Endothelin Receptor Antagonists: all 328 studies that test it

Page 2 of 4. Open to participants first (22), then studies with results posted, then the rest; newest registration first within each.

• Study of Ambrisentan in Participants With Pulmonary HypertensionCompletedNCT00777920Phase 3Results posted
• (ARTEMIS-IPF) Randomized, Placebo-Controlled Study to Evaluate Safety and Effectiveness of Ambrisentan in IPFTerminatedNCT00768300Phase 3Results posted
• The Role of Endothelin in Pulmonary HypertensionCompletedNCT00759408Phase 2Results posted
• ZD4054 (Zibotentan) Phase II Non-Small Cell Lung Cancer StudyCompletedNCT00745875Phase 2Results posted
• Darusentan Effect on PET Uptake HeterogeneityCompletedNCT00738049Phase 2Results posted
• A Study to Evaluate the Efficacy of an Oral Medication in the Treatment and Prevention of Digital Ulcers in Patients With Systemic Sclerosis (Scleroderma).CompletedNCT00725361Not applicableResults posted
• Clinical Study to Assess the Long-term Safety and Tolerability of ACT 064992 in Patients With Symptomatic Pulmonary Arterial HypertensionCompletedNCT00667823Phase 3Results posted
• Study of Macitentan (ACT-064992) on Morbidity and Mortality in Patients With Symptomatic Pulmonary Arterial HypertensionCompletedNCT00660179Phase 3Results posted
• Ph II Atrasentan + DOXIL in Recurrent Ovarian/Fallopian/Peritoneal Serous Papillary AdenocarcinomaTerminatedNCT00653328Phase 2Results posted
• A Study To Evaluate The Dose-Related Efficacy and Safety of PS433540 in Subjects With HypertensionCompletedNCT00635232Phase 2Results posted
• Open Label Extension Study in Patients With Idiopathic Pulmonary Fibrosis Who Completed Protocol AC-052-321/ BUILD 3 / NCT00391443CompletedNCT00631475Phase 3Results posted
• A Phase III Trial of ZD4054 (Zibotentan) (Endothelin A Antagonist) in Non-metastatic Hormone Resistant Prostate CancerTerminatedNCT00626548Phase 3Results posted
• A Phase III Trial of ZD4054 (Zibotentan) (Endothelin A Antagonist) and Docetaxel in Metastatic Hormone Resistant Prostate CancerCompletedNCT00617669Phase 3Results posted
• Study of Add-on Ambrisentan Therapy to Background Phosphodiesterase Type-5 Inhibitor (PDE5i) Therapy in Pulmonary Arterial Hypertension (ATHENA-1)CompletedNCT00617305Phase 4Results posted
• Role of Endothelin in Microvascular Dysfunction Following PCI for NSTEMICompletedNCT00586820Phase 2Results posted
• A Long Term Study of Ambrisentan in Pulmonary Arterial Hypertension Subjects Having Completed AMB-320 (NCT00423748) or AMB-321 (NCT00423202)CompletedNCT00578786Phase 3Results posted
• A Study to Evaluate GSK1325760A - a Long-Term Extension StudyCompletedNCT00554619Phase 3Results posted
• A Phase III Trial of ZD4054 (Zibotentan) (Endothelin A Antagonist) in Hormone Resistant Prostate Cancer With Bone MetastasesCompletedNCT00554229Phase 3Results posted
• Evaluate the Efficacy, Safety and Pharmacokinetics of GSK1325760A in the Treatment of Pulmonary Arterial HypertensionCompletedNCT00540436Phase 2Results posted
• A Trial to Evaluate the Safety and Efficacy of PS433540 to Treat HypertensionCompletedNCT00522925Phase 2Results posted
• Combination Therapy in Pulmonary Arterial HypertensionCompletedNCT00433329Phase 4Results posted
• Phase 2 Extension Study of Ambrisentan in Pulmonary Arterial HypertensionCompletedNCT00424021Phase 2Results posted
• Phase 2 Study of Ambrisentan for Liver Function Test Rescue in Pulmonary Arterial HypertensionCompletedNCT00423592Phase 2Results posted
• BUILD 3: Bosentan Use in Interstitial Lung DiseaseCompletedNCT00391443Phase 3Results posted
