Opioid-Induced Constipation: all 98 studies

Page 1 of 1. Open to participants first (6), then studies with results posted, then the rest; newest registration first within each.

• Naldemedine in Clinical Practice in Cancer Patients With Opioid Induced CONstipation: Clinical Outcomes and Patient ExperienceRecruitingNCT07231796
• Real World Study of Oxycodone/Naloxone Sustained-Release Tablets (Mimeixin) for Patients With Severe Cancer PainNot yet recruitingNCT06897917Phase 4
• The Effect of Naldemedine on Opioid-induced Bowel DysfunctionRecruitingNCT06334198Phase 2
• Safety and Pharmacokinetics Study of Naldemedine in Paediatric Participants Receiving OpioidsRecruitingNCT05588323Phase 1/2
• Prevention of Opioid-induced Constipation in Patients With Advanced CancerRecruitingNCT05216328Phase 4
• Risk of Major Adverse Cardiovascular Events for Naldemedine & Other Medications for Opioid Induced ConstipationRecruitingNCT03720613
• Methylnaltrexone vs Naloxegol in the Treatment of Opioid-Induced ConstipationCompletedNCT03523520Phase 4Results posted
• To Evaluate Patient Preference of Movantik and Polyethylene Glycol 3350 for Opioid Induced ConstipationCompletedNCT03060512Phase 4Results posted
• Tolerability, Safety, and Feasibility of Naloxegol in Patients With Cancer and OIC (Opioid Induced Constipation)TerminatedNCT02839889Phase 4Results posted
• Naloxegol in Cancer Opioid-Induced ConstipationTerminatedNCT02745353Phase 2Results posted
• Phase 2 Randomized, Double-Blind, Placebo-Controlled, Parallel Group Trial of Linaclotide Administered to Patients With Opioid-Induced Constipation Receiving Chronic Opioid Treatment for Non-Cancer PainCompletedNCT02270983Phase 2Results posted
• Efficacy and Safety of Naldemedine in Treating Opioid-induced ConstipationCompletedNCT01993940Phase 3Results posted
• Long Term Safety of NaldemedineCompletedNCT01965652Phase 3Results posted
• Efficacy and Safety of Naldemedine in the Treatment of Opioid-induced ConstipationCompletedNCT01965158Phase 3Results posted
• The Efficacy and Safety Study of CB-5945 for the Treatment of Opioid-Induced ConstipationTerminatedNCT01901341Phase 3Results posted
• Efficacy and Safety Study of CB-5945 for the Treatment of Opioid-Induced ConstipationTerminatedNCT01901328Phase 3Results posted
• Efficacy and Safety Study of CB-5945 for the Treatment of Opioid-Induced ConstipationTerminatedNCT01901302Phase 3Results posted
• Safety Study of CB-5945 for the Treatment of Opioid-Induced ConstipationTerminatedNCT01696643Phase 3Results posted
• A Study of Naldemedine (S-297995) for the Treatment of Opioid-Induced Constipation in Adults With Non-Malignant Chronic Pain Receiving Opioid TherapyCompletedNCT01443403Phase 2Results posted
• A 12-week Extension of the Phase III Study (D3820C00004) to Assess the Effect and Safety of NKTR-118 in Patients With Non-cancer-related Pain and Opioid-induced ConstipationCompletedNCT01395524Phase 3Results posted
• Assessment of Efficacy and Safety in Relieving Opioid-induced Constipation in Patients With Cancer-related PainTerminatedNCT01384292Phase 3Results posted
• Compassionate Use Study of MethylnaltrexoneCompletedNCT01368562Not applicableResults posted
• Assessment of Long-term Safety in Patients With Non-cancer-related Pain and Opioid-induced ConstipationCompletedNCT01336205Phase 3Results posted
• Assessment of Efficacy and Safety in Patients With Non-cancer-related Pain and Opioid-induced ConstipationCompletedNCT01323790Phase 3Results posted
• Assessment of Efficacy and Safety in Patients With Non-cancer-related Pain and Opioid-induced ConstipationCompletedNCT01309841Phase 3Results posted
• Opioid-induced Bowel Dysfunction (OBD) Pivotal Assessment of Lubiprostone (OPAL)CompletedNCT01298219Phase 3Results posted
• Evaluation of the Efficacy and Safety of ADL5945 Once Daily for the Treatment of Opioid-induced Constipation in Adults Taking Opioid Therapy for Chronic Noncancer PainCompletedNCT01275755Phase 2Results posted
• Evaluation of the Efficacy and Safety of ADL5945 for the Treatment of Opioid-induced Constipation in Adults Taking Opioid Therapy for Chronic Noncancer PainCompletedNCT01207427Phase 2Results posted
• Polyethylene Glycol (PEG) Versus Sennosides Study in Opioid-Induced Constipation in Cancer PatientsTerminatedNCT01189409Phase 4Results posted
