Leukoplakia clinical trials
The registry lists 21 studies for Leukoplakia across more than 10 countries. 7 are recruiting or about to start. 10 of them are mainly about Leukoplakia (how this is decided). Per ClinicalTrials.gov, last updated 2026-08-20. Counting its narrower condition Leukoplakia, Oral too: 66 studies, 18 open.
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Who runs them
National Cancer Institute (NCI) (2) · Proteocyte Diagnostics Inc. (2) · Beni-Suef University (1) · Association for the Japanese Academy of Maxillofacial Implants (1) · Cairo University (1) · Medical University of Vienna (1) · University of Wisconsin, Madison (1) · Istituto Italiano di Tecnologia (1)
What is being tested here
Drugs under test in Leukoplakia studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Pembrolizumab | 1 | 0 | 1 |
| Imiquimod | 1 | 0 | 1 |
| Aminolevulinic Acid | 0 | 0 | 1 |
| Metformin | 0 | 0 | 1 |
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 2
- Aug 2027Pembrolizumab in Treating Participants With Leukoplakia · Jonsson Comprehensive Cancer Center
- Oct 2027Topical Imiquimod Treatment of Oral Dysplasia · University of Southern California
Who these studies take
Of the 6 Leukoplakia studies recruiting now, 5 (83%) set no upper age limit and 0 (0%) stop at 75 or younger. 2 (33%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 2 (33%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 1 (17%) | 1 (17%) |
| 18 | 6 (100%) | 6 (100%) |
| 30 | 6 (100%) | 6 (100%) |
| 40 | 6 (100%) | 6 (100%) |
| 50 | 6 (100%) | 6 (100%) |
| 65 | 6 (100%) | 6 (100%) |
| 75 | 6 (100%) | 6 (100%) |
| 85 | 6 (100%) | 6 (100%) |
Across all 21 studies, recruiting or not: 5% stop at 75 or younger and 0% at 65; 19% take children; 5% are for women only and 0% for men only; 14% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
Studies
Recruiting first, then most recently updated. Showing 21 of 21. search them.
- Pembrolizumab in Treating Participants With LeukoplakiaRecruitingNCT03603223Phase 21 country
- AI-Assisted Endoscopy for Upper Aerodigestive Tract LesionsNot yet recruitingNCT075963553 countries
- Topical Imiquimod Treatment of Oral DysplasiaRecruitingNCT07210775Phase 1/21 country
- Early Prediction of Oral Cancer by S100A7 Immunohistochemistry Signature-based AssessmentRecruitingNCT046224621 country
- Evaluation of Oral Potentially Malignant Disorders (OPMDs) with STRATICYTE™RecruitingNCT058537831 country
- Oral Cancer Screening for Early Detection of Premalignant Disorders (PMOD)RecruitingNCT05296941Not applicable1 country
- International Pachyonychia Congenita Research RegistryRecruitingNCT023214231 country
- Vitamin A Status in Patients With Vocal Fold LeukoplakiaActive, not recruitingNCT053232921 country
- Biomarkers for Oral CancerCompletedNCT003414971 country
- Artificial Intelligence Based Program to Classify Oral Cavity Findings Based on Clinical Image AnalysisCompletedNCT063255141 country
- Metformin for the Prevention of Oral Cancer in Patients With Oral Premalignant LesionsTerminatedNCT05536037Phase 11 country
- The CO2RE® System for Vulvar Lichen SclerosusCompletedNCT04148651Not applicable1 country
- Malondialdehyde and Nitrous Oxide as Salivary Biomarkers for Different Oral LesionsCompletedNCT042674191 country
- Photodynamic Therapy With Metil 5-aminolevulinate for Actinic Cheilitis - Phase 2 Clinical TrialStatus unknownNCT03990636Phase 2
- Natural History of Oro-pharyngeal Cancer PrecursorsCompletedNCT001793611 country
- Comparison Between Two Different High Power Ablative Lasers in the Treatment of Oral LeukoplakiaCompletedNCT03233165Not applicable
- Photodynamic Therapy for Oral Precursor LesionsCompletedNCT01497951Phase 31 country
- Tobacco Cessation Intervention Study for Oral DiseasesStatus unknownNCT02737176Not applicable1 country
- Treatment of Oral Premalignant Lesions With 5-ALA PDTCompletedNCT00571974Phase 1/21 country
- Photodynamic Therapy for Oral Leukoplakia and ErythroleukoplakiaCompletedNCT00155337Phase 41 country
- Randomized, Double Blind, Placebo-Controlled, Phase IIB Trial of Ketorolac Mouth Rinse Evaluating the Effect of Cyclooxygenase Inhibition on Oropharyngeal Leukoplakia: Collaborative Study of the NCI, NIDCD and the NIDCRCompletedNCT00001698Phase 21 country