Squamous Cell Carcinoma of Head and Neck: all 1,711 studies

Page 2 of 18. Open to participants first (544), then studies with results posted, then the rest; newest registration first within each.

• Nano-Carbon Iron Suspension Injection Combined With Radiotherapy for Solid Tumors Phase II Clinical TrialNot yet recruitingNCT07491783Phase 2
• Effect of Postbiotics on Microbiota and Systemic Immunomodulation of Pembrolizumab as First-Line Therapy in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma (RM HNSCC)RecruitingNCT07485296Phase 2
• H&N NEO-COMBAT XL: Neoadjuvant XL-092 (Zanzalintinib) and Pembrolizumab (Keytruda) in Surgically Resectable, HPV Negative Oral Cavity Squamous Cell Carcinoma (OCSCC)Not yet recruitingNCT07484139Phase 2
• Development of Patient Derived Xenografts (PDXs) and Analysis of Tyrosine Kinase Receptor Expression in Patients With Squamous Cell Head and Neck Cancer (HNSCC) to Study Resistance Mechanisms Induced by Standard TherapyNot yet recruitingNCT07471009
• Neoadjuvant Ficerafusp Alfa With Pembrolizumab in Resectable SCCRecruitingNCT07465276Phase 2
• A Phase 1 Study of EPI-326 in EGFR-mutant NSCLC and HNSCCRecruitingNCT07462377Phase 1
• Safety and Feasibility of Nivolumab-IRDye800CW in Patients With Head and Neck Squamous Cell Carcinoma (HNSCC)RecruitingNCT07460765Phase 1
• Neoadjuvant CADI-05 in Combination With Pembrolizumab for Surgically Resectable Locally Advanced Head and Neck Squamous Cell CarcinomasRecruitingNCT07455032Phase 1
• Impact of Early Response to First-line Anti-PD-1 Monotherapy in Patients With Recurrent and/or Metastatic (R/M) Head and Neck Squamous Cell Carcinoma, Assessed by 18F-FDG PET/CTRecruitingNCT07448727
• Iparomlimab and Tuvonralimab Plus Hypofractionated Radiotherapy and Chemotherapy for HAHNSCCRecruitingNCT07447570Phase 2
• Postoperative Radiotherapy Combined With Nimotuzumab Followed by Benmelstobart in High-Risk Patients With Head and Neck Squamous Cell CarcinomaRecruitingNCT07445048Phase 3
• Comparing Radiation Plus Cetuximab to Radiation Plus Chemotherapy in People With Head and Neck Cancer Who Cannot Receive CisplatinRecruitingNCT07441681Phase 3
• Camrelizumab Combined With EGFR Monoclonal Antibody or Chemotherapy for Perioperative Treatment of Locally Advanced Head and Neck Squamous Cell CarcinomaNot yet recruitingNCT07432087Phase 3
• Lattice-Based Radiotherapy and Chemoimmunotherapy for Oropharyngeal Squamous Cell CarcinomaNot yet recruitingNCT07428148Phase 1/2
• Window of Opportunity in Preserving Laryngeal Function TrialRecruitingNCT07423078Phase 2
• 5-Fluorouracil Response and Optimization STudy (The FROST Trial)RecruitingNCT07419464Phase 2
• A Single Arm Phase II Trial in p16-positive Oropharynx Cancer of Selective Dose De-escalation of nodAl VolumEs at Minimal Risk and Primary Site Disease (SAVED)Not yet recruitingNCT07418034Phase 2
• Diagnostic Performance Of 4D Dynamic LAFOV FDG-PET Acquisition for Differentiation of Residual Disease and Post-radiation Inflammation in Head Neck SCC Treated by Radiotherapy.RecruitingNCT07417605
• A Study Evaluating the Contribution of Non-Coplanar Beam Arrangement in Reducing Toxicity in Radiotherapy for Upper Aerodigestive Tract CancersNot yet recruitingNCT07413627Not applicable
• A Comprehensive Multiomic Biomarker Evaluation Across Two Single-arm Cohorts to Elucidate Mechanisms of Response and Resistance in Recurrent/Metastatic (R/M) Head and Neck Squamous Cell Carcinoma (HNSCC)RecruitingNCT07408063Phase 2
• Morning Versus Afternoon Administration of Immunotherapy for the Treatment of Advanced or Metastatic Solid Tumors, The Knight SHIFT StudyRecruitingNCT07405086Phase 4
