Alkylating agents: all 3,295 studies that test it
Page 1 of 33. Open to participants first (456), then studies with results posted, then the rest; newest registration first within each.
- Lifileucel (TIL) Therapy After PD-1 Blockade Failure in Kidney CancerNot yet recruitingNCT07925333Phase 2
- Thiotepa + TBI + Fludarabine + Etoposide for Allo-HSCT in Patients With R/R or High-risk Acute LeukemiaEnrolling by invitationNCT07920796Phase 2
- Risk-Enabled Therapy After Initiating EV/Pembro for Bladder CancerRecruitingNCT07908979Phase 2
- Efficacy and Safety of Polatuzumab Vedotin, Rituximab Combined With Reduced-dose Cyclophosphamide, Doxorubicin and Prednisone Regimen in the Treatment of Elderly Patients With Diffuse Large B-cell Lymphoma: A Multicenter, Single-arm, Prospective StudyRecruitingNCT07908888Phase 4
- A Prospective, Phase II, Exploratory Study Protocol of a Chemotherapy Sensitivity-based Culmerciclib Combination Regimen in Neoadjuvant Therapy for HR+/HER2- Breast Cancer.RecruitingNCT07900516Phase 2
- A Single-Arm, Open-Label, Multicenter Clinical Study of Teniposide Combined With Temozolomide for the Treatment of Newly Diagnosed Glioblastoma (nGBM) With MGMT Promotor Region UnmethylatedNot yet recruitingNCT07894549Not applicable
- Comparing Bispecific Antibody Treatment to Autologous Stem Cell Transplant for Newly Diagnosed, Standard Risk Multiple MyelomaNot yet recruitingNCT07887984Phase 2/3
- Metronomic Temozolomide With Dexbrompheniramine for Recurrent High-Grade Glioma/GlioblastomaNot yet recruitingNCT07859059Phase 1/2
- Efficacy and Safety of Cyclophosphamide in Amyotrophic Lateral SclerosisNot yet recruitingNCT07834450Phase 2
- A Clinical Study of HS-IT101 Injection in Patients With Advanced Non-Small Cell Lung Cancer(FASTIL-Lung02)RecruitingNCT07830342Phase 1
- Pembrolizumab and Radiation Therapy With or Without Neoadjuvant Doxorubicin and Ifosfamide for the Treatment of High-Risk Resectable Undifferentiated Pleomorphic Sarcoma or Liposarcoma of the Extremity or Trunk WallNot yet recruitingNCT07823491Phase 3
- Depletion of CD45RA Positive Naive T Cells for the Prevention of Graft Versus Host Disease in Older Patients Undergoing Allogeneic Hematopoietic Cell Transplantation for Acute Leukemia or Myelodysplastic SyndromeNot yet recruitingNCT07819396Phase 2
- Trial of Temozolomide in BAP1 Mutated Patients With Advanced or Metastatic Cutaneous MelanomaNot yet recruitingNCT07807878Phase 2
- 26DT052; Scaling Busulfan Dose to Body Surface Area in ChildrenNot yet recruitingNCT07792369Phase 1
- Thiotepa Administration Via Ommaya Reservoir for Leptomeningeal Metastases in Non-Small Cell Lung Cancer Resistant to EGFR-TKI.Not yet recruitingNCT07778940Phase 2
- Base-Edited Hematopoietic Stem/Progenitor Cell Gene Therapy for Treatment of CXCR4-WHIMEnrolling by invitationNCT07775313Phase 1/2
- A Study of VABu Conditioning Regimen in Allo-HSCT for AML PatientsNot yet recruitingNCT07762508Not applicable
- Genetically Engineered Cells (BAFFR-CAR T Cells) for the Treatment of Relapsed or Refractory B-cell Acute Lymphoblastic Leukemia and B-cell Lymphoblastic LymphomaNot yet recruitingNCT07758673Phase 1
