Hoffmann-La Roche: Macular Edema trials

The registry lists 28 Macular Edema studies with Hoffmann-La Roche as lead sponsor. 1 are open to participants now and 17 have results posted.

Phase 1 4Phase 2 5Phase 3 14Phase 4 2No phase 4(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• A Study to Evaluate the Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of RO7823653 in Participants With Diabetic Macular Edema (DME)RecruitingNCT07425522Phase 1
• A Study in Patients With Neovascular Age-Related Macular Degeneration or Diabetic Macular Edema to Evaluate the Safety of the Faricimab Prefilled SyringeCompletedNCT05569148Phase 3Results posted
• A Study to Investigate Vamikibart (RO7200220) in Combination With Ranibizumab in Diabetic Macular EdemaCompletedNCT05151744Phase 2Results posted
• A Study to Investigate Vamikibart (RO7200220) in Diabetic Macular EdemaCompletedNCT05151731Phase 2Results posted
• A Study to Evaluate the Efficacy and Safety of Faricimab in Participants With Macular Edema Secondary to Central Retinal or Hemiretinal Vein OcclusionCompletedNCT04740931Phase 3Results posted
• A Study to Evaluate the Efficacy and Safety of Faricimab in Participants With Macular Edema Secondary to Branch Retinal Vein OcclusionCompletedNCT04740905Phase 3Results posted
• A Study to Investigate Aqueous Humor and Multimodal Imaging Biomarkers in Treatment-Naïve Participants With Diabetic Macular Edema Treated With FaricimabCompletedNCT04597918Phase 2Results posted
• A Study to Evaluate the Long-Term Safety and Tolerability of Faricimab in Participants With Diabetic Macular EdemaCompletedNCT04432831Phase 3Results posted
• A Study to Evaluate the Efficacy and Safety of Faricimab (RO6867461) in Participants With Diabetic Macular EdemaCompletedNCT03622593Phase 3Results posted
• A Study to Evaluate the Efficacy and Safety of Faricimab (RO6867461) in Participants With Diabetic Macular Edema (YOSEMITE)CompletedNCT03622580Phase 3Results posted
• A Study of Faricimab (RO6867461) in Participants With Center-Involving Diabetic Macular EdemaCompletedNCT02699450Phase 2Results posted
• A Study in Patients With Neovascular Age Related Macular Degeneration or Macular Edema Secondary To Retinal Vein Occlusion to Evaluate Usability of the Ranibizumab (Lucentis®) Prefilled Syringe (PFS)CompletedNCT02698566Phase 3Results posted
• An Extension Study to Evaluate Safety and Tolerability of Ranibizumab in Macular Edema Secondary to Retinal Vein Occlusion (Cohort 2)CompletedNCT01442064Not applicableResults posted
• A Study Evaluating Dosing Regimens for Treatment With Intravitreal Ranibizumab Injections in Subjects With Macular Edema Following Retinal Vein OcclusionCompletedNCT01277302Phase 4Results posted
• A Study of the Efficacy and Safety of Ranibizumab Injection in Patients With Macular Edema Secondary to Branch Retinal Vein Occlusion (BRAVO)CompletedNCT00486018Phase 3Results posted
• A Study of the Efficacy and Safety of Ranibizumab Injection in Patients With Macular Edema Secondary to Central Retinal Vein Occlusion (CRUISE)CompletedNCT00485836Phase 3Results posted
• A Study of Ranibizumab Injection in Subjects With Clinically Significant Macular Edema (ME) With Center Involvement Secondary to Diabetes Mellitus (RIDE)CompletedNCT00473382Phase 3Results posted
• A Study of Ranibizumab Injection in Subjects With Clinically Significant Macular Edema (ME) With Center Involvement Secondary to Diabetes Mellitus (RISE)CompletedNCT00473330Phase 3Results posted
• A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of RO7446603 Administered Alone or in Combination With Aflibercept or Faricimab in Participants With Diabetic Macular EdemaCompletedNCT06850922Phase 1/2
• A Study to Investigate the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of RO7497372 in Participants With Diabetic Macular Edema (DME)Active, not recruitingNCT06847854Phase 1
• A Study to Investigate RO7200220 as Monotherapy and in Combination With Ranibizumab in Participants With Diabetic and Uveitic Macular EdemaCompletedNCT06771271Phase 1
• A Study Conducted to Evaluate the Conjunctiva and Tenon's Capsule Status of Healthy Subjects and in Participants With Neovascular Age-related Macular Degeneration (nAMD)/Diabetic Macular Edema (DME)CompletedNCT06723288
• A Real-World Study to Gain Clinical Insights Into Faricimab (FaReal Study)Active, not recruitingNCT06680817
• Vamikibart in Participants With Uveitic Macular EdemaCompletedNCT05642325Phase 3
• A Study to Investigate Vamikibart in Participants With Uveitic Macular EdemaCompletedNCT05642312Phase 3
• A Study to Investigate Faricimab Treatment Response in Treatment-Naive, Underrepresented Patients With Diabetic Macular EdemaActive, not recruitingNCT05224102Phase 4
• A Study to Evaluate Efficacy, Safety & Pharmacokinetics of the Port Delivery System (PDS) With Ranibizumab in Participants With Diabetic Macular Edema (DME) Compared With Intravitreal Ranibizumab; A Substudy to Evaluate the Safety of Re-implanting the PDS With Ranibizumab in Participants With DMEActive, not recruitingNCT04108156Phase 3
• Study to Evaluate Home Vision Testing in Participants Who Receive Ranibizumab (Lucentis®)CompletedNCT02420132