Leukoencephalopathies clinical trials

The registry lists 39 studies for Leukoencephalopathies across more than 10 countries. 16 are recruiting or about to start. 21 of them are mainly about Leukoencephalopathies (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-06. Counting its 13 narrower conditions too, such as Multiple Sclerosis: 4,184 studies, 859 open.

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Status

Recruiting: 15
Completed: 10
Terminated: 5
Active, not recruiting: 4
Status unknown: 2
No longer available: 1

Phase

Phase 2: 5
Phase 1: 4
Early Phase 1: 2

Where

United States: 20
Netherlands: 7
Canada: 5
Italy: 5
Germany: 4
France: 4

Who runs them

Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta (2) · Aspa Therapeutics (2) · SwanBio Therapeutics, Inc. (2) · IRCCS Eugenio Medea (2) · Children's Hospital of Philadelphia (2) · McGill University Health Centre/Research Institute of the McGill University Health Centre (2) · Vigil Neuroscience, Inc. (2) · Fondation Ophtalmologique Adolphe de Rothschild (1)

Coming up

0phase 3 studies under way

5studies finish main data collection within a year

Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.

All 5

Dec 2026Natural History and Genotype-Phenotype Correlations in Mitochondrial Leukoencephalopathies · Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Dec 2026North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC) · Columbia University
Dec 2026Natural History Study of Patients with HPDL Mutations · University of California, San Diego
Nov 2027An Open-Label Exploratory Study of Fosigotifator in Participants With Vanishing White Matter Disease · Calico Life Sciences LLC
Nov 2027Research Study for Single-Patient Treatment of Cree Leukoencephalopathy/Vanishing White Matter Disease · McGill University Health Centre/Research Institute of the McGill University Health Centre

Who these studies take

Of the 15 Leukoencephalopathies studies recruiting now, 11 (73%) set no upper age limit and 3 (20%) stop at 75 or younger. 11 (73%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 3 (20%) take healthy volunteers.

Recruiting studies that take each age, of 15
Age	Women	Men
10	9 (60%)	9 (60%)
18	12 (80%)	12 (80%)
30	13 (87%)	13 (87%)
40	13 (87%)	13 (87%)
50	13 (87%)	13 (87%)
65	13 (87%)	13 (87%)
75	13 (87%)	13 (87%)
85	11 (73%)	11 (73%)

Across all 39 studies, recruiting or not: 23% stop at 75 or younger and 15% at 65; 56% take children; 0% are for women only and 5% for men only; 23% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.

Studies

Recruiting first, then most recently updated. Showing 39 of 39. search them.