Rheumatic Fever clinical trials
The registry lists 55 studies for Rheumatic Fever across more than 10 countries. 21 are recruiting or about to start. 31 of them are mainly about Rheumatic Fever (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-02. Counting its narrower condition Rheumatic Heart Disease too: 109 studies, 42 open.
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Who runs them
University Hospital, Brest (3) · Molde University College (2) · Diakonhjemmet Hospital (2) · Starship Child Health, Te Toka Tumai Auckland (2) · Aesculap AG (2) · Assiut University (2) · Assistance Publique - Hôpitaux de Paris (2) · National Human Genome Research Institute (NHGRI) (1)
What is being tested here
Drugs under test in Rheumatic Fever studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 5, phase 3 first
- May 2027TREAT-SC: Early, Short Course Oral Dexamethasone for the Treatment of Sydenham Chorea in Children · Phase 3 · Starship Child Health, Te Toka Tumai Auckland
- Nov 2026Effects of Paraffin Wax Therapy and Dry Cupping on Pain and Wrist Function in Patients With Rheumatoid Arthritis · University of Baghdad
- Jan 2027Intervention to Support Partners and Informal Caregivers of Frail RA-patients · Glostrup University Hospital, Copenhagen
- Oct 2027Dynamics in Bone Turnover Markers During and After Short-term Glucocorticoid Treatment in Patients With an Inflammatory Joint Disease · Diakonhjemmet Hospital
- Oct 2027Clinical Trial Phase I/IIa to Evaluate the Safety and Immunogenicity of StreptInCor · University of Sao Paulo General Hospital
Who these studies take
Of the 11 Rheumatic Fever studies recruiting now, 7 (64%) set no upper age limit and 3 (27%) stop at 75 or younger. 3 (27%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 4 (36%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 3 (27%) | 3 (27%) |
| 18 | 8 (73%) | 8 (73%) |
| 30 | 9 (82%) | 9 (82%) |
| 40 | 9 (82%) | 9 (82%) |
| 50 | 9 (82%) | 9 (82%) |
| 65 | 9 (82%) | 9 (82%) |
| 75 | 8 (73%) | 8 (73%) |
| 85 | 8 (73%) | 8 (73%) |
Across all 55 studies, recruiting or not: 47% stop at 75 or younger and 44% at 65; 29% take children; 4% are for women only and 2% for men only; 25% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
What changed recently
From the registry's own updates since Oct 13, 2026.
Newly registered2
Studies
Recruiting first, then most recently updated. Showing 50 of 55. Browse all 55 → or search them.
- Effects of Paraffin Wax Therapy and Dry Cupping on Pain and Wrist Function in Patients With Rheumatoid ArthritisNot yet recruitingNCT07905651Not applicable1 country
- Glucocorticoid-induced Osteoporosis in Patients With Chronic Inflammatory Rheumatic Diseases or PsoriasisRecruitingNCT027193141 country
- MENA/Levant Epidemiological, Registry of Immunological & Clinical Traits (MERIT)Not yet recruitingNCT078926511 country
- ACT4RHD is an Open-label, Randomised, Adaptive Platform Trial to Evaluate Novel and Repurposed Clinical Interventions for Patients With Acute Rheumatic Fever and Carditis. ACT4RHD Seeks to Determine Whether These Interventions Reduce RHD Severity at 6 Months.Not yet recruitingNCT07830108Phase 32 countries
- Dynamics in Bone Turnover Markers During and After Short-term Glucocorticoid Treatment in Patients With an Inflammatory Joint DiseaseRecruitingNCT063958831 country
- Justification of the Initial Diagnosis and Evaluation of the Overall Evolution of a Cohort of Recent Polymyalgia Rheumatica (JADORE)Not yet recruitingNCT071321641 country
- Improving Management and Secondary Prevention Through Azithromycin Comparative Trial in Rheumatic Heart Disease in Nigeria)- IMPACT-RHD NigeriaNot yet recruitingNCT07625228Not applicable
- Intervention to Support Partners and Informal Caregivers of Frail RA-patientsRecruitingNCT07442773Not applicable1 country
- IDENTIFICATION OF BIOMARKERS ASSOCIATED WITH THE SEVERITY AND RADIO-CLINICAL PROGRESSION OF KNEE OSTEOARTHRITISRecruitingNCT066009581 country
- Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation ResearchRecruitingNCT048066201 country
- School-based Program for the Prevention of Rheumatic Heart Disease in Endemic RegionsRecruitingNCT06720272Not applicable2 countries
- Study on the Detection of Pleuropulmonary Manifestations in Rheumatoid ArthritisRecruitingNCT069653221 country
- Effect of Home-Based Transcranial Direct Current Stimulation on Pain in Patients With Rheumatoid Arthritis With Low Inflammatory ActivityEnrolling by invitationNCT07162311Not applicable1 country
- Efficacy and Safety of Resveratrol in Patients With Rheumatoid Arthritis.RecruitingNCT07089381Not applicable1 country
