Rectal Neoplasms: all 1,804 studies

Page 4 of 19. Open to participants first (520), then studies with results posted, then the rest; newest registration first within each.

• Online Adaptive Radiotherapy Using a Novel Linear Accelerator (ETHOS)RecruitingNCT06116019
• RATME Vs LATME in Middle and Low Rectal CancerNot yet recruitingNCT06105203Not applicable
• Neoadjuvant Chemoradiotherapy Versus Total Neoadjuvant Therapy in the Treatment of T3 Rectal CancerNot yet recruitingNCT06097416Phase 3
• Prognostic Factors Affecting Recurrence and Disease-Free Survival After Surgical Resection for Cancer RectumRecruitingNCT06096493
• Study of Brain-Gut Function Reconstruction After Intersphincteric Resection for Ultra-Low Rectal TumorsRecruitingNCT06082648Not applicable
• Reconstruction of the Pelvic Floor and Perineal Wound After Rectal ELAPENot yet recruitingNCT06066931Not applicable
• PET/MRI in Rectal CancerNot yet recruitingNCT06057831Phase 2
• Evaluation of Surgical Complications and DFS in Obese Rectal Cancer PatientsRecruitingNCT06056726
• Efficacy and Safety of Conventional Neoadjuvant Therapy Versus Total Neoadjuvant Therapy in Older Patients With Locally Advanced Rectal CancerRecruitingNCT06052332Not applicable
• A Study to Evaluate the Safety and Efficacy of Mesothelin-Targeting Logic-gated CAR T, in Participants With Solid Tumors That Express MSLN and Have Lost HLA-A*02 ExpressionRecruitingNCT06051695Phase 1/2
• Factors Affecting the Results of Treatment of Patients With Colorectal CancerRecruitingNCT06050447
• Salvage Chemotherapy Versus Total Mesorectal Resection for Local Resection Rectal Cancer PatientsRecruitingNCT06043999Not applicable
• Can we Use a Simple Blood Test to Reduce Unnecessary Adverse Effects From Radiotherapy by Timely Identification of Radiotherapy-resistant Rectal Cancers? MeD-Seq Rectal StudyNot yet recruitingNCT06035471
• Treatment of Low Locally Advanced Rectal Cancer With Radiotherapy Removal TNT Plus Neoadjuvant TherapyNot yet recruitingNCT06035133Not applicable
• Performance of Spectral CT-scan in Patients With Metastatic Colorectal Cancer: a Prospective Multicentre StudyRecruitingNCT06024837
• Neoadjuvant Chemotherapy With PD-1 Inhibitors Combined With SIB-IMRT in the Treatment of Locally Advanced Rectal CancerRecruitingNCT06017583Phase 3
• Short-course Radiotherapy Combined With Furoquintinib and PD-1 Monoclonal AntibodyNot yet recruitingNCT06014944Phase 2
• 68Ga-FAPI-04 PET Imaging in Early Response Evaluation of Rectal Cancer Patients Treated With ImmunotherapyRecruitingNCT05999227Not applicable
• Total Neoadjuvant Chemoradiotherapy Plus Anti-PD-1 in Subperitoneal Patients With Locally Advanced Rectal CancerPatients With Locally Advanced Rectal Cancer: A Prospective, Single Arm, Exploratory StudyNot yet recruitingNCT05998122Phase 2
• Virtual Ileostomy Versus Conventional Loop IleostomyNot yet recruitingNCT05985252Not applicable
• Radiotherapy & Total Neoadjuvant Therapy for Recurrent Rectal Cancer in Previously Irradiated Patients, an Italian Association for Radiotherapy and Clinical Oncology (AIRO)-GI Platform: a Multi-centre Prospective Observational StudyRecruitingNCT05984576
• The Efficacy of Primary Total Mesorectal Excision (TME) Surgery Versus Neoadjuvant Chemotherapy Combined With TME Surgery in Low-risk Locally Advanced Rectal CancerRecruitingNCT05984485Phase 3
