An observational study in Vertigo and MRI, sponsored by University of Pecs. Completed at 1 site in Hungary. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-02-27.
Sponsored by University of Pecs · Observational
Introduction: Dizziness is one of the most common complaints in medical practice and is associated with various underlying conditions, including neurological, otolaryngological, and psychological disorders. Preliminary imaging studies like CT, cervical spine X-rays, and carotid/vertebral artery ultrasound, aids in precise diagnosis and targeted therapeutic decisions. MRI is one of the most effective imaging modalities currently available for examining the brain.
Purpose: To identify structural brain changes linked to vertigo, explore pre-MRI diagnostic approaches, and evaluate treatment strategies.
Methods: The study included 232 patients with vertigo and 232 control subjects. MRI results were categorized, and pre-MRI examinations, symptoms, and treatments were analyzed. Statistical comparisons were conducted using chi-square and t-tests, with significance set at p\<0.05.
Vertigo is a prevalent symptom with multiple underlying etiologies, including neurological, vascular, and musculoskeletal causes. Despite its high prevalence, the exact structural brain abnormalities associated with vertigo remain unclear. This observational study aims to assess brain MRI findings in patients with vertigo and compare them to a control group without vertigo symptoms. The study also evaluates pre-MRI diagnostic procedures, such as vertebral/carotid ultrasound and cervical spine X-rays, to identify potential vascular and musculoskeletal contributors to vertigo. The results may provide insights into the structural brain changes linked to vertigo and help refine diagnostic and treatment strategies.
248 studies on the registry are indexed under Vertigo; 39 are open to participants now.
This study's enrollment of 464 is above the median of 151 across 50 observational studies indexed under Vertigo.
Browse Vertigo studies →University of Pecs is the lead sponsor of 100 studies on the registry; 24 are open to participants now.
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The study population consisted of adult patients (≥18 years) with vertigo who were referred for brain MRI to investigate potential structural abnormalities. A control group of individuals without a history of vertigo or neurological disorders was included for comparison. Exclusion criteria included prior neurological diseases, recent head trauma, and MRI contraindications.
Exclusion Criteria:
Participants in this group reported dizziness as a primary symptom and were referred for brain MRI to investigate potential structural abnormalities. Exclusion criteria included any pre-existing neurological disorders. The most common diagnoses after MRI included benign paroxysmal positional vertigo (BPPV) and vertebrobasilar syndrome.
Other: Observational Study - No intervention
Participants in this group did not report dizziness or other neurological symptoms. They underwent brain MRI for other reasons but had no history of neurological disorders. This group served as a comparison to evaluate the prevalence of brain structural abnormalities in vertigo patients.
Other: Observational Study - No intervention
This is an observational study evaluating brain structural abnormalities in post-COVID headache patients. No experimental intervention is applied.
Occurrences With Specific Structural Brain Abnormalities Observed on MRI
Brain MRI findings were analyzed to compare the occurrences of structural abnormalities between vertigo patients and control participants. The most commonly assessed abnormalities included white matter lesions, lacunar infarcts, Circle of Willis variations, and sinusitis. The occurrences (number and percentage) of these findings in each group will be compared using chi-square tests.
Time frame: From September 2020 to December 2022
Occurrences of associated symptoms in vertigo patients
The study evaluated the occurrences of associated symptoms, including headache, imbalance, visual disturbances, and psychological symptoms (anxiety and depression). Each symptom's occurrences (number and percentage) will be reported separately.
Time frame: From September 2020 to December 2022
Occurrences of pre-MRI diagnostic procedures in vertigo patients
The study assessed the occurrences of patients with vertigo undergoing pre-MRI diagnostic procedures, including carotid/vertebral ultrasound and cervical spine X-rays. Each procedure's occurrences (number and percentage) will be reported separately.
Time frame: From September 2020 to December 2022
Occurrences of post-MRI diagnoses in vertigo patients
The study analyzed the most common diagnoses after MRI, including vestibular migraine, benign paroxysmal positional vertigo (BPPV), and vascular dizziness. Each diagnosis's occurrences (number and percentage) will be reported separately.
Time frame: From September 2020 to December 2022
Occurrences of treatment strategies applied
The study evaluated the most frequent treatment strategies, including physical therapy, pharmacological treatment (e.g., betahistine), and lifestyle modifications. Each treatment's occurrences (number and percentage) will be reported separately.
Time frame: From September 2020 to December 2022
Plan to share: No
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This study is completed, as verified in Feb 2025. You cannot join it, but the record below documents what was studied.
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