Non-Erosive Reflux Disease clinical trials
The registry lists 46 studies for Non-Erosive Reflux Disease across more than 10 countries. 7 are recruiting or about to start. 37 of them are mainly about Non-Erosive Reflux Disease (how this is decided). Per ClinicalTrials.gov, last updated 2026-10-13.
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Who runs them
AstraZeneca (4) · Xiyuan Hospital of China Academy of Chinese Medical Sciences (4) · Nycomed (3) · Seoul National University Bundang Hospital (3) · Braintree Laboratories (2) · Midwest Biomedical Research Foundation (2) · Ningbo Medical Center Lihuili Hospital (1) · Chong Kun Dang Pharmaceutical (1)
What is being tested here
Drugs under test in Non-Erosive Reflux Disease studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Fexuprazan | 1 | 1 | 1 |
| Tegoprazan | 0 | 4 | 4 |
| Esomeprazole | 0 | 0 | 3 |
| Omeprazole | 0 | 3 | 3 |
| Sucralfate | 0 | 0 | 2 |
| YYD601 | 0 | 1 | 1 |
| Ilaprazole | 0 | 1 | 1 |
| Fluoxetine | 0 | 1 | 1 |
| Rabeprazole | 0 | 1 | 1 |
| Pantoprazole | 0 | 0 | 1 |
Drug classes tested here Proton pump inhibitors (PPIs) 12
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The study
- Dec 2026Effect of Inspiratory Muscle Training on Symptom Severity and Quality of Life in Non-Erosive Reflux Disease · Izmir University of Economics
Who these studies take
Of the 3 Non-Erosive Reflux Disease studies recruiting now, 1 (33%) set no upper age limit and 1 (33%) stop at 75 or younger. 0 (0%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 0 (0%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 2 (67%) | 2 (67%) |
| 30 | 3 (100%) | 3 (100%) |
| 40 | 3 (100%) | 3 (100%) |
| 50 | 3 (100%) | 3 (100%) |
| 65 | 3 (100%) | 3 (100%) |
| 75 | 3 (100%) | 3 (100%) |
| 85 | 1 (33%) | 1 (33%) |
Across all 46 studies, recruiting or not: 35% stop at 75 or younger and 4% at 65; 15% take children; 0% are for women only and 0% for men only; 13% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
Studies
Recruiting first, then most recently updated. Showing 46 of 46. search them.
- New Topical tReatment Options for Symptomatic patiEnts With Nonerosive gastroesophageaL Reflux dIsease (The RELIEF Trial)RecruitingNCT07624383Not applicable1 country
- Effect of Inspiratory Muscle Training on Symptom Severity and Quality of Life in Non-Erosive Reflux DiseaseNot yet recruitingNCT07584096Not applicable1 country
- Transcutaneous Electrical Acustimulation (TEA) for the Treatment of Non-Erosive Gastroesophageal Reflux Disease (NERD)Not yet recruitingNCT07572708Not applicable1 country
- Clinical Efficacy Evaluation of Chaizhi Hewei Decoction in the Treatment of Non-Erosive Reflux Disease With Liver-Stomach Disharmony SyndromeNot yet recruitingNCT07518420Not applicable1 country
- Phase 3 Study of JP-1366: Efficacy and Safety of JP-1366 in Patients With Non-erosive Gastroesophageal Reflux DiseaseNot yet recruitingNCT07160790Phase 3
- Real-life Study of Changes of Gastroesophageal Reflux Disease Manifestations Due to Behavioural and Diet AdherenceRecruitingNCT04255693Not applicable1 country
- Study to Evaluate the Efficacy and Safety of DWP14012 in Patients With Non-Erosive Gastroesophageal Reflux Disease (NERD)RecruitingNCT06121830Phase 31 country
- A Study to Evaluate the Efficacy and Safety of BLI5100 in Patients With Non-Erosive Reflux DiseaseCompletedNCT05587322Phase 31 country
- Assessment of Esophageal Epithelium Integrity With Mucosal ImpedanceCompletedNCT02318862Not applicable1 country
- A Study to Evaluate the Long-Term Safety of BLI5100 in Patients With Gastroesophageal Reflux DiseaseCompletedNCT05890001Phase 31 country
- Evaluation of the Efficacy and Safety of Eolo in Patients With NERDCompletedNCT07041060Not applicable1 country
- Diagnosis of Acid Reflux Disease Using Novel Imaging: A Prospective StudyCompletedNCT02081404Not applicable2 countries
- Efficacy and Safety of WPQW Granule for Overlap of NERD and IBS-DStatus unknownNCT05369884Early Phase 11 country
- Confocal Endomicroscopy for Non-Erosive Reflux Disease DetectionTerminatedNCT02788591Not applicable1 country
- Study of Dietary Patterns and Food Diversity in Russian GERD PatientsStatus unknownNCT04252144Not applicable1 country