• A Study of Oral Methylnaltrexone (MNTX) for the Treatment of Opioid-Induced Constipation (OIC) in Participants With Chronic, Non-Malignant PainCompletedNCT01186770Phase 3Results posted
• Study to Evaluate the Safety and Efficacy of Naldemedine (S-297995) for the Treatment of Opioid-Induced Bowel Dysfunction in Subjects With Chronic PainCompletedNCT01122030Phase 2Results posted
• Prucalopride Effects on Subjects With Chronic Non-cancer Pain Suffering From Opioid Induced ConstipationTerminatedNCT01117051Phase 3Results posted
• Methylnaltrexone for Opioid-induced Constipation in Cancer PatientsCompletedNCT01004393Phase 2Results posted
• Naloxone SR Capsules in Patients With Opioid Induced ConstipationCompletedNCT00984334Phase 2Results posted
• Study Evaluating the Efficacy and Safety of Subcutaneous Methylnaltrexone (MOA-728) for the Treatment of Opioid-Induced-ConstipationCompletedNCT00936884Phase 3Results posted
• Study Evaluating Long-Term Safety of MOA-728 in Participants With Opioid-Induced ConstipationCompletedNCT00804141Phase 3Results posted
• Study Evaluating Subcutaneous Methylnaltrexone For Treatment Of Opioid-Induced Constipation In Patients With Advanced IllnessCompletedNCT00672477Phase 4Results posted
• Safety of Subcutaneous Methylnaltrexone for Opioid-Induced Constipation in Patients With Advanced IllnessCompletedNCT00672139Phase 4Results posted
• Lubiprostone (Amitiza®) Vs. Standard Care in Opioid-induced Constipation After Surgery in Inpatient RehabilitationCompletedNCT00662363Not applicableResults posted
• Study of Subcutaneous Methylnaltrexone (MNTX) in the Treatment of Opioid-Induced Constipation During Rehabilitation After Orthopedic ProceduresCompletedNCT00640146Phase 2Results posted
• Opioid-induced Bowel Dysfunction: Long-Term Assessment of LubiprostoneCompletedNCT00620061Phase 3Results posted
• A Phase 2, Double-Blind, Multiple-Dose Escalation Study to Evaluate NKTR-118 (Oral PEG-Naloxol) in Patients With Opioid-Induced Constipation (OIC)CompletedNCT00600119Phase 2Results posted
• Opioid-induced Bowel Dysfunction Pivotal Assessment of LubiprostoneCompletedNCT00597428Phase 3Results posted
• Opioid-induced Bowel Dysfunction: Pivotal Assessment of LubiprostoneCompletedNCT00595946Phase 3Results posted
• Study Evaluating Subcutaneous MOA-728 for the Treatment of Opioid-Induced Constipation (OIC) in Subjects With Chronic Non-Malignant PainCompletedNCT00529087Phase 3Results posted
• Fiber-Enriched Enteral Nutrition and Opioid-Induced Constipation in the ICUCompletedNCT07201428
• Electroacupuncture for Opioid-Induced Constipation in Cancer Patients: A Randomized Clinical TrialCompletedNCT06537440Not applicable
• The Influence of Tramadol on Opioid-induced Bowel DysfunctionCompletedNCT06385561Phase 2
• Colonic Motor Patterns in Healthy VolunteersCompletedNCT05770960Phase 4
• Reflexology Socks and Opioid-induced ConstipationCompletedNCT05314335Not applicable
• European Study of Opioid Induced ConstipationCompletedNCT05149833
• Safety and Preliminary Efficacy of BGP345A in Constipation Due to Opioid-based MedicationsCompletedNCT05133076Phase 2
• The Efficacy of Acupressure in Managing Opioid-induced ConstipationStatus unknownNCT04876508Not applicable
• Effect of Naloxegol on Postoperative Ileus in Patients Undergoing Cardiac SurgeryCompletedNCT04433390Phase 3
• Study of Opioid-Induced Constipation 2 ProjectCompletedNCT04404933
• Study of Opioid-Induced Constipation 1 ProjectCompletedNCT04350112
• Study on Quality of Life in Advanced Cancer Patients With Opioid-induced Constipation Treated With NaloxegolCompletedNCT04294550
• Evaluation of the Quality of Life of Patients With Opioid-induced Constipation Under Treatment With NaloxegolCompletedNCT04173858
• Naloxone HCl PR Tablets in Patients With Opioid Induced ConstipationStatus unknownNCT03687268Phase 3
• Real World Observational Study of Naloxegol for Patients With Cancer Pain Diagnosed With OIC.CompletedNCT03638440
• Use of MgSO4 for Pain After Bariatric SurgeryCompletedNCT03355807Not applicable
• Naloxegol and Opioid-induced ConstipationStatus unknownNCT03316859Phase 2/3
• Targin® for Chronic Pain Management in Patients With Spinal Cord InjuryCompletedNCT03179475Phase 4
• Naloxegol Health Outcome Post Authorisation Safety StudyTerminatedNCT02813369
