Drug
Ethinyl Estradiol clinical trials
Also written Ethinylestradiol.
Counted the way a researcher would: Ethinyl Estradiol with its salts, dosage forms, brands and biosimilars. Looking for a trial to join? Including related medicines shows more you could take part in.
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Approvals
The first approval found in each region, with its record
- United States
- 25 Jun 1943 · ESTINYL · NDA 005292 (FDA, Drugs@FDA)
- European Union
- 22 Aug 2002 · Evra · EMEA/H/C/000410 (EMA; in a combination)
From FDA's Drugs@FDA and Purple Book (through openFDA) and the European Medicines Agency, files of Sept 2026 and 27 Oct 2026. National approvals in Europe and other countries are not included. How this is worked out
How studies write it
Studies that test it under each name
Studies by the year they started
105 studies that test it; most in 2009 (13)
| Year | Studies |
|---|---|
| 1997 | 2 |
| 2002 | 5 |
| 2003 | 3 |
| 2004 | 4 |
| 2005 | 12 |
| 2006 | 7 |
| 2007 | 4 |
| 2008 | 7 |
| 2009 | 13 |
| 2010 | 2 |
| 2011 | 4 |
| 2012 | 4 |
| 2013 | 3 |
| 2014 | 1 |
| 2015 | 5 |
| 2016 | 5 |
| 2017 | 2 |
| 2018 | 2 |
| 2019 | 1 |
| 2020 | 2 |
| 2021 | 4 |
| 2023 | 3 |
| 2024 | 4 |
| 2025 | 2 |
| 2026 | 4 |
By phase
A phase 1/2 study counts in both.
What it is tested for
Each study’s main condition, where its own words name it, so a study counts once.
Who runs them
Industry 68 · Other 39
Bayer (13) · Wyeth is now a wholly owned subsidiary of Pfizer (6) · Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (4) · University of Colorado, Denver (3) · Massachusetts General Hospital (3) · Duramed Research (3) · McNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc. (3) · AbbVie (2)
Often tested with
Tested in the same studies.
Levonorgestrel (36) · Gestodene (13) · Drospirenone (12) · Norethindrone (10) · Norgestimate (9) · Estradiol (9) · Norelgestromin (7) · Desogestrel (4)
Related medicines
As reviewed, each with the page that says it.
Coming up
From the study records. Dates are the sponsors’ own estimates and often move.
Reaching primary completion within a year · 1
Studies that test Ethinyl Estradiol.
- Mar 2027Contraceptive Hormone and Reward Measurement (CHARM Study)Phase 4 · University of Colorado, Denver
Studies
Open first, then newest update. How each study uses Ethinyl Estradiol is read from its arms, and is right about nine times in ten. Ask us to read each study. These are the studies that list it as an intervention; a search of ClinicalTrials.gov also finds studies that mention it only in a description, such as earlier treatment.
Testing it · 107
- A Drug-drug Interaction Study to Evaluate the Effects of Pelabresib on the Pharmacokinetics of Repaglinide, Midazolam, and Combined Oral Contraceptive in Patients With Advanced MalignanciesRecruitingPhase 1Novartis PharmaceuticalsNCT07340190Written as ethinyl estradiol
- Transdermal Ethinyl Estradiol and Norelgestromin for Irregular Bleeding in Contraceptive Implant UsersRecruitingPhase 2Chulalongkorn UniversityNCT07083635Written as Transdermal Ethinyl Estradiol/Norelgestromin Patch
- Contraceptive Hormone and Reward Measurement (CHARM Study)RecruitingPhase 4University of Colorado, DenverNCT05058872Written as Levonorgestrel/ethinyl estradiol
- Oral Contraceptive Pill Compared With Vitamin E in Women With MigraineRecruitingPhase 3Leiden University Medical CenterNCT04007874Written as Ethinylestradiol/levonorgestrel
- Does Vaginal Delivery of Combined Hormonal Contraception Affect the Risk of Metabolic Syndrome in Overweight/Obese Women With PCOSCompletedPhase 4Andrea Roe, MD, MPHNCT04257500Written as Etonogestrel/ethinyl estradiol vaginal ring
