Muscle Hypotonia clinical trials
The registry lists 66 studies for Muscle Hypotonia across more than 10 countries. 14 are recruiting or about to start. 37 of them are mainly about Muscle Hypotonia (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-09.
Get an email when these change. Save the Muscle Hypotonia studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
See an example email
Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
One email a week for all your saved searches. Stop any time.
Who runs them
Assiut University (3) · Brno University Hospital (2) · University of Michigan (2) · SMG-SNU Boramae Medical Center (2) · Technical University of Munich (2) · Columbia University (2) · Universidade Federal de Pernambuco (1) · Purdue University (1)
What is being tested here
Drugs under test in Muscle Hypotonia studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Rocuronium | 1 | 0 | 6 |
| Mivacurium | 1 | 0 | 1 |
| Aprepitant | 1 | 0 | 1 |
| Propofol | 1 | 0 | 1 |
| Sugammadex | 0 | 0 | 2 |
| Succinylcholine | 0 | 0 | 1 |
| Neostigmine | 0 | 0 | 1 |
| Sevoflurane | 0 | 0 | 1 |
| Glutamine | 0 | 0 | 1 |
| rimabotulinumtoxinB | 0 | 0 | 1 |
Drug classes tested here Neuromuscular blockers 2 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 4, phase 3 first
- Dec 2026Efficacy and Safety of HRS-9190 in General Anesthesia · Phase 3 · The Third Xiangya Hospital of Central South University
- Dec 2026Developing a Physiology-Pharmacodynamic Model of Rocuronium Dose and Cardiac Output to Investigate the Onset Time of Neuromuscular Relaxation · Clare Hayes-Bradley
- Jan 2027The Association Between Residual Neuromuscular Block Risk Prediction Score and the Train-of-Four Ratio · Assiut University
- May 2027Aprepitant for the Treatment of CLIFAHDD · The University of Texas Health Science Center at San Antonio
Who these studies take
Of the 8 Muscle Hypotonia studies recruiting now, 3 (38%) set no upper age limit and 3 (38%) stop at 75 or younger. 5 (63%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 0 (0%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 4 (50%) | 4 (50%) |
| 18 | 6 (75%) | 6 (75%) |
| 30 | 7 (88%) | 7 (88%) |
| 40 | 7 (88%) | 7 (88%) |
| 50 | 7 (88%) | 7 (88%) |
| 65 | 6 (75%) | 6 (75%) |
| 75 | 5 (63%) | 5 (63%) |
| 85 | 4 (50%) | 4 (50%) |
Across all 66 studies, recruiting or not: 64% stop at 75 or younger and 52% at 65; 45% take children; 3% are for women only and 3% for men only; 21% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Muscle Hypotonia studies take
Of 17 interventional studies with no phase under Muscle Hypotonia, half reached primary completion within 16 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 16 mo7–28 · 17 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
Studies
Recruiting first, then most recently updated. Showing 50 of 66. Browse all 66 → or search them.
- Clinical and Basic Investigations Into Known and Suspected Congenital Disorders of GlycosylationRecruitingNCT020897891 country
- Aprepitant for the Treatment of CLIFAHDDRecruitingNCT07845825Early Phase 11 country
- The Association Between Residual Neuromuscular Block Risk Prediction Score and the Train-of-Four RatioRecruitingNCT068990481 country
- Small Doses Muscle Relaxant in General AnesthesiaRecruitingNCT04344262Not applicable1 country
- Efficacy and Safety of HRS-9190 in General AnesthesiaEnrolling by invitationNCT07733245Phase 31 country
- The Impact of Ventilator Synchrony on Muscle Relaxant Consumption and Surgeon Satisfaction During Laparoscopic Cholecystectomy.Not yet recruitingNCT07647770Not applicable1 country
- Long-term Evaluation of Nasopharyngeal Airway in HypotoniaEnrolling by invitationNCT06614582Not applicable1 country
- Developing a Physiology-Pharmacodynamic Model of Rocuronium Dose and Cardiac Output to Investigate the Onset Time of Neuromuscular RelaxationNot yet recruitingNCT07168252Phase 4
- Test of Aquatic Mobility of SMA InfantsRecruitingNCT06152302Not applicable1 country
- Longitudinal Study of Neurogenetic DisordersRecruitingNCT034920601 country
- Muscle Relaxant Effect and Safety of Mivacurium Chloride and Succinylcholine for BronchoscopyNot yet recruitingNCT06709066Not applicable
- The Potential Protective Effect of Using Muscle Relaxants During Electroporation Ablation (PFA)RecruitingNCT06707532Not applicable1 country
