Mitral Valve Stenosis clinical trials
The registry lists 61 studies for Mitral Valve Stenosis across more than 10 countries. 21 are recruiting or about to start. 24 of them are mainly about Mitral Valve Stenosis (how this is decided). Per ClinicalTrials.gov, last updated 2026-09-16.
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Who runs them
Assiut University (4) · National Heart, Lung, and Blood Institute (NHLBI) (3) · Edwards Lifesciences (3) · Konkuk University Medical Center (3) · Abbott Medical Devices (3) · Foldax, Inc (2) · French Cardiology Society (2) · Asan Medical Center (2)
What is being tested here
Drugs under test in Mitral Valve Stenosis studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Hydroxyethyl Starch Derivatives | 1 | 0 | 2 |
| Edoxaban | 1 | 0 | 1 |
| Dabigatran | 0 | 0 | 2 |
| Ivabradine | 0 | 1 | 2 |
| Rivaroxaban | 0 | 1 | 2 |
| Dapagliflozin | 0 | 1 | 1 |
| Vitamin K 2 | 0 | 0 | 1 |
| Ramipril | 0 | 1 | 1 |
| Warfarin | 0 | 0 | 1 |
| Bosentan | 0 | 0 | 1 |
Drug classes tested here Factor Xa inhibitors 1 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 3
- Dec 2026Management and Clinical Outcomes of Patients With Severe Mitral Valve Disease Not Suitable for Surgery · French Cardiology Society
- Dec 2026The MITRAL II Pivotal Trial (Mitral Implantation of TRAnscatheter vaLves). · Mayra Guerrero
- Nov 2027The Feasibility Study of Polymer Artificial Heart Valve for the Treatment the Mitral Valve Disease. · Shanghai HeartEpoch Medical Technology Co., Ltd
Who these studies take
Of the 16 Mitral Valve Stenosis studies recruiting now, 11 (69%) set no upper age limit and 0 (0%) stop at 75 or younger. 0 (0%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 1 (6%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 13 (81%) | 13 (81%) |
| 30 | 14 (88%) | 14 (88%) |
| 40 | 14 (88%) | 14 (88%) |
| 50 | 15 (94%) | 15 (94%) |
| 65 | 16 (100%) | 16 (100%) |
| 75 | 16 (100%) | 16 (100%) |
| 85 | 13 (81%) | 13 (81%) |
Across all 61 studies, recruiting or not: 30% stop at 75 or younger and 20% at 65; 18% take children; 0% are for women only and 2% for men only; 10% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
Studies
Recruiting first, then most recently updated. Showing 50 of 61. Browse all 61 → or search them.
- Treating Severe Mitral Valve Annular or Valvular Calcification Using Shockwave Balloon SMARTWAVERecruitingNCT06952374Not applicable1 country
- Abbott Cephea Mitral Valve Disease RegistryRecruitingNCT070696731 country
- Assessment of Exercise Capacity, Muscle Oxygenation and Aortic Stiffness in Patients With Mitral StenosisRecruitingNCT073949981 country
- The Feasibility Study of Polymer Artificial Heart Valve for the Treatment the Mitral Valve Disease.RecruitingNCT07243184Not applicable1 country
- Management and Clinical Outcomes of Patients With Severe Mitral Valve Disease Not Suitable for SurgeryRecruitingNCT029258191 country
- The MITRAL II Pivotal Trial (Mitral Implantation of TRAnscatheter vaLves).RecruitingNCT04408430Not applicable2 countries
- ALLIANCE Mitral: Safety and Effectiveness of SAPIEN X4 Transcatheter Heart Valve - MitralNot yet recruitingNCT06167213Not applicable
- Cohort Observing Mechanisms, Progression and Sequelae of Valvular Heart DiseaseRecruitingNCT072671171 country
- Prospective Multicenter Registry of Patients With Mitral Stenosis Undergoing Percutaneous Mitral Balloon CommissurotomyRecruitingNCT071755321 country
- Early Feasibility Study of Surgical Implantation of a Polymer Prosthetic Mitral and Aortic ValveRecruitingNCT07097740Not applicable1 country
- Influence of Lung Ultrasonography on the Prognosis and Postoperative Outcomes in Cardiac Surgical PatientsRecruitingNCT06377449Not applicable1 country
- Mild ANH on Pre-bypass Coagulation Function During Cardiac SurgeryNot yet recruitingNCT06664320Not applicable1 country
- European Association of Cardiovascular Imaging Multiple and Mixed Valvular Disease StudyRecruitingNCT062353851 country
- Rate Control Efficacy in Atrial Fibrillation With Rheumatic Mitral Stenosis: Lenient vs Strict Rate Control StrategiesRecruitingNCT06409533Not applicable1 country
- Impact of Percutaneous Transvenous Mitral Commissurotomy on The Left Atrial Appendage Function in Patients With Mitral Stenosis.Not yet recruitingNCT06340997Not applicable
