Drug
Belzutifan clinical trials
Also written WELIREG™, MK-6482 and PT2977.
- studies test it
- 34
- open now
- 11
- in phase 3
- 7
- first study started
- 2016
Keep track of what changes. Save the belzutifan studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Studies by the year they started
34 studies that test it; most in 2025 (6)
| Year | Studies |
|---|---|
| 2016 | 2 |
| 2018 | 3 |
| 2020 | 5 |
| 2021 | 5 |
| 2022 | 5 |
| 2024 | 4 |
| 2025 | 6 |
| 2026 | 4 |
By phase
A phase 1/2 study counts in both.
- Phase 1
- 14
- Phase 2
- 17
- Phase 3
- 7
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 26 · Other 8
Merck Sharp & Dohme LLC (21) · Peloton Therapeutics, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) (4) · Dana-Farber Cancer Institute (2) · M.D. Anderson Cancer Center (2) · Vall d'Hebron Institute of Oncology (1) · HiberCell, Inc. (1) · Cambridge University Hospitals NHS Foundation Trust (1) · José Claudio Casali da Rocha (1)
Often tested with
Tested in the same studies.
Pembrolizumab (6) · Pembrolizumab/Quavonlimab MK-1308A (4) · Lenvatinib (4) · Vibostolimab/Pembrolizumab MK-7684A (2) · Cabozantinib (2) · Favezelimab (2) · Palbociclib (1) · Carboplatin (1)
Studies
Open first, then newest update. How each study uses belzutifan is read from its arms, and is right about nine times in ten.
Testing it · 34
- A Study of Belzutifan in Adolescent Participants With Solid Tumors (MK-9999-01E/LIGHTBEAM-U01)RecruitingPhase 2Merck Sharp & Dohme LLCNCT07700758Written as Belzutifan
- Belzutifan/MK-6482 for the Treatment of Advanced Pheochromocytoma/Paraganglioma (PPGL), Pancreatic Neuroendocrine Tumor (pNET), Von Hippel-Lindau (VHL) Disease-Associated Tumors, Advanced Gastrointestinal Stromal Tumor (wt GIST), or Solid Tumors With HIF-2α Related Genetic Alterations (MK-6482-015)RecruitingPhase 2Merck Sharp & Dohme LLCNCT04924075Written as Belzutifan
- Extension Study for Participants in Studies That Include Belzutifan (MK-6482-043/LITESPARK-043)RecruitingPhase 3Merck Sharp & Dohme LLCNCT07405164Written as Belzutifan
- A Study of HC-7366 in Combination With Belzutifan (WELIREG™) in Patients With Renal Cell CarcinomaRecruitingPhase 1HiberCell, Inc.NCT06234605Written as Belzutifan
- Phase II Trial of Single Agent Belzutifan or Pembrolizumab Versus Combination as Neoadjuvant Therapy in Clear Cell Renal Cell Carcinoma (BLAZE)RecruitingPhase 2M.D. Anderson Cancer CenterNCT07187778Written as Belzutifan
- A Clinical Study of Belzutifan and Zanzalintinib in People With Recurrent Kidney Cancer Following Adjuvant Therapy (MK-6482-033)RecruitingPhase 3Merck Sharp & Dohme LLCNCT07227402Written as Belzutifan
- An Experimental Study of Belzutifan Impact on Catecholamine MetabolismRecruitingPhase 2Cambridge University Hospitals NHS Foundation TrustNCT07680205Written as Belzutifan
- Belzutifan's Role in Active Surveillance Versus Treatment for Indolentmetastatic Clear Cell Renal Ccell Carcinoma (BRAVE-RCC)RecruitingPhase 2M.D. Anderson Cancer CenterNCT07023432Written as Belzutifan
- Pembrolizumab Plus Belzutifan With or Without Lenvatinib in Localized Renal Cell CarcinomaNot yet recruitingPhase 2Vall d'Hebron Institute of OncologyNCT07593040Written as Belzutifan
- Belzutifan in Recurrent Clear Cell Carcinoma of Gynecologic OriginRecruitingPhase 2Dana-Farber Cancer InstituteNCT06677190Written as Belzutifan
- Real-World Effectiveness and Pharmacogenetics of Belzutifan in VHL Syndrome: The BELIEVE-VHL TrialRecruitingPhase 2José Claudio Casali da RochaNCT07167329Written as Belzutifan
- Effects of Belzutifan on 89Zr-DFO-girentuximab PET Uptake in Patients With Renal Cell Carcinoma (RCC)WithdrawnPhase 1NYU Langone HealthNCT07179770Written as Belzutifan
- A Study of Belzutifan (MK-6482) Versus Everolimus in Participants With Advanced Renal Cell Carcinoma (MK-6482-005)Active, not recruitingPhase 3Merck Sharp & Dohme LLCNCT04195750Written as Belzutifan