- The Efficacy of CAPCT in Patients With PTCLNot yet recruitingNCT07746245Phase 2
- Neoadjuvant Angiogenesis-Targeting Bispecific Chemoimmunotherapy for TNBCNot yet recruitingNCT07743632Phase 2
- Paclitaxel Oral Solution in Triple Neagtive Breast Cancer Neoadjuvant Therapy: A Dose-Finding StudyRecruitingNCT07739485Phase 1/2
- Clinical Study of XNW5004 Combined With CHOP/CHOEP in the Treatment of Untreated Peripheral T-Cell LymphomaRecruitingNCT07730515Phase 1/2
- Low-Dose TBI Plus CAR T-Cell Therapy for Relapsed/Refractory DLBCL and Multiple MyelomaRecruitingNCT07725406Phase 1
- Testing the Addition of a New Anti-Cancer Drug, Glofitamab to Usual Chemotherapy for Burkitt and Double Hit LymphomaNot yet recruitingNCT07724457Phase 2/3
- Study of Autologous, Metabolically Optimized, CD137+ Tumor-Infiltrating Lymphocytes Followed by Consolidative Oral Cyclophosphamide, Bevacizumab, and PembrolizumabNot yet recruitingNCT07720180Phase 2
- To Study Lower Dose of Cyclophosphamide After Stem Cell Transplant for Blood CancersRecruitingNCT07719946Phase 2
- Temozolomide, With or Without WSD0922-FU, for the Treatment of EGFR-Mutant, IDH-Wildtype GlioblastomaRecruitingNCT07708961Phase 2
- Orelabrutinib Combined With Induction Therapy Followed by Sequential Monotherapy Maintenance in MCD Subtype Diffuse Large B-cell LymphomaNot yet recruitingNCT07677813Phase 2
- Metronomic Gemcitabine, Mitomycin C, and Thalidomide for Advanced Solid TumorsRecruitingNCT07671534Phase 2
- KCD (Carfilzomib/Cyclophosphamide/Dexamethasone) Regimen for the Treatment of Newly Diagnosed POEMS SyndromeRecruitingNCT07652879Phase 2
- Immuno-Targeted Therapy Plus Low-Dose Chemotherapy for Newly Diagnosed Adult Ph-Negative B-ALL: A Prospective Umbrella TrialNot yet recruitingNCT07643103Phase 2
- Automated Total Marrow and Lymphoid Irradiation for Allogeneic Hematopoietic Cell TransplantNot yet recruitingNCT07634536Phase 2
- Lomustine Combined With Anlotinib as Interventional Therapy for Extensive-stage Small Cell Lung Cancer Resistant to Second-line and Above TreatmentNot yet recruitingNCT07632209Phase 2
- VorAsidenib With Lomustine In Patients With rEcurrent IDH-mutaNT Glioma Harboring IDH1 and/or IDH2 MutationsNot yet recruitingNCT07629089Phase 1
- EGFR/HER2 Dual-Target CAR-NK Cells for Recurrent or Metastatic HNSCCRecruitingNCT07617805Phase 1/2
- Dual-Targeting CAR-NK Cells for Recurrent Ovarian Cancer (MSLN, FRα, MUC16) pt2RecruitingNCT07617753Phase 1/2
- Haploidentical Donor Hematopoietic Cell Transplant for Sickle Cell DiseaseRecruitingNCT07616154Phase 2
- A Prospective, Single-arm Clinical Study on the Safety and Efficacy of Ivoximab Combined With Temozolomide in the Treatment of Relapsed/Refractory GliomaRecruitingNCT07599371Phase 1/2
- Target-Selected CAR-NK Cells (CD30, CD5, or Mesothelin) for Relapsed/Refractory B2 Thymoma or Thymic CarcinomaRecruitingNCT07598955Phase 1/2
- FLUDARABINE-TREOSULFAN REDUCED INTENSITY CONDITIONING REGIMEN PRIOR HAPLOIDENTICAL STEM CELL TRANSPLANTATION WITH POST TRANSPLANTATION CYCLOPHOSPHAMIDE FOR OLDER AND/OR FRAIL PATIENTS WITH AMLNot yet recruitingNCT07598110Phase 2