• Postoperative Radiotherapy for Early-stage Oral Tongue Squamous Cell Carcinoma Patients With Risk Factors: a Prospective, Multicenter, Randomized Controlled, Open-labelled TrialRecruitingNCT07402525Not applicable
• Neoadjuvant Chemoimmunotherapy (Camrelizumab + Paclitaxel + Carboplatin) for Resectable HNSCCNot yet recruitingNCT07400094Phase 2
• H101 Plus TACE for r/m HNSCCRecruitingNCT07398664Phase 2
• Neoadjuvant Becotatug Vedotin Plus Pucotenlimab and Cisplatin for Locally Advanced Head and Neck Squamous Cell CarcinomaNot yet recruitingNCT07393477Phase 2
• Intralesional Chemotherapy (IC): Cisplatin + EpinephrineRecruitingNCT07392580Phase 2
• A Phase II Clinical Trial of Anti-EGFR Antibody-drug Conjugate (ADC) Combined With or Without Immune Checkpoint Inhibitors in the Neoadjuvant Treatment of Resectable Locally Advanced Head and Neck Squamous Cell CarcinomaRecruitingNCT07381075Phase 2
• A Single-arm, Phase II, Multi-center Clinical Trial of Sintilimab During the Perioperative Period in Patients With Resectable Locally Advanced Head and Neck Squamous Cell CarcinomaNot yet recruitingNCT07379424Phase 2
• Toripalimab ± Chemo as Neoadjuvant Therapy in LA-HNSCC: A Phase III TrialNot yet recruitingNCT07371897Phase 3
• Sintilimab Plus Chemotherapy as Neoadjuvant and Adjuvant Treatment for Locally Advanced Oral Squamous Cell CarcinomaRecruitingNCT07371611Phase 3
• Comparison of Efficacy Between De-escalated Surgery and Standard Surgery After Neoadjuvant Immunotherapy in Locally Advanced Head and Neck Squamous Cell CarcinomaRecruitingNCT07369882Not applicable
• Cyclophosphamide and Etoposide as a Metronomic Therapy in Advanced Head and Neck Squamous Cell CancerNot yet recruitingNCT07361133Phase 2
• Anti-Ly6E Exatecan ADC M7437 in Advanced Solid TumorsRecruitingNCT07360314Phase 1
• First in Human Study of QLS5316 in Solid TumorsNot yet recruitingNCT07358884Phase 1
• A Single-Arm Phase II Clinical Study of Docetaxel Combined With Nimotuzumab and Pucotenlimab as Second-Line and Beyond Therapy for Recurrent/Metastatic Head and Neck Squamous Cell CarcinomaNot yet recruitingNCT07354984Phase 2
• First in Human Study of SIM0610 in Solid TumorsRecruitingNCT07348211Phase 1
• Dual-energy CT vs. MRI in the Evaluation of Squamous Cell Carcinomas of the Oral Cavity and OropharynxRecruitingNCT07343271
• Intratumoral N17350 in Advanced Solid TumorsRecruitingNCT07339176Phase 1/2
• Lattice-Based Radiotherapy and Chemo-Immunotherapy for Oral Cavity Squamous Cell CarcinomaNot yet recruitingNCT07335380Phase 1
• Compare Radiotherapy Plus Nimotuzumab Versus Radiotherapy Alone in Platinum-ineligible Patients With Locoregionally Advanced Head and Neck Squamous Cell CarcinomaRecruitingNCT07333274Phase 3
• De-Escalation Surgery After Immunotherapy in Locally Advanced Head and Neck Squamous Cell CarcinomaNot yet recruitingNCT07320690Phase 3
• Effectiveness of Hydrogen Water Intervention on Acute Oral Inflammation, Oral Microbiota, and Pain Following Free Flap Reconstruction in Patients With Oral CancerNot yet recruitingNCT07306546Not applicable
• ABY-029 Head & Neck TrialNot yet recruitingNCT07279116Phase 1
• A Study of Amivantamab in Addition to Standard of Care Agents (SOC) Compared With SOC Alone in Participants With Recurrent/Metastatic Head and Neck CancerRecruitingNCT07276399Phase 3
• A Study of Lutetium [177Lu]-BL-ARC001 in Patients With Locally Advanced or Metastatic Lung Cancer, Breast Cancer, Head and Neck Squamous Cell Carcinoma and Other Solid TumorsRecruitingNCT07274852Phase 1
• A Phase 1, Multicenter Imaging Study of LNTH-2403 in Participants With Locally Advanced or Metastatic Solid Tumors.Not yet recruitingNCT07272642Phase 1
• Study Comparing Ivonescimab Alone or Ivonescimab in Combination With Ligufalimab Versus Pembrolizumab for the Treatment of SCCHNRecruitingNCT07264075Phase 3