- Ventricular-arterial Coupling of the Heart Among Patients With Mitral Stenosis Undergoing Percutaneous Trans-luminal Mitral Commissurotomy. Cardiac Magnetic Resonance StudyNot yet recruitingNCT06054568
- Assessment of Right Ventricular Function in Patients With Severe Mitral Stenosis Before and After Balloon Mitral ValvuloplastyNot yet recruitingNCT06067815
- The China Mviv RegistryRecruitingNCT05925335Not applicable1 country
- Polish Transcatheter Transfemoral Mitral Valve-in-Valve Implantation (Mitral ViV) RegistryRecruitingNCT056256071 country
- Efficacy and Safety of Edoxaban in Patients With Atrial Fibrillation and Mitral StenosisRecruitingNCT05540587Phase 21 country
- The Prospecive OBSERVational Munich Interventional MITRAl-Valve RegistryRecruitingNCT045772481 country
- Cephea South America Feasibility StudyActive, not recruitingNCT07244939Not applicable2 countries
- Real-world Clinical Outcomes of the MITRIS RESILIA Mitral ValveActive, not recruitingNCT055265604 countries
- ProspeCtive, nOn-randoMized, MulticENter Clinical Evaluation of Edwards Pericardial Bioprostheses With a New Tissue Treatment Platform (COMMENCE)CompletedNCT01757665Not applicable3 countries
- Dabigatran for Mitral Stenosis Atrial FibrillationActive, not recruitingNCT04045093Phase 41 country
- Early Percutaneous Mitral Intervention in Asymptomatic Moderate Mitral StenosisActive, not recruitingNCT01406353Not applicable1 country
- Aortic or Mitral Valve Replacement With the Braile Biomédica® Bovine Pericardium Valvular BioprosthesisCompletedNCT059028971 country
- Surgical Implantation of TRAnscatheter vaLve in Native Mitral Annular Calcification (SITRAL) StudyCompletedNCT02830204Not applicable1 country
- Role of Ivabradine on Heart Rate and Quality of Life in Patients With Mitral Stenosis in Sinus RhythmCompletedNCT06371222Phase 41 country
- Clinical Investigation for the Foldax Tria Mitral Valve- IndiaActive, not recruitingNCT06191718Not applicable1 country
- Early Feasibility Study for the Foldax TRIA Mitral Heart Valve ReplacementActive, not recruitingNCT04717570Not applicable1 country
- NHLBI DIR LAMPOON Study: Intentional Laceration of the Anterior Mitral Leaflet to Prevent Left Ventricular Outflow Tract Obstruction During Transcatheter Mitral Valve ImplantationCompletedNCT03015194Not applicable1 country
- Dapagliflozin Effect on Rheumatic Mitral StenosisStatus unknownNCT05618223Phase 31 country
- French National Observatory of Percutaneous Mitral CommissurotomyCompletedNCT027832481 country
- Neurologic Outcome After Mitral Valve SurgeryWithdrawnNCT037980151 country
- Epidemiology and Long-term Outcome of Patients With VHDCompletedNCT045273671 country
- Left Atrial Appendage (LAA) Clot With Severe Mitral StenosisStatus unknownNCT051866491 country
- Non-invasive Characterization of the Mechanisms of Atrial Fibrillation MaintenanceCompletedNCT024972481 country
- SLOW-Slower Progress of caLcificatiOn With Vitamin K2Status unknownNCT04429035Not applicable1 country
- RIvoraxaban in Mitral StenosisTerminatedNCT03926156Phase 31 country
- The Effect of Ramipril in Suppressing ST2 Expression in Rheumatic Mitral Stenosis PatientsStatus unknownNCT03991910Phase 31 country
- Three Dimensional Versus Two Dimensional Echocardiography in Assessment of Severity and Scoring of Rheumatic Mitral Stenosis.Status unknownNCT04968431
- Acute Normovolemic Hemodilution on ROTEM in Cardiac SurgeryCompletedNCT02502448Not applicable1 country
- Late Clinical Outcomes of Percutaneous Mitral Commissurotomy in Patients With Mitral StenosisCompletedNCT041121081 country
- Post-Approval Study for the MOSAIC® BioprosthesesCompletedNCT015746251 country
- Aortic or Mitral Valve Replacement With the Biocor and Biocor SupraCompletedNCT00636987Not applicable1 country
- Efficacy and Safety of Rivaroxiban Compare With Vitamin K Antagonist WarfarinWithdrawnNCT03673605Phase 41 country
- Physical and Functional Recovery From Cardiac Surgery in Hospitalized Patients: A Feasibility Pilot StudyCompletedNCT02375282Not applicable1 country
- Dabigatran in Patients With Atrial Fibrillation and Mitral Biological ProsthesesStatus unknownNCT03183843Phase 41 country
- Surgical Ablation Versus No Surgical Ablation for Patients With Atrial Fibrillation Undergoing Mitral Valve SurgeryCompletedNCT00903370Phase 22 countries