- Bendamustine Versus Fludarabine/Cyclophosphamide for Lymphodepletion in Chimeric Antigen Receptor T-cell Immunotherapy (CAR-T): a Randomized Trial.RecruitingNCT07593482Phase 2
- Haplo-Cord HSCT for AML/MDSRecruitingNCT07588360Not applicable
- BSB-2002 After Cyclophosphamide and Fludarabine for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia Patients With NPM1 MutationNot yet recruitingNCT07583303Phase 1
- Total Marrow and Lymphoid Irradiation in Combination With Fludarabine and Melphalan as Conditioning for Allogeneic Peripheral Blood Stem Cell Hematopoietic Cell Transplant in Older Patients With Refractory and Relapsed Acute Myeloid Leukemia and High-risk Myelodysplastic SyndromeRecruitingNCT07582172Phase 2
- Clinical Study of the Safety and Efficacy of Allogeneic TCR-enhanced Vδ2 T Cell in Patients With Malignant Tumors.RecruitingNCT07570563Phase 1/2
- Cord Blood Transplantation in Children and Young Adults With Blood CancerRecruitingNCT07566377Phase 2
- Phase II Study of Ultrasound and ctDNA Guided Neoadjuvant Systemic Therapy for Patients With HER2-positive Early Breast Cancer (UC HER Trial)Not yet recruitingNCT07565324Phase 2
- Thiotepa-based Conditioning Regimen With De-escalated Post-graft Cyclophosphamide for Allogeneic Stem Cell Transplantation in Hematologic MalignanciesRecruitingNCT07565220Phase 1
- TBF Conditioning Regimen for Haploidentical Stem Cell Transplantation in Elderly AML Patients in First Complete RemissionNot yet recruitingNCT07563920Not applicable
- Focused Ultrasound Blood-Brain Barrier Opening in Pontine Diffuse Midline Glioma to Enhance Temozolomide Therapy: Pilot Feasibility Study (FIDES)Not yet recruitingNCT07562971Phase 1/2
- Comparative Evaluation of Clinical and Radiographic Outcomes of Mustard Gel (Brassica Nigra) and Mineral Trioxide Aggregate (MTA) as Pulpotomy Agents in Deciduous Molars- A Randomized Controlled TrialNot yet recruitingNCT07557290Phase 1
- Dual-target CLDN18.2/HER2 CAR-NK Cells for Advanced Gastric/GEJ CancerRecruitingNCT07551362Phase 1/2
- Dual-Targeting CAR-NK Cells for Recurrent/Progressive Glioblastoma and High-Grade GliomaRecruitingNCT07551336Phase 1
- Aclarubicin Plus Cyclophosphamide, Vincristine, and Prednisone (CAOP) in Patients With Previously Untreated Peripheral T-Cell LymphomaNot yet recruitingNCT07535762Phase 2
- Aclarubicin Plus Cyclophosphamide, Vincristine, and Prednisone (CAOP) in Patients With Previously Treated Cutaneous T-cell LymphomaNot yet recruitingNCT07535710Phase 1/2
- Stem Cell Transplantation for Participants With Germline RUNX1 Associated Blood CancersNot yet recruitingNCT07524530Phase 2
- SELECT-SLE: Biomarker-Guided CAR-T Target Selection for Refractory LupusRecruitingNCT07523542Phase 1/2
- Biomarker-Guided Dual-Target CAR-T Cells for Advanced Solid TumorsRecruitingNCT07523529Phase 1/2
- MT2025-35 Allogeneic Hematopoietic Stem Cell Transplantation Using Reduced Intensity Conditioning Treosulfan and Fludarabine, With Post-Transplant Cytoxan (PTCy) for the Treatment of Hematological DiseasesRecruitingNCT07493538Phase 2
- Dual-Target Nectin-4/HER2 CAR-NK Cells in Advanced Urothelial CarcinomaRecruitingNCT07492628Phase 1
- Safety and Efficacy of PIPAC Using Single Agent Mitomycin in Solid TumorsRecruitingNCT07487168Phase 1
