An observational study in Sperm Count, Low and Reproductive Sterility, sponsored by Reproductive & Genetic Hospital of CITIC-Xiangya. Completed at 1 site in China. Per ClinicalTrials.gov, last updated 2019-05-21.
Sponsored by Reproductive & Genetic Hospital of CITIC-Xiangya · Observational
The investigators plan to retrospectively analyze clinical data from 14,189 fresh ICSI cycles in Reproductive and Genetic Hospital of CITIC-Xiangya from January 2016 to December 2017.The investigators will regard total progressive sperm number of 2 x 10\^6 after pretreatment as the boundary value, and will divide total progressive sperm number of 2 x 10\^6 after pretreatment into 2 x 10\^6 or higher and \< 2 x 10\^6 groups, and will further divide \< 2 x 10\^6 group into: = 0, (0,10\^6], (10\^6, 2 x 10\^6) three groups. Propensity score matching will be used to balance the baseline data between four groups. The matching variables are age, female BMI, AFC, AMH and ICSI.
64 studies on the registry are indexed under Oligospermia; 17 are open to participants now.
This study's enrollment of 12,215 is above the median of 300 across 17 observational studies indexed under Oligospermia.
Browse Oligospermia studies →Reproductive & Genetic Hospital of CITIC-Xiangya is the lead sponsor of 26 studies on the registry; 2 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Infertile couples take ART treament due to poor male semen quality.
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Exclusion Criteria:
A+B grade sperm count after treatment=0
Other: semen pretreatment
0\<A+B grade sperm count after treatment≤10\^6
Other: semen pretreatment
10\^6\<A+B grade sperm count after treatment\<2\*10\^6
Other: semen pretreatment
A+B grade sperm count after treatment≥2\*10\^6
Other: semen pretreatment
semen pretreatment
high quality embryo rate for ICSI
rate of embryo grade above 6CI on the third day after fertilization
Time frame: two years
fertilization rate of ICSI
number of fertilized oocytes/ number of metaphase II oocytes
Time frame: two years
normal fertilization rate of ICSI
number of 2PN fertilized oocytes/ number of metaphase II oocytes
Time frame: two years
Plan to share: No
No publications or documents are linked to this record.
Ran from Jan 2016 to primary completion in Dec 2017, 23 months.
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This study is completed, as verified in Jul 2018. You cannot join it, but the record below documents what was studied.
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Reproductive & Genetic Hospital of CITIC-Xiangya