Estrogen Antagonists clinical trials
A class of medicines: the studies that test any of its 7 members, each study once. Members are as MeSH files each medicine’s actions, and as the NCI Thesaurus classes newer ones.
Get an email when these change. Save the estrogen antagonists studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Medicines in this class
Studies that test each. A study of two counts under both, and once above.
- Naringenin
- 2
Studies by the year they started
380 studies that test it; most in 2017 (22); 1 more planned to start later
| Year | Studies |
|---|---|
| 1990 | 2 |
| 1991 | 2 |
| 1992 | 2 |
| 1993 | 7 |
| 1994 | 3 |
| 1995 | 4 |
| 1996 | 6 |
| 1997 | 5 |
| 1998 | 10 |
| 1999 | 5 |
| 2000 | 10 |
| 2001 | 10 |
| 2002 | 12 |
| 2003 | 12 |
| 2004 | 11 |
| 2005 | 3 |
| 2006 | 12 |
| 2007 | 10 |
| 2008 | 13 |
| 2009 | 14 |
| 2010 | 13 |
| 2011 | 19 |
| 2012 | 15 |
| 2013 | 10 |
| 2014 | 19 |
| 2015 | 18 |
| 2016 | 13 |
| 2017 | 22 |
| 2018 | 15 |
| 2019 | 10 |
| 2020 | 12 |
| 2021 | 11 |
| 2022 | 10 |
| 2023 | 6 |
| 2024 | 9 |
| 2025 | 12 |
| 2026 | 13 |
By phase
A phase 1/2 study counts in both.
What it is tested for
Each study’s main condition, where its own words name it, so a study counts once.
Who runs them
Industry 65 · Other 321
Repros Therapeutics Inc. (24) · Eli Lilly and Company (10) · National Cancer Institute (NCI) (9) · AstraZeneca (8) · Northwestern University (5) · ETOP IBCSG Partners Foundation (5) · Mayo Clinic (5) · Ain Shams University (5)
Studies
Open first, then newest update. How each study uses a medicine is read from its arms, and is right about nine times in ten. These are the studies that list it as an intervention; a search of ClinicalTrials.gov also finds studies that mention it only in a description, such as earlier treatment.
Testing one of them · 386
- Early Study on Tamoxifen Safety/Tolerability in Cystic Fibrosis Patients Unable to Use CFTR Modulators.RecruitingPhase 2Azienda Ospedaliera Universitaria Integrata VeronaNCT07289035Written as Tamoxifen Citrate 20Mg Tab
- Tamoxifen Versus Etoposide After First Recurrence in GBM PatientsRecruitingPhase 2AHS Cancer Control AlbertaNCT04765098Written as Tamoxifen
- A Study of Skipping Radiation Therapy in People With Breast CancerRecruitingNot applicableMemorial Sloan Kettering Cancer CenterNCT07895511Written as Tamoxifen
- Clinical Trial to Observe the Effects of Tamoxifen on Testosterone Recovery in Medically Castrated Prostate Cancer PatientsRecruitingPhase 2University Health Network, TorontoNCT07535905Written as Tamoxifen
- Combination Therapy With Danazol, Prednisolone, and Thalidomide for Thalidomide-Refractory Transfusion-Dependent β-ThalassemiaRecruitingPhase 3Khyber Medical University PeshawarNCT07884773Written as Danazol
- HRT-PC Trial: Hormone Recovery After Treatment for Prostate Cancer Trial. An Open-label Phase II Study of Clomiphene Citrate in Patients With Persistent Hypogonadism After ADT for Treatment of Localized Prostate CancerNot yet recruitingPhase 2University of NebraskaNCT07882862Written as Clomiphene Citrate 25mg
- Chemoprevention With Tamoxifen in Pre-Invasive Pancreas Mucinous Cystic Neoplasms Not Undergoing Immediate ResectionRecruitingPhase 1University of NebraskaNCT06320990Written as Tamoxifen 20mg
- Comparative Efficacy of Antioxidants Alone Versus Combined Therapy With SERMs or FSH in Normogonadotropic Idiopathic OAT Patients: A Randomized Controlled TrialNot yet recruitingPhase 4Hamad Medical CorporationNCT07862725Written as Antioxidants + Clomiphene Citrate
- A Study of MK-5684 in People With Certain Solid Tumors (MK-5684-015/OMAHA-015)RecruitingPhase 2Merck Sharp & Dohme LLCNCT06979596Written as Tamoxifen
- Memantine +/- Raloxifene for Cognitive Preservation After Radiation Therapy to the BrainRecruitingPhase 2The University of Texas Health Science Center at San AntonioNCT07470606Written as Raloxifene
- ETHAN - ET for Male BCRecruitingPhase 2Jose Pablo LeoneNCT05501704Written as Tamoxifen
- Evaluation of a Long Versus Short Clomid Protocol for Controlled Ovarian StimulationRecruitingPhase 4University of Southern CaliforniaNCT06701071Written as Clomiphene Citrate
- Low Dose Tamoxifen With or Without Omega-3 Fatty Acids for Breast Cancer Risk ReductionRecruitingPhase 2National Cancer Institute (NCI)NCT06195306Written as Tamoxifen
- Finding the Best Tamoxifen Dose for Breast Cancer Risk Reduction in Premenopausal Women, RENAISSANCE TrialRecruitingPhase 2National Cancer Institute (NCI)NCT06184750Written as Tamoxifen
- Endocrine Treatment Alone for Elderly Patients With Estrogen Receptor Positive Operable Breast Cancer and Low Recurrence ScoreRecruitingPhase 2Washington University School of MedicineNCT02476786Written as Tamoxifen
- FES Imaging to Optimize Tamoxifen for Metastatic Breast CancerRecruitingEarly Phase 1University of Wisconsin, MadisonNCT04174352Written as Tamoxifen
- Fertility Preservation Using Tamoxifen and Letrozole in Estrogen Sensitive Tumors TrialRecruitingPhase 3University of California, San FranciscoNCT03011684Written as Tamoxifen
- Efficacy and Safety of Dalpiciclib Combined With Endocrine Adjuvant Therapy for Early HR +/HER2- Breast Cancer: a Multicenter, Prospective Clinical StudyRecruitingPhase 2Fujian Cancer HospitalNCT07581834Written as Endocrine Therapy (ET): letrozole, anastrozole, exemestane, tamoxifen
- Impact of Medically Supervised Performance-Enhancing Substances (PES) on Elite AthletesEnrolling by invitationNot applicableEnhanced Emirates LimitedNCT07568574Written as Clomiphene
- Tamoxifen and Pegylated Liposomal Doxorubicin for the Treatment of Patients With Metastatic or Inoperable, Locally Advanced Triple Negative Breast CancerRecruitingPhase 2Roswell Park Cancer InstituteNCT06434064Written as Tamoxifen
See all 386 studies that test one of the estrogen antagonists →