- Register for Patients With Thyroid Hormone Resistance.RecruitingNCT065660661 country
- Patterns Of Floppy Infants Attending Assiut University Children HospitalNot yet recruitingNCT06183996
- Orthosis to Improve Trunk Control in Infants Age 6-18 MonthsCompletedNCT060275801 country
- Osteopathic Treatment on Motor Development of Hypotonic Infants.TerminatedNCT03852004Not applicable1 country
- The Effect of Deep Versus Moderate Muscle Relaxants in Men During and After Robotic Surgery for Prostate CancerActive, not recruitingNCT03808077Phase 21 country
- Tolerability, Safety and Activity of a Muscle Relaxant Molecule IDN5243 in Patients With Low Back PainWithdrawnNCT02568826Phase 21 country
- North Carolina Genomic Evaluation by Next-generation Exome Sequencing, 2CompletedNCT03548779Not applicable1 country
- Interindividual Variability in Duration of Action of Rocuronium in Pediatric PatientsCompletedNCT055294201 country
- PREPL in Health and DiseaseActive, not recruitingNCT02263781Not applicable1 country
- Muscle Relaxants and Laryngeal Local Anesthetics for Laryngeal Mask Airway Insertion Decreasing Propofol in ElderlyCompletedNCT05310110Not applicable1 country
- Pilot Study of a Self-Supporting Nasopharyngeal Airway in HypotoniaCompletedNCT04846400Not applicable1 country
- A RETROspective Study of Patients With TK2dCompletedNCT037015683 countries
- Use of Muscle Relaxants in Parotidectomy Operation With NeuromonitoringCompletedNCT05432570Not applicable1 country
- Myotonometer Intra- and Inter Examiner Reliability on Spinal Muscular AtrophyStatus unknownNCT055212171 country
- Perioperative Muscle Relaxant and Postoperative OutcomesCompletedNCT043715881 country
- Effect of Trunk Support on Academic Engagement of Children With Severe DisabilityCompletedNCT05391594Not applicable1 country
- Down Syndrome and Effects of Foot Muscle ExerciseCompletedNCT05251935Not applicable1 country
- Vestibular Stimulation and Neurodevelopmental Technique on Hypotonic Cerebral Palsy While Controlling the GenderCompletedNCT04894799Not applicable1 country
- Assessment of Hypotonia in Children With Down SyndromeCompletedNCT051315421 country
- Neonatal Hypotonia Associated With in Utero Exposure to AntidepressantStatus unknownNCT048302411 country
- Gonyautoxin 2/3 in the Treatment of Acute Back Pain: A Clinical Proof-of-concept StudyCompletedNCT04799041Phase 1/21 country
- A Randomized Controlled Crossover Study Comparing Sugammadex and PlaceboCompletedNCT03087513Phase 41 country
- Effect of Intraoperative Neuromuscular Blockade on Postoperative Sore Throat and HoarsenessCompletedNCT033977971 country
- Muscle Relaxants on Efficacy of LMA InsertionCompletedNCT03487003Not applicable1 country
- Evaluation and Comparison of Women Pelvic Floor With and Without Sexual Dysfunction (Vaginismus)CompletedNCT03176069Not applicable1 country
- Effect of Different Electric Muscle Stimulation in Patients With Severe Sepsis and Respiratory FailureTerminatedNCT01895647Not applicable1 country
- Causes of Peripheral Hypotonia in Assiut University Children HospitalStatus unknownNCT03857555
- Myorelaxation Practice in Paediatric AnesthesiaCompletedNCT030869151 country
- Effect of Intraoperative Muscle Relaxation Depth on Postoperative Sore Throat and Hoarseness After General AnesthesiaStatus unknownNCT03391700Not applicable1 country
- Prospective, Longitudinal Study of the Natural History and Functional Status of Patients With Myotubular Myopathy (MTM)CompletedNCT020577057 countries
- Efficacy and Safety of Poly-L-lactic AcidCompletedNCT03225066Not applicable1 country
- Standard of Care Versus Urine Testing With Selective PHarmacogenomics for Effective Drug and Dosing REgimensStatus unknownNCT02625155Phase 41 country
- Fade Upon TOF Stimulation Induced by SuccinylcholineCompletedNCT02425449Phase 41 country
- Effect of Neostigmine on the Recovery of Rocuronium: A Comparison Between Partial and TOF Ratio-Based DoseCompletedNCT03058263Phase 1/21 country
- Effect of Massage Therapy in a Multisensory Environment for Intellectual DisabilitiesCompletedNCT02120820Not applicable1 country
- Mapping Human Muscle Satellite Cell Fate By Real-Time ImagingCompletedNCT02685319Not applicable1 country
- Endotracheal Intubation Without Muscle RelaxantsCompletedNCT03112564Not applicable1 country
- The Dose-Response Relationship of Rocuronium in Patients Taking PyridostigmineWithdrawnNCT021575451 country