- Clinical Trial to Assess the Efficacy and Safety of YYD601 in NERD PatientsCompletedNCT03967886Phase 31 country
- Comorbid Esophageal Disorders in IBS PatientsStatus unknownNCT04759378Not applicable
- Overlap FGIDs and Genetic PolymorphismCompletedNCT04712617
- Phase III Study to Evaluate Safety and Efficacy of Ilaprazole in Patients With NERDCompletedNCT03444883Phase 31 country
- Study on the Rule and Mechanism of Treating Functional Gastrointestinal Diseases From the Perspective of Liver and SpleenStatus unknownNCT04454996Phase 41 country
- A Multi-center, Randomized, Double-blind, Parallel-group, Placebo Controlled Phase III Study to Evaluate the Efficacy and Safety of LXI-15028 in Non-erosive Reflux Disease in Chinese Patients for 4 WeeksCompletedNCT03591653Phase 31 country
- Clinical Trial to Evaluate the Efficacy and Safety of EsoDuo Tab. 20/800mgCompletedNCT03928470Phase 41 country
- Efficacy of Traditional Chinese Medicine Combined With Omeprazole in Patients With Non-erosive Reflux DiseaseStatus unknownNCT02892357Phase 1/21 country
- Study to Evaluate the Safety and Efficacy of CJ-12420 in Patients With Non Erosive Reflux DiseaseCompletedNCT02556021Phase 31 country
- Diagnostic Value of Linked Color Imaging for Minimal Change Esophagitis in Nonerosive Reflux Esophagitis and GERDStatus unknownNCT030685721 country
- Image-Enhanced Endoscopy (IEE) for Diagnosis of Non-Erosive Reflux DiseaseCompletedNCT026290811 country
- Minimal Injuries From Esophagus Detected by Optical Enhancement System™ Associated to Optical Magnification HD ScopesCompletedNCT025752871 country
- Confocal Endomicroscopy for Non-Erosive Reflux Disease (CE NERD)WithdrawnNCT02039869Not applicable1 country
- The Changes of Ryodoraku and HRV After PPI Treatment in GERD PatientsStatus unknownNCT02149914Not applicable1 country
- S-pantoprazole 10mg Phase III Clinical StudyStatus unknownNCT02274961Phase 31 country
- Phase 2 Clinical Trial to Investigate the Safety, Tolerability and Efficacy of YH1885L in Patients With Non-erosive Reflux Disease(NERD)CompletedNCT01750437Phase 21 country
- Nexium Capsules Clinical Experience InvestigationCompletedNCT014344851 country
- Predictors of Proton Pump Inhibitor Response in Gastroesophageal Reflux Disease PatientsCompletedNCT017979391 country
- A Study to Evaluate the Role of Alternative Medicine in Difficult to Treat GERD PatientsWithdrawnNCT00591877Not applicable1 country
- Esomeprazole Treatment Co-diagnosed Non Erosive Reflux Disease (NERD) and Chronic Gastritis PatientsCompletedNCT01119768Phase 41 country
- Efficacy of Pantoprazole in Patients Older Than 12 Years Who Have Symptoms of Non-Erosive Reflux Disease (NERD) or Erosive Gastroesophageal Reflux Disease (eGERD)CompletedNCT005617301 country
- Efficacy of Pantoprazole in Patients Older Than 12 Years With Reflux Associated Sleep Disorders (PULS)CompletedNCT005620941 country
- Pantoprazole 20/40 mg in the Treatment of Symptomatic Reflux Disease With Focus on Sleep DisordersCompletedNCT008301151 country
- The CONQUEST-Study. Evaluation of Clinical Endpoints for Treatment-induced Changes in GERD-related Symptoms (BY1023/NL511)TerminatedNCT00449813Phase 42 countries
- Detection of Minimal Change Esophagitis by I-scanCompletedNCT015609101 country
- Comparing Omeprazole With Fluoxetine for Treatment of Non Erosive Reflux Disease and Its Subgroups: a Double-blind Placebo-controlled Clinical TrialCompletedNCT01269788Phase 2/31 country
- Analysis of GERD Symptoms Using Gastroesophageal Reflux Impact Score Questionnaire for Quality of LifeCompletedNCT015360801 country
- A Study to Investigate the Pharmacodynamic Effect After Four-week Omeprazole Treatment of Non-erosive Reflux Disease in a Japanese PopulationCompletedNCT00259051Phase 31 country
- Four-week Omeprazole Treatment of Non-erosive Reflux Disease in a Japanese PopulationCompletedNCT00259077Phase 31 country
- A Study of Efficacy and Safety of "On-demand" Maintenance Therapy With Rabeprazole in Patients With Non-erosive Reflux Disease (NERD)CompletedNCT00236392Phase 3
- The Use of Proton Pump Inhibitor for the Treatment of Non-erosive Gastro-oesophageal Reflux Disease in Chinese PopulationStatus unknownNCT00516971Not applicable1 country