Endothelin Receptor Antagonists: all 328 studies that test it

Page 3 of 4. Open to participants first (22), then studies with results posted, then the rest; newest registration first within each.

• A Study to Evaluate ACT-132577 in Healthy Male SubjectsCompletedNCT03100591Phase 1
• Clinical Study Evaluating the Effects of First-line Oral cOmbination theraPy of maciTentan and tadalafIl in Patients With Newly Diagnosed pulMonary Arterial Hypertension (OPTIMA)TerminatedNCT02968901Phase 4
• Mechanisms of Cerebrovascular ControlCompletedNCT02936687Phase 1
• Macitentan in the Treatment of Organ Rejection After Lung TransplantationWithdrawnNCT02893176Phase 4
• A Study to Investigate the Effect of ACT-132577 on the Pharmacokinetics of Midazolam and 1-hydroxy Midazolam in Healthy Male SubjectsCompletedNCT02841761Phase 1
• The Role of Endothelin-1 in Sickle Cell DiseaseCompletedNCT02712346Phase 1
• Clinical Study to Assess Body Fluid Homeostasis After Administration of ACT-132577 in Healthy SubjectsCompletedNCT02708004Phase 1
• Evaluation of the Efficacy and Safety of Clazosentan in Reversing Cerebral Vasospasm in Adult Subjects With Aneurysmal Subarachnoid HemorrhageCompletedNCT02560532Phase 2
• The Clinical And Subclinical Effects on Arterial Stiffness of Bosentan in Patients With Systemic SclerosisCompletedNCT02480335Phase 4
• Treatment of Resistant Port-wine Stains With Bosentan and Pulsed Dye Laser: a Pilot StudyCompletedNCT02317679Phase 2
• Clinical Study on Macitentan, RT and TMZ Concurrent Therapy Followed by Maintenance Macitentan and TMZ in Newly Diagnosed GlioblastomaTerminatedNCT02254954Phase 1
• Ambrisentan for the Improvement in Right Ventricular Strain in Scleroderma Associated Pulmonary Arterial HypertensionTerminatedNCT02169752Not applicable
• Endothelin Receptor Function and Acute StressActive, not recruitingNCT02116335Not applicable
• Extension of the Psychometric Validation Study ORCHESTRA in Patients With PAHCompletedNCT02112487Phase 3
• Study of Bosentan in the Treatment of Stable Severe Chronic Obstructive Pulmonary Disease PatientsStatus unknownNCT02093195Phase 2
• Endothelin Antagonism in ANCA VasculitisCompletedNCT02062346Not applicable
• Study to Assess the Effect of Macitentan on the Electrocardiogram (ECG) in Healthy Male and Female SubjectsCompletedNCT02050802Phase 1
• Zibotentan Better Renal Scleroderma Outcome StudyCompletedNCT02047708Phase 2
• Clinical Trial to Investigate the Pharmacokinetic Drug Interaction Between Udenafil and Bosentan After Oral AdministrationStatus unknownNCT01929213Phase 1
• Zibotentan, an Endothelin Receptor Antagonist, Patients With Intermittent ClaudicationCompletedNCT01890135Phase 2
• To Compare the Pharmacokinetics of Traclear 62.5 mg Tablets and HGP1206 125mg 1 Tablet in Healthy Male VolunteersCompletedNCT01864863Phase 1
• Bosentan In Exercise Induced Pulmonary Arterial Hypertension in CongenitaL Heart diseasEStatus unknownNCT01827059Phase 2
• A Study to Test the Safety of Combined Dosing With Aminophylline and Ambrisentan in Exercising Healthy Human Volunteers at Simulated High AltitudeCompletedNCT01794078Phase 1
• ET-blockade and Exercise-induced Vascular Adaptations in T2DMCompletedNCT01779609Phase 4
• ET-blockade and Exercise Induced Blood Flow in T2DMCompletedNCT01779596Phase 4
• Safety and Efficacy Study of Bosentan for Intermittent Claudication in Peripheral Arterial DiseaseCompletedNCT01738542Not applicable
• Ambrisentan for Treatment of Portopulmonary HypertensionWithdrawnNCT01733095Phase 1/2
• Bosentan Therapy in Children With Functional Single VentricleCompletedNCT01662037Phase 2
• Short-term Endothelin A Receptor Blockade in Patients With On-pump CABGStatus unknownNCT01658410Phase 2
• Examination of the Bronchoprotective Effect of Endothelin Receptor Blockade in AsthmaStatus unknownNCT01617746Phase 2
• Bosentan for Treatment of Hepatopulmonary Syndrome in Patients With Liver CirrhosisTerminatedNCT01518595Phase 2
• Clinical Study on the Safety and Tolerability of Macitentan in Combination With Dose-dense Temozolomide in Patients With Recurrent GlioblastomaTerminatedNCT01499251Phase 1