• Safety and Efficacy Study of Ambrisentan in Subjects With Pulmonary HypertensionCompletedNCT00380068Phase 3Results posted
• Placebo Controlled Trial of Bosentan in Scleroderma PatientsTerminatedNCT00377455Phase 2Results posted
• BREATHE 5-OL: Tracleer (Bosentan) in Patients With Pulmonary Arterial Hypertension Related to Eisenmenger PhysiologyCompletedNCT00367770Phase 4Results posted
• Bosentan in Digital UlcersCompletedNCT00319696Phase 3Results posted
• Bosentan in Patients With Inoperable Chronic Thromboembolic Pulmonary Hypertension (CTEPH)CompletedNCT00319111Phase 3Results posted
• Bosentan in Children With Pulmonary Arterial Hypertension Extension StudyCompletedNCT00319020Phase 3Results posted
• Effects of the Combination of Bosentan and Sildenafil Versus Sildenafil Monotherapy on Pulmonary Arterial Hypertension (PAH)CompletedNCT00303459Phase 4Results posted
• S0421, Docetaxel and Prednisone With or Without Atrasentan in Treating Patients With Stage IV Prostate Cancer and Bone Metastases That Did Not Respond to Previous Hormone TherapyCompletedNCT00134056Phase 3Results posted
• ZD4054 (Zibotentan) in Pain-free or Mildly Symptomatic Patients With Prostate Cancer and Bone Metastases Who Have Rising Serum Prostate Specific Antigen (PSA)CompletedNCT00090363Phase 2Results posted
• A Phase IIa. Open-label, Multicenter, Dose-escalation Study to Assess the Tolerability and Pharmacokinetics of ZD4054 (Zibotentan) Given Orally Once Daily in Subjects With Metastatic Prostate CancerCompletedNCT00055471Phase 2Results posted
• Endothelin Role In COronary MicrocirculationActive, not recruitingNCT07670091Not applicable
• A Study in Healthy Men to Test How Bosentan Influences the Amount of Zongertinib in the BloodCompletedNCT07649941Phase 1
• A Study to Investigate the Concentrations of Zibotentan and Dapagliflozin in Blood When Given With and Without FoodCompletedNCT07404137Phase 1
• Sparsentan in Posttransplant Immunoglobulin A Nephropathy or Focal Segmental GlomerulosclerosisActive, not recruitingNCT07219121Phase 4
• A Study in Healthy Men to Test How Bosentan Influences the Amount of Nerandomilast in the BloodCompletedNCT07081932Phase 1
• A Study to Investigate the Effects of Zibotentan/Dapagliflozin Combination Compared to Dapagliflozin Alone in Adult Participants With Chronic Kidney Disease and High ProteinuriaActive, not recruitingNCT06942910Phase 2
• A Drug-drug Interaction Trial in Healthy Female Participants to Investigate the Effect of Aprocitentan on Combined Hormonal ContraceptivesCompletedNCT06799884Phase 1
• A Study to Investigate the Blood Concentrations of 4 Different Oral Doses of Zibotentan in Healthy Non-Asian and Japanese ParticipantsCompletedNCT06715670Phase 1
• Macitentan and Tadalafil Film-coated Tablets 10 mg/40 mg and 'PrOpsynvi®' Macitentan and Tadalafil Film-coated Tablets 10 mg/40 mgCompletedNCT06553924Phase 1
• Bioequivalence Study to Compare Bosentan 32 mg Dispersible Tablets Versus Tracleer® 32 mg TabletsCompletedNCT06484673Phase 1
• Endothelin Receptor Antagonism With Ambrisentan to Treat Hepatorenal SyndromeActive, not recruitingNCT06256432Phase 2
• Study to Investigate Efficacy, Safety, and Tolerability of Zibotentan/Dapagliflozin Compared to Dapagliflozin in Participants With Chronic Kidney Disease and High Proteinuria (ZENITH High Proteinuria)Active, not recruitingNCT06087835Phase 3
• Macitentan to Prevent PRVOWithdrawnNCT05946811Phase 3
• A Study of Macitentan in Children Below 2 Years of AgeWithdrawnNCT05731492Phase 1