• SYS6010 Combined With Enlonstobart In Recurrent Or Metastatic Head And Neck Squamous Cell CarcinomaRecruitingNCT07254585Phase 2
• Neutrophil Biomarker Test for Predicting Clinical Benefit From Immunotherapy Based on Flow Cytometry AnalysisNot yet recruitingNCT07246759
• SPECT-CT Guided ELEctive Contralateral Neck Treatment in Lateralized Oropharyngeal CancerNot yet recruitingNCT07241273Not applicable
• A Study to Assess the Adverse Events, Change in Disease Activity, and How Oral ABBV-711 Tablets Move Through the Body as a Monotherapy and in Combination With Intravenously Infused Budigalimab (ABBV-181), in Adults With Advanced Squamous TumorsRecruitingNCT07241039Phase 1
• A Study of BL-M24D1 in Patients With Locally Advanced or Metastatic Head and Neck Squamous Cell Carcinoma and Other Solid TumorsRecruitingNCT07232524Phase 1
• A Study of KIVU-107 in Participants With Locally Advanced or Metastatic Solid TumorsRecruitingNCT07229313Phase 1
• A Study of JNJ-90301900 in Combination With Chemoradiation Therapy in Participants With Locally Advanced Head and Neck Squamous Cell CarcinomaRecruitingNCT07219212Phase 1
• Study Evaluating [18F]NOTA-ABY030 for Safety and Tolerability of Indeterminate Primary and/or Metastatic Disease in Head and Neck Squamous Cell CarcinomaRecruitingNCT07217028Phase 1
• FT836 With or Without Chemotherapy and/or Monoclonal Antibodies, in Participants With Advanced Solid TumorsRecruitingNCT07216105Phase 1
• PDT For Induction Therapy For Head And Neck CancerRecruitingNCT07214987Phase 2
• Phase I/ II Trial Combining PD-1 Inhibition and Neoadjuvant Proton or Photon Radiation Therapy in Recurrent Head and Neck Squamous Cell CarcinomaRecruitingNCT07213934Phase 1/2
• Surgeon-performed Ultrasound for Real-time Guidance In Oral Cancer Surgeries - A Multicenter Randomized Controlled TrialRecruitingNCT07203911Not applicable
• Impact of Patient-Reported Outcomes for Symptom Monitoring in Patients Followed for Head and Neck Squamous Cell Carcinoma (HNSCC)RecruitingNCT07190755Not applicable
• 177Lu-BetaBart in Patients With Relapsed/Refractory, Locally Advanced Inoperable, or Metastatic Solid TumorsRecruitingNCT07189871Phase 1/2
• A Phase 1 Study of NRM-823 in Participants With Locally Advanced or Metastatic Refractory Solid TumorsRecruitingNCT07182149Phase 1
• Proactive Risk-based Optimization & Notifications for Treatment & Outcomes in Head & Neck CancerRecruitingNCT07180901Not applicable
• A Study of GI-108, an Anti-CD73-IgG4 Fc-IL-2v Bispecific Fusion Protein, as Monotherapy in Patients With Advanced or Metastatic Solid TumorsRecruitingNCT07172802Phase 1/2
• CUE-101with Pembrolizumab for Locally Advanced HPV+HNSCCsRecruitingNCT07172256Phase 2
• [18F]-AraG PET Imaging in LA HNSCCNot yet recruitingNCT07168785Early Phase 1
• Testing the Addition of an Anti-Cancer Drug, Camonsertib, to Radiation Therapy for Recurrent Head and Neck Squamous Cell CarcinomaRecruitingNCT07156227Phase 1
• Phase 1/2 Study to Evaluate TH9619 in the Treatment of Advanced Solid TumorsRecruitingNCT07151040Phase 1/2
• Intraoperative Molecular Imaging Using ICG for Head and Neck TumorsRecruitingNCT07149207Phase 2
• Adebrelimab Combined With Carboplatin and Albumin-bound Taxanol in the Treatment of Resectable Locally Advanced Oral Squamous Cell Carcinoma Cardiac, Randomized, Phase II Exploratory StudyNot yet recruitingNCT07137858Phase 2
• A Phase I/II Trial of HCB101 in Combination With Pembrolizumab for Patients With Platinum-Refractory, Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma (SirH&N Trial)RecruitingNCT07136545Phase 1/2
• A Bidirectional Observational Clinical Study of NAIC in the Treatment of Tumor Regression Patterns in LA-OSCC and LA-OPSCCRecruitingNCT07133958