• Comparison of Efficacy Different Treatment Regimens in Pulmonary Hypertension Secondary to Lung Disease and or HypoxiaStatus unknownNCT01449253Phase 4
• A Prospective, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate Efficacy and Safety of Atrasentan, Including Thoracic Bioimpedance, in Type 2 Diabetic Subjects With NephropathyCompletedNCT01399580Phase 2
• Bosentan in Systemic SclerosisCompletedNCT01395732Phase 4
• Prognostic Influence of Light Rheography Measurement of Patients With Secondary Raynaud Syndrome With Ulcers on HandsStatus unknownNCT01378845Not applicable
• Effect of Bosentan on Endothelial Function in Patients With Type 2 DiabetesCompletedNCT01357109Phase 2
• Evaluate the Efficacy and Safety of Once Daily Administration of Atrasentan Tablets (Low and High) Compared to Placebo in Reducing Residual Albuminuria in Type 2 Diabetic Patients With Nephropathy Who Are Treated With the Maximum Tolerated Labeled Dose of a Renin Angiotensin System (RAS) InhibitorCompletedNCT01356849Phase 2
• Characterization and Detection of Prolonged Endothelin Receptors Antagonists AdministrationCompletedNCT01352065Phase 2/3
• Safety and Tolerability Study of Macitentan in Patients With Idiopathic Pulmonary FibrosisWithdrawnNCT01346930Phase 2
• Study of Placebo or Bosentan to Treat Patients With Single Ventricle Physiology.CompletedNCT01292551Phase 2
• Bosentan for Severe Mitral Valve DysfunctionStatus unknownNCT01270750Phase 1/2
• Drug Interaction Between Ritonavir And SitaxsentanWithdrawnNCT01251848Phase 1
• Effect Of Rifampin On Pharmacokinetics Of SitaxsentanWithdrawnNCT01251835Phase 1
• Effect of Bosentan in Scleroderma Renal CrisisCompletedNCT01241383Phase 2
• Bosentan for Mild Pulmonary Vascular Disease in Asd Patients.CompletedNCT01218607Phase 3
• Irinotecan Hydrochloride, Fluorouracil, and Leucovorin Calcium With or Without Zibotentan in Treating Patients With Metastatic Colorectal CancerCompletedNCT01205711Phase 2
• Bosentan Improves Clinical Outcome of Adults With Congenital Heart Disease or Mitral Valve Lesions Who Undergo CArdiac SurgeryStatus unknownNCT01184404Not applicable
• Window Study of ZD4054 in Metastatic Prostate CancerStatus unknownNCT01168141Not applicable
• Carboplatin With or Without ZD4054 in Patients With Metastatic Breast CancerWithdrawnNCT01134497Phase 2
• The Role of Endothelin in the Supine Hypertension of Autonomic FailureWithdrawnNCT01119417Phase 1
• Tezosentan in Patients With Pulmonary Arterial HypertensionTerminatedNCT01094067Phase 2
• Tezosentan in Pulmonary Arterial HypertensionTerminatedNCT01077297Phase 2
• Effect of Bosentan in Patients With Metastatic Melanoma Treated With Dacarbazine (DTIC)CompletedNCT01009177Phase 2
• A Safety Study of ZD4054 in Prior Chemotherapy Treated Patients With Metastatic Hormone-resistant Prostate CancerTerminatedNCT01000948Phase 2
• 10mg ZD4054 (Zibotentan) PK Study in Male, Elderly Chinese Patients With Advanced Solid MalignanciesCompletedNCT00997945Phase 1
• Clazosentan in Aneurysmal Subarachnoid HemorrhageTerminatedNCT00940095Phase 3
• Safety and Efficacy Study of Bosentan in Progressive Pulmonary SarcoidosisTerminatedNCT00926627Phase 2
• Role of Endothelin-1 in Optic Nerve Head Blood Flow Regulation During Isometric Exercise in Healthy HumansCompletedNCT00915070Not applicable
• Early Therapy of Pulmonary Arterial HypertensionCompletedNCT00909337Not applicable
• A Study to Evaluate the Use of Bosentan in Patients With Exercise Induced Pulmonary Arterial Hypertension Associated With Connective Tissue DiseaseStatus unknownNCT00864201Phase 3
• Ambrisentan (Letairis) for Sarcoidosis Associated Pulmonary HypertensionCompletedNCT00851929Phase 2/3
• Safety and Efficacy of Bosentan in Patients With Diastolic Heart Failure and Secondary Pulmonary HypertensionCompletedNCT00820352Phase 3
• Sitaxsentan in Proteinuric Chronic Kidney DiseaseCompletedNCT00817037Phase 2
• Preventive Effects of Bosentan on the Systemic Cardiovascular Consequence of Sleep ApneaCompletedNCT00777985Phase 2
• The Effects of Diesel Exhaust Inhalation on Vascular Function - the Role of EndothelinCompletedNCT00745693Not applicable