- A Study of ABBV-295 Subcutaneous Injections to Assess Pharmacokinetics and Adverse Events in Healthy Adult Women Participants With Overweight or Obesity Taking Oral ContraceptivesCompletedPhase 1AbbVieNCT07414784Written as Levonorgestrel/Ethinyl Estradiol
- A Phase 1 Study to Assess the Effect of ABBV-722 on Ethinyl Estradiol and Levonorgestrel Drug Levels in Healthy Adult Female ParticipantsCompletedPhase 1AbbVieNCT07502417Written as Ethinyl Estradiol + Levonorgestrel
- Premature Discontinuation of Contraceptive ImplantsCompletedPhase 4University of Colorado, DenverNCT04828824Written as Ethinyl Estradiol / Norgestimate Oral Tablet
- A Study of Elenestinib in Healthy Adult Female ParticipantsCompletedPhase 1Blueprint Medicines CorporationNCT07388511Written as Levonorgestrel/Ethinyl Estradiol
- A Research Study Looking Into the Effect of NNC0519-0130 on Blood Levels of a Birth Control Pill and Emptying of the Stomach in Women After MenopauseCompletedPhase 1Novo Nordisk A/SNCT06513104Written as Levonorgestrel + Ethinylestradiol
- Potential Drug Interaction Study Between Vemircopan and Rosuvastatin, Metformin, Levonorgestrel/Ethinyl Estradiol-containing Oral Contraceptives, and CarbamazepineCompletedPhase 1Alexion Pharmaceuticals, Inc.NCT06071442Written as Levonorgestrel / Ethinyl Estradiol
- Pemvidutide (ALT-801) DDI Study in Healthy VolunteersCompletedPhase 1Altimmune, Inc.NCT04972396Written as Ethinylestradiol and Levonorgestrel
- Desogestrel-containing COCP Pharmacokinetic Validation StudyCompletedPhase 4University of Colorado, DenverNCT05002738Written as Desogestrel and Ethinyl Estradiol Tablets
- A Study in Healthy Participants to Evaluate the Effects of Multiple Doses of JNJ-55308942 on Cytochrome P450 Substrate Activity and on the Pharmacokinetics of Levonorgestrel/Ethinyl EstradiolCompletedPhase 1Janssen-Cilag International NVNCT03547024Written as Levonorgestrel/Ethinyl Estradiol Fixed Dose combination (FDC)
- A Study to Evaluate the Effect of Multiple Oral Doses of JNJ-42847922 on the Steady-state Pharmacokinetics of an Oral Contraceptive Containing Ethinyl Estradiol and Levonorgestrel in Healthy Female Adult ParticipantsCompletedPhase 1Janssen-Cilag International NVNCT03249402Written as Ethinyl Estradiol + Levonorgestrel
- A Drug-drug Interaction Trial in Healthy Female Participants to Investigate the Effect of Aprocitentan on Combined Hormonal ContraceptivesCompletedPhase 1Idorsia Pharmaceuticals Ltd.NCT06799884Written as Ethinyl Estradiol / Levonorgestrel Oral Tablet
- A Drug-Drug Interaction Study of MK 8527 With a Combined Oral Contraceptive (LNG/EE)CompletedPhase 1Merck Sharp & Dohme LLCNCT06783192Written as LNG/EE
- Evaluate the Pharmacokinetics of a Combined Oral Contraceptive (COC) With and Without ObicetrapibCompletedPhase 1NewAmsterdam PharmaNCT06250205Written as Obicetrapib + Drospirenone / Ethinyl Estradiol (COC)
- A Study of LY3437943 in Postmenopausal Female Participants Who Are Overweight or ObeseCompletedPhase 1Eli Lilly and CompanyNCT06039826Written as Ethinyl Estradiol
- A Study to Evaluate the Drug Interaction Between Povorcitinib and the Oral Contraceptive Levonorgestrel/Ethinyl Estradiol in Healthy Adult FemalesCompletedPhase 1Incyte CorporationNCT06380205Written as Levonorgestrel/Ethinyl estradiol
See all 107 studies that test Ethinyl Estradiol →
Given beside what is tested · 24 — Ethinyl Estradiol is usual care or a partner of the new treatment
- A Study of LY4515100 in Healthy ParticipantsRecruitingPhase 1Eli Lilly and CompanyNCT07339722Written as Ethinyl Estradiol
- An Ethno-bridging Study of Pergoveris in Healthy Premenopausal Participants of Japanese or Caucasian OriginCompletedPhase 1Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, GermanyNCT07269327Written as Desogestrel and ethinylestradiol fixed dose combination
