Tongue Neoplasms clinical trials
The registry lists 121 studies for Tongue Neoplasms across more than 10 countries. 12 are recruiting or about to start. 28 of them are mainly about Tongue Neoplasms (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-03.
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Who runs them
National Cancer Institute (NCI) (20) · Alpha Tau Medical LTD. (5) · Ohio State University Comprehensive Cancer Center (5) · Fox Chase Cancer Center (5) · Roswell Park Cancer Institute (4) · Memorial Sloan Kettering Cancer Center (4) · Alliance for Clinical Trials in Oncology (3) · Cairo University (3)
What is being tested here
Drugs under test in Tongue Neoplasms studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Panitumumab | 1 | 1 | 2 |
| Ficerafusp alfa | 1 | 0 | 1 |
| IRDye800 | 1 | 0 | 1 |
| Cetuximab | 0 | 1 | 11 |
| Cisplatin | 0 | 1 | 9 |
| Docetaxel | 0 | 1 | 6 |
| Erlotinib | 0 | 0 | 5 |
| Paclitaxel | 0 | 0 | 4 |
| Everolimus | 0 | 0 | 4 |
| Carboplatin | 0 | 1 | 3 |
Drug classes tested here Tyrosine kinase inhibitors (TKIs) 15 · Antimitotic agents 11 · mTOR inhibitors 6 · Angiogenesis inhibitors 3
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 6
- Dec 2026Alpha Radiation Emitters Device for the Treatment of Cutaneous, Mucosal or Superficial Soft Tissue Neoplasia (DaRT) · Alpha Tau Medical LTD.
- Dec 2026Customized 3D Printed Oral Stents During Head and Neck Radiotherapy · M.D. Anderson Cancer Center
- Dec 2026Transoral Robotic Surgery in Treating Patients With Benign or Malignant Tumors of the Head and Neck · Ohio State University Comprehensive Cancer Center
- Jan 2027Alpha Radiation Emitters Device (DaRT) for the Treatment of Cutaneous, Mucosal or Superficial Soft Tissue Neoplasia · Alpha Tau Medical LTD.
- May 2027High-Resolution PET-CT Imaging for Surgical Margin Visualization · Vanderbilt-Ingram Cancer Center
- Sep 2027Surgeon-performed Ultrasound for Real-time Guidance In Oral Cancer Surgeries - A Multicenter Randomized Controlled Trial · Tobias Todsen
Who these studies take
Of the 11 Tongue Neoplasms studies recruiting now, 9 (82%) set no upper age limit and 1 (9%) stop at 75 or younger. 1 (9%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 1 (9%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 10 (91%) | 10 (91%) |
| 30 | 11 (100%) | 11 (100%) |
| 40 | 11 (100%) | 11 (100%) |
| 50 | 11 (100%) | 11 (100%) |
| 65 | 10 (91%) | 10 (91%) |
| 75 | 10 (91%) | 10 (91%) |
| 85 | 10 (91%) | 10 (91%) |
Across all 121 studies, recruiting or not: 12% stop at 75 or younger and 2% at 65; 9% take children; 0% are for women only and 0% for men only; 3% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
Studies
Recruiting first, then most recently updated. Showing 50 of 121. Browse all 121 → or search them.
