Plaque, Atherosclerotic clinical trials
The registry lists 105 studies for Plaque, Atherosclerotic across more than 10 countries. 27 are recruiting or about to start. 30 of them are mainly about Plaque, Atherosclerotic (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10.
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Who runs them
Cardio Med Medical Center (4) · Radboud University Medical Center (3) · Second Affiliated Hospital, School of Medicine, Zhejiang University (3) · Novartis Pharmaceuticals (3) · Assistance Publique Hopitaux De Marseille (2) · Seoul National University Hospital (2) · Massachusetts General Hospital (2) · GlaxoSmithKline (2)
What is being tested here
Drugs under test in Plaque, Atherosclerotic studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Recaticimab | 2 | 0 | 2 |
| Inclisiran | 1 | 2 | 4 |
| Rosuvastatin | 1 | 0 | 4 |
| Alirocumab | 1 | 2 | 2 |
| Evolocumab | 1 | 0 | 1 |
| Eicosapentaenoic acid ethyl ester | 1 | 1 | 1 |
| Fish Oils | 1 | 0 | 1 |
| Metformin | 1 | 0 | 1 |
| Aspirin | 1 | 0 | 1 |
| Niacin | 0 | 1 | 2 |
Drug classes tested here Statins 2 open · PCSK9 inhibitors 2 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Dec 2026Targeting Vascular INflammation in Patients With Community-Acquired Pneumonia · Phase 3 · Ottawa Heart Institute Research Corporation
- Nov 2027A CCTA Imaging Trial to Evaluate the Effect of Obicetrapib/Ezetimibe on Coronary Plaque · Phase 3 · NewAmsterdam Pharma
- Dec 2026Intravascular Imaging Study of the Effect of Inclisiran on Plaque in Patients With Acute Myocardial Infarction · Novartis Pharmaceuticals
- Dec 2026Fish Oil, Metformin and Heart Health in PCOS · University of Alberta
- Dec 2026Identifying Vulnerable CoronAry PLaqUes With Artificial IntElligence-assisted CT Angiography · Jinling Hospital, China
- Dec 2026Optical Coherence Tomography for Intracranial Atherosclerotic Stenosis · jiaoliqun
- Jan 2027Randomized Controlled Trial of Moderate-Intensity Rosuvastatin With Ezetimibe Combination Therapy Versus High-Intensity Rosuvastatin on Progression of Coronary Atherosclerotic Plaque · Samsung Medical Center
- Feb 2027Carotid Plaque Characterization Using Innovative Ultrasound Techniques · Hospices Civils de Lyon
- Aug 2027Transcutaneous ARFI Ultrasound for Differentiating Carotid Plaque With High Stroke Risk · University of North Carolina, Chapel Hill
- Sep 2027Prospective Management of Plaque Instability With Statins and Extra Folic Acid · Ruijin Hospital
Who these studies take
Of the 16 Plaque, Atherosclerotic studies recruiting now, 7 (44%) set no upper age limit and 4 (25%) stop at 75 or younger. 0 (0%) take children under 18. 1 (6%) are for women only and 0 (0%) for men only; 1 (6%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 11 (69%) | 11 (69%) |
| 30 | 12 (75%) | 11 (69%) |
| 40 | 14 (88%) | 13 (81%) |
| 50 | 15 (94%) | 15 (94%) |
| 65 | 15 (94%) | 15 (94%) |
| 75 | 14 (88%) | 14 (88%) |
| 85 | 8 (50%) | 8 (50%) |
Across all 105 studies, recruiting or not: 17% stop at 75 or younger and 4% at 65; 7% take children; 2% are for women only and 1% for men only; 10% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Plaque, Atherosclerotic studies take
Of 31 observational studies under Plaque, Atherosclerotic, half reached primary completion within 36 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Observational | 36 mo22–105 · 31 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
Studies
Recruiting first, then most recently updated. Showing 50 of 105. Browse all 105 → or search them.