- Dual-Targeting CAR-NK Cells for Recurrent/Progressive Glioblastoma and High-Grade GliomaRecruitingNCT07480941Phase 1
- Combined Systemic and Intraperitoneal Chemotherapy for Synchronous Gastric and/or Gastroesophageal Peritoneal CarcinomatosisRecruitingNCT07475286Phase 2
- A Study Comparing Higher Dose Chemotherapy Over a Shorter Amount of Time to Lower Dose Chemotherapy Plus Maintenance Over a Longer Amount of Time in Patients With Newly Diagnosed Intermediate-Risk Rhabdomyosarcoma (IR RMS)RecruitingNCT07466316Phase 3
- Integrating Biology for Safe Intensification of Glioblastoma Hypofractionated Treatment on the MR-LinacNot yet recruitingNCT07457307Phase 1
- A Study of Elranatamab and Cyclophosphamide in People With Multiple MyelomaRecruitingNCT07454382Phase 2
- The Safety and Efficacy of the Regimen of Thiotepa + Fludarabine +Granulocyte Colony-Stimulating Factor+ Cytarabine + Busulfan in Single Unrelated Umbilical Cord Blood TransplantationNot yet recruitingNCT07441967Phase 2
- Evaluating Efficacy of B7-H3-CAR T Cells Administered at the End of Upfront Map Chemotherapy in Patients With Newly Diagnosed High-Risk OsteosarcomaRecruitingNCT07428993Phase 2
- Thiotepa in Combination With Pirtobrutinib (a BTK Inhibitor) and Sintilimab (a PD-1 Inhibitor) for Frail or Relapsed/Refractory Primary or Secondary Central Nervous System LymphomaRecruitingNCT07416890Phase 2
- CAR BCMA-70 CAR-T Cells for the Treatment of High-risk Plasma Cell NeoplasmsRecruitingNCT07416682Early Phase 1
- Dual Administration Of Intraperitoneal And Intravenous TROP2-Directed CAR-NK With TGF-Beta Receptor 2 (TGFBR2) Knock Out (KO) Therapy For Colorectal Cancer-Related Peritoneal Carcinomatosis: A Phase 1/2 Trial ("Chip-CRC Trial")RecruitingNCT07411599Phase 1/2
- Fludarabine Plus Melphalan Versus Addition of Venetoclax to Fludarabine/Melphalan Conditioning Regimen for Allogeneic Hematopoietic Stem Cell Transplantation in AML/MDS Patients Aged > 50 Years: a Multicenter, Randomized, Phase 3 TrialRecruitingNCT07396480Phase 3
- 5G-PEARL: Paxalisib in Malignant Brain TumoursRecruitingNCT07391215Phase 1/2
- Modified R-MINE Regimen vs. R-GemOx Regimens on the Treatment of Late Relapsed DLBCLNot yet recruitingNCT07389356Not applicable
- Combination ADI-PEG 20, TMZ, and RT for Treatment of Newly Diagnosed High-grade Glioma (HGG)Not yet recruitingNCT07389278Phase 1/2
- Chemoimmunotherapy Combined With Autologous NK Cell Therapy for Pediatric Patients With Refractory and Relapsed High-Risk Neuroblastoma and GanglioneuroblastomaRecruitingNCT07375563Phase 3
- Neoantigen-Pulsed Autologous Dendritic Cell Vaccine Combined With Temozolomide for Newly Diagnosed GlioblastomaNot yet recruitingNCT07365280Phase 2
- Cyclophosphamide and Etoposide as a Metronomic Therapy in Advanced Head and Neck Squamous Cell CancerNot yet recruitingNCT07361133Phase 2
- TCR-T Cell Therapy for KRAS Mutation in Advanced Solid TumorsNot yet recruitingNCT07342738Early Phase 1
- Study of Treosulfan-Based Conditioning for HSCT in Nijmegen Breakage SyndromeNot yet recruitingNCT07316595Phase 2
- Framework for Optimizing, Refining, and Unifying Management of HSCT in Pediatric ALLRecruitingNCT07297914Phase 2/3
