An observational study in Lipedema, Venous Insufficiency and Venous Disease, sponsored by Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey. Recruiting at 1 site in Turkey (Türkiye). Open to female participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2026-07-14.
Sponsored by Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey · Observational
Among 41 studies in Lipedema with a site in Turkey — 18 open to participants now, 19 under way, none of them phase 3. Lipedema · Turkey.
Among the 41 studies in Lipedema with a site in Turkey, this one is the 13th largest by planned enrollment of the 27 observational ones, is one of 18 that started in 2026, is one of 27 observational ones, reaches primary completion later than 5 of the 18 other live ones, and was the 27th registered.
85 studies on the registry are indexed under Lipedema; 32 are open to participants now.
This study's planned enrollment of 82 is close to the median of 90 across 42 observational studies indexed under Lipedema.
Browse Lipedema studies →18 of the 41 studies in Lipedema with a site in Turkey are open now, in 1 country. Each count lists the studies.
Of the 19 Lipedema studies recruiting now, 3 (16%) set no upper age limit and 16 (84%) stop at 75 or younger; 0 take children under 18; 4 take healthy volunteers.
This study: 18 Years to 65 Years · female · no healthy volunteers.
The full table on the hub →41 studies; the count open now beside each. This study's row is marked.
First in 2019; this study’s year is marked. 18 started in 2026.
Median enrollment 37 across the 14 interventional studies, 76 across the 27 observational. Of the 22 that completed or were terminated, 0 (0%) have results posted.
None of the 41 has an industry lead sponsor. The 10 most frequent:
Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey is the lead sponsor of 108 studies on the registry; 31 are open to participants now.
Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey has 4 studies filed under Lipedema — fewer than ten, so there is no comparison to draw.
10 of the studies in Lipedema with a site in Turkey that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07878299Sultan Abdulhamid Han Training and Research Hospital, Istanbul, TurkeyComparison of Segmental Body Composition Characteristics in Lipedema and Obesity | 2026-11-20 |
| NCT07683559Atlas UniversityExtracorporeal Shock Wave Therapy in Patients With Lipedema | 2026-12-01 |
| NCT07919574Hatice Zehra FERHATLAREffectiveness of Kinesio Taping as an Adjunct to Conservative Treatment in Women With Lipedema | 2027-01-15 |
| NCT07803926Merve SEVINC GUNDUZManual and Self-Lymphatic Drainage Combined With Exercise in Women With Lipedema | 2027-01-20 |
| NCT07468097Marmara UniversityThe Impact of Metabolic Status on Pain and Central Sensitization in Women With Lipedema: A Cross-Sectional Observational Study | 2027-02-01 |
Among the 41 studies in Lipedema with a site in Turkey, from their registry updates:
Lipedema is a chronic adipose tissue disorder characterized by disproportionate fat accumulation, pain, tenderness, edema, and functional impairment. Venous symptoms such as heaviness, swelling, and discomfort are frequently reported in individuals with lipedema; however, the relationship between venous Doppler ultrasonography findings and lipedema-related clinical manifestations remains insufficiently investigated. This cross-sectional controlled study aims to evaluate venous insufficiency parameters in patients with lipedema using Doppler ultrasonography and to examine their associations with pain severity, lower extremity function, disease severity, and quality of life.
Lipedema is a chronic progressive disorder of subcutaneous adipose tissue that predominantly affects women and is characterized by symmetrical enlargement of the lower extremities, pain, tenderness, easy bruising, and functional limitation. Beyond adipose tissue abnormalities, vascular and microcirculatory alterations have increasingly been implicated in the pathophysiology of the disease. Many individuals with lipedema report symptoms suggestive of venous dysfunction, including leg heaviness, swelling, discomfort, and exercise intolerance. Nevertheless, the clinical significance of venous insufficiency in lipedema has not been fully clarified.This cross-sectional controlled observational study aims to investigate venous insufficiency findings in individuals with lipedema using venous Doppler ultrasonography and to explore their relationship with clinical symptoms and functional status. Venous reflux characteristics, venous diameters, and affected venous segments will be evaluated in the superficial and deep venous systems. These vascular findings will subsequently be analyzed in relation to lipedema severity, pain intensity, lower extremity function, anthropometric measurements, and patient-reported outcomes. By improving the understanding of venous involvement in lipedema, this study may contribute to more comprehensive diagnostic assessment and multidisciplinary management strategies for affected individuals. Patients with lipedema are expected to show more frequent venous insufficiency findings, which may be associated with increased symptom severity and functional limitation.