• Immune Response in Cervical Lymph Nodes of Patients With Head and Neck CancerRecruitingNCT07131566
• Primary Tumor Depth of Invasion and Lymph Node Management in Oral Squamous Cell CarcinomaNot yet recruitingNCT07127614
• Personalized Neck Radiation Therapy Directed by Sentinel Lymph Node Biopsy for the Treatment of Oral Cavity Squamous Cell Carcinoma, PRECEDENT TrialRecruitingNCT07121595Phase 2
• A Study to Investigate Safety of AZD6750 in Adult Participants With Select Advanced or Metastatic Solid TumorsRecruitingNCT07115043Phase 1/2
• A Phase 1/2 Trial of TER-2013 in Patients With Solid Tumors Harboring AKT/PI3K/PTEN Pathway AlterationsRecruitingNCT07109726Phase 1/2
• A Study of GV20-0251 in Advanced or Refractory Solid TumorsRecruitingNCT07106827Phase 1
• A Study of Nimotuzumab Plus Adebrelimab With Chemotherapy in Cisplatin-Ineligible Patients With Head And Neck Squamous Cell CarcinomaRecruitingNCT07105592Phase 1/2
• PD-1 Inhibitor Therapy Versus Radiotherapy in MPR Patients With Locally Advanced HNSCC After Neoadjuvant Immunochemotherapy (HNC-SYSU-006)Not yet recruitingNCT07090707Phase 2
• A Study to Learn About the Study Medicine Called PF-08046876 in People With Advanced Solid TumorsRecruitingNCT07090499Phase 1
• Iparomlimab and Tuvonralimab in HNSCCRecruitingNCT07090317Phase 2
• Evaluating Treatment Strategies for p53 Mutant Oral Cancer and Oral Cancer PrecursorsRecruitingNCT07090070Not applicable
• Sacituzumab Tirumotecan and Toripalimab in the First-line Treatment of HNSCCRecruitingNCT07088211Phase 2
• A First in Human Study of ALX2004 With Advanced or Metastatic Selected Solid TumorsRecruitingNCT07085091Phase 1
• Study of TI-0093 Injection With Recurrent/Metastatic HPV-16 Positive Solid TumorsRecruitingNCT07081984Phase 1
• Neoadjuvant and Adjuvant Sintilimab Plus Cetuximab in Locally Advanced Oral and Oropharyngeal Squamous Cell CarcinomaNot yet recruitingNCT07079410Phase 2
• A Study of Sacituzumab Govitecan in Combination With Cetuximab in People With Head and Neck Squamous Cell Cancer (HNSCC)RecruitingNCT07063212Phase 2
• A Trial of SHR-A2102 With Adebrelimab With or Without Other Anti-tumor Therapies in Recurrent/MetastaticHead and Neck Squamous Cell Carcinoma CancerRecruitingNCT07059221Phase 1/2
• Compartmentalized Postoperative Radiotherapy in Head and Neck CancerRecruitingNCT07058805Phase 2
• Single-Arm Exploratory Study of PD-L1 Antibody Plus Neoadjuvant Chemotherapy in Locally Advanced Head and Neck Squamous Cell CarcinomaRecruitingNCT07055841Phase 2
• Shortened Course of Radiation Therapy After Trans-oral Robotic Surgery in Patients With HPV-Mediated Oropharyngeal Squamous Cell Carcinoma.RecruitingNCT07044635Phase 2
• Finotonlimab Combined With Stapokibart in the Treatment of Recurrent/Metastatic HNSCCRecruitingNCT07040072Phase 1
• A Clinical Trail of KJ015 in Patients With HER2-Expressing Solid TumorsNot yet recruitingNCT07036185Phase 1
• DCSZ11 in Combination With Standard Therapy in Advanced or Metastatic Solid TumorsRecruitingNCT07035249Phase 1/2
• Study of CP-383 in Patients With Advanced or Metastatic Solid TumorsRecruitingNCT07030257Phase 1/2
• A Prospective Single-Arm Study（NCLDR）Not yet recruitingNCT07028918Early Phase 1
• Re-Radiochemotherapy and Pembrolizumab vs. Immuno(Chemo)Therapy for Locoregionally Recurrent PD-L1 Positive (CPS≥1) HNSCCRecruitingNCT07026474Phase 3
• Neoadjuvant Low-Dose Radiotherapy Combined With Adebrelimab and Single-Agent Albumin-Bound Paclitaxel Chemotherapy for Early-Stage Oral Squamous Cell Carcinoma: A Prospective, Single-Arm Clinical TrialRecruitingNCT07007364Phase 2
• A Study of DR-0202 in Patients With Locally Advanced or Metastatic, Relapsed or Refractory CarcinomasRecruitingNCT06999187Phase 1

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