Prolactinoma clinical trials
The registry lists 28 studies for Prolactinoma across more than 10 countries. 5 are recruiting or about to start. 18 of them are mainly about Prolactinoma (how this is decided). Per ClinicalTrials.gov, last updated 2026-10-23.
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Who runs them
Zhebao Wu (3) · Cedars-Sinai Medical Center (2) · University Hospital, Basel, Switzerland (2) · Hospices Civils de Lyon (2) · Universidade Federal do Rio de Janeiro (2) · Seoul National University Hospital (2) · University of Alberta (1) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (1)
What is being tested here
Drugs under test in Prolactinoma studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Cabergoline | 2 | 2 | 5 |
| Ropinirole | 0 | 0 | 1 |
| Lapatinib | 0 | 0 | 1 |
| Pasireotide | 0 | 1 | 1 |
| Clomiphene | 0 | 0 | 1 |
| RG-4733 | 0 | 0 | 1 |
| Medication | 0 | 0 | 1 |
| Temozolomide | 0 | 0 | 1 |
Drug classes tested here Dopamine agonists 2 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 2, phase 3 first
- Aug 2027Safety and Potency of a High Cabergoline Dosage in Microprolactinomas · Phase 3 · University of Sao Paulo General Hospital
- Dec 2026Long Term Outcome Study in Patients With Pituitary Disorders · University of Alberta
Who these studies take
Of the 5 Prolactinoma studies recruiting now, 3 (60%) set no upper age limit and 2 (40%) stop at 75 or younger. 1 (20%) take children under 18. 1 (20%) are for women only and 0 (0%) for men only; 1 (20%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 1 (20%) | 1 (20%) |
| 18 | 5 (100%) | 4 (80%) |
| 30 | 5 (100%) | 4 (80%) |
| 40 | 5 (100%) | 4 (80%) |
| 50 | 5 (100%) | 4 (80%) |
| 65 | 4 (80%) | 3 (60%) |
| 75 | 3 (60%) | 2 (40%) |
| 85 | 3 (60%) | 2 (40%) |
Across all 28 studies, recruiting or not: 43% stop at 75 or younger and 21% at 65; 21% take children; 14% are for women only and 4% for men only; 18% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
Studies
Recruiting first, then most recently updated. Showing 28 of 28. search them.
- An Investigation of Pituitary Tumors and Related Hypothalmic DisordersRecruitingNCT000015951 country
- Safety and Potency of a High Cabergoline Dosage in MicroprolactinomasRecruitingNCT07463235Phase 31 country
- Metabolic Outcomes in Patients With Prolactinomas Under Dopamine Agonist TreatmentRecruitingNCT07045935Phase 41 country
- PRolaCT - Three Prolactinoma RCTsRecruitingNCT04107480Phase 41 country
- Study on Therapy of Non-invasive ProlactinomaRecruitingNCT03353025Not applicable1 country
- How Estrogen Fluctuations Before Diagnosis Affect the Size Prolactin-secreting TumorsCompletedNCT072681831 country
- Long Term Outcome Study in Patients With Pituitary DisordersActive, not recruitingNCT03665064
- The PROMISE SurveyActive, not recruitingNCT069368131 country
- Validation of a Quality of Life Metric "Prolac-10"TerminatedNCT041065311 country
- Treatment of Hyperprolactinemia With the Non-ergoline Dopamine Agonist RopiniroleCompletedNCT03038308Phase 1/21 country
- Exercise Capacity and Physical Activity Level in Prolactinoma PatientsCompletedNCT052368291 country
- Temozolomide in Treating Patients With Invasive Pituitary TumorsWithdrawnNCT00601289Phase 2
- Comparison of Treatment Outcome of Cabergoline According to Target Prolactin Levels in Patients With ProlactinomaStatus unknownNCT03457389Not applicable1 country
- Seoul National University Pituitary Disease Cohort StudyStatus unknownNCT034746011 country
- Targeted Therapy With Lapatinib in Patients With Recurrent Pituitary Tumors Resistant to Standard TherapyCompletedNCT00939523Phase 21 country
- Dopamine D2 Receptors(D2R) Imaging in ProlactinomasStatus unknownNCT03717454Not applicable
- Cabergoline Combined Hydroxychloroquine/Chloroquine to Treat Resistant ProlactinomasStatus unknownNCT03400865Not applicable1 country
- Rhinological Outcomes in Endonasal Pituitary SurgeryCompletedNCT015043991 country
- Dopamine Agonists Withdrawal Study of Invasive Prolactinomas Involving the Cavernous SinusStatus unknownNCT025362611 country
- Response to Cabergoline and Pasireotide in Non-functioning Pituitary Adenomas and Resistant ProlactinomasCompletedNCT01620138Phase 2/31 country
- PITUItary Carcinoma or Aggressive Tumors REgistry -LyonStatus unknownNCT028542281 country
- Interdisciplinary Pituitary Disorders Centre of Excellence: Assessment of Patient Education ToolsStatus unknownNCT01775332Not applicable1 country
- Gamma-Secretase Inhibitor RO4929097 in Treating Young Patients With Relapsed or Refractory Solid Tumors, CNS Tumors, Lymphoma, or T-Cell LeukemiaTerminatedNCT01088763Phase 12 countries
- Prevalence of Pituitary Incidentaloma in Relatives of Patients With Pituitary AdenomaStatus unknownNCT005989491 country
- Efficacy of Rapid Escalation of Cabergoline in Comparison to Conventional Dosing in Prolactin Secreting Macroadenomas.Status unknownNCT01143584Not applicable1 country
- Clomiphene in Males With Prolactinomas and Persistent HypogonadismCompletedNCT00697814Phase 21 country
- Cardiac Valve Complications in Prolactinomas Treated With CabergolineCompletedNCT004606161 country
- Insulin Resistance in Women With ProlactinomaCompletedNCT004812991 country