ClinicalTrials.gg
CompletedNCT04713280Updated Feb 7, 2024

Maxillary Versus Bi-Maxillary Posterior Segments Intrusion Adult Subjects With Skeletal Open Bite

An interventional study of Maxillary posterior dento-alveolar intrusion in Dental Malocclusion, sponsored by Cairo University. Completed at 1 site in Egypt. Open to participants aged 17 Years to 25 Years. Per ClinicalTrials.gov, last updated 2024-02-07.

Primary conditionOpen BiteRegistry: MalocclusionReclassifiedWhy we changed it
Registry
Malocclusion — the first condition term the registry derived for this study.
ClinicalTrials.gg
Open Bite
Why
  1. The study's title name Open Bite, a narrower term within Malocclusion.
Confidence
High: the new condition is named in the study's own title. Of 46 hand-checked studies reclassified this way, 72% were exactly right and 89% in the right disease family; the registry's first term was right for 4% (measured 2026-10-21). How we classify →
Wrong?
Tell us the study's main condition →

Sponsored by Cairo University · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Registered 3 months after the study started (first participant enrolled Sep 2020, registered Jan 2021).
Phase
Not applicable
Study type
Interventional
Enrollment
20
Allocation
Randomized
Ages
17 Years to 25 Years
Sex
All
01

Study summary

Compare between bi-maxillary (maxillary and mandibular) posterior dento-alveolar intrusion and maxillary posterior dento-alveolar intrusion as regards open bite closure.

Read the detailed description

Now, maxillary posterior dento-alveolar intrusion has been validated as a conservative treatment modality for treatment of skeletal open bite in adult patients. However, it was proved that mandibular posterior teeth extrusion take place during the treatment which results in reduction in the amount of open. bite closure. Therefore, the aim of our study is to compare in a randomized clinical trial methodology between maxillary posterior dento-alveolar intrusion and combined maxillary and mandibular posterior dento-alveolar intrusion in terms of anterior open bite closure.

02

Conditions studied

  • Dental Malocclusion

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Keywords

  • molar intrusion
  • open bite
  • mini-screws
03

In context

Open Bite Reclassified

34 studies on the registry are indexed under Open Bite; 8 are open to participants now.

This study's enrollment of 20 is below the median of 30 across 28 interventional studies indexed under Open Bite.

Browse Open Bite studies →

Lead sponsor

Cairo University is the lead sponsor of 4,941 studies on the registry; 1,458 are open to participants now.

Of its 37 completed or terminated interventional studies of FDA-regulated products, 5 (14%) have results posted.

Compared within Open Bite, this study's primary condition as ClinicalTrials.gg classifies it; the registry's first condition term is Malocclusion. The counts are of registry records indexed under each term, refreshed daily. How we classify →

04

Who can participate

Ages eligible
17 Years to 25 Years
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Skeletal open bite with a dental open bite ranging from 3-8 mm.
  • Adequate incisal show at rest and on smiling
  • Full set of posterior teeth from first premolar to second molar (with the exception of one tooth in one quadrant).

Exclusion criteria

Exclusion Criteria:

  • Dental open bites without skeletal components
  • Previous orthodontic treatment
  • Medically compromised patients
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Double (Participant, Outcomes assessor)
Enrollment
20 participants (actual)

Study arms

  • Active comparator
    Maxillary posterior dento-alveolar intrusion

    Mini-screw supported maxillary posterior dento-alveolar intrusion

    Procedure: Maxillary posterior dento-alveolar intrusion

  • Experimental
    Bi-maxillary posterior dento-alveolar intrusion

    Mini-screw supported bi-maxillary posterior dento-alveolar intrusion

    Procedure: Maxillary posterior dento-alveolar intrusion

Interventions

  • ProcedureMaxillary posterior dento-alveolar intrusion

    Mini-screw supported maxillary or bi-maxillary posterior dento-alveolar intrusion

    Also known as: Bi-maxillary posterior dento-alveolar intrusion

06

What researchers measure

Primary outcomes

  1. Anterior open bite closure

    The amount of overbite gained as a result of posterior dento-alveolar intrusion

    Time frame: 6 months

Secondary outcomes

  1. Maxillary posterior teeth intrusion radiographically in millimeters.

    The distance travelled by maxillary premolars and molars of the right and left sides to a reference plane

    Time frame: 6 months

  2. Mandibular posterior teeth intrusion radiographically in millimeters.

    The distance travelled by mandibular premolars and molars of the right and left sides to a reference plane

    Time frame: 6 months

  3. Tip and torque of intruded teeth radiographically in degrees.

    • Torque change is measured as the change in the angle between the long axis of the intruded teeth and the FH plane (for tip) mid-sagittal plane (for torque).

    Time frame: 6 months

07

Study locations

1 site
  • Orthodontic Department, Faculty of Dentistry, Cairo University
    Cairo, 11451, Egypt
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Feb 7, 2024, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT04713280
Lead sponsor
Cairo University
Responsible party
Heba El-Sayed Kamel Akl (Principal investigator, Cairo University) — Principal investigator
First posted
Jan 19, 2021
Start date
Sep 17, 2020
Primary completion
Sep 30, 2021
Completion
Dec 1, 2021
Last update
Feb 7, 2024

Study contacts

Heba Akl, MSc.
principal investigator · Assistant lecturer, PhD candidate

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Feb 2024. You cannot join it, but the record below documents what was studied.

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