• Combination of AK104 and Neoadjuvant Chemoradiotherapy in pMMR/MSS Locally Advanced Rectal CancerRecruitingNCT05980689Phase 2
• PTC Drug Sensitivity Detection to Guide Postoperative Adjuvant of Colorectal CancerRecruitingNCT05978349Not applicable
• Nodes-sparing Short-course Radiation Combined With CAPOX and Tislelizumab for MSS Middle and Low Rectal CancerRecruitingNCT05972655Phase 2
• Preoperative Imatinib Mesylate Combined With Rectal-sparing Surgery in Patients With c-KIT Gene-mutant Rectal GISTNot yet recruitingNCT05970900Phase 3
• Organ Preservation Following Enverolimab-based Total Neoadjuvant Therapy for Locally Advanced Very Low Rectal CancerNot yet recruitingNCT05969847Phase 2
• Treating Locally Advanced Rectal Cancer With TAS-102 Chemotherapy Plus Neoadjuvant RadiotherapyRecruitingNCT05965531Phase 2
• Radical vs Local Excision for Rectal Cancer With Clinically Complete RemissionRecruitingNCT05964530Not applicable
• Neoadjuvant CIETAI With Concurrent Chemoradiotherapy in Local Advanced Rectal CancerRecruitingNCT05957016Phase 2
• Comparison of Postoperative Anal Function Between Parks and Bacon Techniques in Low Rectal CancerRecruitingNCT05943444Not applicable
• The Radiation Oncology-Biology Integration Network (ROBIN) Molecular Characterization Trial (MCT) of Standard Short Course Radiotherapy for Rectal CancerRecruitingNCT05943210Not applicable
• Prophylactic Mesh Placement During Stoma Closure After Low Anterior ResectionRecruitingNCT05939687Phase 3
• A Multicenter Single-arm P2 to Evaluate Safety and Efficacy of the Total Neoadjuvant Therapy for cT2 Rectal CancerRecruitingNCT05939661Phase 2
• Ketogenic Diet Compliance in Patients Undergoing Radiotherapy for Pelvic CancersRecruitingNCT05938322Not applicable
• Study of the Prevalence of Sexual Dysfunction in Women After Rectal Cancer Surgery and Analysis of the Impact of a Sexologist InterventionRecruitingNCT05933122Not applicable
• Local Excision for Organ Preservation in Early REctal Cancer With No Adjuvant TreatmentRecruitingNCT05927584
• Comparison of the Clinical Response of Total Neoadjuvant Treatment of Two Methods of Long-term or Short-term Chemoradiotherapy in Rectal CancerNot yet recruitingNCT05920928Not applicable
• Total Neoadjuvant Treatment of Rectal Cancer by MRI-guided RadiotherapyRecruitingNCT05916040
• An Informational and Supportive Care Intervention for Patients With Locally Advanced Rectal CancerRecruitingNCT05914766Not applicable
• Preoperative Radiotherapy And ASTX660 in Rectum CancerRecruitingNCT05912075Phase 1
• Online Adaptive Radiation Therapy for Rectal CancerNot yet recruitingNCT05911789Phase 1/2
• Taking a Look at Patient Experiences In Rectal Cancer Clinical TrialsNot yet recruitingNCT05910099
• Total Neoadjuvant Treatment Combined With Adaptive Radiotherapy for Rectal CancerRecruitingNCT05883800Not applicable
• Toripalimab Combined With Neoadjuvant Chemoradiotherapy as First-line Treatment for Locally Advanced，High-Risk，MSS Rectal CancerRecruitingNCT05877573Not applicable
• Choice of the Optimal Treatment Strategies for Mid-low REctal CancerRecruitingNCT05871762
• PRE-ISPY Phase I/II Oncology Platform ProgramRecruitingNCT05868226Phase 1/2
• Total Neoadjuvant Therapy Combined With Tislelizumab for Local Advanced of Middle and Low Rectal CancerRecruitingNCT05845268Phase 2
• Sentinel Lymph Node Biopsy in Rectal CancerNot yet recruitingNCT05830890Not applicable