- Prospective Multicenter Cohort Study to Validate Four Groups of Biomarkers for Assessing Lung Cancer Risk Among Patients With Atheromatous Cardiovascular Disease in a Screening PathwayRecruitingNCT06387017Not applicable1 country
- Carotid Plaque Characterization Using Innovative Ultrasound TechniquesRecruitingNCT06804707Not applicable1 country
- A Trial Assessing the Effectiveness of Evolocumab in Reducing the Plaque Burden in Participants With Subclinical AtheromaNot yet recruitingNCT07803679Phase 4
- Atherosclerotic Plaque Imaging Project (CPIP)RecruitingNCT058218941 country
- Early Intensive Lipid-Lowering With Inclisiran for Plaque Stabilization in Acute Coronary SyndromeNot yet recruitingNCT07799779Phase 41 country
- Measuring Athlete's Risk of Cardiovascular Events 3 (MARC-3)Enrolling by invitationNCT076254881 country
- PCSK9 Inhibitor for Intracranial Atherosclerosis Related Acute Ischemic StrokeNot yet recruitingNCT07466251Phase 41 country
- Prospective Management of Plaque Instability With Statins and Extra Folic AcidRecruitingNCT07680595Phase 1/21 country
- PCSK9 Inhibitor With Statin Therapy for Asymptomatic Intracranial AtherosclerosisRecruitingNCT06902740Phase 41 country
- Changes in Plaque Characteristics After Short-term Statin Therapy as Assessed With Coronary CTRecruitingNCT06603363Not applicable1 country
- Targeting Vascular INflammation in Patients With Community-Acquired PneumoniaRecruitingNCT06710080Phase 31 country
- Identifying Vulnerable CoronAry PLaqUes With Artificial IntElligence-assisted CT AngiographyEnrolling by invitationNCT060253051 country
- Assessment of GARP Expression in Acute and Chronic Coronary SyndromeNot yet recruitingNCT07384910Not applicable1 country
- Assessment of Platelet-derived GARP in Atherosclerotic DiseaseNot yet recruitingNCT073640581 country
- Can the BeatMove Device Help Patients With Obliterative Arterial Disease of the Lower Limbs?RecruitingNCT06226844Not applicable1 country
- Fish Oil, Metformin and Heart Health in PCOSRecruitingNCT06424860Phase 11 country
- Identification of Asymptomatic Patients at Very High Cardiovascular Risk: Contribution of a Strategy Based on Carotid and Coronary Explorations, Compared to Simple Risk Calculation Using the European "SCORE 2" Algorithm. (IDEA-CVR)RecruitingNCT072528301 country
- Evaluation of Atherectomy in the Management of Occlusive Lesions of the Common Femoral ArteriesNot yet recruitingNCT071423301 country
- Multimodal Imaging Evaluation of Vulnerability of Atherosclerotic Plaques: A Comparison of HR-VWI, OCT, and RWSNot yet recruitingNCT071334511 country
- Coated or Chewable Aspirin and a Hybrid Strategy to Mitigate Adverse Effects of Air Pollution in Stable Atherosclerotic DiseaseRecruitingNCT06541691Not applicable1 country
- STabilization of Atheroma by Lipid-reducing Effect of Drug-Coated Balloon (STABLE-DCB)RecruitingNCT054381211 country
- Whole Blood Transcriptomic Signal According to Coronary Atherosclerotic Plaque Burden Assessed by CT AngiographyEnrolling by invitationNCT061945261 country
- Extra Alirocumab in Addition to Statin Therapy in Asymptomatic Intracranial Atherosclerotic Stenosis (EAST-aICAS)Not yet recruitingNCT06080256Phase 31 country
- Molecular Imaging of Plaque VulnerabilityRecruitingNCT02640313Phase 31 country
- Biomarkers of Acute Stroke in ClinicRecruitingNCT038974781 country
- Pakistan Study of Premature Coronary Atherosclerosis in Young AdultsRecruitingNCT051567361 country
