Venous Insufficiency clinical trials
The registry lists 162 studies for Venous Insufficiency across more than 10 countries. 14 are recruiting or about to start. 113 of them are mainly about Venous Insufficiency (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10. Counting its 2 narrower conditions too, such as Postthrombotic Syndrome: 231 studies, 34 open.
Get an email when these change. Save the Venous Insufficiency studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
See an example email
Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
One email a week for all your saved searches. Stop any time.
Who runs them
Boehringer Ingelheim (7) · Medical University of South Carolina (4) · Intervene, Inc. (4) · University of Zurich (4) · Imperial College London (3) · Medtronic Endovascular (3) · Izmir Democracy University (3) · University of Johannesburg (2)
What is being tested here
Drugs under test in Venous Insufficiency studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 6, phase 3 first
- May 2027Randomized, Placebo-crontrolled Clinical Trial Evaluating the Efficacy and Safety of Heparan Sulfate 120 mg Prolonged-Release Tablets Compared With Placebo in Patients With Chronic Venous Disease · Phase 3 · Barbara Maglione
- Jun 2027Design and Rationale of the COLT Study · Phase 3 · Azienda Sanitaria Locale ASL 6, Livorno
- Nov 2026HEMOVAR Study on Hemorrhoids and Varicose Veins · Aydin Adnan Menderes University
- Dec 2026Open Label Safety Investigation of Solutio™ Tumescent Catheter · MedVasc AB
- Feb 2027Therapeutic Efficacy of the Phlebology-oriented Thermal Cure at the Saint-Eloy Thermal Center in the Treatment of Symptoms of Severe Chronic Venous Insufficiency · Société d'Exploitation des Thermes d'Amnéville
- May 2027Impact of Chronic Venous Insufficiency on Outcomes After Total Knee Arthroplasty · SB Istanbul Education and Research Hospital
Who these studies take
Of the 9 Venous Insufficiency studies recruiting now, 6 (67%) set no upper age limit and 2 (22%) stop at 75 or younger. 0 (0%) take children under 18. 2 (22%) are for women only and 0 (0%) for men only; 1 (11%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 9 (100%) | 7 (78%) |
| 30 | 9 (100%) | 7 (78%) |
| 40 | 8 (89%) | 7 (78%) |
| 50 | 8 (89%) | 7 (78%) |
| 65 | 8 (89%) | 7 (78%) |
| 75 | 7 (78%) | 7 (78%) |
| 85 | 6 (67%) | 6 (67%) |
Across all 162 studies, recruiting or not: 24% stop at 75 or younger and 11% at 65; 8% take children; 6% are for women only and 0% for men only; 18% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Venous Insufficiency studies take
Of 46 interventional studies with no phase under Venous Insufficiency, half reached primary completion within 15 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 15 mo9–38 · 46 studies | — | 14 mo9–60 · 37 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
Studies
Recruiting first, then most recently updated. Showing 50 of 162. Browse all 162 → or search them.
- Open Label Safety Investigation of Solutio™ Tumescent CatheterNot yet recruitingNCT07823088Not applicable1 country
- Therapeutic Efficacy of the Phlebology-oriented Thermal Cure at the Saint-Eloy Thermal Center in the Treatment of Symptoms of Severe Chronic Venous InsufficiencyRecruitingNCT07362719Not applicable1 country
- Assessment of Venous Insufficiency and Clinical Features in LipedemaRecruitingNCT076030761 country
- Randomized, Placebo-crontrolled Clinical Trial Evaluating the Efficacy and Safety of Heparan Sulfate 120 mg Prolonged-Release Tablets Compared With Placebo in Patients With Chronic Venous DiseaseNot yet recruitingNCT07684833Phase 3
- HEMOVAR Study on Hemorrhoids and Varicose VeinsRecruitingNCT073174921 country
- Design and Rationale of the COLT StudyNot yet recruitingNCT07432529Phase 3
- Minimally Invasive Superficial Venous Insufficiency Surgery and Digital SedationRecruitingNCT06228365Not applicable1 country
- Clinical Study in Adult Patients With Purulent-inflammatory Processes of the Skin and Soft Tissues, Phase I-II of the Wound ProcessNot yet recruitingNCT06232421Phase 2/31 country
- Effects of Reformer Pilates in Pregnant WomenRecruitingNCT06777771Not applicable1 country
- The ROle of Compression StocKings in Heart Failure PatientsRecruitingNCT06350695Not applicable1 country
- Daily Duration of Compression Treatment in Patients With Symptomatic Chronic Venous DiseaseEnrolling by invitationNCT06175546Not applicable1 country
- Sulodexide in the Treatment of Chronic Primary Venous Disease of the Lower ExtremitiesRecruitingNCT05005052Phase 31 country
- Assessment of the Relationship Between Severity of Chronic Venous Obstruction and Venous ClaudicationRecruitingNCT056627611 country
- Feasibility of the InnoVein Valve and Delivery System for Chronic Venous InsufficiencyRecruitingNCT04253301Not applicable1 country