• XELOX Combined With Cadonilimab Versus XELOX as Neoadjuvant Treatment for Locally Advanced, pMMR Rectal CancerRecruitingNCT05815303Phase 2
• Re-irradiation Therapy of Locally Recurrent Rectal Cancer With Carbon IonNot yet recruitingNCT05807984Phase 2
• Reduced Dissemination of Tumor Cells With Primary Ligation of the Inferior Mesenteric Vein in Rectal Cancer Patients.Not yet recruitingNCT05807646Not applicable
• Sequential TAS-OX Alternating With TAS-IRI Plus Bevacizumab for Late-Line Metastatic Colorectal CancerRecruitingNCT05806931Phase 2
• Assess the Efficacy of Radiotherapy and Sequential Chemotherapy and AK104 Before TME Surgery for Local CRC（AK104-IIT-13）Not yet recruitingNCT05794750Phase 2
• CLASSICA: Validating AI in Classifying Cancer in Real-Time SurgeryRecruitingNCT05793554
• Effects of Aerobic Exercise on Skeletal Muscle Remodeling in Colorectal CancerRecruitingNCT05789433Not applicable
• Organ Preservation in Rectal Cancer: Contact X-ray Brachytherapy vs Extending the Waiting Interval and Local ExcisionRecruitingNCT05772923Not applicable
• Interest of PET-MRI in the Evaluation of the Response After Neoadjuvant Treatment of Locally Advanced Rectal AdenocarcinomaRecruitingNCT05772481
• Preoperative Short-course Radiation Followed by Envafolimab Plus CAPEOX for MSS Locally Advanced Rectal AdenocarcinomaRecruitingNCT05752136Phase 3
• Exogenous and Endogenous Risk Factors for Early-onset Colorectal CancerRecruitingNCT05732623
• Immunotherapy in Patients With Early dMMR Rectal CancerRecruitingNCT05732389Phase 2
• Serplulimab Combined With CAPEOX + Celecoxib as Neoadjuvant Treatment for Locally Advanced Rectal CancerRecruitingNCT05731726Phase 2
• Comparison of Ultrasound-guided Erector Spinae Plane Block and Transmuscular Quadratus Lumborum BlockNot yet recruitingNCT05709899Not applicable
• Advanced Pelvic Surgical Oncology Database - Prospective Observational StudyRecruitingNCT05696002
• Reconstruction After Abdominoperineal Resection With Robot-assisted Harvest of VRAM FlapRecruitingNCT05689775
• A Study of Tucatinib and Trastuzumab in People With Rectal CancerRecruitingNCT05672524Phase 2
• Effects of Different Treatment for Anorectal Function of Patients With Rectal CancerNot yet recruitingNCT05671809
• Sarcopenia and Multimodal Rehabilitation on the Prognosis of Rectal Cancer Patients Receiving CCRTNot yet recruitingNCT05664607Not applicable
• Machine Learning-based Surgical Guidance System for Robot-assisted Rectal SurgeryRecruitingNCT05652361Not applicable
• The Anatomical Localization of the Inferior Mesenteric Artery in Relation to the Left Colonic ArteryRecruitingNCT05651971
• TNT of SCRT+CAPOX vs SCRT+CAPOXIRI for Locally Advanced Rectal CancerRecruitingNCT05646511Phase 3
• PREHAB - Improving Condition Before SurgeryRecruitingNCT05646043Not applicable
• Neoadjuvant Envafolimab in Resectable and Locally Advanced MSI-H/dMMR Rectal CancerNot yet recruitingNCT05645094
• The First-line Treatment of RCLM With RAS Mutation Was Local Short-course Radiotherapy (SCRT) + PD-1+ Standard TherapyNot yet recruitingNCT05640726Phase 2
• ctDNA and Organ Preservation/Pathologic CR in Rectal CancerNot yet recruitingNCT05629442
• The Combination of Hypofractionated Radiotherapy and Immunotherapy in Locally Recurrent Rectal CancerRecruitingNCT05628038Phase 2
• Evaluation of AL Prediction for Rectal CancerNot yet recruitingNCT05610904Not applicable