- Ficerafusp Alfa, Pembrolizumab, and Stereotactic Body Radiotherapy (SBRT) for Head and Neck Squamous Cell Carcinoma (HNSCC)Not yet recruitingNCT07552558Phase 1/21 country
- Biomarkers in Patients With Respiratory Tract Dysplasia or Lung Cancer, Head and Neck Cancer, or Aerodigestive Tract Cancer and in Normal VolunteersRecruitingNCT009004191 country
- Window Trial of Fluorescently Labeled Panitumumab (Panitumumab-IRDye800) in Head and Neck CancerRecruitingNCT06819228Phase 11 country
- Normative Ranges of Lingual Strength and Endurance and the Impact of the IOPI Lingual Strength Trainer on Quantitative Functional Outcomes and Patient-Reported Outcomes After Partial Glossectomy or Hemiglossectomy for Oral Tongue Cancer, An Unblinded: Randomized Pilot StudyRecruitingNCT07124520Not applicable1 country
- Alpha Radiation Emitters Device (DaRT) for the Treatment of Cutaneous, Mucosal or Superficial Soft Tissue NeoplasiaRecruitingNCT04534127Not applicable1 country
- Surgeon-performed Ultrasound for Real-time Guidance In Oral Cancer Surgeries - A Multicenter Randomized Controlled TrialRecruitingNCT07203911Not applicable5 countries
- Prosthesis Guided Speech Rehabilitation of T1/T2 Cancers of the TongueRecruitingNCT02584270Not applicable1 country
- High-Resolution PET-CT Imaging for Surgical Margin VisualizationRecruitingNCT06915454Not applicable1 country
- Transoral Robotic Surgery in Treating Patients With Benign or Malignant Tumors of the Head and NeckRecruitingNCT01473784Not applicable1 country
- Alpha Radiation Emitters Device (DaRT) for the Treatment of Cutaneous, Mucosal or Superficial Soft Tissue Neoplasia.RecruitingNCT03889899Not applicable1 country
- Arabic PRO Measures for Head and Neck Cancer Radiotherapy.RecruitingNCT066629291 country
- Assessment of the Effect of Tumor Thickness and Site on Level IV Cervical Lymph Nodes in Squamous Cell Carcinoma of the Tongue and Floor of the Mouth: A Case Series StudyRecruitingNCT06169605Not applicable1 country
- Chemotherapy With or Without Bevacizumab in Treating Patients With Recurrent or Metastatic Head and Neck Squamous Cell CarcinomaActive, not recruitingNCT00588770Phase 33 countries
- Customized 3D Printed Oral Stents During Head and Neck RadiotherapyActive, not recruitingNCT04870762Phase 21 country
- Study of Blood and Tissue Samples From Patients With Larynx Cancer, Pharynx Cancer, or Oral Cavity CancerCompletedNCT009633261 country
- Submental Island Flap vs Radial Forearm Free Flap in Tongue ReconstructionCompletedNCT078196171 country
- Anterolateral Thigh Myofascial Fat Composite Flap for Reconstruction of Hemiglossectomy Defects in Obese Patients With Tongue CancerActive, not recruitingNCT076824671 country
- Reduced-Dose Intensity-Modulated Radiation Therapy With or Without Cisplatin in Treating Patients With Advanced Oropharyngeal CancerCompletedNCT02254278Phase 24 countries
- Alpha Radiation Emitters Device for the Treatment of Cutaneous, Mucosal or Superficial Soft Tissue Neoplasia (DaRT)Active, not recruitingNCT03737734Not applicable1 country
- Phase II Randomized Trial of the Combination of Cetuximab and Sorafenib or Single Agent CetuximabCompletedNCT00939627Phase 21 country
- Adjuvant Radiotherapy in Early Stage Oral CancersCompletedNCT03853655Not applicable1 country
- RT With or Without Cetuximab in Treating Patients Who Have Undergone Surgery for Locally Advanced Head and Neck CancerActive, not recruitingNCT00956007Phase 34 countries
- Alpha Radiation Emitters Device for the Treatment of Cutaneous, Mucosal and Superficial Soft Tissue Neoplasia (DaRT)TerminatedNCT03886181Not applicable1 country
- Retreatment With Intratumoral Diffusing Alpha Radiation EmittersCompletedNCT04540588Not applicable1 country