• A Study to Evaluate the Efficacy and Safety of SC0062 in the Treatment of Chronic Kidney DiseaseActive, not recruitingNCT05687890Phase 2
• ETA and AT1 Antagonism in ANCA-vasculitis (SPARVASC)Active, not recruitingNCT05630612Phase 2
• Zibotentan and Dapagliflozin in Patients With Type 2 Diabetes and Elevated AlbuminuriaCompletedNCT05570305Phase 2
• Study to Evaluate the Pharmacokinetics of Oral Sparsentan SuspensionCompletedNCT05562362Phase 1
• Assessing the Effect of Multiple Doses of Zibotentan on the Pharmacokinetics of Single Doses of Combined Oral Contraceptives in Healthy Female Participants of Non-childbearing Potential.CompletedNCT05505162Phase 1
• Efficacy and Safety Study of Ambrisentan in Chinese Patients With Pulmonary Arterial HypertensionCompletedNCT05437224Phase 3
• A Study of Two Macitentan Formulations in Healthy Adult ParticipantsCompletedNCT05433675Phase 1
• A Study of Two Different Test Formulations Compared to the Reference Formulation of Macitentan in Healthy Adult ParticipantsCompletedNCT05392530Phase 1
• A Study of Fixed Dose Combination of Macitentan/Tadalafil (10 mg/20 mg) Compared to the Reference Free Combination of Macitentan and Tadalafil in Healthy Adult ParticipantsCompletedNCT05236231Phase 1
• Bioequivalence Study of Different Aprocitentan Tablet FormulationsCompletedNCT05196399Phase 1
• Reflex Responses to Intermittent Hypoxia in Humans: Mechanisms and ConsequencesCompletedNCT05146089Early Phase 1
• Effects of Combination Medical Therapy Followed by BPA on Right Ventricular-PA Coupling and Hemodynamics in CTEPHTerminatedNCT05140525Phase 3
• A Study to Assess Zibotentan Pharmacokinetics in Participants With Moderate Hepatic and Moderate Renal ImpairmentCompletedNCT05112419Phase 1
• Study to Collect Samples for MIST Analysis of Zibotentan and Bioavailability of Zibotentan and Dapagliflozin in Heatlhy ParticipantsCompletedNCT04991571Phase 1
• Effect of BIA 5-1058 400 mg on the Steady State Pharmacokinetics of BosentanCompletedNCT04991207Phase 1
• A Study of Two Macitentan Pediatric Formulations in Healthy Adult ParticipantsCompletedNCT04963439Phase 1
• Insulin Stimulated Vasodilation in Patients With Type 2 DiabetesStatus unknownNCT04907838Not applicable
• Initial Dual Oral Combination Therapy Versus Standard-of-care Initial Oral Monotherapy Prior to Balloon Pulmonary Angioplasty in Patients With Inoperable Chronic Thromboembolic Pulmonary HypertensionCompletedNCT04780932Phase 2/3
• A Study of Micro Dose Ambrisentan in Hospitalized Patients With Respiratory Insufficiency Due to COVID-19TerminatedNCT04771000Phase 2
• Atrasentan in Patients With Proteinuric Glomerular DiseasesActive, not recruitingNCT04573920Phase 2
• Atrasentan in Patients With IgA NephropathyActive, not recruitingNCT04573478Phase 3
• A Study of Macitentan/Tadalafil Combination Administered a Fixed-dose Combination Formulation Compared to the Reference Free Combination of Macitentan and TadalafilCompletedNCT04540744Phase 1
• Pilot Study of the Safety and Efficacy of Sulfasalazine in Pulmonary Arterial HypertensionStatus unknownNCT04528056Phase 1/2
• A Study of Macitentan, in Healthy Japanese Male ParticipantsCompletedNCT04500808Phase 1
• Effects of Endothelin Receptor Antagonist on Ischemic Kidney Injury During Nephron Sparing SurgeryStatus unknownNCT04450095Phase 2
• mulTi-Arm Therapeutic Study in Pre-ICu Patients Admitted With Covid-19 - Experimental Drugs and MechanismsCompletedNCT04393246Phase 2/3
• To Study the Effect of Aprocitentan on the Electrical Activity of the Heart in Healthy Men and WomenCompletedNCT04281342Phase 1