- Relatıonshıp Between Pelvıc Floor and Venous InsuffıcıencyCompletedNCT07478406Not applicable1 country
- Non-healing Venous Leg Ulcers Treated With Standard Care With or Without BR-ACCompletedNCT06811909Not applicable1 country
- Comparison of the Effects of Kinesio Taping and Interval Exercise in Patients Diagnosed With Venous Insufficiency: A Randomised Controlled TrialActive, not recruitingNCT07228585Not applicable1 country
- Impact of Chronic Venous Insufficiency on Outcomes After Total Knee ArthroplastyActive, not recruitingNCT075771411 country
- Respiratory and Physical Functions in Individuals With Chronic Venous InsufficiencyCompletedNCT061965411 country
- Apixaban vs Rivaroxaban vs No Anticoagulant to Prevent EHIT After Great Saphenous Vein Laser AblationCompletedNCT07699796Phase 41 country
- Prospective Cohort Study for Varicose Veins Incidence and Natural CourseActive, not recruitingNCT045467501 country
- Isolated Great Saphenous Vein Stripping for Treatment of Varicose Veins in Lower LimbsCompletedNCT07616115Not applicable1 country
- Cook Venous Valve System for Treatment of Chronic Venous InsufficiencyActive, not recruitingNCT05883943Not applicable1 country
- Investigation of Femoropopliteal In Situ Valve Formation With the InterVene SystemTerminatedNCT03216005Not applicable3 countries
- Venclose digiRF System Post Market StudyActive, not recruitingNCT05504070Not applicable1 country
- Chronic Venous Thrombosis: Relief With Adjunctive Catheter-Directed Therapy (The C-TRACT Trial)Active, not recruitingNCT03250247Not applicable1 country
- PICO Venous Leg Ulcers (VLU) Reimbursement StudyTerminatedNCT06510777Not applicable1 country
- Clinical Trial of Aesculus Hippocastanum and Associations Versus Diosmina and Hesperidina in Chronic Venous InsuficiencyCompletedNCT06579482Phase 41 country
- Digital Supported Compression Bandaging in Patients With Chronic Edema in the Lower LimbsCompletedNCT064381331 country
- Transient Elastography DEdicated to Cosmetology And Dermatology (TEDECAD)CompletedNCT02061254Not applicable1 country
- The Effects of Compression Stockings on Pressure Parameters in Patients With Chronic Venous InsufficiencyCompletedNCT01558024Not applicable1 country
- A Clinical Study to Evaluate the Effectiveness of a Novel Portable Non-Pneumatic Active Compression Device vs. an Advanced Pneumatic Compression Device for Treating Lower Extremity LymphedemaCompletedNCT05507346Not applicable1 country
- The Feasibility, Efficacy and Safety of UZit®: Single-arm Clinical Trial in Patients With Symptomatic Chronic Venous DiseaseCompletedNCT07236307Not applicable1 country
- Efficacy of Complex Decongestive Therapy (CDT) in Patients With Venous Insufficiency: a Experimental StudyCompletedNCT06231940Not applicable1 country
- Investigation of Femoropopliteal In Situ Valve Formation With the InterVene System (INFINITE-US)TerminatedNCT04225806Not applicable1 country
- Chronic Venous Insufficiency and BalneotherapyCompletedNCT060547371 country
- A Feasibility Study of the ReLeaf Catheter SystemTerminatedNCT02462096Not applicable1 country
- Investigation of Femoropopliteal In Situ Valve Formation With the InterVene System (INFINITE-Canada)WithdrawnNCT05047302Not applicable
- Efficacy of Diosmin and Hesperidin on Early Rehabilitation After Total Knee ArthroplastyCompletedNCT067534481 country
- Long-term Effects of Inspiratory Muscle Training in Chronic Venous InsufficiencyTerminatedNCT05982405Not applicable1 country
- The Effect of Inelastic Compression System on Quality of Life in People With Chronic Venous InsufficiencyCompletedNCT05051540Not applicable1 country
- Assessment of the Effect of Spa Therapy on the Quality of Life of Patients with Chronic Venous Insufficiency (NEYRAC)CompletedNCT05449743Not applicable1 country
- Lower Limb Venous Insufficiency and the Effect of Radiofrequency Treatment Versus Open SurgeryActive, not recruitingNCT02397226Not applicable1 country
- Investigation of the Transmission Pathways of Reflux in Patients With Chronic Venous InsufficiencyCompletedNCT063692071 country
- Impact of Endovenous Water Vapor Treatment on Quality of Life in Superficial Venous Insufficiency of the Lower LimbsWithdrawnNCT04534244Not applicable
- VAP-PRO-C6. Effectiveness and Tolerability of Venoactive Drugs in Combination Therapy in Patients With CVD (CEAP C6)CompletedNCT047577661 country
- Head Circumference Growth in Children With Ehlers-Danlos Syndrome Who Develop Dysautonomia Later in LifeCompletedNCT013679771 country
- Plantar Pressure Analysis and Foot Biomechanics in Lipedema and Chronic Venous DiseaseCompletedNCT062387911 country
- Game-Based Foot & Ankle Exercise for Those With Lower Extremity EdemaCompletedNCT05520008Not applicable1 country
- EdemaWear to Reduce Edema in Hospitalized Patients With CVI:TerminatedNCT03904602Not applicable1 country