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CompletedNCT07268235Updated Dec 5, 2025

Timing of Oocyte Retrieval and Micro Testicular Sperm Extraction

An observational study in Microdissection Testicular Sperm Extraction, sponsored by Clinique Ovo. Completed at 1 site in Canada. Open to male participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-12-05.

Sponsored by Clinique Ovo · Observational

Study type
Observational
Model
Cohort
Time perspective
Retrospective
Enrollment
129
Ages
18 Years and older
Sex
Male
01

Study summary

This is a retrospective study to assess outcomes of micro-TESE performed 24 or 48 hours before oocyte retrieval and ICSI.

Read the detailed description

This retrospective study evaluates patients undergoing ICSI following micro-TESE. Participants are assigned to two groups based on the interval between sperm extraction and oocyte retrieval (24 vs. 48 hours). Clinical and embryological outcomes from the first embryo transfer will be assessed.

02

Conditions studied

  • Microdissection Testicular Sperm Extraction

Keywords

  • Nonobstructive Azoospermia
  • oligoasthenoteratozoospermia
  • intracytoplasmic sperm injection
  • In vitro fertilization
  • cryptozoospermia
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In context

Azoospermia, Nonobstructive

23 studies on the registry are indexed under Azoospermia, Nonobstructive; 7 are open to participants now.

This study's enrollment of 129 is above the median of 94 across 10 observational studies indexed under Azoospermia, Nonobstructive.

Browse Azoospermia, Nonobstructive studies →

Lead sponsor

Clinique Ovo is the lead sponsor of 36 studies on the registry; 1 is open to participants now.

Browse Clinique Ovo studies →

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
Male
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Men who underwent a micro-TESE for IVF treatment

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Men who underwent a micro-TESE at the OVO clinic from June 2015 to January 2025.
  • Patients with non-obstructive azoospermia (NOA), (absence of spermatozoa in multiple semen analyses)
  • Patients with cryptozoospermia, (presence of a small number of spermatozoa detectable only after semen centrifugation)
  • Patients with oligoasthenoteratozoospermia (OAT), (sperm concentration of less than 15 million/mL, reduced motility and abnormal morphology)

Exclusion criteria

Exclusion Criteria:

  • Patients who did not have any sperm noted following micro-TESE
  • Use of donor sperm or oocytes
  • Frozen sperm or oocytes
  • Same day oocyte retrieval and sperm extraction
  • Reversible cause of cryptozoospermia (i.e presence of a varicocele, febrile illness, or recent toxin exposure) Partial genital tract obstruction (i.e post-vaso-vasostomy, post-vasoepididymostomy, and low volume cryptozoospermia with ejaculatory duct obstruction)
05

Study design

Observational model
Cohort
Time perspective
Retrospective
Enrollment
129 participants (actual)
Patient registry
No
06

What researchers measure

Primary outcomes

  1. Number of live births following ICSI with micro-TESE either 24 or 48 hours prior to oocyte retrieval

    Time frame: For IVF performed from June 2015 to January 2025

Secondary outcomes

  1. Percentage of fertilized oocytes with two pronuclei (2PN)

    Time frame: For IVF performed from June 2015 to January 2025

  2. Percentage of usable blastocyst (defined as frozen and transferred blastocysts)

    Time frame: For IVF performed from June 2015 to January 2025

  3. Pregnancy rate based on positive β-hCG

    Time frame: For IVF performed from June 2015 to January 2025

07

Study locations

1 site
  • Clinique ovo
    Montreal, Quebec H4P 2S4, Canada
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Dec 5, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT07268235
Lead sponsor
Clinique Ovo
Responsible party
Sponsor
First posted
Dec 5, 2025
Start date
Nov 15, 2025
Primary completion
Nov 30, 2025
Completion
Nov 30, 2025
Last update
Dec 5, 2025

Study contacts

Isaac-Jacques Kadoch, MD
principal investigator · Clinique Ovo

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Dec 2025. You cannot join it, but the record below documents what was studied.

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Discussion

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