Oligospermia clinical trials
The registry lists 64 studies for Oligospermia across more than 10 countries. 17 are recruiting or about to start. 43 of them are mainly about Oligospermia (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-06.
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Who runs them
Staidson (Beijing) Biopharmaceuticals Co., Ltd (3) · Mst.Sumyara Khatun (2) · Clinique Ovo (2) · Reproductive & Genetic Hospital of CITIC-Xiangya (2) · National Cheng-Kung University Hospital (1) · Ankara City Hospital Bilkent (1) · University of California, Los Angeles (1) · Herbarium Laboratorio Botanico Ltda (1)
What is being tested here
Drugs under test in Oligospermia studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Carnitine | 1 | 1 | 2 |
| STSP-0902 | 1 | 0 | 2 |
| Isotretinoin | 1 | 0 | 1 |
| Clomiphene | 1 | 0 | 1 |
| Follicle Stimulating Hormone | 1 | 0 | 1 |
| Tribulus extract | 1 | 0 | 1 |
| Coenzyme Q10 | 1 | 0 | 1 |
| Letrozole | 0 | 2 | 2 |
| Geritol | 0 | 0 | 1 |
| BCG Vaccine | 0 | 0 | 1 |
Drug classes tested here Aromatase inhibitors 3
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 6
- Dec 2026Probiotics on Sperm Quality in Male Infertility Patients · Mackay Memorial Hospital
- Apr 2027Maternal Inheritance of a Pathogenic MT-ND1 Mutation Causes Mitochondrial Dysfunction and Spermatogenic Failure in Men · The Third Affiliated Hospital of Guangzhou Medical University
- Jun 2027Sperm, Exposure and Endocrine Disruptors · Million Marker Wellness, Inc.
- Jun 2027Isotretinoin vs hCG for Male Infertility Due to Low or Absent Sperm · University of Nebraska
- Sep 2027A Study to Evaluate the Safety and Efficacy of Multiple Dose of STSP-0902 in Patients With Oligozoospermia and/or Asthenozoospermia. · Staidson (Beijing) Biopharmaceuticals Co., Ltd
- Oct 2027Comparative Efficacy of Antioxidants Alone Versus Combined Therapy With SERMs or FSH in Normogonadotropic Idiopathic OAT Patients: A Randomized Controlled Trial · Hamad Medical Corporation
Who these studies take
Of the 13 Oligospermia studies recruiting now, 4 (31%) set no upper age limit and 8 (62%) stop at 75 or younger. 2 (15%) take children under 18. 0 (0%) are for women only and 10 (77%) for men only; 4 (31%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 1 (8%) | 2 (15%) |
| 18 | 3 (23%) | 9 (69%) |
| 30 | 3 (23%) | 13 (100%) |
| 40 | 3 (23%) | 13 (100%) |
| 50 | 3 (23%) | 9 (69%) |
| 65 | 3 (23%) | 5 (38%) |
| 75 | 3 (23%) | 5 (38%) |
| 85 | 3 (23%) | 5 (38%) |
Across all 64 studies, recruiting or not: 67% stop at 75 or younger and 66% at 65; 13% take children; 2% are for women only and 88% for men only; 31% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Oligospermia studies take
Of 16 interventional studies with no phase under Oligospermia, half reached primary completion within 26 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 26 mo17–36 · 16 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Newly registered2
Studies
Recruiting first, then most recently updated. Showing 50 of 64. Browse all 64 → or search them.
- Sperm, Exposure and Endocrine DisruptorsNot yet recruitingNCT07703046Not applicable1 country
- Comparative Efficacy of Antioxidants Alone Versus Combined Therapy With SERMs or FSH in Normogonadotropic Idiopathic OAT Patients: A Randomized Controlled TrialNot yet recruitingNCT07862725Phase 41 country
- A Study to Evaluate the Safety and Efficacy of Multiple Dose of STSP-0902 in Patients With Oligozoospermia and/or Asthenozoospermia.Not yet recruitingNCT07833943Phase 21 country
- Efficacy and Safety of a New Sperm Capacitation MethodRecruitingNCT067424371 country
- Maternal Inheritance of a Pathogenic MT-ND1 Mutation Causes Mitochondrial Dysfunction and Spermatogenic Failure in MenRecruitingNCT076918271 country
- A Study to Evaluate the Safety and Tolerability of Single and Multiple Dose of STSP-0902 in Healthy SubjectsRecruitingNCT06948799Phase 11 country
- Hyperbaric Oxygen Therapy for Men Suffering From Infertility Due to Oligospermia.RecruitingNCT05842239Not applicable1 country
- Fertility Restoration With Autografting of Cryopreserved Immature Testicular TissueRecruitingNCT07542626Not applicable1 country
- Isotretinoin vs hCG for Male Infertility Due to Low or Absent SpermEnrolling by invitationNCT07481370Phase 21 country
- Identifying Genome Variants in Non-Obstructive Azoospermia (NOA) or Primary Ovarian Insufficiency (POI)RecruitingNCT073577011 country
- Effect of Daily Intake of Gazpacho on Semen Quality and Oxidative StressRecruitingNCT07375238Not applicable1 country
- Probiotics on Sperm Quality in Male Infertility PatientsRecruitingNCT07345455Not applicable1 country
- Efficacy and Safety Study of Products Based on Tribulus Terrestris, L. in Men With OligospermiaRecruitingNCT06260007Phase 41 country
