An interventional study of Extended endoscopic sinus surgery and Limited endoscopic sinus surgery in Sinusitis, Chronic, Asthma and Nasal Polyps, sponsored by Helsinki University Central Hospital. Completed at 3 sites in 2 countries. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2025-03-18.
Sponsored by Helsinki University Central Hospital · Not applicable, Interventional, and Treatment
This randomized study compares operative techniques in chronic rhinosinusitis with polyposis (CRSwNP) surgery. It aims to evaluate outcomes in asthma and CRSwNP, safety and costs. The investigators want to see if patients with certain clinical and/or genetic predispositions will benefit from extended surgery. They also aim to find biomarkers for detection and management models for of severe airway inflammation and to further develop markers for progressive disease forms.
Please see study protocol
415 studies on the registry are indexed under Sinusitis; 46 are open to participants now.
This study's enrollment of 97 is above the median of 60 across 313 interventional studies indexed under Sinusitis.
Browse Sinusitis studies →Helsinki University Central Hospital is the lead sponsor of 299 studies on the registry; 60 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Extended sinus surgery including all sinuses
Procedure: Extended endoscopic sinus surgery
Limited sinus surgery with partial ethmoidectomy
Procedure: Limited endoscopic sinus surgery
ESS of all sinuses
Partial ethmoidectomy
Sino-nasal outcome test (SNOT-22)
Change from baseline in patient symptoms as measured by the Sino-Nasal Outcomes Test (SNOT-22) survey. Scores are measured from 0-5 in a 22 item validated survey. Total scores range from 0-110 with higher scores indicating greater burden of sinonasal symptoms.
Time frame: Baseline, Post-intervention every 3 months during 2 years
Documents are hosted by the registry — open the source record to download them.
Plan to share: Yes — Individual participant data that underlie the results reported in this article, after deidentification (text, tables, figures and appendices) can be shared.
Supporting information: Study protocol, Sap
This study is completed, as verified in Mar 2025. You cannot join it, but the record below documents what was studied.
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Helsinki University Central Hospital