• Outcome Study Assessing a 75 Milligrams (mg) Dose of Macitentan in Patients With Pulmonary Arterial HypertensionActive, not recruitingNCT04273945Phase 3
• The Effect of Hepatic Impairment on Aprocitentan PharmacokineticsCompletedNCT04252495Phase 1
• A Study of Macitentan and Tadalafil as a Fixed Dose Combination and the Free Combination in Healthy Adult ParticipantsCompletedNCT04235270Phase 1
• A 2-part Study to Investigate the Effect of Macitentan in Healthy Male ParticipantsCompletedNCT04211272Phase 1
• A Research Study to Show Aprocitentan is Efficacious and Safe to Treat Patients With Uncontrolled Blood Pressure and Chronic Kidney Disease.WithdrawnNCT04162366Phase 3
• Gemcitabine, Nab-Paclitaxel, and Bosentan for the Treatment of Unresectable Pancreatic CancerSuspendedNCT04158635Phase 1
• Bioequivalence Study of Bosentan 125 mg Tablets Immediate Release (IR) Versus Tracleer® 125 mg Tablets IR In Healthy SubjectsCompletedNCT04101370Phase 1
• Precision Medicine With Zibotentan in Microvascular AnginaCompletedNCT04097314Phase 2
• Safety of Bosentan in Type II Diabetic PatientsCompletedNCT04068272Phase 1
• A Study Evaluating the Utility of Ambrisentan in Lowering Portal Pressure in Patients With Liver CirrhosisTerminatedNCT03827200Phase 2
• A Clinical Study to Find Out if Macitentan is Effective and Safe in Japanese Patients With Chronic Thromboembolic Pulmonary Hypertension (CTEPH).TerminatedNCT03809650Phase 3
• CompRehensive Phenotypic Characterization of Patients With Scleroderma-Associated ILD and PHWithdrawnNCT03726398Phase 2/3
• The Effect of Endothelin and L-Arginine on Racial Differences in VasoconstrictionCompletedNCT03679780Phase 1
• A Study in Healthy Subjects to Investigate Whether Administration of Clazosentan Can Affect Normal Heart FunctionCompletedNCT03657446Phase 1
• A Study in Healthy Male Subjects to Investigate Whether Administration of Rifampicin Can Affect the Fate of Clazosentan in the Body of ClazosentanCompletedNCT03596294Phase 1
• A Study to Evaluate How Aprocitentan is Safe and How it is Absorbed and Broken Down in the Body of Japanese and Caucasian SubjectsCompletedNCT03586570Phase 1
• A Clinical Study to Investigate the Long-term Safety of the Drug Macitentan in Patients With Pulmonary Hypertension Who Were Previously Treated With Macitentan in Clinical Studies.CompletedNCT03422328Phase 3
• Clinical Study to Investigate Effect of Macitentan on Riociguat PharmacokineticsCompletedNCT03389321Phase 1
• (RIGHT HEART III Study - Right Ventricular Hemodynamic Evaluation and Response to Treatment)CompletedNCT03362047Phase 2
• Clinical Study to Investigate the Effect of Macitentan on the Concentrations of Rosuvastatin in the Blood of Healthy Male SubjectsCompletedNCT03359291Phase 1
• Efficacy and Safety of Combination Ambrisentan and Tadalafil in Patients With Portopulmonary HypertensionWithdrawnNCT03309592Phase 4
• A Study in Healthy Male Subjects to Investigate Whether Administration of ACT-132577 Can Affect Rosuvastatin's Fate in the Body (Amount and Time of Presence in the Blood)CompletedNCT03245229Phase 1
• the Effect of Tracleer on Tourniquet-associated HypertensionStatus unknownNCT03229694Phase 4
• A Study to Compare the Macitentan-tadalafil Fixed Dose Combination Tablet Relative to the Concomitant Administration of the Reference Tablets of Macitentan and Tadalafil in Healthy SubjectsCompletedNCT03215966Phase 1
• A Study to Evaluate ACT-132577 in Healthy Subjects and in People With Severe Kidney DiseaseCompletedNCT03165071Phase 1

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