posted
• Romidepsin and Erlotinib Hydrochloride in Treating Patients With Stage III or Stage IV Non-Small Cell Lung CancerCompletedNCT01302808Phase 1Results posted
• Clinical Study of Vorinostat in Combination With Etoposide in Pediatric Patients < 21 Years at Diagnosis With Refractory Solid TumorsCompletedNCT01294670Phase 1/2Results posted

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