- Study of Tolerability, Safety, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy of the Medicinal Product MediReg®RecruitingNCT06869863Phase 1/21 country
- The Association of Gut Microbiota and Spermatogenic DysfunctionRecruitingNCT056289871 country
- Study of the ZyMōt Sperm Selection Method and Its Effect on Embryo Ploidy.RecruitingNCT06384794Not applicable1 country
- Evaluation of Treatment With Coenzyme Q10 and L-Carnitine on Semen Parameters in Infertile Men With Idiopathic OligoasthenoteratospermiaRecruitingNCT06342856Early Phase 11 country
- Letrozole in Oligospermia With Eugonadotropic-Hypogonadism and Low Testosterone Estradiol RatioCompletedNCT07922512Not applicable1 country
- Effect of Intravesical B.C.G and Gemcitabine on Semen Analysis and Testicular Volume in NMIBCCompletedNCT05701332Phase 41 country
- Evaluation of Assisted Reproductive Technology (ART) Outcomes in Couples With Nonobstructive Azoospermia, Cryptozoospermia, and Severe OligozoospermiaCompletedNCT078972791 country
- Evaluating Traditional Medicine Syndromes in Male Infertility With OligoasthenoteratozoospermiaCompletedNCT075292881 country
- DHEA Plus Coenzyme Q10 Verus Coenzyme Q10 Alone on Sperm Concentration in Subfertile Male With Oligospermia.CompletedNCT07771153Not applicable1 country
- Varicocelectomy for Cryptozoospermic Men.CompletedNCT07759713Not applicable1 country
- Comparative Evaluation of the Efficacy of Letrozole, L-Carnitine, and Their Combination on Sperm Quality, Oxidative Stress, and ART Outcomes in Men With Idiopathic Oligoasthenoteratozoospermia.CompletedNCT07669402Phase 2/31 country
- PRP Improves Blastocyst Formation in ICSI CyclesCompletedNCT07579858Phase 31 country
- Effect of Walnuts on Sperm Parameters and Male FertilityCompletedNCT01954498Not applicable1 country
- Identifying Candidates for Limited Dissection at Microdissection TESE.CompletedNCT072862791 country
- Timing of Oocyte Retrieval and Micro Testicular Sperm ExtractionCompletedNCT072682351 country
- A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Immunogenicity of STSP-0902 in Healthy SubjectsCompletedNCT06563713Phase 11 country
- Safety of Cultured Allogeneic Adult Umbilical Cord Derived Mesenchymal Stem Cells for Testicular Injury and OligospermiaWithdrawnNCT05158114Phase 11 country
- Effect of Eurycoma Longifolia (DLBS5055) and Multivitamins (Vitamin C+Vitamin E+ Β-carotene) for Infertile MalesActive, not recruitingNCT06100432Phase 41 country
- Comparison of ICSI Outcomes in Cycles Using Testicular and Ejaculate Sperm From Couples With High SDFCompletedNCT04795440Not applicable1 country
- Creatine and Ubiquinol for Sperm QualityCompletedNCT06202469Not applicable1 country
- Administration of Antioxidants to Infertile Men and Sperm QualityCompletedNCT04256278Not applicable1 country
- Effects of a Fasting Mimicking Diet on Sperm QualityCompletedNCT04908774Not applicable1 country
- The Role of Electroacupuncture With Standard Therapy on Sperm Analysis and SOD Levels in Oligozoospermia.CompletedNCT06088693Not applicable1 country
- Using of Testes Shocker in Improving the Spermatogenesis and Sperms ActivityStatus unknownNCT05506722Not applicable1 country
- Myo-inositol on Human Semen ParametersCompletedNCT01828710Not applicable1 country
- A Clinical Study of Gulingji Capsule in the Treatment of Idiopathic Oligospermia, Asthenia, and TeratozoospermiaStatus unknownNCT05320536Phase 41 country
- Detection of Microdeletions in the Azoospermia Factor (AZF) Regions in Infertile Male PatientsTerminatedNCT034977281 country
- Efficacy Comparison of Tamoxifen and Tamoxifen With Antioxidants on Semen Quality of Male With Idiopathic InfertilityStatus unknownNCT05200663Phase 21 country
- Is Oxidative Stress in Semen Reduced by Lifestyle InterventionCompletedNCT03898752Not applicable1 country
- Semen Parameters and COVID-19 in Infertile MenCompletedNCT046435221 country
- Autologous Adipose-Derived Adult Stromal Vascular Cell Administration for Male Patients With InfertilityStatus unknownNCT03762967Phase 21 country
- Impact of Immunotherapy on the Sperm Count of Patients With CancerStatus unknownNCT045540301 country
- Seminal Fluid's Changes Over 20 YearsCompletedNCT04349345
- Sperm Pathology Samples and MorphokineticsCompletedNCT021551791 country
- A Retrospective Study on the Effect of Male Progressive Sperm Count After Semen Pretreatment on ICSI Fertilization OutcomeCompletedNCT035942011 country
- The Role of Artery-Preserving Varicocelectomy in Subfertile Men With Severe Oligozoospermia.CompletedNCT03344588Not applicable1 country
- Effect of Letrozole on Seminal Parameters in Men With Non Obstructive Azoospermia and Severe Oligozoospermia.CompletedNCT02900105Phase 31 country