- A Study of Pembrolizumab (MK-3475) in Combination With Belzutifan (MK-6482) and Lenvatinib (MK-7902), or Pembrolizumab/Quavonlimab (MK-1308A) in Combination With Lenvatinib, Versus Pembrolizumab and Lenvatinib, for Treatment of Advanced Clear Cell Renal Cell Carcinoma (MK-6482-012)Active, not recruitingPhase 3Merck Sharp & Dohme LLCNCT04736706Written as Belzutifan
- Substudy 03B: A Study of Immune and Targeted Combination Therapies in Participants With Second Line Plus (2L+) Renal Cell Carcinoma (MK-3475-03B/KEYMAKER-U03)CompletedPhase 1/2Merck Sharp & Dohme LLCNCT04626518Written as Belzutifan
- Substudy 03A: A Study of Immune and Targeted Combination Therapies in Participants With First Line (1L) Renal Cell Carcinoma (MK-3475-03A)CompletedPhase 1/2Merck Sharp & Dohme LLCNCT04626479Written as Belzutifan
- A Study of Belzutifan (MK-6482) in Participants With Advanced Renal Cell Carcinoma (MK-6482-013)CompletedPhase 2Merck Sharp & Dohme LLCNCT04489771Written as Belzutifan
- A Trial of Belzutifan (PT2977, MK-6482) Tablets In Patients With Advanced Solid Tumors (MK-6482-001)Active, not recruitingPhase 1Peloton Therapeutics, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)NCT02974738Written as Belzutifan
- Study of Belzutifan (MK-6482) Plus Fulvestrant for ER+/HER2- Metastatic Breast Cancer (MK-6482-029/LITESPARK-029)Active, not recruitingPhase 2Merck Sharp & Dohme LLCNCT06428396Written as Belzutifan
- A Study of Pembrolizumab (MK-3475) in Combination With Belzutifan (MK-6482) and Lenvatinib (MK-7902), or Pembrolizumab/Quavonlimab (MK-1308A) in Combination With Lenvatinib, vs Pembrolizumab and Lenvatinib, for Treatment of Advanced Clear Cell Renal Cell Carcinoma (MK-6482-012)-China Extension StudyActive, not recruitingPhase 3Merck Sharp & Dohme LLCNCT05899049Written as Belzutifan
See all 34 studies that test belzutifan →
Given in every arm · 6 — belzutifan is usual care beside what is tested
- A Clinical Study of Belzutifan (MK-6482) and Zanzalintinib in People With Renal Cell Carcinoma (RCC) (LITESPARK-034/LS-034/MK-6482-034)RecruitingPhase 3Merck Sharp & Dohme LLCNCT07489495Written as Belzutifan
- A Clinical Trial of MK-2010 Alone and With Other Treatments in Participants With Advanced Solid Tumors (MK-2010-002)Not yet recruitingPhase 2Merck Sharp & Dohme LLCNCT07793942Written as Belzutifan
- Substudy 03C: A Study of Combination Therapies in Participants With Renal Cell Carcinoma With Recurrent Disease During or After Anti-PD-(L)1 Therapy (MK-3475-03C/KEYMAKER-U03)RecruitingPhase 1/2Merck Sharp & Dohme LLCNCT07049926Written as Belzutifan
- Neoadjuvant Belzutifan Plus Pembrolizumab in High-Risk, Locally Advanced Clear Cell Renal Cell CarcinomaNot yet recruitingPhase 2Peter MacCallum Cancer Centre, AustraliaNCT07840001Written as Belzutifan
- A Study of Belzutifan (MK-6482) as Monotherapy and in Combination With Lenvatinib (E7080/MK-7902) With or Without Pembrolizumab (MK-3475) in China Participants With Advanced Renal Cell Carcinoma (MK-6482-010)Active, not recruitingPhase 1Merck Sharp & Dohme LLCNCT05030506Written as Belzutifan
- A Phase 1, Dose-Escalation Trial of PT2385 Tablets In Patients With Advanced Clear Cell Renal Cell Carcinoma (MK-3795-001)Active, not recruitingPhase 1Peloton Therapeutics, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)NCT02293980Written as Bezlutifan
Codes
What other systems call belzutifan · ClinicalTrials.gg INT001767
- MeSH (NLM) C000720612belzutifanConfirmed ClinicalTrials.gov, NLM
- UNII (FDA) 7K28NB895LBELZUTIFANConfirmed FDA, NLM, Wikidata
- RxNorm 2567226One source FDA
- Wikidata Q27456641belzutifanConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C135627BelzutifanOne source FDA
- DrugBank DB15463One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | C000720612 | belzutifan | Confirmed ClinicalTrials.gov, NLM |
| UNII (FDA) | 7K28NB895L | BELZUTIFAN | Confirmed FDA, NLM, Wikidata |
| RxNorm | 2567226 | — | One source FDA |
| Wikidata | Q27456641 | belzutifan | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C135627 | Belzutifan | One source FDA |
| DrugBank | DB15463 | — | One source Wikidata |
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.