• Circulating Tumor DNA-guided Neoadjuvant Treatment Strategy for Locally Advanced Rectal CancerRecruitingNCT05601505Phase 2
• SCRT Sequential Penpulimab in Combination With CAPEOX in the Neoadjuvant Treatment of MSS Locally Advanced Rectal CancerRecruitingNCT05576480Phase 2
• Neoadjuvant Treatment of Fruquintinib Combined With Concurrent Chemoradiotherapy for LARCNot yet recruitingNCT05575635Phase 2
• Organ Preservation Strategy of Total Neoadjuvant Chemoradiotherapy for Low Rectal CarcinomaRecruitingNCT05563922Phase 2
• The Combination of Immunotherapy and Neoadjuvant Short-course Radiotherapy in Early Rectal CancerRecruitingNCT05555888Phase 2
• Predicting the Efficacy of Neoadjuvant Therapy in Patients With Locally Advanced Rectal Cancer Using an AI Platform Based on Multi-parametric MRIRecruitingNCT05523245
• A Randomized, Controlled, Multicenter, Noninferiority Clinical Study of Perioperative and Oncological Safety in Patients With Rectal CancerNot yet recruitingNCT05503381Not applicable
• Neoadjuvant Chemoradiotherapy and Consolidation Chemotherapy for Rectal Cancer: A Randomized Controlled TrialRecruitingNCT05496491Not applicable
• Short-course Radiotherapy Followed by Chemotherapy and PD-1 Inhibitor for Locally Advanced Rectal CancerNot yet recruitingNCT05484024Phase 2/3
• Neoadjuvant Chemoradiotherapy Combined With Tislelizumab in the Treatment of Locally Advanced Rectal CancerNot yet recruitingNCT05479240Phase 2
• Robotic Transanal Specimen Extraction Surgery Versus Robotic Transabdominal Incision Specimen Extraction Surgery for Patients With Rectal Cancer: A Multicenter Randomized Controlled TrialNot yet recruitingNCT05468944Not applicable
• Neoadjuvant Chemoradiotherapy Plus Sintilimab for Intermediate/High Immunoscore Locally Advanced Rectal CancerRecruitingNCT05450029Phase 2
• Neoadjuvant Arterial Embolization Chemotherapy Combined PD-1 Inhibitor for Locally Advanced Rectal CancerRecruitingNCT05420584Phase 2
• Neoadjuvant Therapy vs Standard Therapy in Locally Advanced Rectal CancerRecruitingNCT05378919Phase 2
• A Combination Therapy Including Anti-PD-1 Immunotherapy in MSS Rectal Cancer With Resectable Distal MetastasisNot yet recruitingNCT05359393Phase 2
• Interventional Study on DEterminants and Factors of Physical ACtivity After Treatments in OncologyRecruitingNCT05354882Not applicable
• The Clinical Efficacy of Drug Sensitive Neoadjuvant Chemotherapy Based on Organoid Versus Traditional Neoadjuvant Chemotherapy in Advanced Rectal CancerNot yet recruitingNCT05352165Not applicable
• Chemotherapy Combined With High-dose Radiotherapy for Low Rectal Cancer Using MR Guided Linear AcceleratorEnrolling by invitationNCT05338866
• The Pandemic's Effect on Diagnosis and Treatment of Rectal CancerRecruitingNCT05328960
• Targeted Optical Biopsy for Local Rectal Scars in Rectal Cancer Patients After Neoadjuvant ChemoradiotherapyRecruitingNCT05316103Not applicable
• Rectal Artery Infusion Chemotherapy Combined With Anti-PD1 Antibody for MSS LARCRecruitingNCT05307198Phase 2
• SHR-1701 in Combination With Chemotherapy and Radiotherapy in Locally Advanced Rectal CancerRecruitingNCT05300269Phase 2
• Comparative Effectiveness Trial of Two Supportive Cancer Care Delivery Models for Adults With CancerRecruitingNCT05297734Not applicable

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