• Naloxegol US PMR CV Safety.Active, not recruitingNCT02813356
• Naloxegol Drug Utilization Post Authorisation Safety StudyCompletedNCT02813148
• Study of Methylnaltrexone in Opioid-Induced Constipation PatientsStatus unknownNCT02574819Phase 2/3
• Opioid Induced Bowel Dysfunction in Patients Undergoing Spinal SurgeryCompletedNCT02573922Phase 4
• Opioid Induced Bowel Dysfunction in Patients Undergoing Cesarean SectionStatus unknownNCT02571881Phase 4
• Feasibility Study of Oral Naloxone for Treatment of Methadone-induced ConstipationCompletedNCT02137213Phase 2
• Dose-ranging Study to Assess Safety and Efficacy of SP-333 for the Treatment of Opioid-induced Constipation (OIC)CompletedNCT01983306Phase 2
• A Single-arm, Study to Assess the Effect and Tolerability of Standardised Laxative Therapy (SLT) for the Reversal of Opioid-induced Constipation (OIC).CompletedNCT01957046Phase 4
• Longitudinal Study of Patients With Opioid-Induced ConstipationCompletedNCT01928953
• Non-interventional Study Comparing Targiniq and Oxycodone/LaxativesCompletedNCT01812733
• TD-1211 IV/Oral Mass Balance StudyCompletedNCT01702194Phase 1
• TD-1211 Single-Dose Study in Elderly and Young Healthy SubjectsCompletedNCT01655771Phase 1
• Assessing a Stool Symptom Screener in Patients With Chronic Opioid-Induced ConstipationCompletedNCT01645371
• Open Label, Healthy Volunteers, Bioequivalence Study With NaloxegolCompletedNCT01623609Phase 1
• A Double-Blind, Randomized, Placebo-Controlled, Parallel-Group Study to Assess the Safety and Efficacy of TD-1211 in Subjects With Opioid-Induced ConstipationCompletedNCT01459926Phase 2
• A Study of Oxycodone/Naloxone Controlled-release Tablets (OXN) to Assess Analgesic Efficacy and Management of Opioid-induced Constipation (OIC) in Opioid-experienced Subjects With Moderate to Severe Chronic Low Back PainCompletedNCT01427283Phase 3
• Analgesic Efficacy and Management of Opioid-induced Constipation (OIC) for Uncontrolled Moderate - Severe Low Back PainCompletedNCT01427270Phase 3
• ALK37-007: Evaluation of Safety and Efficacy of ALKS 37 (RDC-1036) in Adults With Opioid-induced Constipation (OIC)CompletedNCT01418092Phase 2
• A Study of TD-1211 in Subjects With Opioid-Induced Constipation (OIC)CompletedNCT01401985Phase 2
• ALK37-005: A Study of ALKS 37 (RDC-1036) in Adults With Opioid-induced Constipation (OIC)CompletedNCT01382797Phase 2
• Methylnaltrexone in Patients With Opioid-Induced Bowel DysfunctionCompletedNCT01367574Phase 2
• A Study to Assess the Safety, Tolerability and Clinical Activity of TD-1211 in Patients With Opioid-Induced ConstipationCompletedNCT01333540Phase 2
• A Comparison of Oxycodone/Naloxone and Oxycodone After Laparoscopic HysterectomyCompletedNCT01109511Phase 4
• ALK37-003: A Study of RDC-1036 (ALKS 37) in Adults With Opioid-induced Constipation (OIC)CompletedNCT01100151Phase 2
• Methylnaltrexone for Treatment of Opiate-Induced Constipation in the Intensive Care UnitStatus unknownNCT01050595Phase 3
• A Multiple Dose Study of TD-1211 in Healthy Volunteers and Patients With Opioid-Induced ConstipationCompletedNCT01040637Phase 1/2
• Efficacy of Oxycodone/Naloxone(OXN), Versus Oxycodone (OXY), for the Reduction of Intensity of Opioid-induced Constipation in Pain PatientsTerminatedNCT01014559Phase 3
• Study Evaluating Safety & Efficacy of Subcutaneous Methylnaltrexone on Opioid-Induced Constipation in Cancer SubjectsWithdrawnNCT00858754Phase 4
• Safety and Efficacy of Tegaserod in Opioid-induced Constipation in Patients With Non-cancer Pain.TerminatedNCT00414024Phase 3
• A a Single Dose Efficacy Study in Inducing Laxation in Advance Illness PatientsCompletedNCT00401362Phase 3
• Safety and Efficacy of Tegaserod in Opioid-induced Constipation in Patients With Non-cancer Pain.TerminatedNCT00399659Phase 3
• Study Evaluating Oral MOA-728 for the Treatment of Opioid-Induced Bowel Dysfunction (OIBD) in Subjects With Chronic Non-Malignant PainCompletedNCT00366431Phase 2
• Efficacy and Safety of Tegaserod in Opioid-induced Constipation in Patients With Non-cancer PainTerminatedNCT00365820Phase 2/3
• Study 767905/008 Extension Study: Alvimopan for Treatment of Opioid-Induced Bowel Dysfunction in Cancer Pain SubjectsCompletedNCT00135577Phase 2

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