- A Drug-Drug Interaction Study Between HS-10374 Tablets and Drospirenone and Ethinyl Estradiol Tablets(Yasmin®)CompletedPhase 1Hansoh BioMedical R&D CompanyNCT07181343Written as Drospirenone and Ethinyl Estradiol tablets
- A Study of Milvexian in Healthy Adult FemalesCompletedPhase 1Janssen Pharmaceutica N.V., BelgiumNCT05706753Written as Ethinylestradiol
- A Research Study Looking at How the Compound NNC0194-0499 Works With Birth Control Pills in Women Not Able to Bear Children.CompletedPhase 1Novo Nordisk A/SNCT06188026Written as ethinylestradiol/levonorgestrel
- STUDY TO EVALUATE THE EFFECT OF PF-06882961 ON SINGLE DOSE ATORVASTATIN, MEDAZOLAM AND ORALCONTRACEPTIVE PHARMACOKINETICS IN HEALTHY ADULT PARTICIPANTSCompletedPhase 1PfizerNCT05093205Written as Levonorgestrel & Ethinyl Estradiol
- Efficacy and Safety of Dingkundan Combined With Combination Oral Contraceptives in the Treatment of PCOSCompletedNot applicableGuangdong Women and Children HospitalNCT05872425Written as Drospirenone and Ethinylestradiol Tablets (Ⅱ)
- Phlebotomy and Polycystic Ovary SyndromeCompletedNot applicableManuel Luque RamírezNCT02460445Written as ethinylestradiol
- Pharmacokinetics Study to Evaluate Drug-Drug Interactions and Safety of Elpida® in Co-Administration With Other DrugsCompletedPhase 1ViriomNCT03709355Written as Levonorgestrel+Ethinylestradiol
- A Study to Evaluate Hormone Patterns and Ovarian Follicular Activity With DR-1021CompletedPhase 3Teva Branded Pharmaceutical Products R&D, Inc.NCT00544882Written as Kariva®
- The Effects of Annovera™ and Tampon Co-Usage on the Pharmacokinetics of Segesterone Acetate and Ethinyl EstradiolCompletedPhase 1TherapeuticsMDNCT04272008Written as Segesterone Acetate and Ethinyl Estradiol
- Study in Women on the Effect of JNJ-64530440 on Oral Contraceptive and Midazolam, and the Effect of a High-fat Meal on JNJ-64530440WithdrawnPhase 1Janssen Research & Development, LLCNCT03890341Written as Drospirenone/Ethinylestradiol
- Effect Of Multiple Dose PF-06700841 On The Pharmacokinetics Of Single Dose Oral Contraceptive SteroidsCompletedPhase 1PfizerNCT04267250Written as Ethinyl estradiol (EE) and levonorgestrel (LN)
- Drug-drug Interaction Between Rifampicin and Progestins/Ethinylestradiol and MidazolamCompletedPhase 1BayerNCT03353857Written as Drospirenone, Ethinylestradiol/ Yasmin
- A Study to Assess CYP3A4 Modulator, Oral Contraceptive, and pH Modifier Drug Interactions for ABI-H2158 in Healthy AdultsCompletedPhase 1Assembly BiosciencesNCT04142762Written as Ethinyl Estradiol / Levonorgestrel
- A Study to Evaluate the Effect of Ibrutinib on the Pharmacokinetics of Oral Contraceptives, CYP2B6, and CYP3A4 Substrates in Female Participants With B Cell MalignancyCompletedPhase 1Janssen Research & Development, LLCNCT03301207Written as OC: Ethinylestradiol (EE) 30 mcg and Levonorgestrel (LN) 150 mcg
- Effect of PF-06651600 on the Pharmacokinetics of Oral Contraceptive SteroidsCompletedPhase 1PfizerNCT04018274Written as Ethinyl estradiol (EE) and levonorgestrel(LN)
- A Study in Healthy Female Participants to Investigate the Effect of JNJ-56136379 at Steady-state on the Single-dose Pharmacokinetics of Ethinylestradiol and Drospirenone (Oral Contraceptive) and on the Single-dose Pharmacokinetics of Midazolam (Probe Substrate for Cytochrome P450 3A4)CompletedPhase 1Janssen Sciences Ireland UCNCT03111511Written as Drospirenone/Ethinylestradiol
- Treatment of Menstrually Related Disorders With Continuous v. Interrupted Oral ContraceptivesTerminatedPhase 2National Institute of Mental Health (NIMH)NCT00089414Written as Ethinyl Estradiol/Drospirenone
- To Evaluate the Effects of Odalasvir and AL-335 With Simeprevir on the Single-Dose Pharmacokinetics of Ethinylestradiol and Drospirenone in Healthy Female ParticipantsCompletedPhase 1Janssen Research & Development, LLCNCT02885454Written as Drospirenone/ethinylestradiol
Showing 20 of 24.