• Endothelin Receptor Antagonism in Proteinuric NephropathyCompletedNCT00722215Phase 1
• Relative Bioavailability Study in Healthy Male Subjects for ZD4054 (Zibotentan) Immediate Release Tablets.CompletedNCT00713791Phase 1
• Food Effect Study of a Single Dose of ZD4054 (Zibotentan)CompletedNCT00710047Phase 1
• Drug Interaction Study to Asses Multiple Doses of ZD4054 (Zibotentan)CompletedNCT00709553Phase 1
• Effects of Non-Specific Endothelin-A Receptor Blockade on Ocular Blood Flow in Patients With GlaucomaCompletedNCT00701597Phase 1
• Effects of Bosentan on Respiratory MechanicsTerminatedNCT00679068Phase 4
• Pharmacokinetics, Safety & Tolerability of ZD4054 (Zibotentan) in Subjects With Normal, Mild, Moderate and Severe Hepatic ImpairmentCompletedNCT00672581Phase 1
• Bosentan Use in Patients With Diabetic NephropathyTerminatedNCT00638131Phase 3
• Bosentan in Pulmonary Hypertension in Interstitial Lung Disease Treatment StudyStatus unknownNCT00637065Phase 4
• Pulmonary Arterial Hypertension Secondary to Idiopathic Pulmonary Fibrosis and Treatment With BosentanWithdrawnNCT00625469Phase 4
• Pulmonary Artery Remodelling With BosentanCompletedNCT00595049Phase 4
• Double Blind, Randomized Trial of Bosentan for Sarcoidosis Associated Pulmonary HypertensionCompletedNCT00581607Phase 2/3
• Clazosentan in Reducing Vasospasm-related Morbidity and All-cause Mortality in Adult Patients With Aneurysmal Subarachnoid Hemorrhage Treated by Surgical ClippingCompletedNCT00558311Phase 3
• Tezosentan in Acute Heart FailureCompletedNCT00525707Phase 3
• Tezosentan in the Treatment of Acute Heart FailureCompletedNCT00524433Phase 3
• Endothelin Receptor Blockade in Acute ST-elevation Myocardial InfarctionCompletedNCT00502528Phase 2
• Study of the Efficacy and Safety of Tezosentan in Patients With Pre-operative Pulmonary Hypertension, Due to Left Heart Disease, Undergoing Open Heart SurgeryTerminatedNCT00458276Phase 3
• Endothelin-Receptor Blockade in Coronary Heart DiseaseCompletedNCT00427232Phase 1
• A Study of GSK1325760A in Healthy Japanese SubjectsCompletedNCT00424034Phase 1
• Study to Assess Safety and Efficacy of Ambrisentan in Subjects With Pulmonary Arterial Hypertension.CompletedNCT00423748Phase 3
• A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Assess Safety and Efficacy of Ambrisentan in Subjects With Pulmonary Arterial Hypertension.CompletedNCT00423202Phase 3
• DORADO-AC - Optimized Doses of Darusentan as Compared to an Active Control in Resistant HypertensionCompletedNCT00389779Phase 3
• DORADO-AC-EX - A Long-Term Safety Extension Study to the Phase 3 DORADOC-AC Study (Protocol DAR-312) of Darusentan in Resistant HypertensionTerminatedNCT00389675Phase 3
• A Clinical Study to Evaluate the Effects of Darusentan on Safety and Efficacy in Subjects With Resistant Systolic Hypertension Receiving Combination Therapy With Three or More Blood Pressure Lowering DrugsCompletedNCT00364026Phase 2
• A Study of Patients Having Pulmonary Hypertension Associated With Sickle Cell Disease and Completing an ASSET StudyTerminatedNCT00360087Phase 3
• DORADO-EX: Long-Term Safety Extension Study to the Phase 3 DORADO Study (Protocol DAR-311) of Darusentan in Resistant HypertensionTerminatedNCT00353574Phase 3
• DORADO - Fixed Doses of Darusentan as Compared to Placebo in Resistant HypertensionCompletedNCT00330369Phase 3
• Bosentan in Children With Pulmonary Arterial HypertensionCompletedNCT00319267Phase 3
• Open-label Study With Bosentan in Interstitial Lung DiseaseCompletedNCT00319033Phase 2/3
• Effect of Bosentan on Skin Fibrosis in Patients With Systemic SclerosisCompletedNCT00318175Phase 2
• Effects of Tracleer (Bosentan) on Pulmonary Arterial Hypertension Related to Eisenmenger PhysiologyCompletedNCT00317486Phase 4
• Phase I Study of ZD4054 (Zibotentan) and Docetaxel in Patients With Metastatic HRPCCompletedNCT00314782Phase 1
• Bosentan Effects in Inoperable Forms of Chronic Thromboembolic Pulmonary HypertensionCompletedNCT00313222Phase 3
• Efficacy and Safety of Bosentan in Sickle Cell Disease (SCD) Patients Diagnosed With Pulmonary Hypertension (PH)TerminatedNCT00313196Phase 3

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