The study population will consist of adult female patients diagnosed with lipedema. Participants with lipedema will be recruited from the outpatient physical medicine and rehabilitation clinic. All participants will undergo clinical assessment and lower extremity venous Doppler ultrasonography.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Malignancy means cancer. Criteria about another or earlier malignancy ask whether you have had a different cancer, usually within a set number of years.
Some are commonly allowed, such as treated skin cancers other than melanoma and early cancers removed completely — check the exceptions this study lists.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Cancer (malignancy)
Malignancy means cancer. Criteria about another or earlier malignancy ask whether you have had a different cancer, usually within a set number of years.
Some are commonly allowed, such as treated skin cancers other than melanoma and early cancers removed completely — check the exceptions this study lists.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Patients with lipedema
Diagnostic Test: Venous Doppler Ultrasonography · Other: Numeric Rating Scale · Other: Lower Extremity Functional Scale · Other: Short Form-12 · Other: Lower Extremity Circumference at Standardized Anatomical Landmarks (cm) · Other: Clinical Staging
Participants will undergo lower extremity venous Doppler ultrasonography to evaluate venous insufficiency findings, including venous reflux characteristics, affected venous segments, and venous diameters in the superficial and deep venous systems.
Pain intensity will be evaluated using the Numeric Rating Scale, ranging from 0 (no pain) to 10 (worst imaginable pain).
Also known as: NRS
Functional status will be assessed using the Lower Extremity Functional Scale. The total score ranges from 0 to 80, with higher scores indicating better lower extremity function and lower disability levels.
Also known as: LEFS
Health-related quality of life will be assessed using the SF-12 questionnaire, including the Physical Component Summary (PCS-12) and Mental Component Summary (MCS-12) scores. Scores range from 0 to 100, with higher scores indicating better perceived health status and quality of life.
Also known as: SF-12
Circumference of both lower extremities will be measured using a non-stretch tape measure at the ankle, calf, knee, and thigh according to standardized anatomical landmarks. Measurements will be recorded in centimeters.
Lipedema stage will be determined according to clinical examination findings and established diagnostic criteria.
Presence of Venous Reflux on Doppler Ultrasonography
Venous reflux will be assessed using lower extremity venous Doppler ultrasonography. The presence of pathological reflux in great saphenous vein will be recorded according to standard venous ultrasound criteria.
Time frame: Baseline
Pain Severity (NRS)
Pain intensity will be assessed using the Numeric Rating Scale (NRS), ranging from 0 (no pain) to 10 (worst imaginable pain). Higher scores indicate greater pain severity.
Time frame: Baseline
Lower Extremity Function (LEFS)
Lower extremity function will be evaluated using the Lower Extremity Functional Scale (LEFS). Total scores range from 0 to 80, with higher scores indicating better functional status and lower disability levels.
Time frame: Baseline
Health-Related Quality of Life (SF-12)
Health-related quality of life will be assessed using the Short Form-12 (SF-12) questionnaire, including Physical Component Summary (PCS-12) and Mental Component Summary (MCS-12) scores. Scores range from 0 to 100, with higher scores indicating better quality of life and perceived health status.
Time frame: Baseline
Lower Extremity Circumference Measurements
Lower extremity circumferences will be measured at predefined anatomical landmarks to evaluate limb involvement and tissue distribution.
Time frame: Baseline
Duration of Venous Reflux on Doppler Ultrasonography
Reflux duration (milliseconds) in great saphenous vein will be recorded according to standard venous ultrasound criteria.
Time frame: Baseline
Great Saphenous Vein Diameter Measured by Doppler Ultrasonography
The diameter of the great saphenous vein will be measured in millimeters using lower extremity venous Doppler ultrasonography. Measurements will be recorded at predefined anatomical levels.
Time frame: Baseline
Plan to share: No — Individual participant data will not be made publicly available due to privacy and confidentiality considerations.
Started Jun 2026 (actual). Primary completion is estimated for Jul 2026, 1 month after the start.
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Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey →