Soft Tissue Infections clinical trials
The registry lists 92 studies for Soft Tissue Infections across more than 10 countries. 14 are recruiting or about to start. 44 of them are mainly about Soft Tissue Infections (how this is decided). Per ClinicalTrials.gov, last updated 2026-10-23.
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Who runs them
Pfizer (6) · Paratek Pharmaceuticals Inc (3) · Merck Sharp & Dohme LLC (3) · GBR Academy (3) · Inflammatix (3) · Ole Hyldegaard (3) · London Health Sciences Centre Research Institute and Lawson Research Institute of St. Joseph's (2) · Motif Bio (2)
What is being tested here
Drugs under test in Soft Tissue Infections studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 7
- Dec 2026Irrigating vs Traditional Negative Pressure Wound Therapy to Treat Necrotizing Soft Tissue Infections · HealthPartners Institute
- Dec 2026Shorter Versus Extended Course of Antibiotic Therapy for Necrotizing Soft Tissue Infections · University of California, Irvine
- Dec 2026Delafloxacin Plasma and Tissue Concentration in Patients With Skin, Soft Tissue, and Bone and Joint Infections. · IRCCS San Raffaele
- Jan 2027A Phase I Clinical Trial to Evaluate CMS-F021 Following Single and Multiple Doses in Healthy Participants · Dermavon Holdings Limited
- Feb 2027Follow-up Automatically vs. As-Needed Comparison (FAAN-C) Trial · University of Utah
- Mar 2027Necrotizing Soft Tissue Infections · European Society for Trauma and Emergency Surgery
- Oct 2027Randomized Controlled Study on the Safety and Efficacy of Phage Cocktail in the Treatment of Multidrug-Resistant Bacterial Skin Infections · First Affiliated Hospital Xi'an Jiaotong University
Who these studies take
Of the 8 Soft Tissue Infections studies recruiting now, 5 (63%) set no upper age limit and 3 (38%) stop at 75 or younger. 2 (25%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 2 (25%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 2 (25%) | 2 (25%) |
| 18 | 8 (100%) | 8 (100%) |
| 30 | 7 (88%) | 7 (88%) |
| 40 | 7 (88%) | 7 (88%) |
| 50 | 7 (88%) | 7 (88%) |
| 65 | 6 (75%) | 6 (75%) |
| 75 | 5 (63%) | 5 (63%) |
| 85 | 5 (63%) | 5 (63%) |
Across all 92 studies, recruiting or not: 21% stop at 75 or younger and 18% at 65; 21% take children; 1% are for women only and 1% for men only; 14% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Soft Tissue Infections studies take
Of 14 interventional studies with no phase under Soft Tissue Infections, half reached primary completion within 32 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 32 mo25–45 · 14 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
Studies
Recruiting first, then most recently updated. Showing 50 of 92. Browse all 92 → or search them.
- Irrigating vs Traditional Negative Pressure Wound Therapy to Treat Necrotizing Soft Tissue InfectionsRecruitingNCT07120386Not applicable1 country
- Naproxen Versus Placebo as Adjunct Treatment of CellulitisNot yet recruitingNCT07665476Phase 31 country
- Automatic Versus As-Needed Follow-up After Hospitalization for Children With Medical ComplexityNot yet recruitingNCT07864636Not applicable1 country
- A Phase I Clinical Trial to Evaluate CMS-F021 Following Single and Multiple Doses in Healthy ParticipantsRecruitingNCT07790770Phase 11 country
- Randomized Controlled Study on the Safety and Efficacy of Phage Cocktail in the Treatment of Multidrug-Resistant Bacterial Skin InfectionsEnrolling by invitationNCT07619924Early Phase 11 country
- Delafloxacin Plasma and Tissue Concentration in Patients With Skin, Soft Tissue, and Bone and Joint Infections.Not yet recruitingNCT07426471
- The Role of Circadian Clock Proteins in Innate and Adaptive ImmunityRecruitingNCT03482245Not applicable1 country
- Shorter Versus Extended Course of Antibiotic Therapy for Necrotizing Soft Tissue InfectionsRecruitingNCT060026071 country
- FATAL-NSTI Study (Factors Associated With In-hospital mortALity in NSTI).RecruitingNCT073596511 country
- Follow-up Automatically vs. As-Needed Comparison (FAAN-C) TrialRecruitingNCT05471908Not applicable1 country
- Necrotizing Soft Tissue InfectionsEnrolling by invitationNCT071075551 country
- Fosfomycin I.v. for Treatment of Severely Infected PatientsRecruitingNCT029799515 countries
- PATH Study: People With Injecting Related Infections: Assessing Treatment Outcomes for Those Who Are Hospitalised.Not yet recruitingNCT06220370
- Characteristics of Patients With Necrotizing Soft Tissue InfectionsRecruitingNCT048016151 country
- Discharge Stewardship in Children's HospitalsCompletedNCT05826873Not applicable1 country
- Anchoring Sequential Intermittent Long Acting Antimicrobials With Medication for Opioid Use Disorder (MOUD) for Invasive Infections Related to Opioid UseTerminatedNCT05521880Phase 41 country
- Staph Intervention for Effective Local DefenseCompletedNCT06210594Phase 41 country
- Exploring if Patients Can Safely and Easily Swab Their Own Surgical Wounds at HomeCompletedNCT07200401Not applicable1 country
- Comparing Oral Versus Parenteral Antimicrobial TherapyTerminatedNCT05977868Phase 41 country
- A Pilot Study to Evaluate Skin Swabbing With Chlorhexidine to Prevent Skin And Soft Tissue Infections Among People Who Inject DrugsCompletedNCT06733506Phase 41 country
- Safety, Immunogenicity and Efficacy of GSK S. Aureus Candidate Vaccine (GSK3878858A) When Administered to Healthy Adults (Dose-escalation) and to Adults 18 to 64 Years of Age With a Recent S. Aureus Skin and Soft Tissue Infection (SSTI)CompletedNCT04420221Phase 2
- Reinforced PTFE Meshes Versus Customized Titanium MeshesCompletedNCT04257097Not applicable1 country
- TriVerity in the Diagnosis and Prognosis of Emergency Department Patients With Suspected Infections and Suspected SepsisCompletedNCT040948182 countries
- Comparative Effectiveness of Emergency Ultrasound Guided Management of Pediatric Soft Tissue InfectionsCompletedNCT020992271 country
- Antibiotic Therapy in Infections of the Diabetic Foot SyndromeCompletedNCT056163511 country
- The All Ireland Infectious Diseases Cohort ProjectStatus unknownNCT064100531 country
- Retrospective Chart Review Study to Assess Characteristics, Treatment Outcomes and Resource Use of Adults Hospitalized for CAP and CSSTi Treated With Zinforo in Multiple CountriesCompletedNCT041985717 countries
- Sepsis Prognosis and Diagnosis in the Emergency Department (SPEED)WithdrawnNCT05639504
- ASAP: Access to Syringes at Pharmacies for the Prevention of Bloodborne Infections Among People Who Inject DrugsCompletedNCT05270135Not applicable1 country
- Dalbavancin Outpatient PilotWithdrawnNCT03982030Phase 4
- Clinical Effectiveness of Polymethoxy Flavones Solid Dispersion as a Dressing Material for Palatal Grafts Donor SitesStatus unknownNCT05814003Not applicable1 country
- Staphylococcus Aureus Toxoids Phase 1-2 Vaccine TrialCompletedNCT01011335Phase 1/21 country
- Negative Pressure Wound Therapy and Allogeneic Human Skin Grafts for Wound Bed PreparationWithdrawnNCT02314468Not applicable1 country
- The PLUS Study: Comparison of VicrylPlus® Versus Vicryl® for Repair of Perineal TearsCompletedNCT02863874Not applicable1 country
- Three-dimensional Bone Regeneration Using Custom-made Meshes With and Without Collagen MembraneCompletedNCT04286334Not applicable1 country
- Improving Safety of Diagnosis and Therapy in the Inpatient SettingCompletedNCT04393909Not applicable1 country
- Safety, Efficacy, and Pharmacokinetics (PK) of Daptomycin (MK-3009) in Japanese Pediatric Subjects With Complicated Skin and Soft Tissue Infections (cSSTI) and Bacteremia (MK-3009-029)CompletedNCT03643952Phase 21 country
- Daptomycin for the Treatment of Severe Necrotizing Soft-Tissue InfectionsCompletedNCT00261807Not applicable1 country
- Nurse-led Antimicrobial Stewardship Intervention to Increase Antibiotic Appropriateness in Residential Aged Care FacilitiesStatus unknownNCT03941509Not applicable1 country
- HostDx Sepsis in the Diagnosis and Prognosis of Emergency Department Patients With Suspected Infections: a Multicenter Pilot StudyCompletedNCT037447412 countries
- To Evaluate the Outcomes After Surgery for Necrotizing Soft Tissue InfectionsTerminatedNCT050326251 country
- The Effect of Irrisept for Irrigation of Skin and Soft Tissue Infections (Irrisept USF Study)TerminatedNCT01076049Not applicable1 country
- Evaluation of Safety, PK and Immunomodulatory Effects of AB103 in Necrotizing Soft Tissue Infections PatientsCompletedNCT01417780Phase 21 country
- Less Infections for the Diabetic FootCompletedNCT03615807Not applicable1 country
- Non-resorbable Membranes Versus Titanium Meshes and Resorbable MembranesCompletedNCT04332679Not applicable1 country
- RNAseq Analysis of Microbial Gene Expression in Necrotizing Soft Tissue InfectionsCompletedNCT020258161 country
- Loop Drainage Versus Incision and Drainage for AbscessesWithdrawnNCT03911518Not applicable
- Prognosis and Treatment of Necrotizing Soft Tissue Infections: A Prospective Cohort StudyCompletedNCT031473521 country
- Modulation of Biomarkers in Patients With Flesh-eating Bacterial Infections After With Hyperbaric Oxygen TreatmentCompletedNCT025013821 country
- Omadacycline Versus Linezolid for the Treatment of ABSSSI (EudraCT #2013-003644-23)CompletedNCT02378480Phase 314 countries