- Clinical Trial Phase I/IIa to Evaluate the Safety and Immunogenicity of StreptInCorNot yet recruitingNCT07078357Phase 1/21 country
- Effectiveness of Edutainment-Based Interventions in Increasing Knowledge of Rheumatic Fever and Rheumatic Heart Disease Among School-Going Children in Nepal: Study Protocol for Colors to Save Hearts Quasi-Experimental Pretest-Posttest StudyNot yet recruitingNCT07065474Not applicable1 country
- TREAT-SC: Early, Short Course Oral Dexamethasone for the Treatment of Sydenham Chorea in ChildrenRecruitingNCT06259006Phase 32 countries
- Biomarkers in Inflammatory Rheumatic Diseases DiagnosisRecruitingNCT067783431 country
- Manual Diaphragmatic Release on Ventilatory Functions in Women With Rheumatoid ArthritisNot yet recruitingNCT06716008Not applicable
- Diagnostic Performance of 18-FDG PET-CT Scores for the Diagnosis of Polymyalgia RheumaticaNot yet recruitingNCT065583571 country
- ILD-SARDs Registry and BiorepositoryRecruitingNCT050073401 country
- PRediction Of DIverse Glucocorticoids toxIcity OUtcomeSActive, not recruitingNCT046644651 country
- Impact of COVID-19 Pandemic and Social Distancing on Mental Health of Chronic Inflammatory Rheumatism Affected PatientsCompletedNCT04798053Not applicable1 country
- Plasmafit® Revision Structan® Hip Endoprosthesis CupActive, not recruitingNCT042559661 country
- CoreHip - Post Market Clinical Follow-Up StudyActive, not recruitingNCT036851102 countries
- Treat-to-target by Email During Urate-lowering Therapy in GoutActive, not recruitingNCT04733079Not applicable1 country
- Effects of Task-Oriented Training and Mulligan Mobilization on Hand Function, Pain and Quality of Life in Patients With Rheumatoid ArthritisCompletedNCT07029113Not applicable1 country
- Nonsurgical Periodontal Treatment Combined With Anti-TNF-α in Patients With Rheumatoid Arthritis and PeriodontitisCompletedNCT06818045Not applicable1 country
- Exercise Training and Knee Joint Proprioception in Rheumatoid ArthritisCompletedNCT06887725Not applicable1 country
- Observational Study in Patients Treated with JAK Inhibitors for Inflammatory Rheumatism (MAJIK)Active, not recruitingNCT046020911 country
- Impact of Vitamin D in Rheumatoid ArthritisCompletedNCT06716476Phase 41 country
- Capability of Tofacitinib or Etanercept to Accelerate Tapering of NSAID and Treat-to-target Guided De-escalation of Corticosteroids in RA PatientsCompletedNCT04485325Phase 41 country
- Effectiveness of Chronic Self-management Education on Behavioral and Clinical OutcomesStatus unknownNCT06400628Not applicable1 country
- AESCULAP® Plasmafit® Cementless Acetabular System With Vitelene® Vitamin E Stabilized Highly Crosslinked PolyethyleneCompletedNCT052911301 country
- Catastrophism in Chronic Inflammatory RheumatismCompletedNCT04174092Not applicable1 country
- Prevalence of Rheumatic Heart Disease According to Revised Jones Criteria (2015) in Assiut GovernateStatus unknownNCT043168971 country
- Mental Health Consequences of COVID19 Infection in the French RMD CohortTerminatedNCT045104671 country
- Survey About Diet in Chronic Inflammatory Rheumatic DiseasesStatus unknownNCT052830961 country
- Pain Catastrophizing and Routine Assessment of Patient Index Data 3(RAPID3) in Ten Categories of Rheumatology OutpatientsCompletedNCT033067841 country
- MST in Patients With Inflammatory Rheumatic DiseaseCompletedNCT04998955Not applicable1 country
- Selection of Patients With Chronic Inflammatory Rheumatism Requiring Management During the COVID-19 PandemiaCompletedNCT048068671 country
- Clinical Audit on the Managment in Assiut University Children HospitalCompletedNCT032818631 country
- Clinical Trial to Assess Safety and Immunogenicity of a Synthetic Vaccine Against Streptococcus PyogenesWithdrawnNCT03998592Phase 1
- HIIT for Inflammatory Rheumatic Disease: Man vs MachineCompletedNCT04649528Not applicable1 country
- The Genetic Basis of Acquired Heart Disease in AfricaCompletedNCT021241092 countries
- Guided Self-Management Intervention Targeting Fatigue in Rheumatic Inflammatory DiseasesCompletedNCT03216616Not applicable
- Prevalence of Secondary Cardiac Damage in Rheumatic Fever Patients and Penicillin Secondary ProphylaxisStatus unknownNCT03183180
- Rheumatic Heart Disease in Peru: Prevalence and Cardiovascular Outcomes Among SchoolchildrenCompletedNCT023536632 countries
- Does Etanercept Influence Tweak Modulation of Inflammation During Inflammatory Rheumatisms (Psoriatic Arthritis and Rheumatoid Arthritis)?CompletedNCT02164214Phase 31 country
- Efficacy of BLIS K12 as Preventive Measure for Rheumatic ChildrenStatus unknownNCT02407106Not applicable