As the comparator · 15 — what is tested is compared with Ethinyl Estradiol
- "Quick-starting" of a Quadriphasic Contraceptive Pills, 1 - 3 mg Estradiol Valerate/ 2 - 3 mg Dienogest VS 20 mcg Ethinylestradiol/75 mcg Gestodene Focusing on Ovulation InhibitionCompletedNot applicableChulalongkorn UniversityNCT06396208Written as Ethinylestradiol (EE) 20 mcg/Gestodene 75 mcg (21/7)
- Effect of Dienogest in Symptomatic Endometrioma in Comparison to Combined Oral Contraceptive Pill.CompletedNot applicableMst.Sumyara KhatunNCT07770594Written as Combined oral contraceptive pill (ethinyl estradiol,30mcg+desogestrel,150mcg) tablet
- Effect of Elagolix in Symptomatic Endometrioma in Comparison to Combined Oral Contraceptive Pill.CompletedNot applicableMst.Sumyara KhatunNCT07763847Written as Combined oral contraceptive pill (ethinyl estradiol,30mcg+desogestrel,150mcg) tablet
- Ovulation Incidence in Oral Contraceptive UsersCompletedPhase 3University of Southern CaliforniaNCT03106454Written as Ethinyl Estradiol, Norethindrone acetate, ferrous fumarate
- "Quick-starting" of a New Combined Hormonal Contraceptive Pills, 15 mg Estetrol/3 mg Drospirenone VS 20 mcg Ethinylestradiol/75 mcg Gestodene Focusing on Ovulation InhibitionCompletedNot applicableChulalongkorn UniversityNCT06396221Written as Ethinylestradiol (EE) 20 mcg/Gestodene 75 mcg (21/7)
- Gonadotropin-releasing Hormone (GnRH) Downregulation Versus Oral Anticonception Prior to ART in Postoperative Endometriosis PatientsCompletedNot applicableUniversitaire Ziekenhuizen KU LeuvenNCT02400801Written as ethinylestradiol + dienogest
- Study of the Contraceptive Efficacy and Safety of a NOMAC-E2 Combined Oral Contraceptive (COC)(P06448)TerminatedPhase 3Organon and CoNCT01656434Written as ethinylestradiol (EE)
- A Dose-Finding Study to Evaluate Ovarian Function and Vaginal Bleeding in Next Generation Rings (P06109/MK-8175A/MK-8342B-012)CompletedPhase 2Organon and CoNCT01709318Written as Ethinyl estradiol (EE)
- LCS16 vs. COC User Satisfaction and Tolerability StudyCompletedPhase 3BayerNCT03074045Written as Ethinyl estradiol and drospirenone (Yarina, BAY86-5131)
- Effects on Hemostasis, Lipids, Carbohydrate Metabolism, Adrenal & Thyroid Function of the Combined Oral Contraceptive NOMAC-E2 Compared to a COC Containing LNG-EE (292004)(COMPLETED)(P05764)CompletedPhase 3Organon and CoNCT00511355Written as Levonorgestrel and Ethinyl Estradiol
- Fat Mediated Modulation of Reproductive and Endocrine Function in Young AthletesCompletedPhase 3Massachusetts General HospitalNCT00946192Written as Ethinyl Estradiol + Desogestrel
- The Efficacy and Safety Study of Tung's Acupuncture for Polycystic Ovarian SyndromeCompletedPhase 2Beijing Hospital of Integrated Traditional Chinese and Western MedicineNCT02729545Written as Cyproterone acetate/ethinylestradiol (CPA/EE)
- Effect on Primary DysmenorrheaCompletedPhase 3BayerNCT00909857Written as Ethinyl estradiol, Levonorgestrel (Miranova)
- Efficacy and Safety Study for an Oral Contraceptive Containing FolateCompletedPhase 3BayerNCT00468481Written as Drospirenone/Ethinylestradiol (Yaz)
- An Efficacy and Safety Study Comparing Oral Contraceptive Containing Norgestimate or Desogestrel for Acne TreatmentCompletedPhase 4Janssen-Cilag Ltd.,ThailandNCT01466673Written as Ethinyl estradiol/Desogestrel (EE/DSG)
Codes
What other systems call Ethinyl Estradiol · ClinicalTrials.gg INT007453
- MeSH (NLM) D004997Ethinyl EstradiolConfirmed ClinicalTrials.gov, NLM
- UNII (FDA) 423D2T571UETHINYL ESTRADIOLConfirmed FDA, NLM
- RxNorm 4124One source FDA
- NCI Thesaurus C486Ethinyl EstradiolOne source FDA
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D004997 | Ethinyl Estradiol | Confirmed ClinicalTrials.gov, NLM |
| UNII (FDA) | 423D2T571U | ETHINYL ESTRADIOL | Confirmed FDA, NLM |
| RxNorm | 4124 | — | One source FDA |
| NCI Thesaurus | C486 | Ethinyl Estradiol | One source FDA |
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.