- Optical Coherence Tomography for Intracranial Atherosclerotic StenosisRecruitingNCT055500771 country
- Coronary Computed Tomography Study to Assess the Effect of Inclisiran in Addition to Maximally Tolerated Statin Therapy on Atherosclerotic Plaque Progression in Participants With a Diagnosis of Non-obstructive Coronary Artery Disease Without Previous Cardiovascular EventsActive, not recruitingNCT05360446Phase 318 countries
- Comparison of Moderate-Intensity Statin Plus Ezetimibe vs. High-Intensity Statin for Coronary Plaque StabilizationActive, not recruitingNCT06767345Phase 41 country
- Carotid Plaque RADS vs CPVH: Diagnostic Accuracy ComparisonCompletedNCT078705121 country
- Transcutaneous ARFI Ultrasound for Differentiating Carotid Plaque With High Stroke RiskActive, not recruitingNCT04063709Not applicable1 country
- Carotid Artery Plaque Vulnerability Assessment Using Ultrafast Ultrasound TechniquesCompletedNCT052184211 country
- Intravascular Imaging Study of the Effect of Inclisiran on Plaque in Patients With Acute Myocardial InfarctionActive, not recruitingNCT06372925Phase 41 country
- Multimodal Imaging Assessment of the Inflammatory Atheromatous PlaqueTerminatedNCT01608516Phase 1/21 country
- Strategy for Unstable Coronary Plaque in Patients Presenting to Emergency Department for Chest Pain Suspected of Coronary Artery DiseaseActive, not recruitingNCT06013722Not applicable1 country
- Prospective Evaluation of Femoral Tripod Eversion TechniqueCompletedNCT033571851 country
- A CCTA Imaging Trial to Evaluate the Effect of Obicetrapib/Ezetimibe on Coronary PlaqueActive, not recruitingNCT06305559Phase 31 country
- Efficacy and Safety of Inclisiran as Monotherapy in Chinese Adults With Low or Moderate ASCVD Risk and Elevated Low-density Lipoprotein Cholesterol.CompletedNCT05888103Phase 31 country
- Multimodality Optical and Ultrasound Intravascular Imaging for Stent Optimization and Atheroma AssessmentWithdrawnNCT05753085Not applicable1 country
- Fat Around Heart Arteries as a Measure of Inflammation in Patients With DiabetesCompletedNCT066446511 country
- Randomized Controlled Trial of Moderate-Intensity Rosuvastatin With Ezetimibe Combination Therapy Versus High-Intensity Rosuvastatin on Progression of Coronary Atherosclerotic PlaqueActive, not recruitingNCT03169985Phase 41 country
- Efficacy and Safety of Intravascular High-pressure Cutting Balloon Catheters for PCICompletedNCT06214754Not applicable1 country
- Efficiency of AI Reporting (EAIR).WithdrawnNCT055839681 country
- Spectral CT Protocol Optimization for Atherosclerotic Plaque CharacterizatIONActive, not recruitingNCT068869581 country
- Progression Assessment of Carotid Artery Stenosis by Ultrafast Ultrasound Flow ImagingActive, not recruitingNCT052700051 country
- RANGER™ Paclitaxel Coated Balloon vs Standard Balloon AngioplastyCompletedNCT03064126Phase 36 countries
- Detection of Coronary Artery Calcifications by Whole Blood Transcriptome Analyzed by Artificial InTelligence AlgorithmsCompletedNCT056190421 country
- Structuring of a Lung Cancer Screening Program Including Clinical, Radiological and Biological Phenotyping Useful for the Development of Individualized Risk Prediction Tools: PREVALUNG ETOILEActive, not recruitingNCT05649046Not applicable1 country
- Reduced Radiation Dose and IR-impact on Coronary Calcium QuantificationTerminatedNCT04267094Not applicable1 country
- Plaque Erosion Prospective Study iiCompletedNCT047013851 country