- Chemotherapy, Radiation Therapy, and Cetuximab in Treating Patients With the Head and Neck CancerCompletedNCT00875849Phase 21 country
- Study of Nutrition Regimens in Treating Patients With Cancer of the Upper Aerodigestive TractCompletedNCT00765440Phase 31 country
- Cetuximab and Combination Chemotherapy in Patients With Stage III-IV Resectable Oropharynx CancerCompletedNCT00665392Phase 21 country
- Use of ST250 to Reconstruct Lateral Tongue DefectsCompletedNCT069884491 country
- Clinical Study Evaluating the Proper Surgical Safety Margin for Early Stage Oral Tongue CancersTerminatedNCT04738786Not applicable1 country
- Circulating Tumor DNA in Predicting Outcomes in Patients With Stage IV Head and Neck Cancer or Stage III-IV Non-small Cell Lung CancerCompletedNCT022451001 country
- The Registry of Oncology Outcomes Associated with Testing and TreatmentCompletedNCT040284791 country
- Correlation of FAZA PET Hypoxia Imaging To 3D Histology in Oral Tongue CancerSuspendedNCT03181035Phase 1/21 country
- Paclitaxel Albumin-Stabilized Nanoparticle Formulation and Carboplatin Followed By Chemoradiation in Treating Patients With Recurrent Head and Neck CancerCompletedNCT01847326Phase 11 country
- Radiotherapy of Tongue Cancer Using an Intraoral StentCompletedNCT04337853Phase 11 country
- Study of A166 in Patients With Relapsed/Refractory Cancers Expressing HER2 Antigen or Having Amplified HER2 GeneCompletedNCT03602079Phase 1/21 country
- Induction Chemotherapy Followed By Cetuximab and Radiation in HPV-Associated Resectable Stage III/IV Oropharynx CancerCompletedNCT01084083Phase 21 country
- Everolimus, Erlotinib Hydrochloride, and Radiation Therapy in Treating Patients With Recurrent Head and Neck Cancer Previously Treated With Radiation TherapyWithdrawnNCT01332279Phase 11 country
- Surgical Margin Assessment by 3D UltrasoundStatus unknownNCT05740774Not applicable1 country
- Dose Escalation Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of QBS10072SCompletedNCT04430842Phase 11 country
- Hypofractionated Radiation Therapy Followed by Surgery in Treating Patients With Advanced Squamous Cell Carcinoma of the Oral CavityWithdrawnNCT02295540Not applicable1 country
- Effect of COX-2 and EGFR Suppression on Molecular Markers of Angiogenesis and Proliferation in Squamous Cell Carcinoma of Oral Cavity - Prospective Randomized StudyStatus unknownNCT02748707Phase 21 country
- Ultrasound in Tongue Cancer- a Help to Decide Depth of Invasion and to Improve the Surgical MarginCompletedNCT04059861Not applicable1 country
- Measuring Patient Satisfaction With Facial Appearance: Development and Validation of a New Patient-Reported Outcome MeasureCompletedNCT005300493 countries
- PI3K Inhibitor BKM120 and Cetuximab in Treating Patients With Recurrent or Metastatic Head and Neck CancerCompletedNCT01816984Phase 1/21 country
- Clinical Evaluation of the OncAlert RAPID in Subjects Presenting for Evaluation and/or Initial Biopsy; Impact on Decision-MakingCompletedNCT032398341 country
- GM-CSF Mouthwash for Preventing and Treating Mucositis in Patients Undergoing Radiation Therapy for Head and Neck CancerCompletedNCT00293462Phase 31 country
- Cetuximab and Radiation Therapy in Treating Patients With Stage III-IV Head and Neck CancerTerminatedNCT02177838Not applicable1 country
- Radio/Pathological Evaluation of Tongue Cancer InfiltrationStatus unknownNCT048211281 country
- Oral Stent Device for Radiation Treatments of Oral CancersWithdrawnNCT040411411 country
- FDG-PET/CT in Assessing the Tumor and Planning Neck Surgery in Patients With Newly Diagnosed H&N CancerStatus unknownNCT00983697Not applicable2 countries