- Preconditioning With a Combination of Thiotepa, Cyclophosphamide, and Busulfan for Allogeneic Hematopoietic Stem Cell Transplantation in the Treatment of NK/T-Cell LymphomaNot yet recruitingNCT07276737Phase 2
- Pembrolizumab in Combination With Chemotherapy for the Treatment of Frail Hodgkin Lymphoma Patients Ineligible for Standard TreatmentRecruitingNCT07275216Phase 2
- Pressurized Intraperitoneal Aerosolized Chemotherapy With Mitomycin for the Treatment of Unresectable Appendix or Colorectal Cancer With Peritoneal Metastases, The IMPACT TrialRecruitingNCT07271355Phase 3
- CD45RA-depleted CD19-CAR T Cell Consolidation After TCRαβ+/CD19 B Cell-depleted Haploidentical Hematopoietic Cell Transplantation for Relapsed/Refractory CD19+ ALL and LymphomaRecruitingNCT07257419Phase 1
- Dose-Expansion Study of Low Dose Post-Transplant Cyclophosphamide/Tacrolimus/Ruxolitinib for Graft-versus-Host Disease (GVHD) Prophylaxis in Myeloablative Allogeneic Peripheral Blood Stem Cell TransplantationRecruitingNCT07249346Phase 2
- Combination of Tarlatamab and Temozolomide in Patients With Central Nervous System TumorsRecruitingNCT07243470Phase 1/2
- TC-G203 for Patients With GPC3-Positive Advanced Solid TumorsRecruitingNCT07242417Early Phase 1
- Glofitamab Plus Polatuzumab Vedotin and Zuberitamab in Patients With Newly Diagnosed Diffuse Large B-cell LymphomaNot yet recruitingNCT07231250Phase 2
- Pralatrexate With Bendamustine and Total-Body Irradiation Followed by Donor Stem Cell Transplant for the Treatment of Relapsed or Refractory T-Cell Non-Hodgkin LymphomaRecruitingNCT07225985Phase 1/2
- A Study to Evaluate the Efficacy and Safety of Belantamab Mafodotin in Combination With Cyclophosphamide, Bortezomib, and Dexamethasone in Adult Participants With Newly Diagnosed Amyloid Light Chain (AL) AmyloidosisRecruitingNCT07224672Phase 2
- Fludarabine and Intermediate-dose TBI Followed by PTCy in Patients Undergoing Allo Transplant for Heme MalignanciesRecruitingNCT07214688Phase 2
- Metastatic Ewing's Trial Testing Schedule Enhancement to Improve OutcomesRecruitingNCT07194044Phase 1
- Stupp Treatment With Intrathecal Injection of Thiotepa for Glioblastoma With Advanced SpreadRecruitingNCT07193654Phase 2
- Reduced Post-transplant Cyclophosphamide Dose in Patients Undergoing Haploidentical Hematopoietic Stem Cell Transplantation for Hematological MalignanciesRecruitingNCT07193420Phase 3
- Toripalimab ± Sequential Intravesical Gemcitabine-Mitomycin C for BCG-Unresponsive/-Intolerant High-Risk NMIBC: Open-Label Randomized Phase 2 StudyNot yet recruitingNCT07189793Phase 2
- Ibrutinib Followed by BR (Bendamustine and Rituximab) as a Time-Limited Therapy for Waldenström MacroglobulinemiaNot yet recruitingNCT07169565Phase 1
- Chemotherapy With Rituximab for Aggressive B-NHL in Children and AdolescentsRecruitingNCT07168980Phase 2/3
- Laser Interstitial Thermal Therapy (LITT) and Lomustine (CCNU) for Recurrent GlioblastomaRecruitingNCT07145112Phase 1
- A Study to Evaluate the Safety, Tolerability, and Preliminary Efficacy of NEUK203-215 Injection in Adult Chinese Patients With Relapsed/Refractory Autoimmune DiseasesRecruitingNCT07144462Early Phase 1